PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34440200-6 2021 We confirmed that SARS-CoV-2 RdRp replicated double-stranded RNA using immunofluorescence staining and the inhibition of RdRp activity by remdesivir and lycorine using this system. lycorine 153-161 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 29-33 34440200-6 2021 We confirmed that SARS-CoV-2 RdRp replicated double-stranded RNA using immunofluorescence staining and the inhibition of RdRp activity by remdesivir and lycorine using this system. lycorine 153-161 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 121-125 33376043-12 2021 CONCLUSIONS: Lycorine is a potent non-nucleoside direct-acting antiviral against emerging coronavirus infections and acts by inhibiting viral RdRp activity; therefore, lycorine may be a candidate against the current COVID-19 pandemic. lycorine 13-21 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 142-146 33376043-12 2021 CONCLUSIONS: Lycorine is a potent non-nucleoside direct-acting antiviral against emerging coronavirus infections and acts by inhibiting viral RdRp activity; therefore, lycorine may be a candidate against the current COVID-19 pandemic. lycorine 168-176 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 142-146 33376043-6 2021 PURPOSE: We investigated the direct-inhibiting action of lycorine on CoV"s RdRp, as potential treatment for emerging CoV infections. lycorine 57-65 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 75-79