PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32765787-1	2020	Effects of Vortioxetine on the expression of brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (Trk B) in hippocampus of depressive rats were investigated.	Vortioxetine	11-23	brain-derived neurotrophic factor	Rattus norvegicus	45-78	
33199100-1	2021	We have previously reported that vortioxetine, unlike the selective serotonin reuptake inhibitor fluoxetine, produces a rapid increase of dendritic spine number and Brain Derived Neurotrophic Factor (BDNF)-associated formation of synapses with mitochondrial support in the rat hippocampal CA1 and dentate gyrus.	Vortioxetine	33-45	brain-derived neurotrophic factor	Rattus norvegicus	165-198	
33199100-1	2021	We have previously reported that vortioxetine, unlike the selective serotonin reuptake inhibitor fluoxetine, produces a rapid increase of dendritic spine number and Brain Derived Neurotrophic Factor (BDNF)-associated formation of synapses with mitochondrial support in the rat hippocampal CA1 and dentate gyrus.	Vortioxetine	33-45	brain-derived neurotrophic factor	Rattus norvegicus	200-204	
32765787-1	2020	Effects of Vortioxetine on the expression of brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (Trk B) in hippocampus of depressive rats were investigated.	Vortioxetine	11-23	brain-derived neurotrophic factor	Rattus norvegicus	80-84	
32765787-8	2020	Expression of BDNF and Trk B in the Vortioxetine group was significantly higher than that in the model control group (P<0.05), but lower than that of the normal control group (P<0.05).	Vortioxetine	36-48	brain-derived neurotrophic factor	Rattus norvegicus	14-18	
32765787-10	2020	Vortioxetine can increase the expression of BDNF and Trk B in depressive rats and alleviate their depressive behavior.	Vortioxetine	0-12	brain-derived neurotrophic factor	Rattus norvegicus	44-48	
31642818-14	2019	The level of BDNF was increased with Vrx in the frontal cortex.	Vortioxetine	37-40	brain-derived neurotrophic factor	Rattus norvegicus	13-17	
29933036-0	2018	Effects of vortioxetine and fluoxetine on the level of Brain Derived Neurotrophic Factors (BDNF) in the hippocampus of chronic unpredictable mild stress-induced depressive rats.	Vortioxetine	11-23	brain-derived neurotrophic factor	Rattus norvegicus	91-95	
30735803-4	2019	We found that prolonged vortioxetine administration significantly increased total Bdnf expression in the dorsal and ventral hippocampus of adult male rats and affected the stress-induced modulation of the immediate early genes Arc and Zif268, mainly in the ventral sub-region.	Vortioxetine	24-36	brain-derived neurotrophic factor	Rattus norvegicus	82-86	
29933036-7	2018	In conclusion, vortioxetine, but not fluoxetine, increased hippocampal BDNF levels in rats subject to CUMS.	Vortioxetine	15-27	brain-derived neurotrophic factor	Rattus norvegicus	71-75	
29514282-0	2018	A Critical Role of Mitochondria in BDNF-Associated Synaptic Plasticity After One-Week Vortioxetine Treatment.	Vortioxetine	86-98	brain-derived neurotrophic factor	Rattus norvegicus	35-39	
29514282-3	2018	Taking into consideration that vortioxetine increases spine number and dendritic branching in hippocampus CA1 faster than fluoxetine, we hypothesize that new spines induced by vortioxetine can rapidly form functional synapses by mitochondrial support, accompanied by increased brain-derived neurotrophic factor signaling.	Vortioxetine	31-43	brain-derived neurotrophic factor	Rattus norvegicus	277-310	
29514282-3	2018	Taking into consideration that vortioxetine increases spine number and dendritic branching in hippocampus CA1 faster than fluoxetine, we hypothesize that new spines induced by vortioxetine can rapidly form functional synapses by mitochondrial support, accompanied by increased brain-derived neurotrophic factor signaling.	Vortioxetine	176-188	brain-derived neurotrophic factor	Rattus norvegicus	277-310	
29514282-9	2018	BDNF levels in hippocampus DG and CA1 were significantly higher after vortioxetine treatment.	Vortioxetine	70-82	brain-derived neurotrophic factor	Rattus norvegicus	0-4	
29514282-15	2018	Rapid changes in BDNF levels and synaptic/mitochondria plasticity of hippocampus following vortioxetine compared with fluoxetine may be ascribed to vortioxetine"s modulation of serotonin receptors.	Vortioxetine	91-103	brain-derived neurotrophic factor	Rattus norvegicus	17-21	
29514282-15	2018	Rapid changes in BDNF levels and synaptic/mitochondria plasticity of hippocampus following vortioxetine compared with fluoxetine may be ascribed to vortioxetine"s modulation of serotonin receptors.	Vortioxetine	148-160	brain-derived neurotrophic factor	Rattus norvegicus	17-21