PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28109109-0 2017 [Role of cAMP/CREB/BDNF signaling pathway in anti-depressive effect of vortioxetine in mice]. Vortioxetine 71-83 brain derived neurotrophic factor Mus musculus 19-23 28109109-1 2017 OBJECTIVE: To investigate the effects of vortioxetine on cAMP/CREB/BDNF signal pathway. Vortioxetine 41-53 brain derived neurotrophic factor Mus musculus 67-71 28109109-7 2017 Vortioxetine significantly increased the levels of cAMP and promoted the expression of pCREB and BDNF in the hippocampus of the mice (P<0.01). Vortioxetine 0-12 brain derived neurotrophic factor Mus musculus 97-101 28109109-8 2017 CONCLUSION: Vortioxetine improves the behaviors of mice with depression possibly by affecting the cAMP/CREB/BDNF signal pathway. Vortioxetine 12-24 brain derived neurotrophic factor Mus musculus 108-112