PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25665528-1 2015 RATIONALE: Vortioxetine is a novel multimodal antidepressant that is a 5-HT1B receptor partial agonist, a 5-HT1A receptor agonist, an inhibitor of the serotonin (5-HT) transporter, and a 5-HT1D, 5-HT3, and 5-HT7 receptor antagonist in vitro. Vortioxetine 11-23 5-hydroxytryptamine receptor 1D Rattus norvegicus 187-193 29274875-1 2018 The multimodal antidepressant vortioxetine is thought to mediate its pharmacological effects via 5-HT1A receptor agonism, 5-HT1B receptor partial agonism, 5-HT1D, 5-HT3, 5-HT7 receptor antagonism and 5-HT transporter inhibition. Vortioxetine 30-42 5-hydroxytryptamine receptor 1D Rattus norvegicus 155-161