PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31932990-3 2020 We aim to prepare ergosterol-loaded nanostructured lipid carriers (ERG-NLCs) to enhance the solubility and oral bioavailability of ergosterol. Ergosterol 18-28 ETS transcription factor ERG Homo sapiens 67-70 32541034-4 2020 We report here the discovery of ergosteryl-3beta-O-l-aspartate (Erg-Asp), a conjugated sterol that is produced by the tRNA-dependent addition of aspartate to the 3beta-OH group of ergosterol, the major sterol found in fungal membranes. Ergosterol 180-190 ETS transcription factor ERG Homo sapiens 64-67 33713678-1 2021 Aminoacylated ergosterol such as 1-ergosteryl aspartate (Erg-Asp) is a new lipid component recently discovered in fungi. Ergosterol 14-24 ETS transcription factor ERG Homo sapiens 57-60 33713678-3 2021 Herein, we report the synthesis of Erg-Asp as well as some other aminoacylated ergosterols (Erg-Gly, Erg-Ala, Erg-Leu, Erg-Ile, and Erg-Val) using Boc protected amino acids. Ergosterol 79-90 ETS transcription factor ERG Homo sapiens 92-95 33713678-3 2021 Herein, we report the synthesis of Erg-Asp as well as some other aminoacylated ergosterols (Erg-Gly, Erg-Ala, Erg-Leu, Erg-Ile, and Erg-Val) using Boc protected amino acids. Ergosterol 79-90 ETS transcription factor ERG Homo sapiens 92-95 33713678-3 2021 Herein, we report the synthesis of Erg-Asp as well as some other aminoacylated ergosterols (Erg-Gly, Erg-Ala, Erg-Leu, Erg-Ile, and Erg-Val) using Boc protected amino acids. Ergosterol 79-90 ETS transcription factor ERG Homo sapiens 92-95 33713678-3 2021 Herein, we report the synthesis of Erg-Asp as well as some other aminoacylated ergosterols (Erg-Gly, Erg-Ala, Erg-Leu, Erg-Ile, and Erg-Val) using Boc protected amino acids. Ergosterol 79-90 ETS transcription factor ERG Homo sapiens 92-95 33713678-3 2021 Herein, we report the synthesis of Erg-Asp as well as some other aminoacylated ergosterols (Erg-Gly, Erg-Ala, Erg-Leu, Erg-Ile, and Erg-Val) using Boc protected amino acids. Ergosterol 79-90 ETS transcription factor ERG Homo sapiens 92-95 31504756-3 2020 The data revealed mutations of the ergosterol biosynthetic pathway-related genes in the T. asahii genome of the fluconazole-resistant strain, that is, there were 36 novel mutations of the ERG11 gene, three point mutations (V458L, D457V, and D334S) in the ERG3, and a missense mutation (E349D) in ERG5 in the fluconazole-resistant strain of the T. asahii genome. Ergosterol 35-45 ETS transcription factor ERG Homo sapiens 255-259 31932990-3 2020 We aim to prepare ergosterol-loaded nanostructured lipid carriers (ERG-NLCs) to enhance the solubility and oral bioavailability of ergosterol. Ergosterol 131-141 ETS transcription factor ERG Homo sapiens 67-70 31932990-7 2020 In pharmacokinetic study, Cmax and AUC0- of ergosterol in ERG-NLCs were obviously enhanced, and the relative oral bioavailability of ERG-NLCs was 277.56% higher than that of raw ergosterol. Ergosterol 45-55 ETS transcription factor ERG Homo sapiens 59-62 31932990-7 2020 In pharmacokinetic study, Cmax and AUC0- of ergosterol in ERG-NLCs were obviously enhanced, and the relative oral bioavailability of ERG-NLCs was 277.56% higher than that of raw ergosterol. Ergosterol 45-55 ETS transcription factor ERG Homo sapiens 134-137 31932990-8 2020 Moreover, the in vitro pharmacodynamic study indicated that ERG-NLCs inhibited high-glucose-stimulated mesangial cells over proliferation and ECM accumulation more effectively compared to raw ergosterol. Ergosterol 192-202 ETS transcription factor ERG Homo sapiens 60-63 31932990-9 2020 In conclusion, the validated ERG-NLCs showed that NLCs mediated delivery could be used as potential vehicle to enhance solubility, oral bioavailability and therapeutic efficacy of ergosterol. Ergosterol 180-190 ETS transcription factor ERG Homo sapiens 29-32 16757619-5 2006 Phylogenetic trees inferred from an ergosterol biosynthesis gene (erg-3) were highly discordant with those inferred from the three other partial gene sequences; therefore, this partition was analyzed separately. Ergosterol 36-46 ETS transcription factor ERG Homo sapiens 66-71 27133301-7 2016 NPs/Erg exerted much stronger cytotoxicity against human cancer cells than the free ergosterol, and showed significantly reduced IC50 values (14.69+-0.48 mug/mL in glioma U251 cells; 9.43+-0.52 mug/mL in breast cancer MCF-7 cells; 4.70+-0.41 mug/mL in hepatoma HepG2 cells). Ergosterol 84-94 ETS transcription factor ERG Homo sapiens 4-7