PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25777483-12	2015	Western blot analysis of intracellular signaling factors revealed that withaferin A but not astaxanthin significantly abolished the endothelin-1-stimulated phosphorylation of Raf-1, MEK, ERK, MITF and CREB in human melanocytes.	withaferin A	71-83	cAMP responsive element binding protein 1	Homo sapiens	201-205	
21678520-6	2011	Consistently, treatment with withaferin A, a major component of the Withania somnifera extract, at concentrations of 10-50 microm also significantly down-regulated the EDN1 stimulated phosphorylation of Raf-1, MEK, ERK, MITF and CREB at 15 min after EDN1 treatment.	withaferin A	29-41	cAMP responsive element binding protein 1	Homo sapiens	229-233	
25376854-3	2015	In WFA-treated normal human melanocytes (NHMs), there was a marked deficiency in the SCF-stimulated series of phosphorylations of c-KIT, Shc, Raf-1, MEK, ERK, MITF and CREB.	withaferin A	3-6	cAMP responsive element binding protein 1	Homo sapiens	168-172