PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34482636-5 2022 Neratinib increased expression of Beclin1, ATG5, CD95, and FAS-L and decreased levels of multiple toxic BH3 domain proteins, MCL1, BCL-XL, FLIP-s, and ERBB1/2/4. neratinib 0-9 autophagy related 5 Homo sapiens 43-47 29163826-6 2017 Knock down of Beclin1 or ATG5 prevented HDAC inhibitors or neratinib from reducing ERBB1/3/4 and K-/N-RAS expression and reduced [neratinib + HDAC inhibitor] lethality. neratinib 59-68 autophagy related 5 Homo sapiens 25-29 29163826-6 2017 Knock down of Beclin1 or ATG5 prevented HDAC inhibitors or neratinib from reducing ERBB1/3/4 and K-/N-RAS expression and reduced [neratinib + HDAC inhibitor] lethality. neratinib 130-139 autophagy related 5 Homo sapiens 25-29 29219657-0 2018 The levels of mutant K-RAS and mutant N-RAS are rapidly reduced in a Beclin1 / ATG5 -dependent fashion by the irreversible ERBB1/2/4 inhibitor neratinib. neratinib 143-152 autophagy related 5 Homo sapiens 79-83 29219657-4 2018 Knock down of Beclin1 or of ATG5 prevented neratinib and neratinib combined with sodium valproate / AR42 from reducing the expression of mutant N-RAS in established PDX and fresh PDX models of ovarian cancer and melanoma, respectively. neratinib 43-52 autophagy related 5 Homo sapiens 28-32 29219657-4 2018 Knock down of Beclin1 or of ATG5 prevented neratinib and neratinib combined with sodium valproate / AR42 from reducing the expression of mutant N-RAS in established PDX and fresh PDX models of ovarian cancer and melanoma, respectively. neratinib 57-66 autophagy related 5 Homo sapiens 28-32