PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20682078-0	2010	Up-regulation of p21 and TNF-alpha is mediated in lycorine-induced death of HL-60 cells.	lycorine	50-58	H3 histone pseudogene 16	Homo sapiens	17-20	
23376478-4	2013	Our data showed that LH effectively inhibited mitotic proliferation of Hey1B cells (half maximal inhibitory concentration=1.2muM) with very low toxicity, resulting in cell cycle arrest at the G2/M transition through enhanced expression of the cell cycle inhibitor p21 and marked down-regulation of cyclin D3 expression.	lycorine	21-23	H3 histone pseudogene 16	Homo sapiens	264-267	
20682078-8	2010	RESULTS: When HL-60 cells were treated with different concentration of lycorine, the expression of p21 and TNF-alpha was up-regulated in a concentration-dependent manner as shown by real-time quantitative reverse transcriptase-polymerase chain reaction and Western blotting.	lycorine	71-79	H3 histone pseudogene 16	Homo sapiens	99-102	
20682078-9	2010	Lycorine also down-regulated p21-related gene expression, including Cdc2, Cyclin B, Cdk2 and Cyclin E, promoted Bid truncation, decreased IkappaB phosphorylation and blocked NF-kappaB nuclear import.	lycorine	0-8	H3 histone pseudogene 16	Homo sapiens	29-32	
20682078-11	2010	CONCLUSIONS: The TNF-alpha signal transduction pathway and p21-mediated cell-cycle inhibition were involved in the apoptosis of HL-60 cells induced by lycorine.	lycorine	151-159	H3 histone pseudogene 16	Homo sapiens	59-62	
33455051-4	2021	Here, we demonstrate that the salt of lycorine, lycorine hydrochloride, significantly suppressed stress-induced premature cellular senescence (SIPS) by ~2-fold, as determined by senescence-associated beta-galactosidase (SA-beta-gal) staining and the expression of p16 and p21.	lycorine	38-46	H3 histone pseudogene 16	Homo sapiens	272-275