PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25151749-1	2014	Lanosterol synthase is encoded by the erg7 gene and catalyzes the cyclization of 2, 3-oxidosqualene, which is a rate-limiting step of the inherent mevalonate (MVA)/ergosterol metabolic pathway in Saccharomyces cerevisiae.	Ergosterol	164-174	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	38-42	
19686341-4	2009	The results of DNA microarray and quantitative reverse transcriptase-polymerase chain reaction analysis showed that five genes involved in ergosterol biosynthesis (ERG28, HMG1, MCR1, ERG5, and ERG7) were upregulated in NBRC 1950 compared with strain X2180, suggesting that high expression of genes involved in ergosterol biosynthesis may cause high ergosterol content in strain NBRC 1950.	Ergosterol	139-149	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	193-197	
23022663-0	2013	Characterization of a mutation that results in independence of oxidosqualene cyclase (Erg7) activity from the downstream 3-ketoreductase (Erg27) in the yeast ergosterol biosynthetic pathway.	Ergosterol	158-168	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	86-90	
23022663-5	2013	This strain which was crossed to a wildtype and daughter segregants showed an accumulation of squalene epoxides as well as ergosterol indicating that the mutation entailed a leaky block at ERG7.	Ergosterol	123-133	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	189-193	
23022663-11	2013	These results indicate retention of Erg7p in the ER increases its activity and suggest a novel method of regulation of ergosterol biosynthesis.	Ergosterol	119-129	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	36-41	
19879375-1	2010	In Saccharomyces cerevisiae and Candida albicans, two enzymes of the ergosterol biosynthetic pathway, oxidosqualene cyclase (Erg7p) and 3-keto reductase (Erg27p) interact such that loss of the 3-keto reductase also results in a concomitant loss of activity of the upstream oxidosqualene cyclase.	Ergosterol	69-79	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	125-130	
19879375-7	2010	Following incubation with radiolabeled and non-radiolabeled 3-ketosteroids we detected differences in hydroxysteroid accumulation and ergosterol production between wild-type and ERG7 mutant strains.	Ergosterol	134-144	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	178-182	
19686341-4	2009	The results of DNA microarray and quantitative reverse transcriptase-polymerase chain reaction analysis showed that five genes involved in ergosterol biosynthesis (ERG28, HMG1, MCR1, ERG5, and ERG7) were upregulated in NBRC 1950 compared with strain X2180, suggesting that high expression of genes involved in ergosterol biosynthesis may cause high ergosterol content in strain NBRC 1950.	Ergosterol	310-320	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	193-197	
19686341-4	2009	The results of DNA microarray and quantitative reverse transcriptase-polymerase chain reaction analysis showed that five genes involved in ergosterol biosynthesis (ERG28, HMG1, MCR1, ERG5, and ERG7) were upregulated in NBRC 1950 compared with strain X2180, suggesting that high expression of genes involved in ergosterol biosynthesis may cause high ergosterol content in strain NBRC 1950.	Ergosterol	310-320	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	193-197	
12842197-3	2003	In a previous study, we found that erg27 strains grown on cholesterol- or ergosterol-supplemented media did not accumulate lanosterol or 3-ketosterols but rather squalene, oxidosqualene, and dioxidosqualene intermediates normally observed in ERG7 (oxidosqualene cyclase) mutants.	Ergosterol	74-84	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	242-246	
18555807-0	2008	Genetic analyses involving interactions between the ergosterol biosynthetic enzymes, lanosterol synthase (Erg7p) and 3-ketoreductase (Erg27p), in the yeast Saccharomyces cerevisiae.	Ergosterol	52-62	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	106-111	
2185141-8	1990	The level of OSC produced from expression of a single copy of the Candida ERG7 sequence was sufficient to allow growth of the S. cerevisiae erg7 mutants in the absence of exogenous ergosterol.	Ergosterol	181-191	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	74-78