PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20609360-4	2010	Rimonabant is structurally similar to two other cannabinoid receptor antagonists, AM251 and SR144528, recently identified as potent inhibitors of ACAT.	Rimonabant	0-10	acetyl-CoA acetyltransferase 1	Homo sapiens	146-150	
20609360-6	2010	Rimonabant dose-dependently reduced ACAT activity in Raw 264.7 macrophages (IC(50)=2.9+/-0.38 microM) and isolated peritoneal macrophages.	Rimonabant	0-10	acetyl-CoA acetyltransferase 1	Homo sapiens	36-40	
20609360-7	2010	Rimonabant inhibited ACAT activity in intact CHO-ACAT1 and CHO-ACAT2 cells and in cell-free assays with approximately equal efficiency (IC(50)=1.5+/-1.2 microM and 2.2+/-1.1 microM for CHO-ACAT1 and CHO-ACAT2, respectively).	Rimonabant	0-10	acetyl-CoA acetyltransferase 1	Homo sapiens	21-25	
20609360-7	2010	Rimonabant inhibited ACAT activity in intact CHO-ACAT1 and CHO-ACAT2 cells and in cell-free assays with approximately equal efficiency (IC(50)=1.5+/-1.2 microM and 2.2+/-1.1 microM for CHO-ACAT1 and CHO-ACAT2, respectively).	Rimonabant	0-10	acetyl-CoA acetyltransferase 1	Homo sapiens	49-54	
20609360-7	2010	Rimonabant inhibited ACAT activity in intact CHO-ACAT1 and CHO-ACAT2 cells and in cell-free assays with approximately equal efficiency (IC(50)=1.5+/-1.2 microM and 2.2+/-1.1 microM for CHO-ACAT1 and CHO-ACAT2, respectively).	Rimonabant	0-10	acetyl-CoA acetyltransferase 1	Homo sapiens	189-194	
20609360-8	2010	Consistent with ACAT inhibition, Rimonabant treatment blocked ACAT-dependent processes in macrophages, oxysterol-induced apoptosis and acetylated-LDL induced foam cell formation.	Rimonabant	33-43	acetyl-CoA acetyltransferase 1	Homo sapiens	16-20	
20609360-8	2010	Consistent with ACAT inhibition, Rimonabant treatment blocked ACAT-dependent processes in macrophages, oxysterol-induced apoptosis and acetylated-LDL induced foam cell formation.	Rimonabant	33-43	acetyl-CoA acetyltransferase 1	Homo sapiens	62-66