PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29749444-9	2018	The decrease in CREB phosphorylation revealed additive effects with 100 microM of chelerythrine and 20 microM of PD-98059, and the etomidate-induced decrease in CREB phosphorylation was blocked by 1 mM of NMDA.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	113-121	cAMP responsive element binding protein 1	Mus musculus	16-20	
27840407-8	2017	ARDD also increased the expression of BDNF, CREB and GAP-43 in N1E115 cells, which was reversed by pretreatment with PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	117-124	cAMP responsive element binding protein 1	Mus musculus	44-48	
20803555-8	2011	The CB2-induced stimulation of CREB and cyclin D1 is inhibitable by pertussis toxin, the MEK-Erk1/2 inhibitors PD098059 and U0126, and Mapkapk2 siRNA.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	111-119	cAMP responsive element binding protein 1	Mus musculus	31-35	
14648587-7	2003	On the other hand, inhibition of a mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway by a MAPK/ERK kinase (MEK) inhibitor (PD98059) suppressed both neuritogenesis and neurite outgrowth without CREB phosphorylation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	165-172	cAMP responsive element binding protein 1	Mus musculus	235-239	
16873684-3	2006	We observed that 10 mmol/l glucose-induced CREB phosphorylation was totally inhibited by the protein kinase A (PKA) inhibitor H89 (2 micromol/l) and reduced by 50% with the extracellular signal-regulated kinase (ERK)1/2 inhibitor PD98059 (20 micromol/l).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	230-237	cAMP responsive element binding protein 1	Mus musculus	43-47	
16873684-6	2006	In MIN6 cells and islets cultured for 24-48 h in optimal glucose concentration (10 mmol/l), which promotes survival, blockade of ERK1/2 activity with PD98059 caused a significant decrease in CREB protein level, whereas CREB mRNA remained unaffected (measured by real-time quantitative PCR).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	150-157	cAMP responsive element binding protein 1	Mus musculus	191-195	
15659802-4	2004	The observation that glucose-induced CREB phosphorylation was totally inhibited by the PKA inhibitor H89 (2 microM) and reduced by 50% with the ERK1/2 inhibitor PD98059 (20 microM) indicates that ERK1/2, located downstream of PKA, cooperates with PKA and is responsible for half of the PKA-mediated CREB phosphorylation elicited by glucose in MIN6 beta cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	161-168	cAMP responsive element binding protein 1	Mus musculus	37-41	
12670506-4	2003	Furthermore, the use of specific inhibitors PD98059 (MEK) and H89 (PKA), which block ERK1/2 and CREB phosphorylation, accelerated butyrate induced cell death in 2C4 cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	44-51	cAMP responsive element binding protein 1	Mus musculus	96-100