PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27847203-0	2016	Lycorine induces cell death in MM by suppressing Janus Kinase/signal transducer and activator of transcription via inducing the expression of SOCS1.	lycorine	0-8	suppressor of cytokine signaling 1	Homo sapiens	142-147	
19591492-1	2009	The pentacyclic framework associated with the alkaloid (-)-lycorine (1) can be assembled in as few as six steps from the enantiomerically pure cis-1,2-dihydrocatechol 3 which is itself readily available on a large scale through the whole-cell biotransformation of bromobenzene.	lycorine	55-67	suppressor of cytokine signaling 1	Homo sapiens	143-148	
27847203-6	2016	Further mechanism analysis demonstrated that lycorine inhibited JAK2/STAT signaling through upregulation of SOCS1 in MM cells and patient MM cells.Importantly, we found that knockdown of HDAC8 resulted in increased expression of SOCS1.	lycorine	45-53	suppressor of cytokine signaling 1	Homo sapiens	108-113	
27847203-6	2016	Further mechanism analysis demonstrated that lycorine inhibited JAK2/STAT signaling through upregulation of SOCS1 in MM cells and patient MM cells.Importantly, we found that knockdown of HDAC8 resulted in increased expression of SOCS1.	lycorine	45-53	suppressor of cytokine signaling 1	Homo sapiens	229-234	
27847203-7	2016	Collectively, our findings suggested lycorine acted as a potent novel histone deacetylase inhibitor and inhibited JAK2/STAT signaling through upregulation of SOCS1 in MM cells.	lycorine	37-45	suppressor of cytokine signaling 1	Homo sapiens	158-163