PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11787050-6	2002	Treatment of PI3K inhibitor LY294002 and the MAP kinase inhibitor PD098059, but not p38 inhibitor SB203580, effectively blocks IGF-1-induced upregulation of Pin1, cyclin D1 and RB phosphorylation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	66-74	cyclin D1	Homo sapiens	163-172	
12970168-5	2003	Furthermore, this study also demonstrated that MEK inhibitor PD98059 that inhibits the phosphorylation of p42/44 MAPK also caused reduction of cyclin D1 level and inhibition of cell proliferation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	61-68	cyclin D1	Homo sapiens	143-152	
12869389-11	2003	Pretreatment with PD98059 suppressed AR-induced cyclin D1 mRNA and protein.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	18-25	cyclin D1	Homo sapiens	48-57	
11551901-3	2001	This conclusion is based on observations indicating that cyclin D1 induction by transforming Ha-Ras was depressed in a dose-dependent manner by PD98059, a selective inhibitor of the mitogen-activated kinase kinase MEK-1, demonstrating that Ha-Ras employs extracellular signal-regulated kinases (ERKs) for signal transmission to the cyclin D1 promoter.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	144-151	cyclin D1	Homo sapiens	57-66	
11551901-3	2001	This conclusion is based on observations indicating that cyclin D1 induction by transforming Ha-Ras was depressed in a dose-dependent manner by PD98059, a selective inhibitor of the mitogen-activated kinase kinase MEK-1, demonstrating that Ha-Ras employs extracellular signal-regulated kinases (ERKs) for signal transmission to the cyclin D1 promoter.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	144-151	cyclin D1	Homo sapiens	332-341	
10683762-5	1999	PD98059, a specific inhibitor of MEK1, partially prevented the increase in cyclin D1 caused by PMA and fully reversed the down-regulation of cyclin B1 protein seen in response to PMA treatment.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	cyclin D1	Homo sapiens	75-84	
11341512-3	2001	PD98059, an inhibitor of MEK-1 blocked the mitogenic activity of HDL and cyclin D1 expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	cyclin D1	Homo sapiens	73-82	
10531416-5	1999	The ERK kinase inhibitor PD98059 (3-30 microM) attenuated thrombin-stimulated ERK phosphorylation and activity and the increase in cyclin D1 protein levels, as did albuterol (1-100 nM) or 8-bromo-cAMP (300 microM).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	25-32	cyclin D1	Homo sapiens	131-140	
30311108-6	2019	The addition of ERK inhibitor PD98059 counteracted the upregulation of Snail, Cyclin D1 and Cyclin E1, and restored the expression of E-cadherin, which indicated that C6orf106 was an upstream factor of ERK signaling pathway.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	30-37	cyclin D1	Homo sapiens	78-87	
9652748-10	1998	Preincubation with PD98059 blocked the HRG-dependent induction of cyclin D1 mRNA, p21 and c-Myc protein and pRB phosphorylation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	19-26	cyclin D1	Homo sapiens	66-75	
10385595-5	1999	PD98059 (10 microM), an inhibitor of MEK1 activation, markedly attenuated thrombin stimulation of ERK activity and phosphorylation, DNA synthesis, and cyclin D1 levels.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	cyclin D1	Homo sapiens	151-160	
10329719-3	1999	ERK activity was approximately 2-fold higher in cycling BMM compared with growth-arrested BMM; in addition, CSF-1-stimulated BMM DNA synthesis was partially inhibited by PD98059, a specific inhibitor of MEK activation, suggesting a role for a mitogen-activated protein-ERK kinase (MEK)/ERK pathway in the control of DNA synthesis but surprisingly not in the control of cyclin D1 mRNA or c-myc mRNA expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	170-177	cyclin D1	Homo sapiens	369-378	
9891045-10	1999	Furthermore, the induction of c-Myc and cyclin D1 by oncogenes and growth factors was inhibited by PD098059, a specific MAP kinase kinase (MEK) inhibitor.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	99-107	cyclin D1	Homo sapiens	40-49	
31270645-9	2019	The LX-2 cells treated with apelin-13 displayed an increased expression of pERK1/2 in a time-dependent manner, while the pretreatment with PD98059 abolished the apelin-induced expression of alpha-SMA and cyclinD1.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	139-146	cyclin D1	Homo sapiens	204-212	
28849149-11	2017	ERK inhibitor PD98059 partially inhibited the role of Rab5a on MMP-2, cyclin D1, cell proliferation and invasion.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	14-21	cyclin D1	Homo sapiens	70-79	
30340049-8	2019	In addition, PD98059 (a MEK inhibitor) could block cell differentiation of CML cells and contributed to the expression of c-myc and cyclin D1.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	13-20	cyclin D1	Homo sapiens	132-141	
27181679-8	2016	Importantly, the MEK1 inhibitor PD98059, like MEK1 silencing, induced an augment of cyclin D1 expression that correlated with an increase of MDA-MB-231 cell proliferation suggesting that MEK1 may play a regulatory role in these cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	32-39	cyclin D1	Homo sapiens	84-93	
27832629-9	2016	Co-immunoprecipitation further confirmed that there was an interaction between p-ERK1/2 and cyclin D1, CDK4, cyclin B1, or CDK1, which was blunted in the presence of melatonin or PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	179-186	cyclin D1	Homo sapiens	92-101	
20596608-6	2010	Pre-treatment of NS3 protein expressing cells with ERK inhibitor, PD98059, blocked the activation of AP-1 and NF-kappaB, and inhibited cyclin D1 expression and cell proliferation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	66-73	cyclin D1	Homo sapiens	135-144	
26135903-9	2015	To study the molecular mechanism, cell proliferation, invasion and cyclin D1 were inhibited by pre-treatment with 10 microM of PD98059 (ERK(1/2) inhibitor).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	127-134	cyclin D1	Homo sapiens	67-76	
25898413-7	2015	Moreover, treatment with PD98059, a highly selective ERK inhibitor, blocked PDGF-induced upregulation of cyclin D1 and cyclin E and downregulation of p27kip1.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	25-32	cyclin D1	Homo sapiens	105-114	
21988060-8	2012	Coimmunoprecipitation further confirmed that there was an interaction between phosphorylation of ERK and cyclin D1, CDK4, cyclin B1, or CDK1, which was weaken in the presence of melatonin or PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	191-198	cyclin D1	Homo sapiens	105-114	
20857402-5	2011	Furthermore, treatment with extracellular signal-related kinase (ERK) inhibitor (PD98059) and dominant negative Ras (RasN17) abolished homocysteine-induced cyclin A expression; and treatment with phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002) and mammalian target of rapamycin (mTOR) inhibitor (rapamycin) attenuated the homocysteine-induced cyclin D1 expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	81-88	cyclin D1	Homo sapiens	353-362	
21216934-6	2011	Furthermore, the MAP/ERK kinase inhibitor PD98059 partially abolished modulation of p21 and cyclin D1 expression by p53R2.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	42-49	cyclin D1	Homo sapiens	92-101	
19366876-8	2009	PD-098059 blocked Rb protein phorsphorylation and the increase in cyclin D(1) and E but not the decrease in p15(INK4B) and p16(INK4A) induced by GDF-9.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-9	cyclin D1	Homo sapiens	66-77	
19996316-5	2010	Specifically, we identified the extracellular signal-regulated kinase (ERK) signaling pathway as a mediator of signals from FcgammaR activation to cyclin D1 expression, because cyclin D1 expression associated with FcgammaR cross-linking was attenuated by specific inhibitors of the ERK1/2 signaling pathway, PD98059 and U0126 and the spleen tyrosine kinase (Syk) inhibitor, Piceatannol.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	308-315	cyclin D1	Homo sapiens	147-156	
19996316-5	2010	Specifically, we identified the extracellular signal-regulated kinase (ERK) signaling pathway as a mediator of signals from FcgammaR activation to cyclin D1 expression, because cyclin D1 expression associated with FcgammaR cross-linking was attenuated by specific inhibitors of the ERK1/2 signaling pathway, PD98059 and U0126 and the spleen tyrosine kinase (Syk) inhibitor, Piceatannol.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	308-315	cyclin D1	Homo sapiens	177-186	
17478933-6	2007	PD98059 could inhibit the cell proliferation mediated by HCV NS3 protein, down-regulate the activities of AP-1 and NF-kappaB, and suppress the expression of cyclin D1.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	cyclin D1	Homo sapiens	157-166	
18508473-9	2008	Similarly, treatment with PD98059 partially diminished the apelin-13-induced expression of cyclin D1 and vascular smooth muscle cell proliferation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	26-33	cyclin D1	Homo sapiens	91-100	
17449939-5	2007	We also found that the autocrine ERK activation was associated with the expression of cyclin D1 and the cell cycle regulation at the early stage of calcium triggering by treating the cells with the mitogen-activated protein kinase inhibitor PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	241-248	cyclin D1	Homo sapiens	86-95	
16267018-9	2005	Inhibition of MAPK pathway with either the MEK1 inhibitor PD98059 or a dominant-negative Ras mutant, RasN17, abolished bombesin-induced cyclin D1 activation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	58-65	cyclin D1	Homo sapiens	136-145	
17089025-13	2006	p27(KIP1) phosphorylation and cyclin D1 induction were inhibited by PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	68-75	cyclin D1	Homo sapiens	30-39	
16522728-13	2006	The stimulation of the cyclin D1 promoter by GLP-1 was inhibited by H89, wortmannin, and PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	89-96	cyclin D1	Homo sapiens	23-32	
17329956-4	2006	Induction of cyclin D1 expression in TPA-treated HL60 cells was inhibited with protein kinase C (PKC) inhibitor bisindolylmaleimide I and mitogen activated protein kinase kinase (MEK) inhibitor PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	194-201	cyclin D1	Homo sapiens	13-22	
17161815-4	2007	PD98059 also decreased the Cdk-2, Cdk-4, cyclin D1, and cyclin E expression, and increased high levels of the mitotic inhibitors p16(INIa), p21(Waf1), and p27(Kip1).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	cyclin D1	Homo sapiens	41-50	
15212949-3	2004	Decreasing phospho-ERK with the pharmacological inhibitors, PD98059 and U0126, markedly suppresses hyperoxia-stimulated phospho-p53(Ser15), p53, and p21(CIP1), and also restores the hyperoxia-reduced kinase activities of cyclin D1/E1-Cdks.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	60-67	cyclin D1	Homo sapiens	221-230	
15010259-9	2004	Pretreatment with PD98059 significantly inhibited elastase-induced cyclin D1 activity.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	18-25	cyclin D1	Homo sapiens	67-76