PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25777483-14	2015	Their effects are caused not only by down-regulating the increased secretion of an intrinsic melanogenic cytokine, endothelin-1, by UVB-exposed human keratinocytes, but also by interrupting the endothelin-1-triggered downstream intracellular signaling between protein kinase C and Raf-1 in human melanocytes (only for withaferin A).	withaferin A	318-330	endothelin 1	Homo sapiens	115-127	
25777483-10	2015	Treatment with astaxanthin or withaferin A significantly reduced the increased levels of interleukin-1alpha, interleukin-6/8, granulocyte macrophage stimulatory factor and endothelin-1.	withaferin A	30-42	endothelin 1	Homo sapiens	172-184	
25777483-11	2015	Withaferin A but not astaxanthin also significantly abrogated the endothelin-1-stimulated activity of tyrosinase in melanocytes.	withaferin A	0-12	endothelin 1	Homo sapiens	66-78	
25777483-12	2015	Western blot analysis of intracellular signaling factors revealed that withaferin A but not astaxanthin significantly abolished the endothelin-1-stimulated phosphorylation of Raf-1, MEK, ERK, MITF and CREB in human melanocytes.	withaferin A	71-83	endothelin 1	Homo sapiens	132-144	
25777483-14	2015	Their effects are caused not only by down-regulating the increased secretion of an intrinsic melanogenic cytokine, endothelin-1, by UVB-exposed human keratinocytes, but also by interrupting the endothelin-1-triggered downstream intracellular signaling between protein kinase C and Raf-1 in human melanocytes (only for withaferin A).	withaferin A	318-330	endothelin 1	Homo sapiens	194-206	
21678520-6	2011	Consistently, treatment with withaferin A, a major component of the Withania somnifera extract, at concentrations of 10-50 microm also significantly down-regulated the EDN1 stimulated phosphorylation of Raf-1, MEK, ERK, MITF and CREB at 15 min after EDN1 treatment.	withaferin A	29-41	endothelin 1	Homo sapiens	168-172	
21678520-6	2011	Consistently, treatment with withaferin A, a major component of the Withania somnifera extract, at concentrations of 10-50 microm also significantly down-regulated the EDN1 stimulated phosphorylation of Raf-1, MEK, ERK, MITF and CREB at 15 min after EDN1 treatment.	withaferin A	29-41	endothelin 1	Homo sapiens	250-254