PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25376854-3	2015	In WFA-treated normal human melanocytes (NHMs), there was a marked deficiency in the SCF-stimulated series of phosphorylations of c-KIT, Shc, Raf-1, MEK, ERK, MITF and CREB.	withaferin A	3-6	mitogen-activated protein kinase 1	Homo sapiens	154-157	
32429564-7	2020	Moreover, WFA induces mild phosphorylation of the mitogen-activated protein kinase (MAPK) family, including extracellular signal-regulated kinases 1/2 (ERK1/2), c-Jun N-terminal kinase (JNK), and p38 expression.	withaferin A	10-13	mitogen-activated protein kinase 1	Homo sapiens	108-150	
32429564-7	2020	Moreover, WFA induces mild phosphorylation of the mitogen-activated protein kinase (MAPK) family, including extracellular signal-regulated kinases 1/2 (ERK1/2), c-Jun N-terminal kinase (JNK), and p38 expression.	withaferin A	10-13	mitogen-activated protein kinase 1	Homo sapiens	196-199	
25777483-12	2015	Western blot analysis of intracellular signaling factors revealed that withaferin A but not astaxanthin significantly abolished the endothelin-1-stimulated phosphorylation of Raf-1, MEK, ERK, MITF and CREB in human melanocytes.	withaferin A	71-83	mitogen-activated protein kinase 1	Homo sapiens	187-190	
24632454-7	2014	In addition, treatment with WFA resulted in reduced PMA-stimulated phosphorylation of p38, extracellular regulated kinases (ERK) 1/2, and c-Jun N-terminal kinase (JNK).	withaferin A	28-31	mitogen-activated protein kinase 1	Homo sapiens	86-89	
21678520-6	2011	Consistently, treatment with withaferin A, a major component of the Withania somnifera extract, at concentrations of 10-50 microm also significantly down-regulated the EDN1 stimulated phosphorylation of Raf-1, MEK, ERK, MITF and CREB at 15 min after EDN1 treatment.	withaferin A	29-41	mitogen-activated protein kinase 1	Homo sapiens	215-218