PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30851105-8 2019 Finally, we demonstrated that DA-induced IL-8 is dependent upon ERK1/2 and Mitogen activated protein kinase kinase activation downstream of EGFR signaling using the small molecule inhibitors AG1478 and PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 202-209 C-X-C motif chemokine ligand 8 Homo sapiens 41-45 9096344-5 1997 The regulation of cell migration by IL-8 is independent of ERK kinase and ERK activation since the ERK kinase inhibitor PD098059 had no effect on IL-8-induced cell migration of human neutrophils. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 120-128 C-X-C motif chemokine ligand 8 Homo sapiens 36-40 26848751-6 2016 IL-1beta-induced the degradation of IkappaBalpha, and the phosphorylation of p38 and ERK, and the IL-1beta-induced expression of IL-8 mRNA was inhibited by specific inhibitors, such as BAY-117085 for NF-kB, SB203580 for p38, and PD98059 for ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 229-236 C-X-C motif chemokine ligand 8 Homo sapiens 129-133 30466991-10 2018 These IL-8 levels were decreased by EGFR (Neratinib and Afatinib) and MEK (PD98059) inhibitors in TNBC cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 75-82 C-X-C motif chemokine ligand 8 Homo sapiens 6-10 26483408-9 2016 We show that the A subunit-dependent ERK1/2 activation is mediated through ZAK-dependent signaling, and inhibition of ERK1/2 activation via the MEK1/2 inhibitors U0126 and PD98059 results in decreased Stx1-mediated IL-8 mRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 172-179 C-X-C motif chemokine ligand 8 Homo sapiens 215-219 26431069-9 2016 Administration of 10 muM PD98059 significantly decreased IL-6 levels in the AF-MPhi coculture, and decreased the levels of TNF alpha and IL-8 in both the AF-MPhi and NP-MPhi cocultures. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 25-32 C-X-C motif chemokine ligand 8 Homo sapiens 137-141 24479526-7 2014 IL-33 increased ERK 1/2 phosphorylation in goblet cells (P < 0.05), and PD98059, a MAPK/ERK kinase inhibitor, attenuated IL-33-stimulated CXCL8/IL-8 secretion from goblet cells (P < 0.001). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 75-82 C-X-C motif chemokine ligand 8 Homo sapiens 141-146 24854880-11 2015 Interestingly, small interfering RNA (siRNA) knock down of the TLR2 and ERK1/2 inhibitor, PD98059, abolished the effects of P. gingivalis LPS on the bone sialoprotein mRNA level, whereas siRNA knock down of the TLR2 and p38 MAPK inhibitor, SB203580, blocked the effect of P. gingivalis LPS on IL-8 in hPDLFs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 90-97 C-X-C motif chemokine ligand 8 Homo sapiens 293-297 24106166-6 2015 Upregulation of the IL-8 gene was abrogated by the MEK inhibitor, PD98059, and partially suppressed by the epidermal growth factor receptor inhibitors, AG1478 and PD153035. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 66-73 C-X-C motif chemokine ligand 8 Homo sapiens 20-24 24479526-7 2014 IL-33 increased ERK 1/2 phosphorylation in goblet cells (P < 0.05), and PD98059, a MAPK/ERK kinase inhibitor, attenuated IL-33-stimulated CXCL8/IL-8 secretion from goblet cells (P < 0.001). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 75-82 C-X-C motif chemokine ligand 8 Homo sapiens 147-151 24126532-7 2014 Inhibitors of p38 MAPK (SB203580) and Erk1/2 (PD98059) blocked HbR-induced IL-8 production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 46-53 C-X-C motif chemokine ligand 8 Homo sapiens 75-79 24277696-6 2014 The thrombin-induced increases in IL-8/CXCL8 release and IL-8/CXCL8-luciferase were also inhibited by MEKK1 siRNA, PD98059 (an MEK inhibitor), U0126 (an ERK inhibitor), and RSK1 siRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 115-122 C-X-C motif chemokine ligand 8 Homo sapiens 34-38 24277696-6 2014 The thrombin-induced increases in IL-8/CXCL8 release and IL-8/CXCL8-luciferase were also inhibited by MEKK1 siRNA, PD98059 (an MEK inhibitor), U0126 (an ERK inhibitor), and RSK1 siRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 115-122 C-X-C motif chemokine ligand 8 Homo sapiens 39-44 24277696-6 2014 The thrombin-induced increases in IL-8/CXCL8 release and IL-8/CXCL8-luciferase were also inhibited by MEKK1 siRNA, PD98059 (an MEK inhibitor), U0126 (an ERK inhibitor), and RSK1 siRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 115-122 C-X-C motif chemokine ligand 8 Homo sapiens 57-61 24277696-6 2014 The thrombin-induced increases in IL-8/CXCL8 release and IL-8/CXCL8-luciferase were also inhibited by MEKK1 siRNA, PD98059 (an MEK inhibitor), U0126 (an ERK inhibitor), and RSK1 siRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 115-122 C-X-C motif chemokine ligand 8 Homo sapiens 62-67 21545687-5 2012 Tumour necrosis factor-alpha (TNF-alpha) significantly induced phosphorylation of p38 MAPK, ERK, Akt and production of IL-8 from HCC cells, which were prevented by SB203580 (p38 MAPK inhibitor), PD98059 (ERK inhibitor), LY294002 and Wortmannin (PI3K inhibitor) and SB328437 (CCR3 inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 195-202 C-X-C motif chemokine ligand 8 Homo sapiens 119-123 23357535-4 2013 Thrombin-induced increases in IL-8/CXCL8 release and kappaB-luciferase activity were inhibited by the Shc small interfering RNA (siRNA), p66Shc siRNA, GW 5074 (a Raf-1 inhibitor), and PD98059 (a mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 184-191 C-X-C motif chemokine ligand 8 Homo sapiens 30-34 22721959-7 2012 On the other hand, PD98059 and SB203580 suppressed the toxin-induced production of IL-8. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-26 C-X-C motif chemokine ligand 8 Homo sapiens 83-87 22721959-8 2012 Treatment of the cells with PD98059 resulted in inhibition of IL-8 mRNA expression induced by the toxin and that with SB203580 led to a decrease in the stabilization of IL-8 mRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 28-35 C-X-C motif chemokine ligand 8 Homo sapiens 62-66 23779254-5 2013 The pharmacologic inhibitors of ERK, U0126 and PD98059, effectively reduced IL-8 expression and the active forms of ERK signaling molecules, as detected by anti-phosphorylated p44/42 antibody. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-54 C-X-C motif chemokine ligand 8 Homo sapiens 76-80 23924923-9 2013 HGF-induced expression of Ets-1 and IL-8 was increased more by GRP treatment and inhibited by pretreatment with an ERK 1/2 inhibitor (PD098059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 134-142 C-X-C motif chemokine ligand 8 Homo sapiens 36-40 21932059-6 2012 Preincubation with ERK1/2 inhibitor (PD98059) or p38 inhibitor (SB203580) markedly blocked DEHP-stimulated activation of ICAM-1 and IL-8. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 37-44 C-X-C motif chemokine ligand 8 Homo sapiens 132-136 19029040-9 2009 Nucleotide induction of IL-8 production was blocked by PD98059, and all nucleotides stimulated ERK 1/2 phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 55-62 C-X-C motif chemokine ligand 8 Homo sapiens 24-28 21796149-10 2011 Treatment with the ERK inhibitor PD98059 and with the p38 kinase inhibitor SB203580 effectively suppressed beta-glucan-induced IL-8 production by NHEKs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-40 C-X-C motif chemokine ligand 8 Homo sapiens 127-131 21637924-10 2011 Furthermore, IL-8 mRNA expression was inhibited significantly after co-incubation with PD98059 (ERK inhibitor) and SB203580 (p38 inhibitor), respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 87-94 C-X-C motif chemokine ligand 8 Homo sapiens 13-17 21631990-13 2011 The reduction of VCAM-1, resulting from increased IL-8, could be blocked by the MEK inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 95-102 C-X-C motif chemokine ligand 8 Homo sapiens 50-54 21172926-8 2011 Treatment with SB202190 (p38-MAPK inhibitor) or PD98059 (ERK inhibitor) inhibited AGE-BSA-induced IL-6 and IL-8 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 48-55 C-X-C motif chemokine ligand 8 Homo sapiens 107-111 20412422-8 2010 The p(38) MAPK inhibitors SB203580 and SB202190 and the ERK inhibitor PD98059 inhibited the OxLDL-induced IL-8 production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 70-77 C-X-C motif chemokine ligand 8 Homo sapiens 106-110 20304034-10 2010 Further, the adhesin induced IL-8 secretion was reduced in the presence of the inhibitors of MEK (PD098059), p38-MAPK (SB203580) and JAK (-2,-3)/STAT-3 pathway (AG490). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 98-106 C-X-C motif chemokine ligand 8 Homo sapiens 29-33 19898747-5 2010 Further, pretreatment of these cells with the highly specific MEK inhibitor (PD 098059), the JNK inhibitor (SP 600125), and the p38MAPK inhibitor (SB 203580) resulted in inhibition of the IL-8 secretion by EAEC (wild type as well as plasmid cured)-infected INT-407 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 77-86 C-X-C motif chemokine ligand 8 Homo sapiens 188-192 19558546-9 2009 The secretion of IL-8 and specially TNF and IL-1beta was blocked by PD98059, SP600125, SB203580 and Bay11-7082, suggesting the involvement of the MAP kinases p38, c-Jun N-terminal kinase and ERK and particularly the NF-kappaB pathway, although IL-8 secretion was independent of p38. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 68-75 C-X-C motif chemokine ligand 8 Homo sapiens 17-21 19558546-9 2009 The secretion of IL-8 and specially TNF and IL-1beta was blocked by PD98059, SP600125, SB203580 and Bay11-7082, suggesting the involvement of the MAP kinases p38, c-Jun N-terminal kinase and ERK and particularly the NF-kappaB pathway, although IL-8 secretion was independent of p38. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 68-75 C-X-C motif chemokine ligand 8 Homo sapiens 244-248 20739465-10 2011 Hypertonicity-induced increases in IL-6 and IL-8 releases were suppressed by exposure to capsazepine, AG 1478, ERK inhibitor PD 98059, p38 inhibitor SB 203580, or NF-kappaB inhibitor PDTC. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 125-133 C-X-C motif chemokine ligand 8 Homo sapiens 44-48 19709445-11 2009 The IL-8 induced-IL-8 mRNA expression was inhibited by PD98059 (a MEK inhibitor) or SB203580 (a p38 MAPK inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 55-62 C-X-C motif chemokine ligand 8 Homo sapiens 4-8 19709445-11 2009 The IL-8 induced-IL-8 mRNA expression was inhibited by PD98059 (a MEK inhibitor) or SB203580 (a p38 MAPK inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 55-62 C-X-C motif chemokine ligand 8 Homo sapiens 17-21 19507016-5 2009 In the transfection experiment, PD98059, a MEK1 inhibitor, decreased the transcription of IL-8 in a dose dependent pattern. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 C-X-C motif chemokine ligand 8 Homo sapiens 90-94 19373630-11 2009 SB203580, PD98059, and wedeloactone decreased IL-8 production stimulated by Na(2)SO(3) (p < 0.01). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 10-17 C-X-C motif chemokine ligand 8 Homo sapiens 46-50 18789871-5 2008 In contrast, blockage of the ERK-specific MAP kinase MEK with PD98059, that prevents phosphorylation of ERK1/ERK2, abrogated insulin-induced CXCL8 release in primary monocytes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 62-69 C-X-C motif chemokine ligand 8 Homo sapiens 141-146 19567187-5 2009 (3) The effects of PD98059 and erythromycin on the expression of gamma-GCS, gamma-GCS mRNA, IL-8 and erythromycin on AP-1 combining activity by the 4-HNE were all detected. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-26 C-X-C motif chemokine ligand 8 Homo sapiens 92-96 19526316-7 2009 HGF-induced up-regulations of Egr-1, VEGF, and IL-8 were inhibited by the pretreatment with an MEK inhibitor, PD098059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 110-118 C-X-C motif chemokine ligand 8 Homo sapiens 47-51 18639962-11 2008 Inhibition of ERK1/2, JNK1/2 and p38 MAPK with PD98059, SP600125 and SB203580, respectively, led to the suppression of the shear stress-induced IL-8 gene expression (P<0.01), which was also blocked by JNK1/2 siRNA (small interfering RNA) (P<0.01). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-54 C-X-C motif chemokine ligand 8 Homo sapiens 144-148 18662754-6 2008 The induction of IL-8 by titanium dioxide nanoparticles was inhibited by the pre-treatment with SB203580 and PD98059, which means that the IL-8 was induced through p38 mitogen-activated protein kinase (MAPK) pathway and/or extracellular signal (ERK) pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 109-116 C-X-C motif chemokine ligand 8 Homo sapiens 17-21 18662754-6 2008 The induction of IL-8 by titanium dioxide nanoparticles was inhibited by the pre-treatment with SB203580 and PD98059, which means that the IL-8 was induced through p38 mitogen-activated protein kinase (MAPK) pathway and/or extracellular signal (ERK) pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 109-116 C-X-C motif chemokine ligand 8 Homo sapiens 139-143 18953964-12 2008 The expression of IL-8 and the AP-1 combining activity in groups of pre-incubated with PD98059 2 hours before 4-HNE stimulation were lower than that without PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 87-94 C-X-C motif chemokine ligand 8 Homo sapiens 18-22 18953964-12 2008 The expression of IL-8 and the AP-1 combining activity in groups of pre-incubated with PD98059 2 hours before 4-HNE stimulation were lower than that without PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 157-164 C-X-C motif chemokine ligand 8 Homo sapiens 18-22 17996917-4 2008 The ERK1/2-inhibitor PD98059, the p38-inhibitor SB202190 and the JNK1/2-inhibitor SP600125 partially inhibited the fluoride-induced IL-8 response. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 21-28 C-X-C motif chemokine ligand 8 Homo sapiens 132-136 18974961-12 2008 Pretreatment with PD98059 (ERK inhibitor), SB203580 (p38 inhibitor), or SP600125 (JNK inhibitor) decreased the IL-8 production induced by H(2)O(2). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-25 C-X-C motif chemokine ligand 8 Homo sapiens 111-115 18565136-7 2008 RESULTS: An ERK inhibitor, PD98059, as well as IM, obviated the OMP29-induced increase in IL-8 levels in HGEC. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 27-34 C-X-C motif chemokine ligand 8 Homo sapiens 90-94 18390828-7 2008 Selective MEK inhibitors (U0126 and PD-98059) blocked both IL-8/CXCL8 release and ERK1/2 phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 36-44 C-X-C motif chemokine ligand 8 Homo sapiens 59-63 18390828-7 2008 Selective MEK inhibitors (U0126 and PD-98059) blocked both IL-8/CXCL8 release and ERK1/2 phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 36-44 C-X-C motif chemokine ligand 8 Homo sapiens 64-69 16761312-5 2006 sPLA(2) induced the phosphorylation of the MAPK p38 and ERK1/2, and inhibition of these kinases by SB203580 and PD98059, respectively, reduced TNF-alpha and CXCL8 release. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 112-119 C-X-C motif chemokine ligand 8 Homo sapiens 157-162 17876544-10 2007 Inhibitors for ERK (PD98059 and U0216) and p38 MAPK (SB203580) significantly reduced the IL-17F-induced IL-6, IL-8, LIF, MMP-1, and MMP-3 secretion. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 20-27 C-X-C motif chemokine ligand 8 Homo sapiens 110-114 17178391-8 2007 Selective inhibitors of p38(mapk) (SB203580) or of MEK1/2, the direct upstream activator of ERK1/2 (PD98059), reduced the synthesis of IL-1beta, TNFalpha, IL-6 and IL-8 induced by either the chaperonins or LPS. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 100-107 C-X-C motif chemokine ligand 8 Homo sapiens 164-168 17460254-9 2007 The MMC-related IL-8 and MCP-1 expression was inhibited by both a p38 inhibitor (SB203580) and an ERK inhibitor (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 113-120 C-X-C motif chemokine ligand 8 Homo sapiens 16-20 16343928-5 2005 Pretreatment of MAPK inhibitors (PD98059 and SB203580) markedly blocked Ca(2+)-induced IL-8 production from cells, and anti-inflammatory drugs, such as dexamethasone and cyclosporin A, partially inhibited the activation of ERK1/2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-40 C-X-C motif chemokine ligand 8 Homo sapiens 87-91 16634798-10 2006 PD98059, an inhibitor of ERK phosphorylation, significantly reduced IgA AECA-stimulated endothelial IL-8. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 C-X-C motif chemokine ligand 8 Homo sapiens 100-104 16085674-6 2006 PD-98059, an inhibitor of MAP kinase/ERK kinase, inhibited CAM-induced IL-8 (P < 0.0001) and GM-CSF (P < 0.01) release. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-8 C-X-C motif chemokine ligand 8 Homo sapiens 71-75 16697690-6 2006 It was also found that PD98059, a mitogen-activated protein kinase (MAPK) pathway inhibitor and U0126, an inhibitor of extracellular signal-regulated kinase (ERK) blocks thrombin-induced phosphorylation of ERK1/2 and IL-8 secretion, indicating the involvement of MAPK/ERK signaling pathway in thrombin-induced IL-8 secretion. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 23-30 C-X-C motif chemokine ligand 8 Homo sapiens 217-221 16697690-6 2006 It was also found that PD98059, a mitogen-activated protein kinase (MAPK) pathway inhibitor and U0126, an inhibitor of extracellular signal-regulated kinase (ERK) blocks thrombin-induced phosphorylation of ERK1/2 and IL-8 secretion, indicating the involvement of MAPK/ERK signaling pathway in thrombin-induced IL-8 secretion. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 23-30 C-X-C motif chemokine ligand 8 Homo sapiens 310-314 16202406-11 2006 SB202190, PD98059 and doxycycline markedly suppressed the levels of p-JNK-1/p-JNK-2 and/or p-ERK1/p-ERK2, as well as IL-1beta, TNF-alpha and IL-8 mRNAs and proteins stimulated by hyperosmolar media. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 10-17 C-X-C motif chemokine ligand 8 Homo sapiens 141-145 16197369-7 2006 The LPA-induced secretion of IL-8 was blocked by the p38 MAPK inhibitor SB203580, by p38 MAPK siRNA (small interfering RNA), and by the JNK inhibitor JNK(i) II, but not by the MEK (MAPK/ERK kinase) inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 209-216 C-X-C motif chemokine ligand 8 Homo sapiens 29-33 16491014-8 2006 Ro-31-8220, a PKC inhibitor, and PD98059, a mitogen-activated protein/ERK kinase inhibitor, suppressed the histamine-induced ERK activation and the production of granulocyte macrophage colony-stimulating factor and IL-8. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-40 C-X-C motif chemokine ligand 8 Homo sapiens 215-219 15615716-7 2005 Blockade of MEK1 by PD98059 suppresses c-Fos and Fra-1 expression and, thus, affects two counteractive signals for IL-8 mRNA synthesis simultaneously. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 20-27 C-X-C motif chemokine ligand 8 Homo sapiens 115-119 16220077-7 2005 The inhibitors of ERK 1/2 (PD98059), p38 (SB203580) MAPK, and NF-kappaB (PDTC and MG132) significantly decreased C-reactive protein-induced IL-8 secretion in human monocytes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 27-34 C-X-C motif chemokine ligand 8 Homo sapiens 140-144 15701058-9 2005 Furthermore, specific MAPK inhibitors (PD98059, SB203580 and SP600125) inhibited the expression of IL-8 mRNA induced by CRP (50 microg/ml). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 39-46 C-X-C motif chemokine ligand 8 Homo sapiens 99-103 15585560-6 2005 The increase in IL-8 secretion was inhibited by PD98059, an inhibitor of extracellular signal-regulated kinase 1/2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 48-55 C-X-C motif chemokine ligand 8 Homo sapiens 16-20 15952644-1 2005 OBJECTIVE: This study was to investigate the effect of crocidolite fibers on IL-8 protein and mRNA levels in A549 cells cultured supernatant and the role of tyrosine kinase inhibitor PD98059 on IL-8 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 183-190 C-X-C motif chemokine ligand 8 Homo sapiens 194-198 15952644-3 2005 RESULTS: After incubating cells with 100 microg/ml of crocidolite, IL-8 protein releasing in supernatant was significantly increased and IL-8 mRNA was also higher than that of control, the differences were statistically significant (P < 0.05), however both IL-8 protein and mRNA was abrogated by pretreating cells with tyrosine kinase inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 348-355 C-X-C motif chemokine ligand 8 Homo sapiens 67-71 15952644-4 2005 CONCLUSION: IL-8 was shown as overexpression and could be decreased by PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 71-78 C-X-C motif chemokine ligand 8 Homo sapiens 12-16 15550066-8 2004 Both SB202190 and SP600125 suppressed IL-1beta-induced secretion of IL-6 and IL-8, and PD98059 suppressed IL-1beta-induced secretion of IL-8. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 87-94 C-X-C motif chemokine ligand 8 Homo sapiens 136-140 15218990-3 2004 IL-8 production was dependent on phosphorylation of ERK-1 and -2 and p38 MAPK, as examined by PD 098059 (10 microM), an inhibitor of the upstream activator of MAPK kinase (MKK)-1, and SB 203580 (10 microM), an inhibitor of p38 MAPK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 94-103 C-X-C motif chemokine ligand 8 Homo sapiens 0-4 15207247-3 2004 In this report, we demonstrate, using two potent and selective inhibitors of MEK activation by Raf-1 (PD-098059) and p38 (SB-203580), that both ERK1/2 and p38 pathways play a key role in the production of IL-8 by porins and LPS. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 102-111 C-X-C motif chemokine ligand 8 Homo sapiens 205-209 15207247-4 2004 Porin-stimulated expression of activating protein 1 (AP-1) and correlated IL-8 release is also inhibited by PD-098059 or SB-203580 indicating that the Raf-1/MEK1-MEK2/MAPK cascade is required for their activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 108-117 C-X-C motif chemokine ligand 8 Homo sapiens 74-78 15240896-4 2004 The IL-8 induction was significantly attenuated by inhibitors of the mitogen-activated protein kinases (MAPKs), p38 (SB202190) and extracellular signal-regulated kinase (ERK)-1 and -2 (PD98059), as well as a general protein tyrosine kinase (PTK) inhibitor (genistein). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 185-192 C-X-C motif chemokine ligand 8 Homo sapiens 4-8 12091253-6 2002 The blockade of p38 with the pharmacologic inhibitor SB203580 abrogated IL-8 production by cell stretching, and an inhibitor of the p44/42 pathway, PD98059, partially inhibited the IL-8 response. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 148-155 C-X-C motif chemokine ligand 8 Homo sapiens 181-185 12794155-6 2003 Respective inhibitors of these kinases, PP2 and PD98059, also blocked Ad19-induced IL-8 mRNA and protein expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 48-55 C-X-C motif chemokine ligand 8 Homo sapiens 83-87 14596794-9 2003 An inhibitor of the MAPK/ERK pathway, PD98059, blocked the phosphorylation of ERK1/2 and RANTES induction by LPC, but augmented IL-8 induction. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 38-45 C-X-C motif chemokine ligand 8 Homo sapiens 128-132 14553834-8 2003 Furthermore, the ERK 1/2 inhibitor, PD98059, and the p38 MAPK inhibitor, SB203580, markedly reduced 8-isoprostane-induced IL-8 expression (mRNA and protein), while inhibition of NF-kappaB activation and translocation had no significant effect on IL-8 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 36-43 C-X-C motif chemokine ligand 8 Homo sapiens 122-126 14553834-8 2003 Furthermore, the ERK 1/2 inhibitor, PD98059, and the p38 MAPK inhibitor, SB203580, markedly reduced 8-isoprostane-induced IL-8 expression (mRNA and protein), while inhibition of NF-kappaB activation and translocation had no significant effect on IL-8 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 36-43 C-X-C motif chemokine ligand 8 Homo sapiens 246-250 11989791-5 2002 We demonstrate that blockade of the p42/p44 MAPK signaling pathway by the inhibitor PD98059 suppresses IL-8-mediated PMNL chemotaxis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 84-91 C-X-C motif chemokine ligand 8 Homo sapiens 103-107 11891214-6 2002 Selective MAP kinase kinase (MEK)1/2 inhibitors, PD98059 and U0126, inhibited, in a dose-dependent manner, ML-1-induced expression of IL-6 and IL-8. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 49-56 C-X-C motif chemokine ligand 8 Homo sapiens 143-147 11971003-4 2002 IL-8-stimulated neutrophil adhesion to fibrinogen was blocked 50% by the MAPK/extracellular signal-related kinase-activating enzyme inhibitor PD098059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 142-150 C-X-C motif chemokine ligand 8 Homo sapiens 0-4 12056817-5 2002 The results showed that a MEK1 inhibitor, PD98059, a p38MAPK inhibitor, SB202190, and a protein kinase C (PKC) inhibitor, Calphostin C, markedly decreased the IL-8 secretion from SK-N-MC (RET) cells at 24 h after GDNF stimulation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 42-49 C-X-C motif chemokine ligand 8 Homo sapiens 159-163 11562079-8 2001 PD98059 and SB203580, known as a specific inhibitor of MEKI and p38 kinase, respectively, inhibited IL-8 gene expression showing that both of the kinase pathways are involved in IL-8 regulation in human monocytes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 C-X-C motif chemokine ligand 8 Homo sapiens 100-104 11966773-9 2002 The inhibitors genistein (tyrosine kinase inhibitor) and calphostin C (inhibitor of protein kinase C) reduced significantly the IL-17-stimulated mRNA expression of IL-8, GRO-alpha and GRO-beta in SFC, whereas PD98059 (inhibitor of MEK-1/2) was without effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 209-216 C-X-C motif chemokine ligand 8 Homo sapiens 164-168 11755918-4 2002 Studies to identify the signal transduction pathways involved showed that IL-8 upregulation-mediated by 15d-PGJ2 was markedly inhibited when the THP-1 macrophages were incubated with a highly selective and cell-permeable inhibitor of the mitogen-activated protein kinase (MAPK) signaling pathway, 2"-amino-3"-methoxyflavone (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 297-323 C-X-C motif chemokine ligand 8 Homo sapiens 74-78 11755918-4 2002 Studies to identify the signal transduction pathways involved showed that IL-8 upregulation-mediated by 15d-PGJ2 was markedly inhibited when the THP-1 macrophages were incubated with a highly selective and cell-permeable inhibitor of the mitogen-activated protein kinase (MAPK) signaling pathway, 2"-amino-3"-methoxyflavone (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 325-332 C-X-C motif chemokine ligand 8 Homo sapiens 74-78 11692108-6 2001 A selective MAP kinase kinase inhibitor, PD98059, inhibited IL-17-induced IL-6 and IL-8. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 41-48 C-X-C motif chemokine ligand 8 Homo sapiens 83-87 11562079-8 2001 PD98059 and SB203580, known as a specific inhibitor of MEKI and p38 kinase, respectively, inhibited IL-8 gene expression showing that both of the kinase pathways are involved in IL-8 regulation in human monocytes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 C-X-C motif chemokine ligand 8 Homo sapiens 178-182 11435224-4 2001 The mitogen-activated protein kinase/ERK kinase (MEK) activity inhibitor PD-98059 significantly abolished IL-8 released in response to Utah Valley PM, as did the epidermal growth factor (EGF) receptor kinase inhibitor AG-1478. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 73-81 C-X-C motif chemokine ligand 8 Homo sapiens 106-110 11325811-9 2001 The IL-17-induced release of IL-6 and IL-8 was concentration-dependently inhibited by SB202190 and by PD98059 in bronchial epithelial cells without affecting cell proliferation or survival. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 102-109 C-X-C motif chemokine ligand 8 Homo sapiens 38-42 11222496-9 2001 By blocking activation of ERK1/2 with a MEK-specific inhibitor, PD98059, CD40-dependent secretion of the pro-inflammatory cytokines, TNF-alpha, IL-6 and IL-8, was demonstrated to be linked to the ERK1/2 pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 64-71 C-X-C motif chemokine ligand 8 Homo sapiens 153-157 11028659-8 2000 Furthermore, PD98059 or SB203580 significantly suppressed BK-induced IL-6 and IL-8 production and their gene expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 C-X-C motif chemokine ligand 8 Homo sapiens 78-82 11076803-6 2000 The involvement of mitogen-activated protein kinase (MAPK) in IL-8-induced IL-8 biosynthesis was suggested by the ability of PD-98059, an inhibitor of MAPK kinase, to block this function. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 125-133 C-X-C motif chemokine ligand 8 Homo sapiens 62-66 11076803-6 2000 The involvement of mitogen-activated protein kinase (MAPK) in IL-8-induced IL-8 biosynthesis was suggested by the ability of PD-98059, an inhibitor of MAPK kinase, to block this function. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 125-133 C-X-C motif chemokine ligand 8 Homo sapiens 75-79 11121390-7 2001 Finally, using the specific MAPK inhibitor PD-98059, we demonstrated that MAPK activation is needed for neutrophil chemotaxis toward interleukin-8 and its priming by GM-CSF. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 43-51 C-X-C motif chemokine ligand 8 Homo sapiens 133-146 10722601-8 2000 The release of interleukin-8 was markedly suppressed by the p38 mitogen-activated protein kinase inhibitor SB203580 but was only minimally suppressed by the mitogen-activated protein/extracellular signal-regulated kinase inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 231-238 C-X-C motif chemokine ligand 8 Homo sapiens 15-28 10873157-5 2000 Expression of IL-6 and IL-8 was sensitive to SB203580, the specific inhibitor of p38 mitogen-activated protein (MAP) kinase and PD98059, an inhibitor of MAP kinase kinase. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 128-135 C-X-C motif chemokine ligand 8 Homo sapiens 23-27 10754327-14 2000 PD98059 and LY294002 significantly attenuated IL-8 delay of apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 C-X-C motif chemokine ligand 8 Homo sapiens 46-50 9353345-9 1997 The tyrosine kinase inhibitor, genistein, blocked tyrosine phosphorylation and secretion of interleukin-8, whereas the MAP kinase kinase inhibitor PD98059 partially inhibited secretion of interleukin-8. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 147-154 C-X-C motif chemokine ligand 8 Homo sapiens 188-201 10424432-4 1999 PD98059, an inhibitor of MAP kinase kinase (MEK), inhibited IL-6, IL-8 and basic FGF production in HS and all cytokines production except basic FGF in SW982. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 C-X-C motif chemokine ligand 8 Homo sapiens 66-70 9916078-5 1999 By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 9-17 C-X-C motif chemokine ligand 8 Homo sapiens 221-225 9784408-4 1998 Finally, the specific MEK inhibitor PD98059 inhibited ICAM-1-induced IL-8 and RANTES production in endothelial cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 36-43 C-X-C motif chemokine ligand 8 Homo sapiens 69-73