PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19887566-8 2010 The proteasomal inhibitor epoxomicin and the lysosomal pathway inhibitor 3-methyladenine prevented the degradation of IRS-1 and IR by insulin, respectively, and pretreatment with rapamycin, epoxomicin, or 3-methyladenine prevented attenuation of insulin signaling by long-term insulin exposure. epoxomicin 26-36 insulin receptor substrate 1 Homo sapiens 118-123