PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29304496-8	2018	Furthermore, shikonin also strongly decreased the levels of activated caspase-3, Bax and p-GSK-3beta while increased the p-AKT level.	shikonin	13-21	caspase 3	Rattus norvegicus	70-79	
29311595-6	2018	Furthermore, shikonin has the ability to reduce proapoptotic signaling by reducing the activity of caspase-3 and moderating the ratio of Bcl-2/Bax.	shikonin	13-21	caspase 3	Rattus norvegicus	99-108	
27703516-8	2016	Shikonin administration attenuated the changes in caspase-3 activity and COX-2 expression and Akt phosphorylation in rats with osteoarthritis.	shikonin	0-8	caspase 3	Rattus norvegicus	50-59	
25755716-10	2015	Shikonin pretreatment also decreased the activity of IL-1beta that decreased Bcl-2 expression and levels of p-PI3K and p-Akt, and increased Bax expression, cytochrome c release, and caspase-3 activation.	shikonin	0-8	caspase 3	Rattus norvegicus	182-191	
25755716-12	2015	These data suggested that shikonin may protect chondrocytes from apoptosis induced by IL-1beta through the PI3K/Akt signaling pathway, by deactivating caspase-3.	shikonin	26-34	caspase 3	Rattus norvegicus	151-160