PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30066939-7	2018	Furthermore, lycorine induced the cleavage/activation of Rho associated coiled-coil containing protein kinase 1 (ROCK1) and the downregulation of cofilin, accompanied by an increase in polymerized filamentous actin and a loss of depolymerized globular actin.	lycorine	13-21	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	57-111	
31263414-0	2019	Lycorine Induces Mitochondria-Dependent Apoptosis in Hepatoblastoma HepG2 Cells Through ROCK1 Activation.	lycorine	0-8	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	88-93	
31263414-4	2019	Furthermore, we found Rho associated coiled-coil containing protein kinase 1 (ROCK1) cleavage/activation played a critical role in lycorine-induced mitochondrial apoptosis.	lycorine	131-139	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	22-76	
31263414-4	2019	Furthermore, we found Rho associated coiled-coil containing protein kinase 1 (ROCK1) cleavage/activation played a critical role in lycorine-induced mitochondrial apoptosis.	lycorine	131-139	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	78-83	
31263414-7	2019	Taken together, all these findings suggested that lycorine induced mitochondria-dependent apoptosis through ROCK1 activation in HepG2 cells, and this may be a theoretical basis for lycorine"s anticancer effects.	lycorine	50-58	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	108-113	
31263414-7	2019	Taken together, all these findings suggested that lycorine induced mitochondria-dependent apoptosis through ROCK1 activation in HepG2 cells, and this may be a theoretical basis for lycorine"s anticancer effects.	lycorine	181-189	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	108-113	
30066939-0	2018	Lycorine inhibits cell proliferation and migration by inhibiting ROCK1/cofilin-induced actin dynamics in HepG2 hepatoblastoma cells.	lycorine	0-8	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	65-70	
30066939-7	2018	Furthermore, lycorine induced the cleavage/activation of Rho associated coiled-coil containing protein kinase 1 (ROCK1) and the downregulation of cofilin, accompanied by an increase in polymerized filamentous actin and a loss of depolymerized globular actin.	lycorine	13-21	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	113-118	
30066939-8	2018	Furthermore, pre-incubation of cells with Y-27632, a specific ROCK1 inhibitor, markedly attenuated lycorine-induced anti-proliferative and anti-migration effects.	lycorine	99-107	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	62-67	
30066939-9	2018	Taken together, the results demonstrated that lycorine inhibited the proliferation and migration of HepG2 cells by suppressing ROCK1/cofilin-induced actin dynamics, which suggests that lycorine has the potential to be developed into a novel drug for hepatoblastoma treatment.	lycorine	46-54	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	127-132	
30066939-9	2018	Taken together, the results demonstrated that lycorine inhibited the proliferation and migration of HepG2 cells by suppressing ROCK1/cofilin-induced actin dynamics, which suggests that lycorine has the potential to be developed into a novel drug for hepatoblastoma treatment.	lycorine	185-193	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	127-132