PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29274875-2 2018 Here we studied vortioxetine"s functional effects across species (canine, mouse, rat, guinea pig and human) in cellular assays with heterologous expression of 5-HT3A receptors (in Xenopus oocytes and HEK-293 cells) and in mouse neuroblastoma N1E-115 cells with endogenous expression of 5-HT3A receptors. Vortioxetine 16-28 5-hydroxytryptamine receptor 3A Cavia porcellus 159-165 29274875-5 2018 Whereas, both vortioxetine and the 5-HT3 receptor antagonist ondansetron potently antagonized 5-HT-induced currents in the cellular assays, vortioxetine had a slower off-rate than ondansetron in oocytes expressing 5-HT3A receptors. Vortioxetine 140-152 5-hydroxytryptamine receptor 3A Cavia porcellus 214-220 29274875-7 2018 Vortioxetine had the highest potency at rat and the lowest potency at guinea pig 5-HT3A receptors. Vortioxetine 0-12 5-hydroxytryptamine receptor 3A Cavia porcellus 81-87