PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20093382-6	2010	These events were dependent on extracellular signal-regulated kinase (ERK) activation: indeed inhibition of ERK activation in siTRPV2-U87MG transfected cells by treatment with PD98059, a specific mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor, reduced Bcl-X(L) protein levels, promoted Fas expression, and restored Akt/protein kinase B pathway activation leading to reduced U87MG cell survival and proliferation, and increased sensitivity to Fas-induced apoptosis.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	176-183	protein tyrosine kinase 2 beta	Homo sapiens	360-376	
17947702-9	2007	Through inhibition studies using genistein and PD98059 we found that the Pyk-2 tyrosine kinase-ERK1/2 pathway is in part responsible for the AM/AMBP-1-mediated induction of PPAR-gamma and the anti-inflammatory effect.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	47-54	protein tyrosine kinase 2 beta	Homo sapiens	73-78	
10800936-10	2000	Glutamate-stimulated DNA synthesis is PTX sensitive and can be inhibited by the MAP kinase kinase inhibitor PD98059, suggesting that in primary astrocytes, glutamate might signal via RAFTK and MAP kinase to promote DNA synthesis and cell proliferation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	108-115	protein tyrosine kinase 2 beta	Homo sapiens	183-188	
22224416-7	2012	ATP increased phosphorylated PKB (Akt) and ERK1/2 levels; an effect antagonized by suramin, reactive blue-2, the PI3-kinase inhibitor, wortmannin, PKB inhibitor, API-2, and MAPK inhibitor, PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	189-196	protein tyrosine kinase 2 beta	Homo sapiens	29-32	
19720055-9	2009	On the other hand, the PTK inhibitors caused disparate effects on ERK phosphorylation, and co-treatment with the MEK/ERK inhibitor PD98059 enhanced the pro-apoptotic capacity of the PTK inhibitors.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	131-138	protein tyrosine kinase 2 beta	Homo sapiens	23-26	
19720055-9	2009	On the other hand, the PTK inhibitors caused disparate effects on ERK phosphorylation, and co-treatment with the MEK/ERK inhibitor PD98059 enhanced the pro-apoptotic capacity of the PTK inhibitors.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	131-138	protein tyrosine kinase 2 beta	Homo sapiens	182-185	
18198130-3	2008	In NB4 acute promyelocytic leukemia cells, the expression of Pyk2 was increased in parallel with differentiation, and inhibited by PD98059, indicating Pyk2 expression is regulated through MAPK/ERK pathway.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	131-138	protein tyrosine kinase 2 beta	Homo sapiens	61-65	
18198130-3	2008	In NB4 acute promyelocytic leukemia cells, the expression of Pyk2 was increased in parallel with differentiation, and inhibited by PD98059, indicating Pyk2 expression is regulated through MAPK/ERK pathway.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	131-138	protein tyrosine kinase 2 beta	Homo sapiens	151-155