PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8649379-4	1996	Cells growing anaerobically on ergosterol-containing medium are not sensitive to SR. Disruption of the sterol isomerase-encoding gene is lethal in cells growing in the absence of exogenous ergosterol, except in SR-resistant mutants lacking either the SUR4 or the FEN1 gene product.	Ergosterol	31-41	multifunctional nuclease RAD27	Saccharomyces cerevisiae S288C	263-267	
8649379-5	1996	The results suggest that sterol isomerase is the target of SR 31747 and that both the SUR4 and FEN1 gene products are required to mediate the proliferation arrest induced by ergosterol depletion.	Ergosterol	174-184	multifunctional nuclease RAD27	Saccharomyces cerevisiae S288C	95-99	
7548216-6	1995	Mutants for SUR4 and FEN1 have the same pleiotropic phenotype, including bud localization defects, resistance to an immunosuppressor and resistance to ergosterol biosynthesis inhibitors.	Ergosterol	151-161	multifunctional nuclease RAD27	Saccharomyces cerevisiae S288C	21-25	
8246690-2	1993	Among the mutants isolated, one bearing the recessive fen1-1 mutation was characterized by a 1.5-fold increase in the ergosterol level and a general resistance to sterol biosynthesis inhibitors.	Ergosterol	118-128	multifunctional nuclease RAD27	Saccharomyces cerevisiae S288C	54-58	
8246690-6	1993	The fen1-1 mutation permits viability in aerobiosis of yeast disrupted for sterol-14 reductase in absence of exogenous ergosterol supplementation, whereas the corresponding strain bearing the wild type FEN1 allele grows only in anaerobiosis.	Ergosterol	119-129	multifunctional nuclease RAD27	Saccharomyces cerevisiae S288C	4-8	
8246690-7	1993	This result shows that ignosterol is able to efficiently replace ergosterol as bulk membrane component and that the fen1-1 mutation eliminates the specific ergosterol requirement in yeast.	Ergosterol	156-166	multifunctional nuclease RAD27	Saccharomyces cerevisiae S288C	116-120