PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23603979-3 2013 METHODS: PC12 cells overexpressing either wild-type or A30P mutant alpha-synuclein were treated with the proteasome inhibitor epoxomicin, the macroautophagy inhibitor 3-MA and the macroautophagy activator rapamycin alone or in combination. epoxomicin 126-136 synuclein alpha Rattus norvegicus 67-82 23603979-7 2013 RESULTS: When the proteasome and macroautophagy in the wild-type and mutant cells were inhibited with epoxomicin and 3-MA, respectively, the cell viability was significantly decreased, and the alpha-synuclein level was increased. epoxomicin 102-112 synuclein alpha Rattus norvegicus 193-208 23603979-11 2013 Macroautophagy inducer rapamycin increased the cell viability and reduced epoxomicin-induced alpha-synuclein accumulation. epoxomicin 74-84 synuclein alpha Rattus norvegicus 93-108 28619113-10 2017 Experiments with epoxomicin and chloroquine showed that proteasomal targeting of insoluble Ser129-phosphorylated alpha-synuclein was enhanced under lysosome inhibition and it reduced accumulation of insoluble total alpha-synuclein. epoxomicin 17-27 synuclein alpha Rattus norvegicus 113-128