PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34011234-2 2021 The mechanism of action of the drug consisting in inhibits sterol 14alpha-demethylase which interferes with ergosterol biosynthesis. Ergosterol 108-118 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 59-85 3288361-4 1988 The oxidative metabolism of lanosterol, that is included in the biosynthetic pathway of ergosterol, is one of the important functions of the microsomal electron transport system, which is catalyzed by P450(14DM). Ergosterol 88-98 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 201-210 33374996-1 2020 The fungal cytochrome P450 enzyme sterol 14alpha-demethylase (SDM) is a key enzyme in the ergosterol biosynthesis pathway. Ergosterol 90-100 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 34-60 33183866-7 2021 Preliminary mechanism study has proved these target compounds can block the biosynthesis of ergosterol by inhibiting the activity of dual targets (SE, CYP51). Ergosterol 92-102 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 151-156 32220664-2 2020 Ergosterol is an important structural component of the fungal cell membrane, its synthetases (squalene epoxidase (SE) and 14alpha-demethylase (CYP51)) are considered as the key points to block the ergosterol synthesis. Ergosterol 0-10 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 143-148 32791399-2 2020 The squalenee epoxidase (SE) and 14-demethylase (CYP51) are the important rate-limiting enzymes for ergosterol synthesis. Ergosterol 100-110 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 49-54 32220664-2 2020 Ergosterol is an important structural component of the fungal cell membrane, its synthetases (squalene epoxidase (SE) and 14alpha-demethylase (CYP51)) are considered as the key points to block the ergosterol synthesis. Ergosterol 197-207 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 143-148 31062656-2 2020 The target of triazoles is the product of the ERG11 gene, the cytochrome P450 sterol 14alpha-demethylase (CYP51), which is part of the ergosterol biosynthetic pathway. Ergosterol 135-145 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 62-104 31062656-2 2020 The target of triazoles is the product of the ERG11 gene, the cytochrome P450 sterol 14alpha-demethylase (CYP51), which is part of the ergosterol biosynthetic pathway. Ergosterol 135-145 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 106-111 31200551-2 2019 The azole drug fluconazole, used in the treatment of diseases caused by some species of Tremellomycetes, inhibits cytochrome P450 monooxygenase CYP51, an enzyme that converts lanosterol into an essential component of the fungal cell membrane ergosterol. Ergosterol 242-252 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 144-149 30076924-3 2018 Coruscanone A analogues, natural derivatives which target the fungal lanosterol enzyme, were docked against lanosterol 14 alpha-demethylase (CYP51A1) that converts lanosterol to 4,4-dimethylcholesta-8,14,24-trien-3beta-ol in the ergosterol biosynthesis pathway in order to stabilize the plasma membrane of the fungal species, and hence can be targeted for an effective antifungal therapy. Ergosterol 229-239 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 108-139 30524481-4 2018 The action mechanism of main antifungal compound was investigated by molecular docking using the enzyme sterol 14-alpha demethylase, CYP51, required for ergosterol biosynthesis. Ergosterol 153-163 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 104-131 30524481-4 2018 The action mechanism of main antifungal compound was investigated by molecular docking using the enzyme sterol 14-alpha demethylase, CYP51, required for ergosterol biosynthesis. Ergosterol 153-163 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 133-138 30126959-6 2018 Overexpression of LDM or Ncp1 modified the ergosterol content of yeast and affected growth inhibition by the polyene antibiotic amphotericin B. Ergosterol 43-53 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 18-21 30076924-3 2018 Coruscanone A analogues, natural derivatives which target the fungal lanosterol enzyme, were docked against lanosterol 14 alpha-demethylase (CYP51A1) that converts lanosterol to 4,4-dimethylcholesta-8,14,24-trien-3beta-ol in the ergosterol biosynthesis pathway in order to stabilize the plasma membrane of the fungal species, and hence can be targeted for an effective antifungal therapy. Ergosterol 229-239 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 141-148 27907120-1 2016 Azole antifungals, known as demethylase inhibitors (DMIs), target sterol 14alpha-demethylase (CYP51) in the ergosterol biosynthetic pathway of fungal pathogens of both plants and humans. Ergosterol 108-118 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 66-92 28395217-7 2017 Finally, we demonstrated with our best derivative that the mechanism of action of our compounds is the inhibition of the sterol 14alpha-demethylase enzyme involved in ergosterol biosynthesis. Ergosterol 167-177 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 121-147 30663547-2 2018 Posaconazole is an orally administered second-generation triazole antifungal agent which inhibits lanosterol 14-alpha-demethylase, an enzyme that converts lanosterol to ergosterol, a vital component of the fungal cell membrane. Ergosterol 169-179 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 98-129 27859799-3 2016 Resistance to the commonly used azole fungicides is thought to be driven mainly by mutations in a gene (CYP51) encoding a protein of the ergosterol biosynthesis pathway. Ergosterol 137-147 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 104-109 27907120-1 2016 Azole antifungals, known as demethylase inhibitors (DMIs), target sterol 14alpha-demethylase (CYP51) in the ergosterol biosynthetic pathway of fungal pathogens of both plants and humans. Ergosterol 108-118 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 94-99 19835945-1 2010 Azoles target the ergosterol synthesizing enzyme lanosterol 14alpha-demethylase and are a widely applied class of antifungal agents. Ergosterol 18-28 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 49-79 26082652-2 2015 It inhibits fungal lanosterol 14alpha-demethylase in the ergosterol biosynthesis pathway, has potent antifungal activity against dermatophytes, as well as activity against Candida spp. Ergosterol 57-67 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 19-49 27161631-6 2016 Finally, the cellular mode of action for VT-1129 was confirmed to be CYP51 inhibition, resulting in the depletion of ergosterol and ergosta-7-enol and the accumulation of eburicol, obtusifolione, and lanosterol/obtusifoliol in the cell membranes. Ergosterol 117-127 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 69-74 23638723-1 2013 Sterol 14alpha-demethylase (CYP51) is a cytochrome P450 heme thiolate containing enzyme involved in biosynthesis of membrane sterols, including sterol in animals, ergosterol in fungi, and a variety of C24-modified sterols in plants and protozoa. Ergosterol 163-173 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 0-26 23638723-1 2013 Sterol 14alpha-demethylase (CYP51) is a cytochrome P450 heme thiolate containing enzyme involved in biosynthesis of membrane sterols, including sterol in animals, ergosterol in fungi, and a variety of C24-modified sterols in plants and protozoa. Ergosterol 163-173 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 28-33 34731761-1 2022 Ergosterol exert the important function in maintaining the fluidity and osmotic pressure of fungal cells, and its key biosynthesis enzymes (Squalene epoxidase, SE; 14 alpha-demethylase, CYP51) displayed the obvious synergistic effects. Ergosterol 0-10 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 186-191 14712470-3 2004 KTZ blocks ergosterol biosynthesis by inhibiting the fungal cytochrome P450 (CYP51). Ergosterol 11-21 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 77-82 17954932-2 2007 In particular, the P450 protein Erg11/Cyp51 catalyzes a critical step in ergosterol synthesis, and the azole class of antifungal drugs inhibits Erg11. Ergosterol 73-83 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 38-43 16961575-1 2006 Posaconazole, a new triazole antifungal, exerts principally the same mechanism of action as the other azole derivatives, i.e. it inhibits the ergosterol production by binding and inhibiting the lanosterol-14alpha-demethylase which is present in almost all fungi except Pneumocystis and Pythium. Ergosterol 142-152 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 194-224 9661017-4 1998 The complementation of function was observed both in vitro and in vivo for the monoxygenases squalene epoxidase, CYP51, and CYP61 in the ergosterol biosynthesis pathway with which CPR is coupled. Ergosterol 137-147 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 113-118 34731761-7 2022 Preliminary mechanism studies have confirmed that these compounds effectively inhibited the dual-target (SE/CYP51) activity, they could cause fungal rupture and death by blocking the bio-synthetic pathway of ergosterol. Ergosterol 208-218 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 108-113 35050009-1 2022 The fungal cytochrome P450 lanosterol 14alpha-demethylase (CYP51) is required for the biosynthesis of fungal-specific ergosterol and is the target of azole antifungal drugs. Ergosterol 118-128 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 59-64