PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23916504-8	2014	Vortioxetine reversed PCPA-induced memory deficits dose-dependently with a minimal effective dose (MED) <=0.1mg/kg (~80% 5-HT3 receptor occupancy; OR) and <=3.0mg/kg (5-HT1A, 5-HT1B, 5-HT3 receptor occupancy: ~15%, 60%, 95%) in SA.	Vortioxetine	0-12	5-hydroxytryptamine receptor 1B	Rattus norvegicus	181-187	
27106166-1	2016	The antidepressant vortioxetine is a 5-HT3-R, 5-HT7-R and 5-HT1D-R antagonist, 5-HT1B-R partial agonist, 5-HT1A-R agonist, and serotonin (5-HT) transporter (SERT) inhibitor.	Vortioxetine	19-31	5-hydroxytryptamine receptor 1B	Rattus norvegicus	79-85	
25665528-1	2015	RATIONALE: Vortioxetine is a novel multimodal antidepressant that is a 5-HT1B receptor partial agonist, a 5-HT1A receptor agonist, an inhibitor of the serotonin (5-HT) transporter, and a 5-HT1D, 5-HT3, and 5-HT7 receptor antagonist in vitro.	Vortioxetine	11-23	5-hydroxytryptamine receptor 1B	Rattus norvegicus	71-77	
25665528-3	2015	OBJECTIVES: The aim of the present study was to investigate the effects of acute and long-term administration of vortioxetine on the terminal 5-HT1B receptor and the tonic activation of 5-HT1A receptor in the rat hippocampus.	Vortioxetine	113-125	5-hydroxytryptamine receptor 1B	Rattus norvegicus	142-148	
25665528-6	2015	RESULTS: Vortioxetine enhanced the inhibitory effect of the stimulation of the 5-HT bundle at a high, but not low frequency and reversed the inhibitory effect of the 5-HT1B receptor agonist CP 94253.	Vortioxetine	9-21	5-hydroxytryptamine receptor 1B	Rattus norvegicus	166-172	
25665528-10	2015	In addition, vortioxetine decreased the function of terminal 5-HT1B autoreceptor following its sustained administration.	Vortioxetine	13-25	5-hydroxytryptamine receptor 1B	Rattus norvegicus	61-67	
25665528-11	2015	CONCLUSIONS: Desensitization of 5-HT1B autoreceptor and an increase of tonic activation of 5-HT1A receptors in the hippocampus may contribute to the antidepressant effect of vortioxetine.	Vortioxetine	174-186	5-hydroxytryptamine receptor 1B	Rattus norvegicus	32-38	
23916504-12	2014	vortioxetine administration significantly improved memory performance in OR and occupied 95%, 66%, and 9.5% of 5-HT3, 5-HT1B, and 5-HT1A receptors, respectively.	Vortioxetine	0-12	5-hydroxytryptamine receptor 1B	Rattus norvegicus	118-124