PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25093489-6 2014 Moreover, blocking ERK activation using the inhibitor PD98059 markedly reduced the effects of IGFBP-2 in glioma cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 54-61 mitogen-activated protein kinase 1 Homo sapiens 19-22 25226537-10 2014 Apoptosis was significantly induced by the combinatorial treatment (p<0.05) and significantly inhibited by ERK inhibitor (PD98059) in MCF-7 cells (p<0.05). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 125-132 mitogen-activated protein kinase 1 Homo sapiens 110-113 23172806-7 2014 Cytotoxicity and apoptosis induced by p-PD were markedly enhanced by ERK activation and selectively inhibited by ERK inhibitor PD98059, thus indicating a negative role of ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 127-134 mitogen-activated protein kinase 1 Homo sapiens 113-116 23172806-7 2014 Cytotoxicity and apoptosis induced by p-PD were markedly enhanced by ERK activation and selectively inhibited by ERK inhibitor PD98059, thus indicating a negative role of ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 127-134 mitogen-activated protein kinase 1 Homo sapiens 113-116 24994563-8 2014 After blocking LG-induced ERK and Sp1 expression using the ERK-specific inhibitor PD98059, monocytic differentiation in both HL60 and KG-1 cells decreased, suggesting that LG-induced differentiation proceeded through an ERK/Sp1 signaling axis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 82-89 mitogen-activated protein kinase 1 Homo sapiens 26-29 24994563-8 2014 After blocking LG-induced ERK and Sp1 expression using the ERK-specific inhibitor PD98059, monocytic differentiation in both HL60 and KG-1 cells decreased, suggesting that LG-induced differentiation proceeded through an ERK/Sp1 signaling axis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 82-89 mitogen-activated protein kinase 1 Homo sapiens 59-62 24994563-8 2014 After blocking LG-induced ERK and Sp1 expression using the ERK-specific inhibitor PD98059, monocytic differentiation in both HL60 and KG-1 cells decreased, suggesting that LG-induced differentiation proceeded through an ERK/Sp1 signaling axis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 82-89 mitogen-activated protein kinase 1 Homo sapiens 59-62 25229432-6 2014 Pretreatment with Y-27632, a Rho kinase inhibitor, or PD98059, an extracellular signal-regulated kinase (ERK) phosphorylation inhibitor, significantly abolished the TNF-alpha- or IL-1beta-induced increases in the permeability of the layers to 4 and 12 kDa dextrans. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 54-61 mitogen-activated protein kinase 1 Homo sapiens 66-103 25229432-6 2014 Pretreatment with Y-27632, a Rho kinase inhibitor, or PD98059, an extracellular signal-regulated kinase (ERK) phosphorylation inhibitor, significantly abolished the TNF-alpha- or IL-1beta-induced increases in the permeability of the layers to 4 and 12 kDa dextrans. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 54-61 mitogen-activated protein kinase 1 Homo sapiens 105-108 24833468-7 2014 Moreover, the level of phosphor-ERK1/2 and connexin43 was remarkably attenuated by a ERK pathway inhibitor (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 108-115 mitogen-activated protein kinase 1 Homo sapiens 32-35 25136261-7 2014 In other experiments, SB203580 and PD98059, which are inhibitors of p38 and ERK1/2, respectively, were used to determine if these kinases are involved in the osteogenic differentiation process. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 35-42 mitogen-activated protein kinase 1 Homo sapiens 68-71 24955924-4 2014 It was observed that the frequency of mEPSCs in the differentiated neurons cultured on both randomly oriented and aligned collagen nanofibrous scaffolds was higher than that on the collagen-coated control and can be inhibited by an ERK inhibitor (PD98059), indicating that the collagen nanofibers affected the maturation of the synapses from presynaptic sites via the MAPK/ERK1/2 pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 247-254 mitogen-activated protein kinase 1 Homo sapiens 232-235 24705173-9 2014 TXL upregulated mitogen-activated protein kinase and extracellular signal-regulated kinase (ERK) phosphorylation; however, PD98059 abrogated ERK phosphorylation and decreased autophagy and increased apoptosis compared with TXL alone. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 123-130 mitogen-activated protein kinase 1 Homo sapiens 141-144 24394624-6 2014 We also found perifosine, a novel AKT inhibitor, down-regulated GLI1 protein by dephosphorylation of AKT and GSK3beta dose-dependently and that pre-treatment with PD98059, a MEK/ERK pathway inhibitor, enhanced this down-regulation by 20%-30%. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 163-170 mitogen-activated protein kinase 1 Homo sapiens 178-181 24647664-7 2014 Quercetin was found to induce the apoptosis of these cells, and this apoptosis was inhibited by SB203580 (a p38 kinase inhibitor), SP600125 (a JNK inhibitor) and PD98059 (an ERK inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 162-169 mitogen-activated protein kinase 1 Homo sapiens 174-177 24390819-9 2014 UTP induced a time-dependent phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2), which was prevented by the incubation with PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 148-155 mitogen-activated protein kinase 1 Homo sapiens 48-94 24857917-6 2014 Furthermore, cell treatment with a JNK inhibitor (SP600125) and ERK inhibitor (PD98059) reduced sulfuretin-induced HO-1 expression and decreased its protective effects. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 79-86 mitogen-activated protein kinase 1 Homo sapiens 64-67 24525463-13 2014 In addition, the downregulation of Rad51 induced by OTA could be significantly attenuated with specific ERK inhibitor PD98059 or specific p38 MAPK inhibitor SB203580 pre-treatment in GES-1 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 118-125 mitogen-activated protein kinase 1 Homo sapiens 104-107 24849420-8 2014 Inhibition of ERK with PD98059 deactivated eNOS-Thr495 and restored super oxide dismutase (SOD) activity, while inhibition of either p38 with SB202190 or c-Jun with SP600125 did no produce such effects. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 23-30 mitogen-activated protein kinase 1 Homo sapiens 14-17 24357020-7 2014 Treatment with an inhibitor of ERK (PD98059) blocked the nitrotetrazolium blue chloride (NBT) reducing activity and CD11b expression in the N. chinensis-treated HL-60 cells, whereas treatment with an inhibitor of p38 MAPK (SB203580) had no significant effect on NBT reducing activity and CD11b expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 36-43 mitogen-activated protein kinase 1 Homo sapiens 31-34 24508476-7 2014 Furthermore, a specific MEK inhibitor, PD98059, could potentiate the pro-apoptotic effects of NC, which indicated that NC might trigger apoptosis in renal cancer cells partly via inhibition of ERK activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 39-46 mitogen-activated protein kinase 1 Homo sapiens 193-196 24385109-5 2014 These effects triggered by HDL were inhibited by pertussis toxin (PTX), protein kinase C (PKC) inhibitor GF109203X, and ERK inhibitor PD98059, suggesting that Galphai/Galphao-coupled GPCR, PKC, and ERK pathways are involved in HDL-induced COX-2/PGI-2 activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 134-141 mitogen-activated protein kinase 1 Homo sapiens 120-123 24424889-11 2014 MHY-449-induced apoptosis was partially prevented by pretreatment with the ERK inhibitor PD98059 suggesting involvement of ERK in the MHY-449-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 89-96 mitogen-activated protein kinase 1 Homo sapiens 75-78 24424889-11 2014 MHY-449-induced apoptosis was partially prevented by pretreatment with the ERK inhibitor PD98059 suggesting involvement of ERK in the MHY-449-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 89-96 mitogen-activated protein kinase 1 Homo sapiens 123-126 24270523-7 2014 Co-treatment with MESC and an ERK inhibitor (PD98059) significantly increased the expression of DR5 to induce apoptosis in MC-3 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 45-52 mitogen-activated protein kinase 1 Homo sapiens 30-33 24019108-7 2014 Addition of the chemical ERK inhibitors, PD98059 and U0126, significantly inhibited ERK protein phosphorylation, accompanied by induced DNA ladder formation, cleavage of caspase 3 and PARP protein in COLO205 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 41-48 mitogen-activated protein kinase 1 Homo sapiens 25-28 24019108-7 2014 Addition of the chemical ERK inhibitors, PD98059 and U0126, significantly inhibited ERK protein phosphorylation, accompanied by induced DNA ladder formation, cleavage of caspase 3 and PARP protein in COLO205 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 41-48 mitogen-activated protein kinase 1 Homo sapiens 84-87 24606459-10 2014 However PD98059, an inhibitor of ERK, enhanced CTL killing of T24 cells by reducing B7-H1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 8-15 mitogen-activated protein kinase 1 Homo sapiens 33-36 24216289-7 2014 The conjugate induced cell death was significantly increased in presence of A6730 (a potent Akt1/2 kinase inhibitor) and PD98059 (a specific ERK inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 121-128 mitogen-activated protein kinase 1 Homo sapiens 141-144 24482702-8 2014 Further, expression of p-ERK was rapidly up-regulated (after 10 min) by E2 (P<0.05), an effect that persisted 16 h after E2 exposure but which was significantly inhibited by PD98059 (P<0.05). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 177-184 mitogen-activated protein kinase 1 Homo sapiens 25-28 24416349-6 2014 Intriguingly, MEK/ERK inhibitors PD98059 and U0126 suppressed RAD001 plus MK-2206-induced beclin-1 expression, autophagy induction and cytotoxicity in HGC-27 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-40 mitogen-activated protein kinase 1 Homo sapiens 18-21 25124623-5 2014 The effects of insulin on the increase in the proliferation and migration of MCF-7 human breast cancer cells were abolished by pretreatment with the extracellular regulated kinase (ERK) inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 196-203 mitogen-activated protein kinase 1 Homo sapiens 181-184 25562159-10 2014 When the Het-1A monolayer was pretreated with melatonin and PD98059 before the acid incubation, the permeability and the expression and phosphorylation of MLCK and ERK decreased. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 60-67 mitogen-activated protein kinase 1 Homo sapiens 164-167 24277696-6 2014 The thrombin-induced increases in IL-8/CXCL8 release and IL-8/CXCL8-luciferase were also inhibited by MEKK1 siRNA, PD98059 (an MEK inhibitor), U0126 (an ERK inhibitor), and RSK1 siRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 115-122 mitogen-activated protein kinase 1 Homo sapiens 153-156 25124623-5 2014 The effects of insulin on the increase in the proliferation and migration of MCF-7 human breast cancer cells were abolished by pretreatment with the extracellular regulated kinase (ERK) inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 196-203 mitogen-activated protein kinase 1 Homo sapiens 149-179 24348851-2 2014 The activation of ERK was inhibited by PD98059, a specific inhibitor of ERK kinase. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 39-46 mitogen-activated protein kinase 1 Homo sapiens 18-21 24213635-6 2014 The effects of leptin on increasing the size and weight of the tumor in the nude mice and the proliferation and migration of MCF-7 human breast cancer cells were eradicated by pretreatment with LA, the extracellular-signal regulated kinase (ERK) inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 256-263 mitogen-activated protein kinase 1 Homo sapiens 202-239 24213635-6 2014 The effects of leptin on increasing the size and weight of the tumor in the nude mice and the proliferation and migration of MCF-7 human breast cancer cells were eradicated by pretreatment with LA, the extracellular-signal regulated kinase (ERK) inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 256-263 mitogen-activated protein kinase 1 Homo sapiens 241-244 24348851-2 2014 The activation of ERK was inhibited by PD98059, a specific inhibitor of ERK kinase. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 39-46 mitogen-activated protein kinase 1 Homo sapiens 72-75 23537125-6 2013 RESULTS: First, hypoxia promoted osteogenic differentiation in PDLSCs and enhanced EC migration, whereas PD98059 (extracellular signal-regulated protein kinase [ERK] inhibitor) blocked, and cocultured ECs further enhanced, hypoxia-induced osteogenic differentiation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 105-112 mitogen-activated protein kinase 1 Homo sapiens 114-159 23948751-2 2013 Therefore, PI3K inhibitor LY294002 (LY) and MEK1/2 inhibitor PD98059 (PD) are used to sensitize many types of cancer cell lines to chemotherapeutic agents, where AKT and ERK pathways are over activated. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 61-68 mitogen-activated protein kinase 1 Homo sapiens 170-173 24095251-8 2013 The activation in extracellular signal-related kinases (ERK) and p38 signaling pathways were observed in rBMSCs-OVX cultured in the extract of SrCS, and these effects could be blocked by ERK inhibitor PD98059, and P38 inhibitor SB203580, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 201-208 mitogen-activated protein kinase 1 Homo sapiens 18-54 24095251-8 2013 The activation in extracellular signal-related kinases (ERK) and p38 signaling pathways were observed in rBMSCs-OVX cultured in the extract of SrCS, and these effects could be blocked by ERK inhibitor PD98059, and P38 inhibitor SB203580, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 201-208 mitogen-activated protein kinase 1 Homo sapiens 56-59 24095251-8 2013 The activation in extracellular signal-related kinases (ERK) and p38 signaling pathways were observed in rBMSCs-OVX cultured in the extract of SrCS, and these effects could be blocked by ERK inhibitor PD98059, and P38 inhibitor SB203580, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 201-208 mitogen-activated protein kinase 1 Homo sapiens 65-68 24095251-8 2013 The activation in extracellular signal-related kinases (ERK) and p38 signaling pathways were observed in rBMSCs-OVX cultured in the extract of SrCS, and these effects could be blocked by ERK inhibitor PD98059, and P38 inhibitor SB203580, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 201-208 mitogen-activated protein kinase 1 Homo sapiens 187-190 24102669-8 2013 The increase in ALP activity in the quercetin-treated cells was not affected by ICI 182,780, an estrogen receptor inhibitor, and was partially blocked by PD98059, an extracellular signal-regulated kinase 1/2 (ERK1/2) inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 154-161 mitogen-activated protein kinase 1 Homo sapiens 166-207 23537125-6 2013 RESULTS: First, hypoxia promoted osteogenic differentiation in PDLSCs and enhanced EC migration, whereas PD98059 (extracellular signal-regulated protein kinase [ERK] inhibitor) blocked, and cocultured ECs further enhanced, hypoxia-induced osteogenic differentiation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 105-112 mitogen-activated protein kinase 1 Homo sapiens 161-164 24095863-9 2013 However, when co-administrating PD98059, an ERK phosphorylation inhibitor, an increased apoptosis was observed. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 44-47 24227918-10 2013 Pretreatment with LY294002 and PD98059 abolished apelin-induced activation of Akt and Erk, proliferation, and collagen I expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 31-38 mitogen-activated protein kinase 1 Homo sapiens 86-89 24370019-0 2013 [Inhibitory effect of PD98059 on MAPK signaling pathway in acute lymphocytic leukemia cells]. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 22-29 mitogen-activated protein kinase 1 Homo sapiens 33-37 23735541-7 2013 When these cells were preincubated for 90min with 20muM PD98059, 2"-amino-3"-methoxyflavone, an inhibitor of ERK phosphorylation, a slight reduction of cell viability was observed in comparison to that produced by Ptx alone. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 56-63 mitogen-activated protein kinase 1 Homo sapiens 109-112 23735541-7 2013 When these cells were preincubated for 90min with 20muM PD98059, 2"-amino-3"-methoxyflavone, an inhibitor of ERK phosphorylation, a slight reduction of cell viability was observed in comparison to that produced by Ptx alone. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 65-91 mitogen-activated protein kinase 1 Homo sapiens 109-112 23924696-7 2013 PD98059 (ERK inhibitor) can inhibit the activation of Jagged-1/Notch3 induced by apelin-13. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 9-12 24015505-8 2013 When the specific inhibitors PD98059 and Y27632 were used to inhibit phosphorylated ERK and p160 ROCKII activity, respectively, F-actin became disordered and the expression level of Runx2 was downregulated. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 29-36 mitogen-activated protein kinase 1 Homo sapiens 84-87 23602052-7 2013 The synergism effect of ERK inhibitor PD98059 with S1 confirmed the protective role of ER stress. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 38-45 mitogen-activated protein kinase 1 Homo sapiens 24-27 23942851-9 2013 Furthermore, IGFBP1 expression, elevated by PL, was suppressed by PD98059, an ERK inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 66-73 mitogen-activated protein kinase 1 Homo sapiens 78-81 24023832-9 2013 The c-fos promoter was suppressed completely in the presence of the MAPK inhibitor PD98059, an inhibitor of the MEK/ERK kinase cascade, but not in the presence of SKF86002, SB202190, or SP600125. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 83-90 mitogen-activated protein kinase 1 Homo sapiens 68-72 24098421-11 2013 Addition of ERK inhibitors (U0126 and PD98059) nullified the stimulatory effect of HLA-G5 on trophoblastic cell invasion. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 38-45 mitogen-activated protein kinase 1 Homo sapiens 12-15 24023832-9 2013 The c-fos promoter was suppressed completely in the presence of the MAPK inhibitor PD98059, an inhibitor of the MEK/ERK kinase cascade, but not in the presence of SKF86002, SB202190, or SP600125. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 83-90 mitogen-activated protein kinase 1 Homo sapiens 116-119 23707609-8 2013 Inhibition of Raf-ERK signaling by PD98059 decreased Nrf2 mRNA expression in HepG2 cells, confirming that the inhibition of Nrf2 expression is mediated by an attenuation of Raf-ERK signaling in cancer cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 35-42 mitogen-activated protein kinase 1 Homo sapiens 18-21 23707609-8 2013 Inhibition of Raf-ERK signaling by PD98059 decreased Nrf2 mRNA expression in HepG2 cells, confirming that the inhibition of Nrf2 expression is mediated by an attenuation of Raf-ERK signaling in cancer cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 35-42 mitogen-activated protein kinase 1 Homo sapiens 177-180 23708383-7 2013 Evodiamine-induced apoptosis was enhanced by its combination with the extracellular signal-regulated kinase (ERK) inhibitor PD98059 or the p38 mitogen-activated protein kinase (p38 MAPK) inhibitor SB203580. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 124-131 mitogen-activated protein kinase 1 Homo sapiens 70-107 23708383-7 2013 Evodiamine-induced apoptosis was enhanced by its combination with the extracellular signal-regulated kinase (ERK) inhibitor PD98059 or the p38 mitogen-activated protein kinase (p38 MAPK) inhibitor SB203580. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 124-131 mitogen-activated protein kinase 1 Homo sapiens 109-112 23163860-5 2013 Pretreatment with antioxidant N-acetyl-l-cysteine (NAC) and ERK inhibitor PD98059, but not NF-kappaB inhibitor Bay 11-7082, JNK inhibitor SP600125, p38 MAPK inhibitor SB203580, and PI3-K inhibitor LY294002, significantly reduced arecoline-induced PlGF protein synthesis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 74-81 mitogen-activated protein kinase 1 Homo sapiens 60-63 23295196-7 2013 We used PD98059, an inhibitor of extracellular signal-regulated kinase (ERK) activation, and demonstrated that PD98059 dramatically reduced MMP-9 production with attenuation of Smad2 activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 8-15 mitogen-activated protein kinase 1 Homo sapiens 33-70 23295196-7 2013 We used PD98059, an inhibitor of extracellular signal-regulated kinase (ERK) activation, and demonstrated that PD98059 dramatically reduced MMP-9 production with attenuation of Smad2 activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 8-15 mitogen-activated protein kinase 1 Homo sapiens 72-75 23295196-7 2013 We used PD98059, an inhibitor of extracellular signal-regulated kinase (ERK) activation, and demonstrated that PD98059 dramatically reduced MMP-9 production with attenuation of Smad2 activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 111-118 mitogen-activated protein kinase 1 Homo sapiens 33-70 23295196-7 2013 We used PD98059, an inhibitor of extracellular signal-regulated kinase (ERK) activation, and demonstrated that PD98059 dramatically reduced MMP-9 production with attenuation of Smad2 activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 111-118 mitogen-activated protein kinase 1 Homo sapiens 72-75 23825585-9 2013 MEK inhibitors PD98059 and U0216 not only inhibited the phosphorylation of STAT1, but also abrogated dasatinib-induced myeloid differentiation, suggesting that MEK/ERK dependent phosphorylation of STAT1 might be indispensable for the differentiating effect of dasatinib in AML cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 15-22 mitogen-activated protein kinase 1 Homo sapiens 164-167 23494124-6 2013 Treatment with the ERK inhibitor PD-98059 decreased PHB-induced ARE activation, suggesting that ERK constitutes a significant portion of PHB-mediated ARE activation in Caco-2-BBE cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-41 mitogen-activated protein kinase 1 Homo sapiens 19-22 23494562-7 2013 Intracellular calcium chelator BAPTA-AM, the selective inhibitor of EGFR AG1478 and the selective inhibitor of Erk PD98059 blocked EP1 receptor activation-induced CREB phosphorylation and MMP2 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 115-122 mitogen-activated protein kinase 1 Homo sapiens 111-114 23494124-6 2013 Treatment with the ERK inhibitor PD-98059 decreased PHB-induced ARE activation, suggesting that ERK constitutes a significant portion of PHB-mediated ARE activation in Caco-2-BBE cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-41 mitogen-activated protein kinase 1 Homo sapiens 96-99 23696862-6 2013 Additionally, DTCD stimulated extracellular signal-regulated kinase (ERK) activation, while the ERK inhibitor PD98059 blocked DTCD-induced DR5 expression and suppressed binding of Sp1 to the DR5 promoter. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 110-117 mitogen-activated protein kinase 1 Homo sapiens 96-99 23395717-9 2013 Inhibition of ERK activation using PD98059 significantly decreased NBT+HL60 cells induced by XC treatment. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 35-42 mitogen-activated protein kinase 1 Homo sapiens 14-17 23397952-11 2013 Blockade of melatonin membrane receptor MT1/MT2 or extracellular signal-regulated kinase (ERK) pathway with luzindole or PD98059, respectively, abolished the inhibitory effects of melatonin on leucocyte apoptosis evoked by TNF-alpha/CHX. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 121-128 mitogen-activated protein kinase 1 Homo sapiens 51-88 23397952-11 2013 Blockade of melatonin membrane receptor MT1/MT2 or extracellular signal-regulated kinase (ERK) pathway with luzindole or PD98059, respectively, abolished the inhibitory effects of melatonin on leucocyte apoptosis evoked by TNF-alpha/CHX. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 121-128 mitogen-activated protein kinase 1 Homo sapiens 90-93 23262982-6 2013 An inhibitor of MEK1 activation (PD98059) that prevents downstream extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and a specific inhibitor of p38 were also used as mitogen activated protein kinase-targeting therapy is being investigated as a treatment modality for osteosarcoma. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-40 mitogen-activated protein kinase 1 Homo sapiens 67-108 23482085-10 2013 The in vitro results showed that EGF induces the upregulation of KCa3.1 and P-ERK in HUVECs and that this upregulation is suppressed by PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 136-143 mitogen-activated protein kinase 1 Homo sapiens 78-81 23345412-8 2013 In the early stage of sulfatide stimulation, phosphorylation of Erk as well as c-Src was noted, and inhibition of Erk activation with either U0126 or PD98059 significantly suppressed Sp1 phosphorylation and integrin alphaV expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 150-157 mitogen-activated protein kinase 1 Homo sapiens 114-117 23490067-5 2013 Furthermore, activation of extracellular-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) by TPA+AA was identified in HL-60 cells, and the ERK inhibitor, PD98059, but not the JNK inhibitor, SP600125, inhibited TPA+AA-induced NBT-positive cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 162-169 mitogen-activated protein kinase 1 Homo sapiens 27-57 23490067-5 2013 Furthermore, activation of extracellular-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) by TPA+AA was identified in HL-60 cells, and the ERK inhibitor, PD98059, but not the JNK inhibitor, SP600125, inhibited TPA+AA-induced NBT-positive cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 162-169 mitogen-activated protein kinase 1 Homo sapiens 59-62 23490067-5 2013 Furthermore, activation of extracellular-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) by TPA+AA was identified in HL-60 cells, and the ERK inhibitor, PD98059, but not the JNK inhibitor, SP600125, inhibited TPA+AA-induced NBT-positive cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 162-169 mitogen-activated protein kinase 1 Homo sapiens 147-150 23490067-6 2013 Suppression of TPA+AA-induced ERK protein phosphorylation by PD98059 and NAC was detected, and AA enhanced ERK protein phosphorylation by TPA was in HL-60 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 61-68 mitogen-activated protein kinase 1 Homo sapiens 30-33 23135225-7 2013 Vaspin stimulated the phosphorylation of ERK, and pretreatment of hOBs with the ERK inhibitor PD98059 blocked the vaspin-induced activation of ERK, however, vaspin did not stimulate the phosphorylation of p38, JNK or Akt. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 94-101 mitogen-activated protein kinase 1 Homo sapiens 80-83 23135225-7 2013 Vaspin stimulated the phosphorylation of ERK, and pretreatment of hOBs with the ERK inhibitor PD98059 blocked the vaspin-induced activation of ERK, however, vaspin did not stimulate the phosphorylation of p38, JNK or Akt. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 94-101 mitogen-activated protein kinase 1 Homo sapiens 80-83 23302779-7 2013 Importantly, PD98059, an ERK inhibitor, partially abrogated the suppression of UCP1 promoter activation and mRNA induction. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 25-28 23306155-6 2013 Derlin-1 overexpression up-regulated MMP-2/9 expression and ERK phosphorylation, which could be reversed by MAP kinase/ERK kinase inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 141-148 mitogen-activated protein kinase 1 Homo sapiens 60-63 23306155-6 2013 Derlin-1 overexpression up-regulated MMP-2/9 expression and ERK phosphorylation, which could be reversed by MAP kinase/ERK kinase inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 141-148 mitogen-activated protein kinase 1 Homo sapiens 119-122 23262982-9 2013 p38 activation by BMP-9 or pBMP-9 was also enhanced by PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 55-62 mitogen-activated protein kinase 1 Homo sapiens 0-3 23354417-7 2013 When the phosphorylation of p38 was inhibited by SB203580 (a p38 inhibitor), the S100A9-induced cell invasion was reversed; when the phosphorylation of ERK1/2 was inhibited by PD98059 (an ERK1/2 inhibitor), the S100A9-induced cell proliferation was reversed. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 176-183 mitogen-activated protein kinase 1 Homo sapiens 28-31 23354417-7 2013 When the phosphorylation of p38 was inhibited by SB203580 (a p38 inhibitor), the S100A9-induced cell invasion was reversed; when the phosphorylation of ERK1/2 was inhibited by PD98059 (an ERK1/2 inhibitor), the S100A9-induced cell proliferation was reversed. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 176-183 mitogen-activated protein kinase 1 Homo sapiens 61-64 23233127-4 2013 Enhanced proliferation in integrin alpha3-silenced cells is mediated by upregulation and nuclear localization of cyclin-dependent kinases, and these effects require the activation of Akt and ERK as evidenced by treatment with LY294002 and PD98059, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 275-282 mitogen-activated protein kinase 1 Homo sapiens 227-230 23184927-10 2013 Moreover, pretreatment with the JAK2/STAT3 inhibitor AG490 and the ERK inhibitor PD98059 significantly inhibited leptin-induced cell growth. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 81-88 mitogen-activated protein kinase 1 Homo sapiens 67-70 23879997-11 2013 When the ERK signaling was blocked by 40 micromol/L PD98059, the 0.001 and 0.01 micromol/L paclitaxel-induced early apoptosis rate in A375 cells was increased by 2.73- and 2.25-fold, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 52-59 mitogen-activated protein kinase 1 Homo sapiens 9-12 22990021-6 2013 PFOS exposure selectively increased activation of ERK that remained above control over 6 h. The inhibitor of ERK pathway, PD98059, substantially blocked caspase-3 activation induced by PFOS, whereas inhibitors of JNK and p38 MAPK, SP600125 and SB203580, respectively, had no effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 122-129 mitogen-activated protein kinase 1 Homo sapiens 50-53 22990021-6 2013 PFOS exposure selectively increased activation of ERK that remained above control over 6 h. The inhibitor of ERK pathway, PD98059, substantially blocked caspase-3 activation induced by PFOS, whereas inhibitors of JNK and p38 MAPK, SP600125 and SB203580, respectively, had no effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 122-129 mitogen-activated protein kinase 1 Homo sapiens 109-112 22716951-6 2013 The levels of phospho-Akt and phospho-extracellular signal-related kinase (ERK) were reduced in cells treated with maslinic acid, and the phosphoinositide 3-kinase inhibitor LY294002 and the mitogen-activated protein kinase kinase inhibitor PD98059 reduced HIF-1alpha levels and VEGF secretion. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 241-248 mitogen-activated protein kinase 1 Homo sapiens 30-73 22716951-6 2013 The levels of phospho-Akt and phospho-extracellular signal-related kinase (ERK) were reduced in cells treated with maslinic acid, and the phosphoinositide 3-kinase inhibitor LY294002 and the mitogen-activated protein kinase kinase inhibitor PD98059 reduced HIF-1alpha levels and VEGF secretion. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 241-248 mitogen-activated protein kinase 1 Homo sapiens 75-78 23589723-4 2013 Conversely, silencing of AMPK alpha blocked PARP cleavage and ERK activation induced by CB-PIC, while ERK inhibitor PD 98059 attenuated the phosphorylation of AMPK alpha in hypoxic SW620 cells, implying cross-talk between ERK and AMPK alpha . 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 116-124 mitogen-activated protein kinase 1 Homo sapiens 102-105 23589723-4 2013 Conversely, silencing of AMPK alpha blocked PARP cleavage and ERK activation induced by CB-PIC, while ERK inhibitor PD 98059 attenuated the phosphorylation of AMPK alpha in hypoxic SW620 cells, implying cross-talk between ERK and AMPK alpha . 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 116-124 mitogen-activated protein kinase 1 Homo sapiens 102-105 23843790-6 2013 Moreover, puerarin activated ERK signaling pathways in hOBs, and the antiapoptotic effect induced by puerarin was abolished by incubation of ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 155-162 mitogen-activated protein kinase 1 Homo sapiens 141-144 23128598-8 2013 The inhibition of ERK (PD98059) significantly prevented the bufalin-induced suppression of T24 cell migration. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 23-30 mitogen-activated protein kinase 1 Homo sapiens 18-21 23468994-6 2013 Inhibition of extracellular signal-regulated kinase 1/2 (ERK1/2) activation with PD98059 and p38 mitogen-activated protein kinase activity by SB203580 resulted in suppression of TGF-beta-induced TIMP-3 expression, indicating that ERK1/2 and p38 MAPK mediate the effect of TGF-beta on TIMP-3 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 81-88 mitogen-activated protein kinase 1 Homo sapiens 14-55 23017243-10 2012 PD98059 (ERK inhibitor) suppressed Comp A-induced phosphorylation of serine 431 and reorganization of K8. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 9-12 22689083-12 2012 Importantly, inactivation of its downstream molecule ERK by PD98059, a MEK inhibitor, also induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 60-67 mitogen-activated protein kinase 1 Homo sapiens 53-56 24027750-8 2013 Treatment with the ERK inhibitor PD98059 or depletion of ERK with siRNA partially reversed IFN-alpha-induced upregulation of TP expression, thus partially preventing apoptosis induced by IFN-alpha and 5"-DFUR. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-40 mitogen-activated protein kinase 1 Homo sapiens 19-22 23308050-6 2012 Inhibition of ERK using ERK inhibitor PD98059 decreased both MICA/B and ULBP2 expressions and NK cell cytotoxicity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 38-45 mitogen-activated protein kinase 1 Homo sapiens 14-17 23308050-6 2012 Inhibition of ERK using ERK inhibitor PD98059 decreased both MICA/B and ULBP2 expressions and NK cell cytotoxicity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 38-45 mitogen-activated protein kinase 1 Homo sapiens 24-27 22678810-6 2012 In addition, inhibition of ERK activity with PD98059 resulted in reversion of the wedelolactone-mediated inhibition of adipogenic differentiation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 45-52 mitogen-activated protein kinase 1 Homo sapiens 27-30 22383088-7 2012 Furthermore, taurine activated the extracellular signal-regulated protein kinase (ERK) pathway via TAUT, and the inhibitor of ERK (PD98059) abolished the effect of taurine on both ALP activity/expression and Cbfalpha1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 131-138 mitogen-activated protein kinase 1 Homo sapiens 35-80 23149874-8 2012 The further study indicated that hexamethonium, PD98059, and SB203580 significantly inhibited ERK1/2 and p38 MAPK phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 48-55 mitogen-activated protein kinase 1 Homo sapiens 105-108 22383088-7 2012 Furthermore, taurine activated the extracellular signal-regulated protein kinase (ERK) pathway via TAUT, and the inhibitor of ERK (PD98059) abolished the effect of taurine on both ALP activity/expression and Cbfalpha1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 131-138 mitogen-activated protein kinase 1 Homo sapiens 126-129 22773582-5 2012 Similar results were found with PD98059, an inhibitor of extracellular signal-regulated kinase (ERK). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 57-94 22795852-10 2012 This increased effect was due to the activation of MAPK/ERK signaling pathway since disruption of this pathway using an ERK inhibitor PD98059 results in down-regulation of these osteogenic genes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 134-141 mitogen-activated protein kinase 1 Homo sapiens 51-55 22795852-10 2012 This increased effect was due to the activation of MAPK/ERK signaling pathway since disruption of this pathway using an ERK inhibitor PD98059 results in down-regulation of these osteogenic genes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 134-141 mitogen-activated protein kinase 1 Homo sapiens 56-59 22795852-10 2012 This increased effect was due to the activation of MAPK/ERK signaling pathway since disruption of this pathway using an ERK inhibitor PD98059 results in down-regulation of these osteogenic genes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 134-141 mitogen-activated protein kinase 1 Homo sapiens 120-123 22749438-9 2012 The MAPK/ERK kinase inhibitor PD98059, the JNK inhibitor SP600125 and the p38 MAPK inhibitor SB203580 all potently inhibited PMB-induced HGF production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 mitogen-activated protein kinase 1 Homo sapiens 4-8 22217516-5 2012 Similarly, soy peptide-induced phosphorylation of the ERK/mTOR/S6RP/eIF4E pathway was blocked in response to pretreatment with PD98059, a specific ERK inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 127-134 mitogen-activated protein kinase 1 Homo sapiens 54-57 22217516-5 2012 Similarly, soy peptide-induced phosphorylation of the ERK/mTOR/S6RP/eIF4E pathway was blocked in response to pretreatment with PD98059, a specific ERK inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 127-134 mitogen-activated protein kinase 1 Homo sapiens 147-150 22781708-1 2012 AIMS: To analyze the combined impact of the histone deacetylase inhibitor (HDACI) Trichostatin A (TSA) and the extracellular-signal-regulated kinase 1/2 (ERK1/2) inhibitor PD98059 on gastric cancer (GC) cell line SGC7901 growth. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 172-179 mitogen-activated protein kinase 1 Homo sapiens 111-152 22828439-6 2012 Pretreatment with the ERK inhibitor PD98059 significantly blocked the loss of viability in calactin-treated cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 36-43 mitogen-activated protein kinase 1 Homo sapiens 22-25 22735740-4 2012 The associated B cell lymphoma (Bcl)-xL overexpression (1.05 +- 0.39 fold) was abolished by both JAK2 and extracellular signal-regulated kinase (ERK)1/2 inhibitors (AG490, 10 muM, and PD98059, 30 muM, respectively), whereas Fas ligand (Fas-L) response (0.91 +- 0.21 fold) was inhibited only by p38MAPK antagonism (SB203580, 10 muM). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 184-191 mitogen-activated protein kinase 1 Homo sapiens 106-152 22842465-7 2012 Omentin, NF-kB inhibitor (BAY11-7082) and ERK inhibitor (PD98059) reduced the up-regulation of ICAM-1 and VCAM-1 induced by TNF-alpha. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 57-64 mitogen-activated protein kinase 1 Homo sapiens 42-45 22659165-11 2012 Furthermore, this stimulation was blocked by a VEGFR-2 neutralizing antibody (MAB3571) and an ERK inhibitor (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 109-116 mitogen-activated protein kinase 1 Homo sapiens 94-97 21988060-8 2012 Coimmunoprecipitation further confirmed that there was an interaction between phosphorylation of ERK and cyclin D1, CDK4, cyclin B1, or CDK1, which was weaken in the presence of melatonin or PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 191-198 mitogen-activated protein kinase 1 Homo sapiens 97-100 22534171-9 2012 In contrast, ERK inhibitor PD98059 and ERK siRNA enhanced TF promoter activity by 2.5 fold and induced an increase in TF mRNA and protein levels in a dose dependent manner in these cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 27-34 mitogen-activated protein kinase 1 Homo sapiens 13-16 22747445-6 2012 JunB overexpression markedly stimulated the S100A2 promoter which was blocked by the dominant-negative JunB and MEK1 [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase 1] inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 223-230 mitogen-activated protein kinase 1 Homo sapiens 118-122 22747445-6 2012 JunB overexpression markedly stimulated the S100A2 promoter which was blocked by the dominant-negative JunB and MEK1 [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase 1] inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 223-230 mitogen-activated protein kinase 1 Homo sapiens 158-161 22731705-5 2012 Total ERK protein did not change under the same experimental conditions, and an inhibitor of p-ERK (PD98059) inhibited the proliferation and migration of EPCs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 100-107 mitogen-activated protein kinase 1 Homo sapiens 95-98 22824956-6 2012 The prevention of MEK by the pharmacologic inhibitors PD98059 and U0126, resulted in decreased UDCA-induced apoptosis as shown by the reduction of apoptotic body formation, caspase-8 activity, and caspase-3, -6 and PARP cleavage, indicating that ERK exerts pro-apoptotic activity upon exposure to UDCA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 66-73 mitogen-activated protein kinase 1 Homo sapiens 282-285 22573375-3 2012 PD98059 (a MEK inhibitor) increases dephosphorylated ERK and enhances the hypotonic-stress-stimulated Na(+) reabsorption. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 53-56 22525867-10 2012 The addition of the extracellular signal-regulated kinase (ERK) inhibitor PD98059 abolished BITC/cisplatin-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 74-81 mitogen-activated protein kinase 1 Homo sapiens 20-57 22525867-10 2012 The addition of the extracellular signal-regulated kinase (ERK) inhibitor PD98059 abolished BITC/cisplatin-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 74-81 mitogen-activated protein kinase 1 Homo sapiens 59-62 22773582-5 2012 Similar results were found with PD98059, an inhibitor of extracellular signal-regulated kinase (ERK). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 96-99 22543706-9 2012 The phosphorylation of ERK in the cells was blocked by pretreatment with the MEK1 specific inhibitor PD98059 (50 mumol/L), but not by the PI3K inhibitor wortmannin (1 mumol/L) or PKA inhibitor H89 (10 mumol/L). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 101-108 mitogen-activated protein kinase 1 Homo sapiens 23-26 22582395-8 2012 An anti-TGFbeta2 antibody and PD98059, an ERK activation inhibitor, inhibited SH-SY5Y cell proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 mitogen-activated protein kinase 1 Homo sapiens 42-45 22425902-15 2012 Finally, rosiglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2) caused phosphorylation of ERK; inhibition of ERK by PD98059 inhibited microparticle generation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 120-127 mitogen-activated protein kinase 1 Homo sapiens 94-97 22425902-15 2012 Finally, rosiglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2) caused phosphorylation of ERK; inhibition of ERK by PD98059 inhibited microparticle generation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 120-127 mitogen-activated protein kinase 1 Homo sapiens 113-116 22652796-5 2012 Furthermore, treatment of PANC-1 cells with 2-MPG or ERK inhibitor PD98059 reduced the phosphorylation of ERK, resulting in attenuation of BMP2-induced cell invasion and MMP-2 activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 67-74 mitogen-activated protein kinase 1 Homo sapiens 53-56 22652796-5 2012 Furthermore, treatment of PANC-1 cells with 2-MPG or ERK inhibitor PD98059 reduced the phosphorylation of ERK, resulting in attenuation of BMP2-induced cell invasion and MMP-2 activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 67-74 mitogen-activated protein kinase 1 Homo sapiens 106-109 22494498-7 2012 This effect was partially reversed by the simultaneous administration of the ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 91-98 mitogen-activated protein kinase 1 Homo sapiens 77-80 22502979-4 2012 PD98059, a specific inhibitor of the mitogen-activated protein kinase kinase (MEK) activator, was administered to block the ERK/MAPK pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 124-127 22103431-7 2012 Inhibition of ERK activation using either PD98059 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] or U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio] butadiene) had no impact on Abeta production, and knockdown of endogenous GCS using small interfering RNA reduced cellular GSL levels without suppressing Abeta production or pERK formation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 42-49 mitogen-activated protein kinase 1 Homo sapiens 14-17 22103431-7 2012 Inhibition of ERK activation using either PD98059 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] or U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio] butadiene) had no impact on Abeta production, and knockdown of endogenous GCS using small interfering RNA reduced cellular GSL levels without suppressing Abeta production or pERK formation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 51-100 mitogen-activated protein kinase 1 Homo sapiens 14-17 22200661-7 2012 However, AG1478, PD98059 and antibody against TGF-alpha deactivating the EGFR-MEK-ERK signaling pathway, abolished up-regulation of MMP-2, MMP-9 and prevented cell invasion. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 29-36 mitogen-activated protein kinase 1 Homo sapiens 94-97 21769870-7 2012 PD98059, an ERK inhibitor, K252a, a specific inhibitor for TrkB, a high affinity receptor of BDNF, and an anti-integrin alpha(V)beta(3) antibody suppressed the BDNF-induced migration. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 12-15 22228200-5 2012 CHPG and CDPPB enhanced the activation of ERK after traumatic neuronal injury, and PD98059 and U0126, two selective MEK/ERK inhibitors, partly revised the protective effects. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 83-90 mitogen-activated protein kinase 1 Homo sapiens 120-123 22019892-6 2012 We detected significant ERK activation in response to CdCl(2) and pretreatment with the ERK inhibitor PD98059 attenuated cadmium-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 102-109 mitogen-activated protein kinase 1 Homo sapiens 24-27 22247346-5 2012 The MAPK-ERK inhibitor PD98059 was applied to delineate the involvement of specific pathways during this interaction process. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 23-30 mitogen-activated protein kinase 1 Homo sapiens 9-12 22247346-7 2012 Upregulation of ADAMTS and MMP under these conditions was correlated with activation of the MAPK-ERK1/2 signaling pathway, and addition of the MAPK-ERK inhibitor PD98059 reversed the overexpression of ADAMTS and MMP in cocultures. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 162-169 mitogen-activated protein kinase 1 Homo sapiens 97-100 22082048-7 2012 Furthermore, PD98059, the inhibitor of the ERK pathway, inhibited the differentiation of HL-60 cells induced by H2O2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 43-46 22293124-8 2012 Furthermore, inhibiting ERK pathway activation with PD98059 markedly blocked MEMAC-induced HL60 monocytic differentiation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 52-59 mitogen-activated protein kinase 1 Homo sapiens 24-27 22230261-5 2012 ERK inhibitor PD98059 and p38 inhibitor SB203580 significantly reversed the depression of Cdc25C/p-Cdc25C, Cdc2/p-Cdc2, cyclinB1 as well as the cyclinB1-Cdc2 complex, thereby, abolished the delay in G2 phase. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 14-21 mitogen-activated protein kinase 1 Homo sapiens 0-3 22364340-7 2012 Interestingly, intrathecal introduction of PD98059, an ERK upstream kinase inhibitor, markedly blocked the acetic acid-stimulated pain responses. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 43-50 mitogen-activated protein kinase 1 Homo sapiens 55-58 22266311-9 2012 Further, stretch suppression of BMP4-induced MSC adipogenesis was significantly deteriorated if cells were stretched with ERK blocked by PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 137-144 mitogen-activated protein kinase 1 Homo sapiens 122-125 22019892-6 2012 We detected significant ERK activation in response to CdCl(2) and pretreatment with the ERK inhibitor PD98059 attenuated cadmium-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 102-109 mitogen-activated protein kinase 1 Homo sapiens 88-91 22182776-9 2012 PD98059, a specific ERK inhibitor, significantly blocked wogonin-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 20-23 22904641-10 2012 This effect was blocked by the ERK inhibitor PD98059, and was dependent on NHE activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 45-52 mitogen-activated protein kinase 1 Homo sapiens 31-34 22799384-6 2012 In addition, ERK1/2 and p38 MAPK were shown to play a crucial role in mediating EGF-induced NF-kappaB translocation and phosphorylation of IkappaBalpha when treated with the MAPK inhibitors, PD98059 and SB203580, which resulted in increased MMP-12 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 191-198 mitogen-activated protein kinase 1 Homo sapiens 24-27 22863969-7 2012 The fomitoside-K induced cell death by ROS was significantly inhibited by NAC, ERK (PD98059) and JNK inhibitor (SP600125). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 84-91 mitogen-activated protein kinase 1 Homo sapiens 79-82 21358682-7 2012 PI3K and p-ERK expression were also decreased in G-CSF-treated NK-92MI cells, and their inhibitors, wortmannin and PD98059, respectively, both enhanced the downregulation of cytotoxicity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 115-122 mitogen-activated protein kinase 1 Homo sapiens 11-14 22466960-8 2012 Interruption of ERK and p53 activities decreased SU11274-induced autophagy, and blocking of ERK by the specific inhibitor PD98059 suppressed SU11274-induced p53 activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 122-129 mitogen-activated protein kinase 1 Homo sapiens 92-95 23243457-6 2012 Conversely, ERK inhibitor PD98059 promoted the intercellular communication in H(2)O(2)-treated HaCaT cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 26-33 mitogen-activated protein kinase 1 Homo sapiens 12-15 22176685-4 2011 Moreover, incubation with an anti-PGRN antibody, an inhibitor of the ERK pathway (PD98059) or both in combination inhibited the ability of MDA-MB-231 cells to invade. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 82-89 mitogen-activated protein kinase 1 Homo sapiens 69-72 22249107-6 2012 The presence of either the mitogen-activated protein kinase (MAPK) inhibitor (PD98059), or PI-3K inhibitor (LY294002), reduced the effect of adiponectin in a dose-dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 78-85 mitogen-activated protein kinase 1 Homo sapiens 61-65 23285101-7 2012 But inhibition of ERK signaling by U0126 or PD98059 could reduce the level of FOXM1 in GRB7-overexpressing ovarian cancer cells, suggesting that GRB7, ERK and FOXM1 are regulated orderly. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 44-51 mitogen-activated protein kinase 1 Homo sapiens 18-21 23285101-7 2012 But inhibition of ERK signaling by U0126 or PD98059 could reduce the level of FOXM1 in GRB7-overexpressing ovarian cancer cells, suggesting that GRB7, ERK and FOXM1 are regulated orderly. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 44-51 mitogen-activated protein kinase 1 Homo sapiens 151-154 23285101-8 2012 Moreover, inhibition of ERK activity by U0126 or PD98059, or decreased FOXM1 expression by Thiostrepton significantly inhibited cell migration/invasion, tumor growth in vitro and in vivo. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 49-56 mitogen-activated protein kinase 1 Homo sapiens 24-27 23024780-7 2012 Although inhibition of ERK phosphorylation by PD98059 promoted actin polymerization, it increased apoptosis and GSIS impairment. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 46-53 mitogen-activated protein kinase 1 Homo sapiens 23-26 22879928-11 2012 Co-treatment of cultures with either Cu(II)(atsm) or an ERK inhibitor, PD98059 both prevented ERK activation and blocked formation of TDP-43-and HuR-positive SGs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 71-78 mitogen-activated protein kinase 1 Homo sapiens 56-59 22879928-11 2012 Co-treatment of cultures with either Cu(II)(atsm) or an ERK inhibitor, PD98059 both prevented ERK activation and blocked formation of TDP-43-and HuR-positive SGs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 71-78 mitogen-activated protein kinase 1 Homo sapiens 94-97 22848623-6 2012 Pretreatment with upstream ERK kinase inhibitor PD98059 prevented food avoidance learning in adult Helix. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 48-55 mitogen-activated protein kinase 1 Homo sapiens 27-30 22848623-10 2012 The acetylation of histone H3 is regulated by ERK kinase, since the upstream ERK kinase inhibitor PD98059 prevented the increase of histone H3 acetylation upon learning. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 98-105 mitogen-activated protein kinase 1 Homo sapiens 46-49 22848623-10 2012 The acetylation of histone H3 is regulated by ERK kinase, since the upstream ERK kinase inhibitor PD98059 prevented the increase of histone H3 acetylation upon learning. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 98-105 mitogen-activated protein kinase 1 Homo sapiens 77-80 22438908-6 2012 Besides, PD98059, a selective inhibitor of MEK that disrupts the activation of downstream ERK, significantly abolished these effects of CCL21/CCR7. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 9-16 mitogen-activated protein kinase 1 Homo sapiens 90-93 21741165-2 2011 In our study, we demonstrated the existence of the integrin cycle and found that inhibition of ERK2 phosphorylation by PD98059 or deletion of the ERK2 direct binding site on the beta6 cytoplasmic domain could interrupt the internalization of integrin alphavbeta6, but had no effect on its recycling. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 119-126 mitogen-activated protein kinase 1 Homo sapiens 95-99 21637924-10 2011 Furthermore, IL-8 mRNA expression was inhibited significantly after co-incubation with PD98059 (ERK inhibitor) and SB203580 (p38 inhibitor), respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 87-94 mitogen-activated protein kinase 1 Homo sapiens 96-99 21771752-11 2011 Increased nuclear NF-kappaB activation was blocked by inhibitors of ERK (PD98059) or JNK (SP600125), but not affected by p38 MAPK inhibitor (SB203580). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 73-80 mitogen-activated protein kinase 1 Homo sapiens 68-71 21995813-9 2011 Furthermore, the extracellular signal-regulated kinase (ERK) inhibitor PD98059 and the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 significantly reduced Erdr1 expression following UVB irradiation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 71-78 mitogen-activated protein kinase 1 Homo sapiens 17-54 21995813-9 2011 Furthermore, the extracellular signal-regulated kinase (ERK) inhibitor PD98059 and the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 significantly reduced Erdr1 expression following UVB irradiation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 71-78 mitogen-activated protein kinase 1 Homo sapiens 56-59 21769916-10 2011 In TGW cells, PD98059, a MEK inhibitor, but not SB203580 (a p38 MAPK inhibitor) and LY294002 (a PI3K inhibitor) inhibited GDNF-induced GAP43 expression, suggesting the MEK/ERK pathway has a major role in GDNF-induced GAP43 transcription. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 14-21 mitogen-activated protein kinase 1 Homo sapiens 172-175 21796149-10 2011 Treatment with the ERK inhibitor PD98059 and with the p38 kinase inhibitor SB203580 effectively suppressed beta-glucan-induced IL-8 production by NHEKs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-40 mitogen-activated protein kinase 1 Homo sapiens 19-22 21732986-9 2011 Furthermore, LL-37 induced phosphorylation of ERK and the ERK inhibitor PD98059 blocked the inhibitory effect of LL-37 on apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 72-79 mitogen-activated protein kinase 1 Homo sapiens 58-61 21832046-11 2011 Pretreatment with extracellular signal-regulated kinase (ERK) inhibitor (PD98059) blocked both PGD(2)-induced ERK mitogen-activated protein kinase (MAPK) activation and MUC5B expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 73-80 mitogen-activated protein kinase 1 Homo sapiens 18-55 21832046-11 2011 Pretreatment with extracellular signal-regulated kinase (ERK) inhibitor (PD98059) blocked both PGD(2)-induced ERK mitogen-activated protein kinase (MAPK) activation and MUC5B expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 73-80 mitogen-activated protein kinase 1 Homo sapiens 57-60 21832046-11 2011 Pretreatment with extracellular signal-regulated kinase (ERK) inhibitor (PD98059) blocked both PGD(2)-induced ERK mitogen-activated protein kinase (MAPK) activation and MUC5B expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 73-80 mitogen-activated protein kinase 1 Homo sapiens 110-113 21832046-11 2011 Pretreatment with extracellular signal-regulated kinase (ERK) inhibitor (PD98059) blocked both PGD(2)-induced ERK mitogen-activated protein kinase (MAPK) activation and MUC5B expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 73-80 mitogen-activated protein kinase 1 Homo sapiens 148-152 21624769-10 2011 PD98059, a specific inhibitor of the MEK/ERK signaling pathway, is involved in this mutual enhancement. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 41-44 21503966-9 2011 The ERK inhibitor PD98059 and the p38 inhibitor SB203580 significantly blocked the increase in USP-19 gene expression induced by CSE. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-25 mitogen-activated protein kinase 1 Homo sapiens 4-7 21781996-7 2011 Interestingly, VEGF and PD98059 (an ERK kinase inhibitor) play a synergistic role in protecting neurons from MPP(+)-induced toxicity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 24-31 mitogen-activated protein kinase 1 Homo sapiens 36-39 21705076-10 2011 An immediate increase in ERK was observed in cells cultured in the 1/4 extract and such osteogenic differentiation of hASCs promoted by released ions could be blocked by MEK1-specific inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 195-202 mitogen-activated protein kinase 1 Homo sapiens 25-28 21841813-7 2011 The ERK inhibitor PD98059 (25 mumol/L) strongly suppressed the expression of the proteins and PIMT. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-25 mitogen-activated protein kinase 1 Homo sapiens 4-7 22593802-5 2011 Using RT-PCR to quantify EGR1 transcripts, we found that EGF induced EGR1 expression in a dose- and time-dependent manner and the ERK pathway inhibitor, PD98059, abrogated the EGF-mediated EGR1 response in LNCaP and PC3 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 153-160 mitogen-activated protein kinase 1 Homo sapiens 130-133 21889036-11 2011 In contrast, inhibition of ERK (extracellular signal-related MAP kinase) by PD98059 had no effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 76-83 mitogen-activated protein kinase 1 Homo sapiens 27-30 21889036-11 2011 In contrast, inhibition of ERK (extracellular signal-related MAP kinase) by PD98059 had no effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 76-83 mitogen-activated protein kinase 1 Homo sapiens 32-71 21641901-8 2011 PD98059, a selective inhibitor of ERK/MAPK pathway, was able to block the motile effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 34-37 21630016-3 2011 When young HDFs were treated with PD98059, a specific inhibitor of extracellular signal-regulated kinase (ERK), H(2)O(2)-induced apoptosis was blocked, whereas staurosporine-induced apoptosis was inhibited by treatment with SB203580, a specific inhibitor of p38. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 34-41 mitogen-activated protein kinase 1 Homo sapiens 67-104 21630016-3 2011 When young HDFs were treated with PD98059, a specific inhibitor of extracellular signal-regulated kinase (ERK), H(2)O(2)-induced apoptosis was blocked, whereas staurosporine-induced apoptosis was inhibited by treatment with SB203580, a specific inhibitor of p38. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 34-41 mitogen-activated protein kinase 1 Homo sapiens 106-109 21630016-3 2011 When young HDFs were treated with PD98059, a specific inhibitor of extracellular signal-regulated kinase (ERK), H(2)O(2)-induced apoptosis was blocked, whereas staurosporine-induced apoptosis was inhibited by treatment with SB203580, a specific inhibitor of p38. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 34-41 mitogen-activated protein kinase 1 Homo sapiens 258-261 21751375-8 2011 The specific Mitogen-activated protein kinase inhibitor PD98059, which promotes cell cycle G1 arrest, concomitantly inhibits the interaction, and the evidences suggest that the MEK/ERK (extracellular signal-regulated kinase) cascade activation is the upstream signal required for Ser92 phosphorylation, leading to enhancement of the interaction of CBP with beta-catenin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 56-63 mitogen-activated protein kinase 1 Homo sapiens 181-184 21613217-5 2011 The pharmacological inhibitor of ERK, PD98059, abrogated Fas-promoted cell survival in FADD knockdown MiaPaCa-2 and BxPC-3 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 38-45 mitogen-activated protein kinase 1 Homo sapiens 33-36 21647617-7 2011 Furthermore, downregulation of AQP1 expression by LPS was blocked by SB203580, SP600125, and PD98059, which are inhibitors of p38, JNK, and ERK1/2, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 93-100 mitogen-activated protein kinase 1 Homo sapiens 126-129 21454612-11 2011 In addition, the ERK inhibitor PD98059 reduced HAS2 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 31-38 mitogen-activated protein kinase 1 Homo sapiens 17-20 22214163-3 2011 The expressions of TGF-beta1, of the HELF acted with the conditioned AM supernatant fluid were detected with the immunocytochemistry method after treatment with PD98059 of inhibitor of ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 161-168 mitogen-activated protein kinase 1 Homo sapiens 185-188 21743149-3 2011 Different concentrations of herbimycin A(FAK inhibitor)and PD98059 (ERK inhibitor) were given to observe the influence on the growth of trophoblast cells, FAK, ERK phosphorylation, and trophoblast invasion abilities. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 59-66 mitogen-activated protein kinase 1 Homo sapiens 68-71 21336837-8 2011 Pretreatment with MEK inhibitor PD98059, which potentiated DHA-mediated MEK and ERK inactivation, intensified DHA-mediated apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 80-83 21161310-6 2011 Meanwhile, ERK inhibitor PD98059 decreased MMP-1 secretion, but did not show a significant influence on TGF-beta1; JNK inhibitor SP600125 increased the secretion of MMP-1 and decreased the TGF-beta1 secretion; P38 inhibitor SB203580 had no significant influence on MMP-1 but increased the secretion of TGF-beta1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 25-32 mitogen-activated protein kinase 1 Homo sapiens 11-14 21300134-13 2011 When Daudi cells were pretreated with MAPK inhibitor PD98059, the phosphorylation of ERK was effectively inhibited as well as the nuclear translocation of YB-1 and the expression of mdr1 gene. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 53-60 mitogen-activated protein kinase 1 Homo sapiens 85-88 21901168-3 2011 Chemical inhibitors U0126 and PD98059 block mitogen-activated protein kinase kinase 1 (MEK1)-mediated phosphorylation of extracellular signal-regulated kinase (ERK) and prevent apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 mitogen-activated protein kinase 1 Homo sapiens 121-158 21901168-3 2011 Chemical inhibitors U0126 and PD98059 block mitogen-activated protein kinase kinase 1 (MEK1)-mediated phosphorylation of extracellular signal-regulated kinase (ERK) and prevent apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 mitogen-activated protein kinase 1 Homo sapiens 160-163 21228323-9 2011 Inhibitors of ERK (PD98059 and U0126) abolish the antiinflammatory signal mediated by APC. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-26 mitogen-activated protein kinase 1 Homo sapiens 14-17 21172926-8 2011 Treatment with SB202190 (p38-MAPK inhibitor) or PD98059 (ERK inhibitor) inhibited AGE-BSA-induced IL-6 and IL-8 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 48-55 mitogen-activated protein kinase 1 Homo sapiens 57-60 21360677-5 2011 Ormeloxifen-induced apoptosis via ERK activation was drastically inhibited by prior treatment of K562 cells with ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 127-134 mitogen-activated protein kinase 1 Homo sapiens 34-37 20857402-5 2011 Furthermore, treatment with extracellular signal-related kinase (ERK) inhibitor (PD98059) and dominant negative Ras (RasN17) abolished homocysteine-induced cyclin A expression; and treatment with phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002) and mammalian target of rapamycin (mTOR) inhibitor (rapamycin) attenuated the homocysteine-induced cyclin D1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 81-88 mitogen-activated protein kinase 1 Homo sapiens 28-63 20857402-5 2011 Furthermore, treatment with extracellular signal-related kinase (ERK) inhibitor (PD98059) and dominant negative Ras (RasN17) abolished homocysteine-induced cyclin A expression; and treatment with phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002) and mammalian target of rapamycin (mTOR) inhibitor (rapamycin) attenuated the homocysteine-induced cyclin D1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 81-88 mitogen-activated protein kinase 1 Homo sapiens 65-68 21360677-5 2011 Ormeloxifen-induced apoptosis via ERK activation was drastically inhibited by prior treatment of K562 cells with ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 127-134 mitogen-activated protein kinase 1 Homo sapiens 113-116 21148411-6 2011 AII significantly induced proliferation in VSMC grown on collagen I or fibronectin, and this effect was blocked by the ERK inhibitor PD-98059, suggesting that AII-induced proliferation requires ERK activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 133-141 mitogen-activated protein kinase 1 Homo sapiens 119-122 22214163-7 2011 CONCLUSION: ERK inhibitor PD98059 have inhibition effect on the expression of transforming growth factor-beta1 and expression of cytokine of human embryonic lung fibroblasts stimulated by SiO2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 26-33 mitogen-activated protein kinase 1 Homo sapiens 12-15 21148411-6 2011 AII significantly induced proliferation in VSMC grown on collagen I or fibronectin, and this effect was blocked by the ERK inhibitor PD-98059, suggesting that AII-induced proliferation requires ERK activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 133-141 mitogen-activated protein kinase 1 Homo sapiens 194-197 21191105-7 2011 Pretreatment with the phosphoinositide 3-kinase (PI3K) inhibitor LY294002 and the ERK inhibitor PD98059 blocked F prostanoid receptor signaling responses, whereas rapamycin blocked heightened p70S6K/eIF4G phosphorylation without influencing ERK1/2 phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 96-103 mitogen-activated protein kinase 1 Homo sapiens 82-85 20948428-5 2011 Inhibiting ERK pathway activation with PD98059 could significantly block the differentiation induced by UA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 39-46 mitogen-activated protein kinase 1 Homo sapiens 11-14 21091268-7 2011 Similarly, administration of the ERK inhibitor PD98059 (500 ng, ICV) also exhibited a suppressive effect on neurogenesis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-54 mitogen-activated protein kinase 1 Homo sapiens 33-36 21143604-3 2011 The addition of 50 muM PD98059, a MEK inhibitor, significantly inhibited the activation of ERK and the enhanced angiogenesis; in contrast, the inhibition of p38 phosphorylation did not inhibit the enhanced angiogenesis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 23-30 mitogen-activated protein kinase 1 Homo sapiens 91-94 20799280-9 2011 JNK2 siRNA together with PD98059, a specific MAPK/ERK kinase inhibitor, suppressed As2O3-induced apoptosis more significantly than JNK2 siRNA alone. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 25-32 mitogen-activated protein kinase 1 Homo sapiens 50-53 21163530-6 2011 PD98059 also reduced c-myc and hTERT expression and inhibited ERK phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 62-65 20015194-10 2011 Other ERK-MAP kinase members were involved as the response was inhibited by dominant negative H-Ras, Raf kinase inhibitor, ERK activation inhibitor and MEK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 166-173 mitogen-activated protein kinase 1 Homo sapiens 6-9 21082355-11 2011 MAP kinase inhibitors SB203580, SP600125 and PD98059 confirm the role of p38 MAPK and JNK in OA induced caspase-3 activation and cell death. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 45-52 mitogen-activated protein kinase 1 Homo sapiens 73-76 20959155-9 2011 The formononetin-mediated sustained activation of Egr-1 was suppressed by the ERK inhibitor PD98059 and the p38 inhibitor SB203580. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 92-99 mitogen-activated protein kinase 1 Homo sapiens 78-81 20309937-7 2011 Only the tumor cells died following treatment with rMnSOD-Lp-CC; molecular analysis revealed that its addition generated an increasing expression of Erk-2 and Bax products, which could be inhibited only by a selective MAP/ERK kinase inhibitor (PD98059), revealing that rMnSOD-Lp-CC has an apoptotic function, exactly as occurs when using the cisplatin alone. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 244-251 mitogen-activated protein kinase 1 Homo sapiens 149-154 21123455-6 2011 Selective blockade of the MAPK pathway with ERK inhibitor PD98059 reduced IL-6/sIL-6Ralpha-mediated endothelial hyperpermeability. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 mitogen-activated protein kinase 1 Homo sapiens 26-30 21123455-6 2011 Selective blockade of the MAPK pathway with ERK inhibitor PD98059 reduced IL-6/sIL-6Ralpha-mediated endothelial hyperpermeability. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 mitogen-activated protein kinase 1 Homo sapiens 44-47 20850495-4 2011 PD098059, a MEK inhibitor, suppressed Pb2+-mediated inflammatory reactions; this indicates the involvement of the phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-8 mitogen-activated protein kinase 1 Homo sapiens 133-179 20739465-10 2011 Hypertonicity-induced increases in IL-6 and IL-8 releases were suppressed by exposure to capsazepine, AG 1478, ERK inhibitor PD 98059, p38 inhibitor SB 203580, or NF-kappaB inhibitor PDTC. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 125-133 mitogen-activated protein kinase 1 Homo sapiens 111-114 21212516-10 2011 PD98059 (inhibitor of mitogen-activated protein kinase kinase (MEK)/ERK) and wortmannin (inhibitor of phosphoinositide 3-kinase (PI3K)/Akt) enhanced silibinin"s cytotoxicity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 68-71 22031842-7 2011 Furthermore, VCAM-1-specific leukocyte migration under physiological laminar flow of 2 dynes/cm(2) was blocked by pretreatment of endothelial cells with dominant-negative ERK2 K52R or the MEK/ERK inhibitors, PD98059 and U0126, indicating for the first time that ERK regulates VCAM-1-dependent leukocyte transendothelial migration. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 208-215 mitogen-activated protein kinase 1 Homo sapiens 171-175 22470391-4 2011 An inhibitor of ERK, PD98059, prevented CyA-induced nuclear translocation of Smad2/3 and apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 21-28 mitogen-activated protein kinase 1 Homo sapiens 16-19 22126617-7 2011 Furthermore, BaP-induced expression of VEGF mRNA was reduced by the ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 82-89 mitogen-activated protein kinase 1 Homo sapiens 68-71 20309637-6 2011 And MxA was up-regulated after Raf-MEK-ERK signal pathway being blocked by PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 75-82 mitogen-activated protein kinase 1 Homo sapiens 39-42 22031842-7 2011 Furthermore, VCAM-1-specific leukocyte migration under physiological laminar flow of 2 dynes/cm(2) was blocked by pretreatment of endothelial cells with dominant-negative ERK2 K52R or the MEK/ERK inhibitors, PD98059 and U0126, indicating for the first time that ERK regulates VCAM-1-dependent leukocyte transendothelial migration. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 208-215 mitogen-activated protein kinase 1 Homo sapiens 171-174 22031842-7 2011 Furthermore, VCAM-1-specific leukocyte migration under physiological laminar flow of 2 dynes/cm(2) was blocked by pretreatment of endothelial cells with dominant-negative ERK2 K52R or the MEK/ERK inhibitors, PD98059 and U0126, indicating for the first time that ERK regulates VCAM-1-dependent leukocyte transendothelial migration. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 208-215 mitogen-activated protein kinase 1 Homo sapiens 192-195 21909400-6 2011 ERK inhibitor PD98059 significantly enhanced TLR4/MD2 expression in Der-p2-treated B cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 14-21 mitogen-activated protein kinase 1 Homo sapiens 0-3 21053344-5 2010 These effects of H(2)O(2) were suppressed by pretreatment of the cells with selenite (0.1-1 microM) for 24 h. In addition, H(2)O(2) activated the phosphorylation of ERK1/2 and inhibition of H(2)O(2)-activated ERK signaling by MEK inhibitor PD98059 blocked the effect of H(2)O(2) on osteoblastic differentiation of VSMCs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 240-247 mitogen-activated protein kinase 1 Homo sapiens 165-168 21698152-10 2011 CCR7 small interfering RNA or PD98059, a selective inhibitor of MEK that disrupts the activation of downstream ERK, significantly abolished the effects of exogenous CCL21. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 mitogen-activated protein kinase 1 Homo sapiens 111-114 21738655-7 2011 Combination treatment of ERK pathway inhibitor PD98059 or AKT pathway inhibitor LY294002 and berberine could result in a synergistic reduction on MMP-9 expression along with an inhibition of cell invasion. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-54 mitogen-activated protein kinase 1 Homo sapiens 25-28 20843518-6 2010 To confirm the involvement of the ERK pathway in MMP-1 expression by U937 cells, we showed that PD98059, a specific inhibitor for the ERK pathway, blocked LPS-stimulated MMP-1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 96-103 mitogen-activated protein kinase 1 Homo sapiens 34-37 20843518-6 2010 To confirm the involvement of the ERK pathway in MMP-1 expression by U937 cells, we showed that PD98059, a specific inhibitor for the ERK pathway, blocked LPS-stimulated MMP-1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 96-103 mitogen-activated protein kinase 1 Homo sapiens 134-137 20854900-11 2010 Pretreatment with the ERK inhibitor PD98059 attenuated NF-kappaB and IKK phosphorylation, indicating that ERK MAPK is mainly involved in DEHP-induced NF-kappaB activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 36-43 mitogen-activated protein kinase 1 Homo sapiens 22-25 22166649-8 2010 RESULTS: PD98059 inhibited the PTH stimulated expression of CTGF, which strongly suggested that the MAPK signaling pathway plays an important role in the PTH-induced CTGF upregulation in renal tubular cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 9-16 mitogen-activated protein kinase 1 Homo sapiens 100-104 20854900-11 2010 Pretreatment with the ERK inhibitor PD98059 attenuated NF-kappaB and IKK phosphorylation, indicating that ERK MAPK is mainly involved in DEHP-induced NF-kappaB activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 36-43 mitogen-activated protein kinase 1 Homo sapiens 106-109 20878765-7 2010 ERK/MAPK pathway is implicated in oligodendrocyte differentiation because PD98059, an inhibitor of MEK1, abrogated oligodendrocyte maturation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 74-81 mitogen-activated protein kinase 1 Homo sapiens 0-3 20564491-6 2010 Moreover, inhibition of ERK by treatment of cells with the ERK-specific inhibitor PD98059 blocked WEGS-mediated p53 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 82-89 mitogen-activated protein kinase 1 Homo sapiens 24-27 20564491-6 2010 Moreover, inhibition of ERK by treatment of cells with the ERK-specific inhibitor PD98059 blocked WEGS-mediated p53 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 82-89 mitogen-activated protein kinase 1 Homo sapiens 59-62 20882567-10 2010 The increased phosphorylation of Sp1 induced by PMA in short treatments could be abolished by the extracellular signal-regulated kinases (ERK) pathway inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 161-168 mitogen-activated protein kinase 1 Homo sapiens 98-136 20882567-10 2010 The increased phosphorylation of Sp1 induced by PMA in short treatments could be abolished by the extracellular signal-regulated kinases (ERK) pathway inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 161-168 mitogen-activated protein kinase 1 Homo sapiens 138-141 20888181-6 2010 It was noteworthy that the ras/raf/MEK/ERK pathway inhibitor PD98059 attenuated the down-regulation of propofol-induced MMP-9 expression of LOVO cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 61-68 mitogen-activated protein kinase 1 Homo sapiens 39-42 20458747-3 2010 Activation of extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK) by TPA was identified, and TPA-induced migration and MMP-9 activity was significantly blocked by ERK inhibitor PD98059 and U0126, but not JNK inhibitor SP600125. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 203-210 mitogen-activated protein kinase 1 Homo sapiens 14-51 20458747-3 2010 Activation of extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK) by TPA was identified, and TPA-induced migration and MMP-9 activity was significantly blocked by ERK inhibitor PD98059 and U0126, but not JNK inhibitor SP600125. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 203-210 mitogen-activated protein kinase 1 Homo sapiens 53-56 20458747-3 2010 Activation of extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK) by TPA was identified, and TPA-induced migration and MMP-9 activity was significantly blocked by ERK inhibitor PD98059 and U0126, but not JNK inhibitor SP600125. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 203-210 mitogen-activated protein kinase 1 Homo sapiens 189-192 21131736-4 2010 SP600125 and PD98059 were used to block the activation of c-Jun terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 90-127 21131736-4 2010 SP600125 and PD98059 were used to block the activation of c-Jun terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 129-132 20731619-10 2010 Inactivation of ERK signaling pathways by PD98059 effectively blocked IL-6, -8, and -10 induction by WTC2.5; the p38 kinase inhibitor SB203580 significantly decreased induction of IL-8 and -10. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 42-49 mitogen-activated protein kinase 1 Homo sapiens 16-19 20101459-6 2010 RESULTS: Our results revealed that the specific MAPK-ERK cascade inhibitor, PD98059, significantly attenuated phosphorylation of c-Myc on Ser-62 and FasL upregulation in QBC-939 cells and these cells showed decreased cytotoxicity against Fas-sensitive Jurkat T cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 76-83 mitogen-activated protein kinase 1 Homo sapiens 53-56 20627382-7 2010 However, this increase was abrogated by pretreatment with an extracellular signal-regulated kinase (ERK) inhibitor PD98059 or p38MAPK inhibitor SB203580; pretreatment with c-Jun N-terminal kinase (JNK) inhibitor SP600125 did not attenuate the effects of VIP on the expression of VEGF. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 115-122 mitogen-activated protein kinase 1 Homo sapiens 61-98 20821752-12 2010 Treating endometriotic cells with A771726, PD98059 or U0126 abrogated the phosphorylation of ERK and significantly decreased the cellular proliferation in vitro. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 43-50 mitogen-activated protein kinase 1 Homo sapiens 93-96 20627382-7 2010 However, this increase was abrogated by pretreatment with an extracellular signal-regulated kinase (ERK) inhibitor PD98059 or p38MAPK inhibitor SB203580; pretreatment with c-Jun N-terminal kinase (JNK) inhibitor SP600125 did not attenuate the effects of VIP on the expression of VEGF. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 115-122 mitogen-activated protein kinase 1 Homo sapiens 100-103 20232299-8 2010 Specific inhibitors of PI3K (10 microM LY290042 or 10 nM wortmannin) or ERK (10 microM PD98059) also blocked GDF15-induced hypertrophy and SMAD activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 87-94 mitogen-activated protein kinase 1 Homo sapiens 72-75 20336745-4 2010 Coating with collagen I induced activation of ERK and Akt but not FAK, and treatment with PD98059 and LY294002 blocked the activation of ERK and Akt, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 90-97 mitogen-activated protein kinase 1 Homo sapiens 137-140 20596606-5 2010 PD98059 and U0126, MEK/ERK inhibitors, inhibit UV-induced AQP3 loss. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 23-26 20596608-6 2010 Pre-treatment of NS3 protein expressing cells with ERK inhibitor, PD98059, blocked the activation of AP-1 and NF-kappaB, and inhibited cyclin D1 expression and cell proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 66-73 mitogen-activated protein kinase 1 Homo sapiens 51-54 20412422-8 2010 The p(38) MAPK inhibitors SB203580 and SB202190 and the ERK inhibitor PD98059 inhibited the OxLDL-induced IL-8 production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 70-77 mitogen-activated protein kinase 1 Homo sapiens 56-59 20360133-8 2010 Preincubation of cells with PD98059, an inhibitor of ERK kinase, suppressed the capsaicin-induced mRNA expression of AQP5. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 28-35 mitogen-activated protein kinase 1 Homo sapiens 53-56 20406306-6 2010 Moreover, addition of a suboptimal dose of PD98059, an extracellular signal-regulated kinase (ERK) kinase inhibitor, to those cells maximally reduced NK cytotoxicity, suggesting that ERK plays an important role in NK-mediated xenoreactivity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 43-50 mitogen-activated protein kinase 1 Homo sapiens 55-92 20406306-6 2010 Moreover, addition of a suboptimal dose of PD98059, an extracellular signal-regulated kinase (ERK) kinase inhibitor, to those cells maximally reduced NK cytotoxicity, suggesting that ERK plays an important role in NK-mediated xenoreactivity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 43-50 mitogen-activated protein kinase 1 Homo sapiens 94-97 20406306-6 2010 Moreover, addition of a suboptimal dose of PD98059, an extracellular signal-regulated kinase (ERK) kinase inhibitor, to those cells maximally reduced NK cytotoxicity, suggesting that ERK plays an important role in NK-mediated xenoreactivity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 43-50 mitogen-activated protein kinase 1 Homo sapiens 183-186 20430109-8 2010 ERK/p38 MAPK inhibitor PD98059 treatment definitely suppressed this apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 23-30 mitogen-activated protein kinase 1 Homo sapiens 0-3 20827342-10 2010 This study is, to the best of our knowledge, the first to demonstrate that the specific inhibitors of the MEK/ERK pathway, U0126 and PD98059, exert differential effects on the ERK phosphorylation induced by RA or DLK1 knockdown. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 133-140 mitogen-activated protein kinase 1 Homo sapiens 110-113 20827342-10 2010 This study is, to the best of our knowledge, the first to demonstrate that the specific inhibitors of the MEK/ERK pathway, U0126 and PD98059, exert differential effects on the ERK phosphorylation induced by RA or DLK1 knockdown. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 133-140 mitogen-activated protein kinase 1 Homo sapiens 176-179 20581856-10 2010 Further, CD151-induced cell proliferation, migration, and tube formation were attenuated by the ERK inhibitor PD98059 (20 micromol/L) but not by a p38 inhibitor (SB203580, 20 micromol/L). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 110-117 mitogen-activated protein kinase 1 Homo sapiens 96-99 20033237-6 2010 Either knockdown of the taurine transporter (TAUT) or treatment with the ERK-specific inhibitor PD98059 blocked the activation of ERK by taurine and abolished taurine-induced Axl/Gas6 expression and calcium deposition reduction in beta-GP-induced VSMC calcification model. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 96-103 mitogen-activated protein kinase 1 Homo sapiens 73-76 20033237-6 2010 Either knockdown of the taurine transporter (TAUT) or treatment with the ERK-specific inhibitor PD98059 blocked the activation of ERK by taurine and abolished taurine-induced Axl/Gas6 expression and calcium deposition reduction in beta-GP-induced VSMC calcification model. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 96-103 mitogen-activated protein kinase 1 Homo sapiens 130-133 20466409-6 2010 PD98059, a specific inhibitor of MAPK kinase (MEK1/2), reduced collagen-induced HSP27 phosphorylation as well as p44/p42 MAPK phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 33-37 20466409-6 2010 PD98059, a specific inhibitor of MAPK kinase (MEK1/2), reduced collagen-induced HSP27 phosphorylation as well as p44/p42 MAPK phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 121-125 20512938-3 2010 Further analyses made on HuVEC showed that the ERK inhibitor PD98059 maximally inhibited the PL-induced endothelial repair, followed in order of importance by the calcium chelator BAPTA-AM, the PI3K inhibitor wortmannin and the p38 inhibitor SB203580. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 61-68 mitogen-activated protein kinase 1 Homo sapiens 47-50 20517899-6 2010 However, treatment with PI3-K inhibitor LY294002 significantly reversed the down-regulation of Runx2 expression and treatment with ERK inhibitor PD98059 remarkably decreased up-regulation of Osx and IGF-1 expression after insulin treatment. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 145-152 mitogen-activated protein kinase 1 Homo sapiens 131-134 20512938-3 2010 Further analyses made on HuVEC showed that the ERK inhibitor PD98059 maximally inhibited the PL-induced endothelial repair, followed in order of importance by the calcium chelator BAPTA-AM, the PI3K inhibitor wortmannin and the p38 inhibitor SB203580. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 61-68 mitogen-activated protein kinase 1 Homo sapiens 228-231 19795151-10 2010 PD98059, a specific inhibitor of ERK phosphorylation, but not the p38 inhibitor SB203580 or the JNK inhibitor SP600125 prevented PDGF-CC induced TF expression in a concentration-dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 33-36 19876716-11 2010 PD98059, a specific ERK inhibitor, blocked the activation of ERK by icaritin and abolished the icaritin-induced growth inhibition and apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 20-23 19876716-11 2010 PD98059, a specific ERK inhibitor, blocked the activation of ERK by icaritin and abolished the icaritin-induced growth inhibition and apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 61-64 20515942-9 2010 Butein also stimulated extracellular signal-regulated kinase (ERK) activation, and the ERK inhibitor PD98059 blocked butein-induced DR5 expression and suppressed binding of Sp1 to the DR5 promoter. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 101-108 mitogen-activated protein kinase 1 Homo sapiens 87-90 20093382-6 2010 These events were dependent on extracellular signal-regulated kinase (ERK) activation: indeed inhibition of ERK activation in siTRPV2-U87MG transfected cells by treatment with PD98059, a specific mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor, reduced Bcl-X(L) protein levels, promoted Fas expression, and restored Akt/protein kinase B pathway activation leading to reduced U87MG cell survival and proliferation, and increased sensitivity to Fas-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 176-183 mitogen-activated protein kinase 1 Homo sapiens 31-68 20093382-6 2010 These events were dependent on extracellular signal-regulated kinase (ERK) activation: indeed inhibition of ERK activation in siTRPV2-U87MG transfected cells by treatment with PD98059, a specific mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor, reduced Bcl-X(L) protein levels, promoted Fas expression, and restored Akt/protein kinase B pathway activation leading to reduced U87MG cell survival and proliferation, and increased sensitivity to Fas-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 176-183 mitogen-activated protein kinase 1 Homo sapiens 70-73 20093382-6 2010 These events were dependent on extracellular signal-regulated kinase (ERK) activation: indeed inhibition of ERK activation in siTRPV2-U87MG transfected cells by treatment with PD98059, a specific mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor, reduced Bcl-X(L) protein levels, promoted Fas expression, and restored Akt/protein kinase B pathway activation leading to reduced U87MG cell survival and proliferation, and increased sensitivity to Fas-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 176-183 mitogen-activated protein kinase 1 Homo sapiens 108-111 20093382-6 2010 These events were dependent on extracellular signal-regulated kinase (ERK) activation: indeed inhibition of ERK activation in siTRPV2-U87MG transfected cells by treatment with PD98059, a specific mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor, reduced Bcl-X(L) protein levels, promoted Fas expression, and restored Akt/protein kinase B pathway activation leading to reduced U87MG cell survival and proliferation, and increased sensitivity to Fas-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 176-183 mitogen-activated protein kinase 1 Homo sapiens 229-266 20103766-8 2010 Inhibition of p38 and JNK but not ERK1/2, with specific inhibitors (SB203580, JNKII, and PD98059, respectively), blocked neutrophil degranulation induced by S100A9. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 89-96 mitogen-activated protein kinase 1 Homo sapiens 14-17 20232365-7 2010 AS-induced cell death was potentiated by inhibition of extracellular signal-regulated kinases (ERK) 1/2 signaling with U0126 and PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 129-136 mitogen-activated protein kinase 1 Homo sapiens 55-103 19949837-5 2010 Meanwhile, supplementation of H89, a specific inhibitor of PKA, and PD98059, a specific inhibitor of MAPK/ERK kinase, reversed the cell growth inhibition, the down-regulation of osteogenic markers and the up-regulation of adipogenic markers as well as the activation of ERK under high glucose. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 68-75 mitogen-activated protein kinase 1 Homo sapiens 106-109 19949837-5 2010 Meanwhile, supplementation of H89, a specific inhibitor of PKA, and PD98059, a specific inhibitor of MAPK/ERK kinase, reversed the cell growth inhibition, the down-regulation of osteogenic markers and the up-regulation of adipogenic markers as well as the activation of ERK under high glucose. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 68-75 mitogen-activated protein kinase 1 Homo sapiens 270-273 19823118-7 2010 Pretreatment with PD98059, an inhibitor of ERK, decreased LTA-enhanced NFkappaB activation and TNF-alpha and IL-6 mRNA syntheses. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-25 mitogen-activated protein kinase 1 Homo sapiens 43-46 21472268-8 2010 However, the inhibition of ERK activity by PD98059 also enhanced the apoptosis-inducing ability of TRAIL. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 43-50 mitogen-activated protein kinase 1 Homo sapiens 27-30 20346918-7 2010 The BMP-2 increase was markedly inhibited by pretreatment with an extracellular signal-regulated kinase (ERK) inhibitor, PD98059, and partially inhibited by the L-type Ca(2+) channels inhibitor, nifedipine. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 121-128 mitogen-activated protein kinase 1 Homo sapiens 105-108 20006595-5 2010 However, the increase in both uPA expression and activity was greatly reduced or alleviated by treatment with either ROS scavenger N-acetylcysteine or extracellular signal-regulated kinase (ERK) inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 205-212 mitogen-activated protein kinase 1 Homo sapiens 151-188 19951697-6 2010 The MEK/ERK inhibitor PD98059 dramatically repressed HtrA3 induction. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 22-29 mitogen-activated protein kinase 1 Homo sapiens 8-11 20373469-5 2010 However, inhibition of JNK with SP600125 had no effect on Zn-BC-AM PDT-induced apoptosis while inhibition of ERK with PD98059 or p38 MAPK with SB203580 significantly increased Zn-BC-AM PDT-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 118-125 mitogen-activated protein kinase 1 Homo sapiens 109-112 20006595-5 2010 However, the increase in both uPA expression and activity was greatly reduced or alleviated by treatment with either ROS scavenger N-acetylcysteine or extracellular signal-regulated kinase (ERK) inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 205-212 mitogen-activated protein kinase 1 Homo sapiens 190-193 20198313-8 2010 Finally, pretreatment with ERK-specific inhibitor PD98059 reversed decursin-induced p21WAF1 expression and decursin-inhibited cell growth. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 50-57 mitogen-activated protein kinase 1 Homo sapiens 27-30 19883629-6 2010 Pre-treatment of 2ME2-treated HK-1 cells with JNK inhibitor (SP600125), ERK inhibitor (PD98059) and p38 MAPK inhibitor (SB203580) resulted in the reduction of endoreduplicating cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 87-94 mitogen-activated protein kinase 1 Homo sapiens 72-75 20215102-3 2010 Both gonadotropins activated the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase 1/2 (ERK1/2) pathway and increased cell migration that was inhibited by the MAPK 1 inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 204-211 mitogen-activated protein kinase 1 Homo sapiens 73-114 20100175-6 2010 At 2 h, IL-1beta-induced expression of GM-CSF protein, but not mRNA, was sensitive to the MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase] inhibitors PD098059 and U0126. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 198-206 mitogen-activated protein kinase 1 Homo sapiens 95-99 20215102-3 2010 Both gonadotropins activated the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase 1/2 (ERK1/2) pathway and increased cell migration that was inhibited by the MAPK 1 inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 204-211 mitogen-activated protein kinase 1 Homo sapiens 187-193 19865096-8 2010 Furthermore, we showed that IL-18 induced phosphorylation of extracellular signal-regulated kinase (ERK) within 10 minutes and that the ERK inhibitor PD98059 blocked the inhibitory effect of IL-18. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 150-157 mitogen-activated protein kinase 1 Homo sapiens 61-98 20231899-13 2010 An ERK pharmacological inhibitor, PD98059, and the PLD inhibitor, 1-BtOH, both attenuate (14)C-glucose uptake in muscle cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 34-41 mitogen-activated protein kinase 1 Homo sapiens 3-6 19333718-6 2010 Furthermore, pretreatment of human osteoblasts with the ERK inhibitor PD98059 abolished the preptin-induced CTGF secretion and blocked the promoting effect of preptin on osteoblasts proliferation and differentiation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 70-77 mitogen-activated protein kinase 1 Homo sapiens 56-59 20018936-5 2010 PD98059, which inhibits mitogen-activated protein kinase kinase/extracellular regulated kinase (MEK/ERK) attenuates IL-1beta-inducible phosphorylation of extracellular signal-regulated kinase 1/2 and mitogen and stress-activated protein kinases 1/2; and reduces levels of phosphorylated and acetylated histone H3. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 100-103 19921217-6 2010 To reveal alternative signalling cascades, experiments were also performed in the presence of the p38MAPK inhibitor SB 203580 and the ERK inhibitor PD 98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 148-156 mitogen-activated protein kinase 1 Homo sapiens 134-137 20004734-5 2010 Treatment of these cells with PD98059 or LY294002 blocked ATL-1 effects, indicating the involvement of ERK-2 and PI3-K, both pathways associated with cell survival. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 mitogen-activated protein kinase 1 Homo sapiens 103-108 19699794-8 2010 In addition, H(2)O(2)-induced cell death was prevented by PD98059, SB203580, and calphostin C, which are MEK, p38 and PKC inhibitors, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 mitogen-activated protein kinase 1 Homo sapiens 110-113 19895795-10 2010 Pharmacological inhibitors of MEK (U0126) and ERK (PD98059) also blocked neurite outgrowth in cells plated on laminin-1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 51-58 mitogen-activated protein kinase 1 Homo sapiens 46-49 19996316-5 2010 Specifically, we identified the extracellular signal-regulated kinase (ERK) signaling pathway as a mediator of signals from FcgammaR activation to cyclin D1 expression, because cyclin D1 expression associated with FcgammaR cross-linking was attenuated by specific inhibitors of the ERK1/2 signaling pathway, PD98059 and U0126 and the spleen tyrosine kinase (Syk) inhibitor, Piceatannol. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 308-315 mitogen-activated protein kinase 1 Homo sapiens 32-69 19996316-5 2010 Specifically, we identified the extracellular signal-regulated kinase (ERK) signaling pathway as a mediator of signals from FcgammaR activation to cyclin D1 expression, because cyclin D1 expression associated with FcgammaR cross-linking was attenuated by specific inhibitors of the ERK1/2 signaling pathway, PD98059 and U0126 and the spleen tyrosine kinase (Syk) inhibitor, Piceatannol. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 308-315 mitogen-activated protein kinase 1 Homo sapiens 71-74 20015475-11 2010 Pretreatment of U87-MG cells with the ERK inhibitor PD98059, accentuated ERK inhibition and increased CREB phosphorylation at Ser-133 and CREB-driven transcription stimulated by PGE(2), suggesting that inhibition of ERK contributes to PGE(2)-induced CREB activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 52-59 mitogen-activated protein kinase 1 Homo sapiens 38-41 19747539-7 2010 Inhibitors of JNK (SP600125) and ERK (PD98059), but not p38 MAPK (SB203580) suppressed NFD-induced S-phase arrest and apoptosis in MDA-MB-231 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 38-45 mitogen-activated protein kinase 1 Homo sapiens 33-36 20080742-4 2010 PTP desensitization and the ensuing resistance to cell death induced by arachidonic acid or EM20-25 could be ablated by inhibiting ERK with the drug PD98059 or with a selective ERK activation inhibitor peptide. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 149-156 mitogen-activated protein kinase 1 Homo sapiens 131-134 19586628-4 2010 Related to these results, HNE increased nuclear translocation of 5-LO promoting 5-LO activity, which was attenuated not only by SB203580, a p38 MAPK inhibitor, but also by PD98059, an ERK inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 172-179 mitogen-activated protein kinase 1 Homo sapiens 184-187 19917268-4 2010 The MEK inhibitor PD98059 and the PI3K inhibitor Wortmannin specifically inhibited sesamin-induced activation of the ERK and Akt/eNOS pathways. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-25 mitogen-activated protein kinase 1 Homo sapiens 117-120 20008963-8 2010 Further study revealed that both MDG-1 and S1P induce Akt and ERK phosphorylation in a dose- and time-dependent manner, an effect that is attenuated by pre-treatment with either the Akt inhibitor wortmannin or the ERK inhibitor PD98059, and MDG-1 can also induce eNOS phosphorylation and increases in production of NO. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 228-235 mitogen-activated protein kinase 1 Homo sapiens 62-65 20008963-8 2010 Further study revealed that both MDG-1 and S1P induce Akt and ERK phosphorylation in a dose- and time-dependent manner, an effect that is attenuated by pre-treatment with either the Akt inhibitor wortmannin or the ERK inhibitor PD98059, and MDG-1 can also induce eNOS phosphorylation and increases in production of NO. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 228-235 mitogen-activated protein kinase 1 Homo sapiens 214-217 19865096-8 2010 Furthermore, we showed that IL-18 induced phosphorylation of extracellular signal-regulated kinase (ERK) within 10 minutes and that the ERK inhibitor PD98059 blocked the inhibitory effect of IL-18. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 150-157 mitogen-activated protein kinase 1 Homo sapiens 100-103 19865096-8 2010 Furthermore, we showed that IL-18 induced phosphorylation of extracellular signal-regulated kinase (ERK) within 10 minutes and that the ERK inhibitor PD98059 blocked the inhibitory effect of IL-18. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 150-157 mitogen-activated protein kinase 1 Homo sapiens 136-139 19956885-8 2010 LY294002 and PD98059 inhibited SCF-induced Akt and Erk activation in H209 cells, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 51-54 19675578-6 2010 Interestingly, the effects of DLK on Hsp27 were blocked by PD98059, a selective inhibitor of the extracellular signal-regulated protein kinase (ERK) pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 59-66 mitogen-activated protein kinase 1 Homo sapiens 97-142 19675578-6 2010 Interestingly, the effects of DLK on Hsp27 were blocked by PD98059, a selective inhibitor of the extracellular signal-regulated protein kinase (ERK) pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 59-66 mitogen-activated protein kinase 1 Homo sapiens 144-147 20402656-10 2010 ERK activation was inhibited by PD98059, Wortmanin and the ROS scavenger NAC (N-acetyl cysteine). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 0-3 19800362-4 2010 Previously, the inhibitors, rapamycin for mTOR, wortmannin for phosphoinositide 3 kinase (PI3K) and PD98059 for ERK, each blocked the upregulation of the System A transporter in IAA depleted APC neurons. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 100-107 mitogen-activated protein kinase 1 Homo sapiens 112-115 20123382-2 2010 The results showed that the phosphylated ERK1/2 was overexpressed in SACC, the ACC-M cell line proliferation was inhibited by PD98059, and the lung metastasis level was reduced by PD98059, indicating that ERK may be a key molecule in targeted therapy of adenoid cystic carcinoma. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 126-133 mitogen-activated protein kinase 1 Homo sapiens 41-44 19885606-6 2009 Among the pathways examined, only PD98059 (ERK-specific inhibitor) abolished EEGS-dependent p27 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 34-41 mitogen-activated protein kinase 1 Homo sapiens 43-46 19494198-8 2009 Wounding increased the phosphorylation of ERK as well as the tyrosine phosphorylation of FAK and paxillin in a manner sensitive to PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 131-138 mitogen-activated protein kinase 1 Homo sapiens 42-45 19494198-9 2009 Furthermore, wounding induced the formation of an ERK-FAK-paxillin complex and this effect as well as the wounding-induced formation of focal adhesions, membrane ruffles, and bundles of F-actin, were inhibited by PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 213-220 mitogen-activated protein kinase 1 Homo sapiens 50-53 20056088-3 2010 Kinase inhibitor PD98059 was used in the cells to analyze the ERK signaling pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 17-24 mitogen-activated protein kinase 1 Homo sapiens 62-65 20056088-5 2010 p-ERK inhibitor PD98059 almost completely blocked the Nef up-regulation of the p-ERK and ICAM-1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 16-23 mitogen-activated protein kinase 1 Homo sapiens 2-5 19557503-7 2009 Furthermore, treatment with the extracellular-regulated protein kinase (ERK) inhibitor PD98059 inhibited the upregulation of Egr-1 by OPN. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 87-94 mitogen-activated protein kinase 1 Homo sapiens 32-70 19557503-7 2009 Furthermore, treatment with the extracellular-regulated protein kinase (ERK) inhibitor PD98059 inhibited the upregulation of Egr-1 by OPN. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 87-94 mitogen-activated protein kinase 1 Homo sapiens 72-75 19720055-9 2009 On the other hand, the PTK inhibitors caused disparate effects on ERK phosphorylation, and co-treatment with the MEK/ERK inhibitor PD98059 enhanced the pro-apoptotic capacity of the PTK inhibitors. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 131-138 mitogen-activated protein kinase 1 Homo sapiens 66-69 19720055-9 2009 On the other hand, the PTK inhibitors caused disparate effects on ERK phosphorylation, and co-treatment with the MEK/ERK inhibitor PD98059 enhanced the pro-apoptotic capacity of the PTK inhibitors. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 131-138 mitogen-activated protein kinase 1 Homo sapiens 117-120 19628677-5 2009 Treating VSMCs with PD98059, the ERK inhibitor, inhibited ERK activation and KLF5 phosphorylation as well as the interaction between KLF5 and c-Jun. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 20-27 mitogen-activated protein kinase 1 Homo sapiens 33-36 19651223-7 2009 HaCaT cells cultured with CGRP had a significant increase in phosphorylated ERK1/2, p38 and JNK, and CGRP induced DNA synthesis was inhibited by PD 98059 or SB 203580, selective inhibitors of MAP kinase kinase (MEK, which is upstream from ERK) and p38, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 145-153 mitogen-activated protein kinase 1 Homo sapiens 84-87 19651223-7 2009 HaCaT cells cultured with CGRP had a significant increase in phosphorylated ERK1/2, p38 and JNK, and CGRP induced DNA synthesis was inhibited by PD 98059 or SB 203580, selective inhibitors of MAP kinase kinase (MEK, which is upstream from ERK) and p38, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 145-153 mitogen-activated protein kinase 1 Homo sapiens 76-79 19651223-7 2009 HaCaT cells cultured with CGRP had a significant increase in phosphorylated ERK1/2, p38 and JNK, and CGRP induced DNA synthesis was inhibited by PD 98059 or SB 203580, selective inhibitors of MAP kinase kinase (MEK, which is upstream from ERK) and p38, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 145-153 mitogen-activated protein kinase 1 Homo sapiens 248-251 19628677-5 2009 Treating VSMCs with PD98059, the ERK inhibitor, inhibited ERK activation and KLF5 phosphorylation as well as the interaction between KLF5 and c-Jun. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 20-27 mitogen-activated protein kinase 1 Homo sapiens 58-61 18656273-2 2009 Pretreatment with the MEK-ERK inhibitor (PD98059) appreciably reversed the mitogenic effects of ET-1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 41-48 mitogen-activated protein kinase 1 Homo sapiens 26-29 19438323-5 2009 Inhibition of ERK activation by PD98059, a specific inhibitor of the ERK signaling pathway, blocked the osteogenic differentiation in a dose-dependent manner, as revealed by an ALP activity assay, extracellular calcium deposition detection, osteocalcin (OCN) secretion examination, and real-time polymerase chain reaction (PCR) analysis for expression of osteogenesis-relative genes: core binding factor alpha 1, collagen type I, ALP, and OCN. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 14-17 19438323-5 2009 Inhibition of ERK activation by PD98059, a specific inhibitor of the ERK signaling pathway, blocked the osteogenic differentiation in a dose-dependent manner, as revealed by an ALP activity assay, extracellular calcium deposition detection, osteocalcin (OCN) secretion examination, and real-time polymerase chain reaction (PCR) analysis for expression of osteogenesis-relative genes: core binding factor alpha 1, collagen type I, ALP, and OCN. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 69-72 19438323-6 2009 Blockage of ERK phosphorylation in osteo-induced hASCs by PD98059 supplemented with dexamethasone (Dex) led to adipogenic differentiation, as confirmed by Nile Red staining to detect intracellular lipid droplets and real-time PCR analysis for expression of adipogenesis-relative genes: peroxisome proliferator-activated receptor gamma 2 and fatty acid-binding protein. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 mitogen-activated protein kinase 1 Homo sapiens 12-15 19733175-6 2009 Furthermore, the ERK-response was abolished by EGF-R antagonist AG 1478 and kinase inhibitor PD98059, whereas p38 and JNK were only inhibited by AG1478. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 93-100 mitogen-activated protein kinase 1 Homo sapiens 17-20 19562672-8 2009 High content analysis of Egr-1 activation showed acid-induced Egr-1 nuclear translocation; a maximum observed at 1-2 h followed by a decline to basal levels beyond 4 h. Acidic pH also activated ERK1/2 phosphorylation, whereas ERK1/2 inhibitors PD98059 and U0216 blocked both acid-induced Egr-1 and ERK translocation and expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 244-251 mitogen-activated protein kinase 1 Homo sapiens 194-197 19292669-8 2009 Treatment with selective inhibitors of p38 MAPK (SB203580) or Erk (PD98059), as well as calcium channel blockers (verapamil and nifedipine), reduced the BEC-mediated increase of VEGF expression and cell proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 67-74 mitogen-activated protein kinase 1 Homo sapiens 62-65 19558546-9 2009 The secretion of IL-8 and specially TNF and IL-1beta was blocked by PD98059, SP600125, SB203580 and Bay11-7082, suggesting the involvement of the MAP kinases p38, c-Jun N-terminal kinase and ERK and particularly the NF-kappaB pathway, although IL-8 secretion was independent of p38. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 68-75 mitogen-activated protein kinase 1 Homo sapiens 191-194 19639579-5 2009 The SP- and IGF-1-induced up-regulation of ZO-1 was accompanied by phosphorylation of extracellular signal-regulated kinase (ERK), and both of these effects were blocked by PD98059, an inhibitor of ERK activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 173-180 mitogen-activated protein kinase 1 Homo sapiens 86-123 19639579-5 2009 The SP- and IGF-1-induced up-regulation of ZO-1 was accompanied by phosphorylation of extracellular signal-regulated kinase (ERK), and both of these effects were blocked by PD98059, an inhibitor of ERK activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 173-180 mitogen-activated protein kinase 1 Homo sapiens 125-128 19639579-5 2009 The SP- and IGF-1-induced up-regulation of ZO-1 was accompanied by phosphorylation of extracellular signal-regulated kinase (ERK), and both of these effects were blocked by PD98059, an inhibitor of ERK activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 173-180 mitogen-activated protein kinase 1 Homo sapiens 198-201 19671676-9 2009 JNK inhibition by SP600125, a specific JNK inhibitor, resulted in restoration of EGFR levels in COX-2-overexpressing cells, whereas ERK inhibition by PD98059 did not. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 150-157 mitogen-activated protein kinase 1 Homo sapiens 132-135 19538337-10 2009 In addition, the expression of P21 and P27 triggered by melatonin was inhibited by the pretreatment of the ERK inhibitor, PD98059 (10 microm). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 122-129 mitogen-activated protein kinase 1 Homo sapiens 107-110 19746843-7 2009 Furthermore, PD98059 attenuated AVS-1357 induced ERK activation, as well as the downregulation of MITF and tyrosinase. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 49-52 20719149-5 2009 Mat or PD98059 (i.e PD), specific inhibitor of MAPK/ERK, was added into the A549CM. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 7-14 mitogen-activated protein kinase 1 Homo sapiens 47-51 20719149-5 2009 Mat or PD98059 (i.e PD), specific inhibitor of MAPK/ERK, was added into the A549CM. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 7-14 mitogen-activated protein kinase 1 Homo sapiens 52-55 19288477-6 2009 US-induced MEK and ERK activation was inhibited by manumycin A, GW5074, and PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 76-83 mitogen-activated protein kinase 1 Homo sapiens 19-22 19561104-9 2009 We determined that acute alcohol decreased but chronic alcohol increased activation of ERK in monocytes and ERK inhibitor, PD98059, prevented the chronic alcohol-induced increase in TNF-alpha. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 123-130 mitogen-activated protein kinase 1 Homo sapiens 108-111 19385062-4 2009 Forskolin-induced CREB phosphorylation, VEGF promoter activity, and VEGF expression were blocked by the PKA inhibitor PKI.Moreover, phosphorylation of ERK by forskolin was inhibited by the MEK inhibitor PD98059, but not PKI. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 203-210 mitogen-activated protein kinase 1 Homo sapiens 151-154 19264897-9 2009 The upregulation of ZO-1 expression by the PHSRN peptide was blocked by inhibitors of signaling by ERK (PD098059), p38 (SB203580), or JNK (JNK inhibitor II). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 104-112 mitogen-activated protein kinase 1 Homo sapiens 99-102 19426671-7 2009 Treatment of SKOV3 cells with PKI-166 (EGFR1/2 inhibitor), LY294002 (AKT inhibitor), and PD98059 (ERK inhibitor) decreased c-FLIP(L) expression and co-treatment with TRAIL further reduced the level of c-FLIP(L,) respectively, as did TSA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 89-96 mitogen-activated protein kinase 1 Homo sapiens 98-101 19539245-7 2009 When compared with monotherapy, combinatorial application of rapamycin and PD98059 had greater inhibitory effects on Tsc2 deficient cell proliferation, suggesting that combined suppression of mTOR and ERK/MAPK signaling pathways may have advantages over single mTOR inhibition in the treatment of TSC patients. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 75-82 mitogen-activated protein kinase 1 Homo sapiens 201-204 18996613-5 2009 Phosphatidylinositol 3-kinase inhibitor (PI3K; Ly294002), Akt inhibitor or ERK inhibitor (PD98059) inhibited the OPN-induced increase in the migration of lung cancer cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 90-97 mitogen-activated protein kinase 1 Homo sapiens 75-78 19027725-6 2009 However, only ERK signaling pathway inhibitor PD98059, but not AKT signaling pathway inhibitor LY294002, suppressed the induction of contactin-1 by NNK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 46-53 mitogen-activated protein kinase 1 Homo sapiens 14-17 19286964-11 2009 4) The enhanced ET-1-induced contraction was reduced by MEK/ERK pathway inhibitors (PD-98059 or U0126). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 84-92 mitogen-activated protein kinase 1 Homo sapiens 60-63 19100683-6 2009 CLP-induced cell apoptosis was reversed by PD98059 (an inhibitor of ERK), but not by SB203580 (an inhibitor of p38) and SP200125 (an inhibitor of JNK), suggesting that the action of CLP on K562 cells was via ERK, but not via p38 and JNK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 43-50 mitogen-activated protein kinase 1 Homo sapiens 68-71 19281788-9 2009 Blockade of ERK signaling by PD098059 or the dominant-negative ERK2 significantly reduced eupatilin-induced TFF1 and p21 expression as well as ZO-1 redistribution, indicating that ERK cascades may mediate eupatilin-induced AGS cell differentiation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 29-37 mitogen-activated protein kinase 1 Homo sapiens 12-15 19206164-8 2009 Inhibition of extracellular signal-regulated kinase (ERK) signaling by a pharmacological inhibitor (10 microM PD98059) or by siERK transfection suppressed the force-induced OPG up-regulation along with the augmentation of osteoclast-like cells that were decreased by the force. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 110-117 mitogen-activated protein kinase 1 Homo sapiens 14-51 19206164-8 2009 Inhibition of extracellular signal-regulated kinase (ERK) signaling by a pharmacological inhibitor (10 microM PD98059) or by siERK transfection suppressed the force-induced OPG up-regulation along with the augmentation of osteoclast-like cells that were decreased by the force. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 110-117 mitogen-activated protein kinase 1 Homo sapiens 53-56 19302374-6 2009 Increased levels of the cytokine and of its specific receptors in 9-ONC-treated cells clearly occurs through stimulation of extracellular signal-regulated kinase 1 and 2 (ERK1/2), as demonstrated by ERK1/2 knockdown experiments using mitogen-activated protein kinase/extracellular signal-regulated kinase 1 and 2 (MEK1 and MEK2) siRNAs, or PD98059, a selective MEK1/2 inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 340-347 mitogen-activated protein kinase 1 Homo sapiens 124-169 19255520-6 2009 The inhibition of ERK using PD98059 synergistically enhanced the TET-induced apoptosis of A549 cells whereas the inhibition of Akt using LY294002 had a less significant effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 28-35 mitogen-activated protein kinase 1 Homo sapiens 18-21 19396019-10 2009 The selective mitogen-activated protein kinase/extracellular regulated kinase (ERK) pathway inhibitor PD98059 decreased GSTP1 expression in 5-aza-2"-deoxycytidine-treated cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 102-109 mitogen-activated protein kinase 1 Homo sapiens 79-82 19223550-5 2009 Pharmacologic inhibition of c-Jun NH(2) terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) activation by SP600125 and PD98059, respectively, blocked LY30-induced increase in sensitization to TRAIL-mediated death. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 137-144 mitogen-activated protein kinase 1 Homo sapiens 66-103 19223550-5 2009 Pharmacologic inhibition of c-Jun NH(2) terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) activation by SP600125 and PD98059, respectively, blocked LY30-induced increase in sensitization to TRAIL-mediated death. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 137-144 mitogen-activated protein kinase 1 Homo sapiens 105-108 18825409-9 2009 Pretreatment of cells with SB203580 (inhibitor of p38) and PD98059 (inhibitor of ERK) attenuated LPS-induced IL-6 expression, whereas LY294002 (inhibitor of PI3K) markedly amplified the LPS-stimulated synthesis of IL-6. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 59-66 mitogen-activated protein kinase 1 Homo sapiens 81-84 19288033-7 2009 As expected, PD98059, an ERK inhibitor, SP600125, a JNK inhibitor and SB203580, a p38 MAPK inhibitor effectively inhibit UVB-induced phosphorylation of ERK, JNK and p38 MAPKs, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 25-28 19288033-7 2009 As expected, PD98059, an ERK inhibitor, SP600125, a JNK inhibitor and SB203580, a p38 MAPK inhibitor effectively inhibit UVB-induced phosphorylation of ERK, JNK and p38 MAPKs, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 152-155 19350687-5 2009 Significant impairment of in vitro migration was observed in the presence of MAPK/ERK kinase (MEK) inhibitor PD98059, whereas two Janus kinase 2 (Jak2) inhibitors completely abolished migration induced by tumor cell-conditioned medium. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 109-116 mitogen-activated protein kinase 1 Homo sapiens 82-85 19320886-6 2009 Western blotting analysis was used to observe the activation of JAK-STAT and mitogen-activated protein kinase signaling pathways, and ERK was inhibited with PD98059 and p38 with SB203580 to observe the effect of TNF-alpha on MSC migration and ICAM-1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 157-164 mitogen-activated protein kinase 1 Homo sapiens 134-137 19143758-9 2009 PD98059, a selective inhibitor of MEK, blocked GM-CSF-induced phosphorylation of MEK and ERK but not p85. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 89-92 19148542-8 2009 Nevertheless, pretreatment of ERK inhibitor PD98059 did not attenuate AST-induced PARP cleavage. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 44-51 mitogen-activated protein kinase 1 Homo sapiens 30-33 19567179-8 2009 The cells were pretreated with PD98059, a specific inhibitor of extracellular signal-regulated kinase (ERK) for 60 min, and then stimulated respectively by tensile stress or compressive stress at the same magnitude of 1000 microstrain for 6 h or were not subjected to mechanical loading. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 31-38 mitogen-activated protein kinase 1 Homo sapiens 64-101 18726116-7 2009 PD98059, a MAPK/ERK kinase inhibitor, significantly inhibited proliferation of PTEN-expressing cells, but not PTEN-null cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 11-15 18726116-7 2009 PD98059, a MAPK/ERK kinase inhibitor, significantly inhibited proliferation of PTEN-expressing cells, but not PTEN-null cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 16-19 19567179-8 2009 The cells were pretreated with PD98059, a specific inhibitor of extracellular signal-regulated kinase (ERK) for 60 min, and then stimulated respectively by tensile stress or compressive stress at the same magnitude of 1000 microstrain for 6 h or were not subjected to mechanical loading. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 31-38 mitogen-activated protein kinase 1 Homo sapiens 103-106 19013215-5 2009 In concomitant with the elevation of intracellular ROS formation, BH4-induced activation of MAPK, p38 and ERK1/2 in SH-SY5Y cells is attenuated by pretreatment with MAPK inhibitors, SB203580 or PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 194-201 mitogen-activated protein kinase 1 Homo sapiens 98-101 19376499-4 2009 When blocked with ERK-specific chemical inhibitor PD98059, cell proliferation and IL-2 production via ICOS costimulation from both CD4(+) and CD8(+) T-cells will be severely inhibited. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 50-57 mitogen-activated protein kinase 1 Homo sapiens 18-21 19027753-9 2009 The ERK inhibitor (PD98059) and FK506 produced similar effects but they were not cumulative. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-26 mitogen-activated protein kinase 1 Homo sapiens 4-7 18658095-9 2009 Wounding-, LPA-, and ATP-induced HB-EGF shedding and EGFR activation were attenuated by the MAPK/ERK kinase (MEK) inhibitors PD98059 and U0126, as well as by ADAM10 and -17 inhibitors. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 125-132 mitogen-activated protein kinase 1 Homo sapiens 97-100 20300579-8 2009 Furthermore, the ERK specific-inhibitor PD98059 blocked DN-PPARgamma-induced phosphorylation of Rb and expression of cyclin A and MCM7. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 40-47 mitogen-activated protein kinase 1 Homo sapiens 17-20 20077196-5 2009 The addition of ERK inhibitor PD98059 or N-acetylcysteine (NAC) abolished HQ-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 mitogen-activated protein kinase 1 Homo sapiens 16-19 19048119-8 2008 Inhibition of ERK using ERK inhibitor PD98059 decreased both ULBP-2/ULBP-3 expression and NK cell cytotoxicity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 38-45 mitogen-activated protein kinase 1 Homo sapiens 14-17 18948081-4 2008 The inhibition of ERK by PD98059 decreased epiregulin and Ets-1 expression and suppressed the growth of 267B1/Ki-ras cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 25-32 mitogen-activated protein kinase 1 Homo sapiens 18-21 19007237-7 2008 The activity of gossypin on LDLR expression was inhibited by the extracellular signal-regulated kinase (ERK) inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 119-126 mitogen-activated protein kinase 1 Homo sapiens 65-102 19007237-7 2008 The activity of gossypin on LDLR expression was inhibited by the extracellular signal-regulated kinase (ERK) inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 119-126 mitogen-activated protein kinase 1 Homo sapiens 104-107 19048119-8 2008 Inhibition of ERK using ERK inhibitor PD98059 decreased both ULBP-2/ULBP-3 expression and NK cell cytotoxicity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 38-45 mitogen-activated protein kinase 1 Homo sapiens 24-27 18834896-7 2008 Furthermore, taurine, the Raf-1 kinase inhibitor GW5074, and the ERK kinase inhibitor PD98059 may have the ability to induce cellular proliferation and cell cycle progression from AGE-treated cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 86-93 mitogen-activated protein kinase 1 Homo sapiens 65-68 19099631-3 2008 The results showed that the ATRA in 0.01-01 micromol/L inhibited the proliferation of NB4 cells in time-and dose-dependent manner and induced the differentiation of NB4 cells into myeloid; the ATRA stimulated ERK activity in this process; ERK inhibitor PD98059 could partially block ATRA effect, specific inhibitor of p38MAPK, SB203580, combined with ATRA also could partially block the effects of ATRA on inhibition of NB4 growth and induction of differentiation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 253-260 mitogen-activated protein kinase 1 Homo sapiens 209-212 18801734-9 2008 ERK inhibitor PD098059 or ERK shRNA abolished the nuclear c-Ets-2 DNA binding activity and hFGL2 induction in response to HBc, whereas JNK inhibitor SP600125 or JNK shRNA abolished the nuclear c-Ets-2 DNA binding activity and hFGL2 induction in response to HBx. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 14-22 mitogen-activated protein kinase 1 Homo sapiens 0-3 18980528-8 2008 PD98059, an extracellular signal-regulated kinase (ERK) inhibitor, obviated the increase in the mRNA levels of ALPase, OPN, OC, and BMP-2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 12-49 18789310-4 2008 Icariin-induced ERK activation and angiogenic events were significantly inhibited by the MEK inhibitor PD98059, without affecting Akt and eNOS phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 103-110 mitogen-activated protein kinase 1 Homo sapiens 16-19 18989579-7 2008 Moreover, the p-ERK protein expression level was attenuated when the HepG2 cells were pretreated with ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 116-123 mitogen-activated protein kinase 1 Homo sapiens 16-19 18762250-8 2008 Further, pretreatment with the MEK1/ERK inhibitor PD98059 enhanced EGF-induced EGFR loss in cells expressing WT EGFR, but not EGFR T669A, suggesting that the ERK-dependent effects on EGFR downregulation required phosphorylation of (669)T. In signaling experiments, EGFR T669A displayed enhanced acute (15 min) EGFR tyrosine phosphorylation (reflecting EGFR kinase activity) compared to WT EGFR. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 50-57 mitogen-activated protein kinase 1 Homo sapiens 36-39 18762250-8 2008 Further, pretreatment with the MEK1/ERK inhibitor PD98059 enhanced EGF-induced EGFR loss in cells expressing WT EGFR, but not EGFR T669A, suggesting that the ERK-dependent effects on EGFR downregulation required phosphorylation of (669)T. In signaling experiments, EGFR T669A displayed enhanced acute (15 min) EGFR tyrosine phosphorylation (reflecting EGFR kinase activity) compared to WT EGFR. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 50-57 mitogen-activated protein kinase 1 Homo sapiens 158-161 18767967-5 2008 In investigating possible involvement of MAPK in mediating the effect of butyrate on GADD153 mRNA expression, the extracellular regulated kinase (ERK) inhibitor PD98059, but neither the JNK inhibitor SP600125 nor the p38 MAPK inhibitor SB203580, blunted the ability of butyrate to upregulate GADD153 mRNA expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 161-168 mitogen-activated protein kinase 1 Homo sapiens 114-144 18767967-5 2008 In investigating possible involvement of MAPK in mediating the effect of butyrate on GADD153 mRNA expression, the extracellular regulated kinase (ERK) inhibitor PD98059, but neither the JNK inhibitor SP600125 nor the p38 MAPK inhibitor SB203580, blunted the ability of butyrate to upregulate GADD153 mRNA expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 161-168 mitogen-activated protein kinase 1 Homo sapiens 146-149 18980528-8 2008 PD98059, an extracellular signal-regulated kinase (ERK) inhibitor, obviated the increase in the mRNA levels of ALPase, OPN, OC, and BMP-2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 51-54 18193228-11 2008 Treatment with a specific MEK1/2 (the upstream of ERK) inhibitor, PD98059, increased the PT-262-induced cytotoxicity in lung cancer cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 66-73 mitogen-activated protein kinase 1 Homo sapiens 50-53 18435720-4 2008 HUVEC were cultured in vitro and treated with ox-LDL, melatonin, and PD98059 (a selective inhibitor of ERK), respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 69-76 mitogen-activated protein kinase 1 Homo sapiens 103-106 18789871-5 2008 In contrast, blockage of the ERK-specific MAP kinase MEK with PD98059, that prevents phosphorylation of ERK1/ERK2, abrogated insulin-induced CXCL8 release in primary monocytes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 62-69 mitogen-activated protein kinase 1 Homo sapiens 109-113 18679784-7 2008 The administration of PD98059 (10 microM) resulted in a decrease in phosphorylated ERK and ACE activity in HASMCs compared to those of the pressurized control. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 22-29 mitogen-activated protein kinase 1 Homo sapiens 83-86 18082740-6 2008 TGF-beta1, rosiglitazone (PPARgamma agonist), and PD98059 (ERK inhibitor) were added to endometrial stromal cell culture according to experimental purposes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 50-57 mitogen-activated protein kinase 1 Homo sapiens 59-62 18974961-12 2008 Pretreatment with PD98059 (ERK inhibitor), SB203580 (p38 inhibitor), or SP600125 (JNK inhibitor) decreased the IL-8 production induced by H(2)O(2). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-25 mitogen-activated protein kinase 1 Homo sapiens 27-30 18768890-10 2008 In addition, pretreatment with PD98059, an inhibitor of ERK kinase (MEK-1), significantly prevented NaHS from aggravating systemic inflammation in sepsis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 31-38 mitogen-activated protein kinase 1 Homo sapiens 56-59 18478239-6 2008 Furthermore, ERK functionally regulated the MbetaCD-induced melanin formation in melanocytes; a ERK inhibitor, PD98059, almost completely attenuated the MbetaCD-mediated inhibition of melanin synthesis and down-regulation of MITF and tyrosinase expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 111-118 mitogen-activated protein kinase 1 Homo sapiens 96-99 18778461-9 2008 This increase was antagonized by; (1) PKC inhibitors (10 microM bisindolylmaleimide I and 10 microM Ro-32-0432), and (2) inhibitors of the p38, extracellular signal related kinases 1 and 2 (ERK1/2) and C-jun terminal kinase (JNK) MAPK pathways (10 microM SB203580, 10 microM PD98059 and 10 microM SP600125, respectively). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 275-282 mitogen-activated protein kinase 1 Homo sapiens 139-142 18296682-6 2008 Among the pathways examined, only PD98059, an ERK-specific inhibitor, blocked naringin-dependent p21WAF1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 34-41 mitogen-activated protein kinase 1 Homo sapiens 46-49 18691227-3 2008 Here, we demonstrate that inhibition of the ERK pathway by the MEK inhibitor U0126 or PD98059 significantly potentiates EGF- and FGF-induced Akt phosphorylation at both Thr308 and Ser473. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 86-93 mitogen-activated protein kinase 1 Homo sapiens 44-47 18628248-3 2008 A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 373-380 mitogen-activated protein kinase 1 Homo sapiens 106-143 18628248-3 2008 A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 373-380 mitogen-activated protein kinase 1 Homo sapiens 145-148 18633031-7 2008 L02 cells treated with propofol (0.01-0.3 mM) alone, led to a dose-dependent activation of ERK and MEK, and such activation was detected within 0.5 h and eventually declined to <50% at 4 h. The addition of the specific inhibitor PD98059 completely abolished the activation of ERK and aggravated the extent of apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 232-239 mitogen-activated protein kinase 1 Homo sapiens 91-94 18525161-7 2008 The overexpression of FGF12 strongly suppressed the marked augmentation of apoptosis induced by inhibition of the MEK/ERK pathway with PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 135-142 mitogen-activated protein kinase 1 Homo sapiens 118-121 18454176-6 2008 Moreover, GATA-6 was phosphorylated at serine residues by MEK-activated ERK, which increased GATA-6 DNA binding, correlating with suppression of the Nox1 promoter activity by an MEK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 192-199 mitogen-activated protein kinase 1 Homo sapiens 72-75 18953090-5 2008 It was also shown that protective effects of DHEA, DHEAS and PGL against staurosporine-induced LDH release were attenuated by extracellular signal-regulated kinase (ERK)--mitogen-activated protein kinase (MAPK) inhibitor--PD 98059 (5 microM) but not by phosphatidylinositol-3-kinase (PI3-K) inhibitors such as LY 294002 (1 microM) or wortmannin (10 nM). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 222-230 mitogen-activated protein kinase 1 Homo sapiens 126-163 18953090-5 2008 It was also shown that protective effects of DHEA, DHEAS and PGL against staurosporine-induced LDH release were attenuated by extracellular signal-regulated kinase (ERK)--mitogen-activated protein kinase (MAPK) inhibitor--PD 98059 (5 microM) but not by phosphatidylinositol-3-kinase (PI3-K) inhibitors such as LY 294002 (1 microM) or wortmannin (10 nM). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 222-230 mitogen-activated protein kinase 1 Homo sapiens 165-168 18288130-7 2008 Further evidence is provided that PD98059 or SB203580 inhibited hNUDC- or TPO-induced cell proliferation and differentiation, suggesting that ERK1/2 and p38 MAPK pathways are necessary in megakaryocyte development. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 34-41 mitogen-activated protein kinase 1 Homo sapiens 153-156 18443432-3 2008 Kaempferol was demonstrated to induce sustained ERK activation concomitantly with MEK1 and ELK1 activation, and this kaempferol-induced apoptosis was suppressed by treatment with PD98059, the overexpression of a kinase-inactive ERK mutant, or ERK siRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 179-186 mitogen-activated protein kinase 1 Homo sapiens 48-51 18443432-3 2008 Kaempferol was demonstrated to induce sustained ERK activation concomitantly with MEK1 and ELK1 activation, and this kaempferol-induced apoptosis was suppressed by treatment with PD98059, the overexpression of a kinase-inactive ERK mutant, or ERK siRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 179-186 mitogen-activated protein kinase 1 Homo sapiens 228-231 18443432-3 2008 Kaempferol was demonstrated to induce sustained ERK activation concomitantly with MEK1 and ELK1 activation, and this kaempferol-induced apoptosis was suppressed by treatment with PD98059, the overexpression of a kinase-inactive ERK mutant, or ERK siRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 179-186 mitogen-activated protein kinase 1 Homo sapiens 228-231 19080373-3 2008 In addition, PD98059 was pretreated with cells to prevent ERK activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 58-61 18387647-9 2008 Moreover, addition of PD98059, a MAPK kinase inhibitor, significantly suppressed the LPS-induced NF-kappaB nuclear translocation and GM-CSF production, suggesting that the PPF-attenuated GM-CSF production in hepatocytes may be attributed to its suppressive effect on MAPK/ERK signaling pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 22-29 mitogen-activated protein kinase 1 Homo sapiens 33-37 18387647-9 2008 Moreover, addition of PD98059, a MAPK kinase inhibitor, significantly suppressed the LPS-induced NF-kappaB nuclear translocation and GM-CSF production, suggesting that the PPF-attenuated GM-CSF production in hepatocytes may be attributed to its suppressive effect on MAPK/ERK signaling pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 22-29 mitogen-activated protein kinase 1 Homo sapiens 272-275 17934787-4 2008 Phosphorylation (activation) of JNK and ERK kinases by THDA was blocked by an ERK inhibitor, PD98059, or a JNK inhibitor, JNK-1, respectively, suggesting that THDA-induced apoptosis in K562 cells is ERK and JNK dependent. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 93-100 mitogen-activated protein kinase 1 Homo sapiens 40-43 18373739-5 2008 For the evaluation of the role of MAPKs, PD98059, SP600125 and SB203580 were used as MAPKs inhibitors for ERK1/2, JNK1/2 and p38 MAPK, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 41-48 mitogen-activated protein kinase 1 Homo sapiens 125-128 18468510-5 2008 The preincubation of NK cells with an ERK inhibitor (PD98059) or phosphoinositide-3-kinase (PI3K) inhibitors (wortmannin and LY294002) completely inhibited LPG-induced chemotactic migration, suggesting the essential role of ERK and PI3K in the process. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 53-60 mitogen-activated protein kinase 1 Homo sapiens 38-41 18468510-5 2008 The preincubation of NK cells with an ERK inhibitor (PD98059) or phosphoinositide-3-kinase (PI3K) inhibitors (wortmannin and LY294002) completely inhibited LPG-induced chemotactic migration, suggesting the essential role of ERK and PI3K in the process. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 53-60 mitogen-activated protein kinase 1 Homo sapiens 224-227 18707587-5 2008 Inhibition of activity of these kinases by treatment of cells with PI-3K/Akt-specific inhibitor LY294002 or Erk-specific inhibitor PD98059 resulted in inhibition of MMP-2 expression and the decrease of invasion in vitro. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 131-138 mitogen-activated protein kinase 1 Homo sapiens 108-111 18403484-6 2008 By applying the kinase inhibitors PD98059 (MAPK kinase-1) and SP600125 (JNK), ERK and JNK were shown to be crucial for the induction of MKP-1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 34-41 mitogen-activated protein kinase 1 Homo sapiens 43-47 18403484-6 2008 By applying the kinase inhibitors PD98059 (MAPK kinase-1) and SP600125 (JNK), ERK and JNK were shown to be crucial for the induction of MKP-1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 34-41 mitogen-activated protein kinase 1 Homo sapiens 78-81 18491380-8 2008 The ERK kinase inhibitor PD98059 and the JNK inhibitor SP600125 potently inhibited maleic acid-induced HGF production, while the p38 inhibitor SB203580 did not significantly inhibit the production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 25-32 mitogen-activated protein kinase 1 Homo sapiens 4-7 18440740-9 2008 We also found that PD98059, a MEK (MAPK/ERK kinase) inhibitor, attenuated the eupatilin-induced HO-1 expression and nuclear translocation of transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-26 mitogen-activated protein kinase 1 Homo sapiens 35-39 18440740-9 2008 We also found that PD98059, a MEK (MAPK/ERK kinase) inhibitor, attenuated the eupatilin-induced HO-1 expression and nuclear translocation of transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-26 mitogen-activated protein kinase 1 Homo sapiens 40-43 18468578-6 2008 Among the pathway inhibitors examined, only PD98059, an ERK-specific inhibitor, blocked magnolol-dependent p27KIP1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 44-51 mitogen-activated protein kinase 1 Homo sapiens 56-59 18563362-7 2008 PD98059, an inhibitor of ERK upstream activators MAPK kinase MKK1 and MKK2, promoted cytotoxicity and apoptosis in HL-60 cells treated with DADS. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 25-28 18346464-7 2008 The inhibitory effect of TGZ on EP4 expression was reversed by PD98059, a MEK-1/Erk inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 63-70 mitogen-activated protein kinase 1 Homo sapiens 80-83 19016005-3 2008 In this study, we demonstrated that IL-6 increased lipolysis in differentiated porcine adipocytes by activation of extracellular signal-related kinase (ERK), which was inhibited by specific ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 204-211 mitogen-activated protein kinase 1 Homo sapiens 115-150 19016005-3 2008 In this study, we demonstrated that IL-6 increased lipolysis in differentiated porcine adipocytes by activation of extracellular signal-related kinase (ERK), which was inhibited by specific ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 204-211 mitogen-activated protein kinase 1 Homo sapiens 152-155 19016005-3 2008 In this study, we demonstrated that IL-6 increased lipolysis in differentiated porcine adipocytes by activation of extracellular signal-related kinase (ERK), which was inhibited by specific ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 204-211 mitogen-activated protein kinase 1 Homo sapiens 190-193 18498889-9 2008 Selective inhibitors of the ERK (PD98059) and AKT (LY294002) pathways amplified HPC cell damage after HEMA exposure. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-40 mitogen-activated protein kinase 1 Homo sapiens 28-31 18622047-6 2008 The leptin-induced changes in arachidonic acid release and PGE(2) generation were blocked by ERK inhibitor, PD98059, but not by PI3K inhibitor, wortmannin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 108-115 mitogen-activated protein kinase 1 Homo sapiens 93-96 19035132-10 2008 (5) The cells were cultured with serum-free culture medium containing PD98059, the inhibitor of mitogen-activated protein kinase (MAPK)/MEK for 60 min. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 70-77 mitogen-activated protein kinase 1 Homo sapiens 130-134 18406507-10 2008 SB203580 and PD98059, specific inhibitors of p38 MAPK and ERK, respectively, suppressed phosphorylation of p53 at Ser15, but the accumulation of p53 was only moderately reduced. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 49-53 18406507-10 2008 SB203580 and PD98059, specific inhibitors of p38 MAPK and ERK, respectively, suppressed phosphorylation of p53 at Ser15, but the accumulation of p53 was only moderately reduced. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 58-61 18325324-7 2008 The inhibition of the ERK pathway by PD98059 markedly attenuated apoptosis in SNOG-treated THP-1 cells, but had a marginal effect on SNOG-treated THP-1 cells expressing NO-insensitive p21Ras. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 37-44 mitogen-activated protein kinase 1 Homo sapiens 22-25 18343213-5 2008 However, ERK inhibitor PD98059 was ineffective to GO-induced COX-2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 23-30 mitogen-activated protein kinase 1 Homo sapiens 9-12 18377872-7 2008 Our data demonstrated that inhibitor of ERK (PD98059), but not p38 MAPK (SB203580) or JNK (SP600125), significantly maintained the intracellular level of survivin during treatment with quercetin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 45-52 mitogen-activated protein kinase 1 Homo sapiens 40-43 18272192-8 2008 The ERK inhibitor (PD98059) enhanced the TB-induced inhibition of thymidine incorporation into HUVEC. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-26 mitogen-activated protein kinase 1 Homo sapiens 4-7 18355352-11 2008 Both extracellular regulated kinase (ERK) inhibitor (PD98059) and protein kinase B (Akt) inhibitor (LY294002) almost completely blocked the inhibitory effect of MIF on apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 53-60 mitogen-activated protein kinase 1 Homo sapiens 5-35 18355352-11 2008 Both extracellular regulated kinase (ERK) inhibitor (PD98059) and protein kinase B (Akt) inhibitor (LY294002) almost completely blocked the inhibitory effect of MIF on apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 53-60 mitogen-activated protein kinase 1 Homo sapiens 37-40 18064629-4 2008 MEK/ERK inhibitors PD98059 and U0126 inhibit UV-induced down-regulation of AQP3. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-26 mitogen-activated protein kinase 1 Homo sapiens 4-7 18398338-5 2008 oxLDL stimulated the extracellular signal-regulated kinase (ERK) phosphorylation in HUVECs, which was blocked by NAC and the mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 205-212 mitogen-activated protein kinase 1 Homo sapiens 21-58 18398338-5 2008 oxLDL stimulated the extracellular signal-regulated kinase (ERK) phosphorylation in HUVECs, which was blocked by NAC and the mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 205-212 mitogen-activated protein kinase 1 Homo sapiens 60-63 18287093-3 2008 The present studies demonstrate that inhibition of MEK activation in HepG2 human hepatoma cells by PD98059 or U0126 blocked the increased phosphorylation of eIF2alpha and ATF4 synthesis triggered by amino acid limitation, showing that the AAR requires activation of the MEK-ERK pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 99-106 mitogen-activated protein kinase 1 Homo sapiens 274-277 18164123-6 2008 Pretreating the macrophages with the NF-kappaB inhibitor, BAY 11-7082, and the ERK inhibitor, PD98059, inhibited NO production and iNOS expression induced by 1-BP. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 94-101 mitogen-activated protein kinase 1 Homo sapiens 79-82 18213633-10 2008 PD98059, which is a selective ERK inhibitor, significantly inhibited estrogen-induced cell proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 30-33 18245089-6 2008 Inhibition of this phosphorylation by dominant-negative forms of ERK or by treatment of cells with the ERK inhibitor PD98059 resulted in the increase in CIITA-mediated gene expression from a class II promoter, enhanced the nuclear concentration of CIITA, and impaired its ability to bind to the nuclear export factor, CRM1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 117-124 mitogen-activated protein kinase 1 Homo sapiens 103-106 18340408-6 2008 The leptin-induced changes in arachidonic acid release and PGE2 generation were blocked by ERK inhibitor, PD98059, but not by PI3K inhibitor, wortmannin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 106-113 mitogen-activated protein kinase 1 Homo sapiens 91-94 18263590-6 2008 Inhibitors for GSK3beta (TDZD and LiCl) and ERK (PD98059) protected cells from FGF2-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 49-56 mitogen-activated protein kinase 1 Homo sapiens 44-47 18056787-9 2008 Pretreatment with an ERK inhibitor, PD-98059 (2.5 x 10(-5) M), blocked the leptin-induced increase in (125)I-ET-1 binding. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 36-44 mitogen-activated protein kinase 1 Homo sapiens 21-24 18285354-7 2008 Pre-treatment with the MAPK inhibitors SP600125 (JNK inhibitor), SB202190 (p38 inhibitor) or PD98059 (ERK inhibitor) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE(2). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 93-100 mitogen-activated protein kinase 1 Homo sapiens 23-27 18285354-7 2008 Pre-treatment with the MAPK inhibitors SP600125 (JNK inhibitor), SB202190 (p38 inhibitor) or PD98059 (ERK inhibitor) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE(2). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 93-100 mitogen-activated protein kinase 1 Homo sapiens 102-105 18167127-5 2008 In BRCA2-overexpressing PC-3 cells, transient transfection with a constitutively active PI3-kinase mutant or treatment with the MAPK/ERK inhibitor PD98059 rescued MMP-9 levels and restored the migratory and invasive capabilities. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 147-154 mitogen-activated protein kinase 1 Homo sapiens 133-136 18079194-8 2008 Interestingly, treatment of the osteoporotic osteoblasts with the MAPK kinase inhibitor PD098059 reduced the elevated levels of Erk phosphorylation and increased basal DNA synthesis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 88-96 mitogen-activated protein kinase 1 Homo sapiens 66-70 18079194-8 2008 Interestingly, treatment of the osteoporotic osteoblasts with the MAPK kinase inhibitor PD098059 reduced the elevated levels of Erk phosphorylation and increased basal DNA synthesis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 88-96 mitogen-activated protein kinase 1 Homo sapiens 128-131 18252950-7 2008 We therefore tested whether ERK1/2 might be involved in the leptin PRL response and found that the ERK inhibitor, PD98059, hindered leptin-induced PRL release. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 114-121 mitogen-activated protein kinase 1 Homo sapiens 28-31 18031783-8 2008 In addition, an ERK-specific inhibitor, PD98059, and a JNK-specific inhibitor, SP600125, showed inhibited sub-G1 phase DNA content, DNA fragmentation, caspase activation, and mitochondrial dysfunction induced by esculetin treatment. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 40-47 mitogen-activated protein kinase 1 Homo sapiens 16-19 18182379-8 2008 Moreover, the inhibition of ERK activation by selective inhibitor PD98059 and FAK expression by FAK-specific RNA interference could significantly abolish the stimulatory effects induced by PGN, flagellin and R837. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 66-73 mitogen-activated protein kinase 1 Homo sapiens 28-31 18198130-3 2008 In NB4 acute promyelocytic leukemia cells, the expression of Pyk2 was increased in parallel with differentiation, and inhibited by PD98059, indicating Pyk2 expression is regulated through MAPK/ERK pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 131-138 mitogen-activated protein kinase 1 Homo sapiens 193-196 18164958-4 2008 Pretreatment with the MEK-ERK inhibitor (PD98059) reversed these effects of HP. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 41-48 mitogen-activated protein kinase 1 Homo sapiens 26-29 18068334-8 2008 Pretreatment of melanoma cells with the JNK inhibitor (SP600125) or the p38 inhibitor (SB203580) blocked taxol-induced UCP2 downregulation, ROS generation and apoptosis, whereas the ERK inhibitor (PD98059) had no such effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 197-204 mitogen-activated protein kinase 1 Homo sapiens 182-185 18204781-7 2008 Inhibition of ERK activity by an inhibitor (PD98059) of MAPK/extracellular signal-regulated kinase kinase (MEK1) decreased the LMP1-induced activation of STAT3 Ser 727. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 44-51 mitogen-activated protein kinase 1 Homo sapiens 14-17 18204781-7 2008 Inhibition of ERK activity by an inhibitor (PD98059) of MAPK/extracellular signal-regulated kinase kinase (MEK1) decreased the LMP1-induced activation of STAT3 Ser 727. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 44-51 mitogen-activated protein kinase 1 Homo sapiens 61-98 17950696-4 2007 Furthermore, we showed that migration toward SDF-1 was reduced by inactivation of either serine/threonine kinase Akt or extracellular signal regulated kinase Erk, which was confirmed by selective pathway inhibitor LY294002 and PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 227-234 mitogen-activated protein kinase 1 Homo sapiens 158-161 17767925-11 2008 PD98059 (ERK inhibitor) and SB203580 (p38 MAPK inhibitor) down-regulated the COX-2 expression induced by TPA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 9-12 19094210-12 2008 In contrast, an inhibitor of the extracellular signal-regulated kinase (ERK/MAPK) (PD98059) demonstrated no significant influence. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 83-90 mitogen-activated protein kinase 1 Homo sapiens 72-75 17949889-12 2008 CONCLUSION: Our results suggest that KIs modulate proliferation of leukemia cells and that the MEK/ERK inhibitor, PD098059, in combination with either SP600125 or LY294002, could have clinical value. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 114-122 mitogen-activated protein kinase 1 Homo sapiens 99-102 18656701-7 2008 Selective inhibitors of p38 MAPK (SB203580), JNK (SP600125) and ERK (PD98059) could suppress TNF-alpha-induced CCL2 and ICAM-1 expression, while only p38 MAPK and ERK inhibitors could suppress TNF-alpha-induced VCAM-1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 69-76 mitogen-activated protein kinase 1 Homo sapiens 64-67 18172082-7 2008 PD98059, a specific inhibitor of signaling by extracellular signal regulated kinase (ERK), prevented the upregulation of tight-junctional proteins in HCE cells by corneal fibroblasts. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 46-83 17991870-6 2008 Monocyte-induced endothelial cell proliferation is accompanied by prolonged extracellular signal-regulated kinase (ERK) activation and is inhibited by the specific ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 178-185 mitogen-activated protein kinase 1 Homo sapiens 115-118 17991870-6 2008 Monocyte-induced endothelial cell proliferation is accompanied by prolonged extracellular signal-regulated kinase (ERK) activation and is inhibited by the specific ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 178-185 mitogen-activated protein kinase 1 Homo sapiens 164-167 17897103-6 2008 Activation of the ERK1/2 (extracellular-signal-regulated kinase 1/2) pathway by Raf-1 also enhanced Ser727 phosphorylation and SUMOylation of STAT1, and this induction was counteracted by PD98059 inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 188-195 mitogen-activated protein kinase 1 Homo sapiens 26-67 18534028-6 2008 This effect was inhibited by the ERK pathway inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 56-63 mitogen-activated protein kinase 1 Homo sapiens 33-36 18639962-11 2008 Inhibition of ERK1/2, JNK1/2 and p38 MAPK with PD98059, SP600125 and SB203580, respectively, led to the suppression of the shear stress-induced IL-8 gene expression (P<0.01), which was also blocked by JNK1/2 siRNA (small interfering RNA) (P<0.01). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-54 mitogen-activated protein kinase 1 Homo sapiens 33-36 18172082-7 2008 PD98059, a specific inhibitor of signaling by extracellular signal regulated kinase (ERK), prevented the upregulation of tight-junctional proteins in HCE cells by corneal fibroblasts. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 85-88 18979154-6 2008 Quercetin-induced cell death was prevented by the ERK inhibitor PD98059, but not by inhibitors of p38 and JNK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 64-71 mitogen-activated protein kinase 1 Homo sapiens 50-53 18523380-8 2008 PD98059, a specific inhibitor of extracellular signal-regulated kinase (ERK), and N-acetylcysteine (NAC), an antioxidant, partially abrogated the stretch-induced ICAM-1 protein upregulation at the 3-hour loading. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 33-70 18523380-8 2008 PD98059, a specific inhibitor of extracellular signal-regulated kinase (ERK), and N-acetylcysteine (NAC), an antioxidant, partially abrogated the stretch-induced ICAM-1 protein upregulation at the 3-hour loading. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 72-75 20020854-8 2008 P38 kinase inhibitor SB203580 (20 muM) and Erk inhibitor PD98059 (50 muM) suppressed silica-induced PAI-1 expression by 35% and 51%, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 57-64 mitogen-activated protein kinase 1 Homo sapiens 43-46 20103886-4 2007 PD98059, a specific ERK pathway inhibitor, was used to evaluate the effect a blockade of ERK activation has on the proliferation of a cutaneous SCC cell line (DJM-1) in culture. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 20-23 17627770-9 2007 Selective inhibitors of p38 MAPK (SB203580), ERK (PD98059), and JNK (SP600125) could differentially inhibit the production of EGF, VEGF and CCL2, thereby suggesting a role for MAPKs in IL-31 functions. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 50-57 mitogen-activated protein kinase 1 Homo sapiens 45-48 17888875-4 2007 Preincubation of HUVECs with an ERK inhibitor (PD98059) completely inhibited LPG-induced chemotactic migration, suggesting the crucial role of ERK in the process. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-54 mitogen-activated protein kinase 1 Homo sapiens 32-35 17563746-7 2007 Elevated ErbB-2 activity in LNCaP cells correlated with increased ERK/MAPK activity and enhanced adhesive ability, which were abolished by the expression of K457A-PYK2 mutant or the treatment of PD98059, a MEK inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 195-202 mitogen-activated protein kinase 1 Homo sapiens 66-69 17888875-4 2007 Preincubation of HUVECs with an ERK inhibitor (PD98059) completely inhibited LPG-induced chemotactic migration, suggesting the crucial role of ERK in the process. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-54 mitogen-activated protein kinase 1 Homo sapiens 143-146 17902045-9 2007 LPS-elicited SCs TNF-alpha production was also drastically suppressed by PD98059 (ERK inhibitor), SB202190 (P38 inhibitor), or SP600125 (SAPK/JNK inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 73-80 mitogen-activated protein kinase 1 Homo sapiens 82-85 17638924-6 2007 The MEK1 inhibitor, PD98059, was used to block the downstream action of oncogenic K-RAS/ERK, as was a dominant-negative (DN) K-RAS construct. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 20-27 mitogen-activated protein kinase 1 Homo sapiens 88-91 17724212-9 2007 Intraluminal administration of an extracellular signal-regulated kinase (ERK) inhibitor (PD98059), but not an estrogen receptor blocker (ICI 182780), also reduced vasodilation by 50%. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 89-96 mitogen-activated protein kinase 1 Homo sapiens 34-71 21180125-4 2007 We analyzed the relationship between HIF-1alpha expression activated by Gin and ERK signal pathway with treatment of PD98059 (100 micromol/L), a selective inhibitor of ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 117-124 mitogen-activated protein kinase 1 Homo sapiens 80-83 21180125-4 2007 We analyzed the relationship between HIF-1alpha expression activated by Gin and ERK signal pathway with treatment of PD98059 (100 micromol/L), a selective inhibitor of ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 117-124 mitogen-activated protein kinase 1 Homo sapiens 168-171 17704059-8 2007 Treatment with the ERK inhibitor PD98059 inhibited MMP-9 induction. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-40 mitogen-activated protein kinase 1 Homo sapiens 19-22 17904532-6 2007 In addition, treatment of A549 cells with ERK inhibitor (PD98059), NF-kappaB inhibitor (PDTC) or IkappaB protease inhibitor (TPCK) inhibited SDF-1alpha-induced cells migration and integrins expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 57-64 mitogen-activated protein kinase 1 Homo sapiens 42-45 17701086-7 2007 ERK2 activation is required for the MHBs(t) effect because ERK2 inhibition by its inhibitor PD98059 significantly reversed TRAIL-induced apoptosis of MHBs(t)-transfected cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 92-99 mitogen-activated protein kinase 1 Homo sapiens 0-4 17701086-7 2007 ERK2 activation is required for the MHBs(t) effect because ERK2 inhibition by its inhibitor PD98059 significantly reversed TRAIL-induced apoptosis of MHBs(t)-transfected cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 92-99 mitogen-activated protein kinase 1 Homo sapiens 59-63 18027151-6 2007 It was noteworthy that the ras/raf/MEK/ERK pathway inhibitor PD98059 attenuated GABA-induced MMP-9 expression and that both PD98059 and MMP inhibitors attenuated the GABA-induced invasive activity of Caki-2 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 61-68 mitogen-activated protein kinase 1 Homo sapiens 39-42 17956673-2 2007 Phosphorate-Erk1/2, the key molecule of MAPK pathway, was examined by Western blot after KM3 cells being pretreated with or without PD98059, the special inhibitor of Erk1 and Erk2 phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 132-139 mitogen-activated protein kinase 1 Homo sapiens 175-179 17724212-9 2007 Intraluminal administration of an extracellular signal-regulated kinase (ERK) inhibitor (PD98059), but not an estrogen receptor blocker (ICI 182780), also reduced vasodilation by 50%. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 89-96 mitogen-activated protein kinase 1 Homo sapiens 73-76 18481201-7 2007 In addition, immunoblot and immunostaining analysis revealed that phosphorylation of ERK was increased by treatment with SB203580; whereas PD98059 increased the phosphorylation of p38, which implies a seesaw-like balance between ERK and p38 phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 139-146 mitogen-activated protein kinase 1 Homo sapiens 180-183 17624368-6 2007 This was inhibited by p38 and ERK MAP kinase inhibitors, SB203580 and PD98059, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 70-77 mitogen-activated protein kinase 1 Homo sapiens 30-33 17590861-7 2007 Functional assays using the MEK inhibitor PD98059 demonstrated that the phosphorylation of MEK and ERK was required for the induction of caspase-3-mediated apoptosis of malignant germ cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 42-49 mitogen-activated protein kinase 1 Homo sapiens 99-102 17329004-6 2007 We further demonstrated that extracellular signal-regulated kinase (ERK) activation by TUBU was needed for Chk1 kinase activation and microtubule formation as shown by the attenuation of these responses by the ERK1/2 specific inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 236-243 mitogen-activated protein kinase 1 Homo sapiens 29-66 17934341-13 2007 PD98059, an inhibitor of the MEK-ERK pathway, completely prevented the TNF-alpha mRNA and protein expression induced by TCDD, whereas inhibitors of JNK and p38 MAPK had no effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 33-36 17329004-6 2007 We further demonstrated that extracellular signal-regulated kinase (ERK) activation by TUBU was needed for Chk1 kinase activation and microtubule formation as shown by the attenuation of these responses by the ERK1/2 specific inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 236-243 mitogen-activated protein kinase 1 Homo sapiens 68-71 17433488-9 2007 SB203580 (p38 inhibitor) and especially PD98059 (ERK inhibitor) blocked quercetin-derived HO-1 induction and Nrf2 translocation, and subsequently inhibited the quercetin-related protection. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 40-47 mitogen-activated protein kinase 1 Homo sapiens 49-52 17581212-14 2007 Cells were exposed to short waves once for seven consecutive days in the presence of 0, 10 micromol/L, 20 micromol/L or 50 micromol/L PD98059 (an ERK inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 134-141 mitogen-activated protein kinase 1 Homo sapiens 146-149 17617806-6 2007 SB203580 [p38-mitogen-activated protein kinase (MAPK) inhibitor] suppressed LPS-induced MDC and IP-10 expression, and PD98059 (ERK-MAPK inhibitor) could only suppress LPS-induced IP-10, but not MDC expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 118-125 mitogen-activated protein kinase 1 Homo sapiens 127-130 17467690-7 2007 Inhibition of the ERK1/2 activity by PD98059 abrogated the synergistic effect of EGF and TGF-beta1 on cell migration, MMP-9 production and activity, indicating that EGF and TGF-beta1 converged at the ERK signaling pathway to mediate cell migration. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 37-44 mitogen-activated protein kinase 1 Homo sapiens 18-21 17610377-6 2007 Addition of the MEK inhibitor PD98059 to reduce ERK activation decreases osteogenic gene expression and matrix mineralization while also blocking strain-induced down-regulation of nonosteogenic lineage marker genes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 mitogen-activated protein kinase 1 Homo sapiens 48-51 17303087-6 2007 Tanshinone IIA-induced Nrf2 activation was association with activation of ERK and PKB, which was prevented by treatment with PD098059 or wortmannin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 125-133 mitogen-activated protein kinase 1 Homo sapiens 74-77 17387271-7 2007 In addition, the upregulation of PrP(C) was reduced by MERK/ERK inhibitor (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 75-82 mitogen-activated protein kinase 1 Homo sapiens 56-59 17183064-7 2007 Inhibitors of ERK (PD98059) or Akt (LY294002), but not p38 MAPK, resulted in significantly decreased cell viability. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-26 mitogen-activated protein kinase 1 Homo sapiens 14-17 17225171-9 2007 Coincubation with PD098059, a MAPK inhibitor, has no effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-26 mitogen-activated protein kinase 1 Homo sapiens 30-34 17460254-9 2007 The MMC-related IL-8 and MCP-1 expression was inhibited by both a p38 inhibitor (SB203580) and an ERK inhibitor (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 113-120 mitogen-activated protein kinase 1 Homo sapiens 98-101 17473185-9 2007 Blocking extracellular signal-regulated kinase 1/2 (ERK 1/2) and phosphoinositide-3-kinase by PD98059 and LY294002, respectively, abolished 16 E6- and E7-induced HIF-1 alpha and VEGF expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 94-101 mitogen-activated protein kinase 1 Homo sapiens 9-50 17457195-9 2007 SB202190 and PD98059 significantly suppressed hyperosmolarity-induced JNK/ERK activation and ISOL-positive cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 74-77 17235324-8 2007 The effect of ACTH on IL-18 production was blocked by specific inhibitors of p38 kinase (SB203580) or extracellular signal-regulated kinase (ERK) (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 147-154 mitogen-activated protein kinase 1 Homo sapiens 102-139 17235324-8 2007 The effect of ACTH on IL-18 production was blocked by specific inhibitors of p38 kinase (SB203580) or extracellular signal-regulated kinase (ERK) (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 147-154 mitogen-activated protein kinase 1 Homo sapiens 141-144 17464174-4 2007 The mRNA and surface protein up-regulation of CCR1 and CCR2 in 9CRA-stimulated cells were weakly blocked by the pretreatment of SB202190, a p38 MAPK inhibitor, and PD98059, an upstream ERK inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 164-171 mitogen-activated protein kinase 1 Homo sapiens 185-188 17513607-6 2007 p15(INK4b) induction was caused by MAPK/ERK kinase inhibitor (PD98059), but not by Akt inhibitor (SH-6, Akt-III). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 62-69 mitogen-activated protein kinase 1 Homo sapiens 35-39 17513607-6 2007 p15(INK4b) induction was caused by MAPK/ERK kinase inhibitor (PD98059), but not by Akt inhibitor (SH-6, Akt-III). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 62-69 mitogen-activated protein kinase 1 Homo sapiens 40-43 17191113-7 2007 For the evaluation of the role of MAPKs, PD98059, SB203580 and SP600125 were used as MAPKs inhibitors for ERK1/2, p38 MAPK and JNK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 41-48 mitogen-activated protein kinase 1 Homo sapiens 114-117 17108007-9 2007 ERK inhibitor PD98059 was found previously to inhibit AP-1 activation by H(2)O(2). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 14-21 mitogen-activated protein kinase 1 Homo sapiens 0-3 17394769-3 2007 Though no apparent elevation of ERK activity was observed during the apoptosis in NB4 cells caused by 20 microM sodium selenite treatment, PD98059 and U0126, specific chemical inhibitors of the MEK/ERK signaling pathway, were shown to strongly prevent the apoptosis process, while ERK activator TPA enhanced the process. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 139-146 mitogen-activated protein kinase 1 Homo sapiens 198-201 17394769-3 2007 Though no apparent elevation of ERK activity was observed during the apoptosis in NB4 cells caused by 20 microM sodium selenite treatment, PD98059 and U0126, specific chemical inhibitors of the MEK/ERK signaling pathway, were shown to strongly prevent the apoptosis process, while ERK activator TPA enhanced the process. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 139-146 mitogen-activated protein kinase 1 Homo sapiens 198-201 17093923-2 2007 Moreover, the protein kinase kinase/extracellular-signal-regulated kinase (MAPKK/ERK-MEK) inhibitor PD98059 accelerates insulin-mediated myogenesis, whereas the phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002 or blockade of mitochondrial respiration abrogates insulin-mediated myogenesis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 100-107 mitogen-activated protein kinase 1 Homo sapiens 81-84 17558919-11 2007 By inhibiting spinal ERK activation with intrathecal administration of PD98059, we verified that ERK phosphorylation does contribute to regulate c-fos expression upon noxious bladder stimulation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 71-78 mitogen-activated protein kinase 1 Homo sapiens 21-24 17558919-11 2007 By inhibiting spinal ERK activation with intrathecal administration of PD98059, we verified that ERK phosphorylation does contribute to regulate c-fos expression upon noxious bladder stimulation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 71-78 mitogen-activated protein kinase 1 Homo sapiens 97-100 17286604-6 2007 Inhibition of MEK/ERK activity by specific MEK inhibitors PD98059 and U0126, or by RNA interference, rapidly caused the loss of self-renewal capacity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 mitogen-activated protein kinase 1 Homo sapiens 18-21 17449939-5 2007 We also found that the autocrine ERK activation was associated with the expression of cyclin D1 and the cell cycle regulation at the early stage of calcium triggering by treating the cells with the mitogen-activated protein kinase inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 241-248 mitogen-activated protein kinase 1 Homo sapiens 33-36 17374154-9 2007 S1P stimulated extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) in HAC, and the PGE2 induction was abrogated by PD98059 and SB203580. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 155-162 mitogen-activated protein kinase 1 Homo sapiens 15-52 17374154-9 2007 S1P stimulated extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) in HAC, and the PGE2 induction was abrogated by PD98059 and SB203580. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 155-162 mitogen-activated protein kinase 1 Homo sapiens 101-105 17592551-7 2007 Interestingly, single or simultaneous inhibition of PI3K by LY294002 and ERK by PD98059 does not prevent IGF-1-mediated survivin expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 80-87 mitogen-activated protein kinase 1 Homo sapiens 73-76 17055484-10 2007 Moreover, inhibition of ERK activation by UO126 and PD98059 markedly decreased HGF-stimulated HBMEC migration. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 52-59 mitogen-activated protein kinase 1 Homo sapiens 24-27 17137556-5 2007 Interruption of ERK signaling, using the specific MEK inhibitors U-0126 and PD-98059, significantly enhanced CdA cytotoxicity, evaluated by the MTT assay. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 76-84 mitogen-activated protein kinase 1 Homo sapiens 16-19 17251521-6 2007 PD-98059, SB-203580, SP-600125, and PDTC-which are inhibitors of ERK1/2, p38, JNK, and nuclear factor-kappaB (NF-kappaB), respectively-attenuated the IL-1alpha-induced COX-2 mRNA expression and activated protein kinase C PGE(2) secretion. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-8 mitogen-activated protein kinase 1 Homo sapiens 73-76 17259394-7 2007 High glucose, high insulin, and high glucose+high insulin increased Erk phosphorylation, which is an upstream regulator of eIF4E phosphorylation, and PD098059, which is a MEK inhibitor that blocks Erk activation, abolished laminin-beta1 synthesis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 150-158 mitogen-activated protein kinase 1 Homo sapiens 197-200 17171453-8 2007 Inactivation of ERK2 by PD98059 partly attenuated rebamipide-induced p21 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 24-31 mitogen-activated protein kinase 1 Homo sapiens 16-20 17097910-8 2007 The presence of ERK inhibitor PD98059, JNK inhibitor SP600125 and p38 inhibitor SB203580 decreased cell death in 4Gy-irradiated thymocytes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 mitogen-activated protein kinase 1 Homo sapiens 16-19 17002919-5 2006 Treatment with PD98059 or UO126, mitogen-activated ERK-activating kinase 1/2 inhibitors, significantly inhibited the Ox-LDL-induced increase in PAI-1 mRNA and nuclear Smad3 expression, DNA/protein complex formation, and PAI-1 promoter activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 15-22 mitogen-activated protein kinase 1 Homo sapiens 51-54 17143532-6 2007 Disruption of MAPK/ERK with PD98059 prevented any BRCA2 upregulation inhibiting DNA synthesis below basal levels. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 28-35 mitogen-activated protein kinase 1 Homo sapiens 14-18 17143532-6 2007 Disruption of MAPK/ERK with PD98059 prevented any BRCA2 upregulation inhibiting DNA synthesis below basal levels. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 28-35 mitogen-activated protein kinase 1 Homo sapiens 19-22 16924673-7 2007 The expression of DC markers was downregulated by PD98059, a specific inhibitor of ERK kinase or transient transfection of mutant-ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 50-57 mitogen-activated protein kinase 1 Homo sapiens 83-86 17251686-5 2007 Moreover, the oridonin-induced apoptosis was augmented by the Ras inhibitor manumycin A, Raf-1 inhibitor GW5074, or ERK inhibitor PD98059, suggesting that inactivation of Ras, Raf, or ERK participates in oridonin-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 130-137 mitogen-activated protein kinase 1 Homo sapiens 116-119 16904202-7 2006 However, this increase was abrogated by pretreatment with an extracellular signal-regulated kinase (ERK) inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 115-122 mitogen-activated protein kinase 1 Homo sapiens 61-98 16904202-7 2006 However, this increase was abrogated by pretreatment with an extracellular signal-regulated kinase (ERK) inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 115-122 mitogen-activated protein kinase 1 Homo sapiens 100-103 17054908-6 2006 However, we observed that mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase (MEK-1/ERK) inhibitors (PD98059 and U0126) significantly sensitized the GC-induced transactivation of anti-inflammatory genes (glucocorticoid-induced leucine zipper (GILZ) and mitogen-activated protein kinase phosphatase (MKP)-1) and FK506 binding protein (FKBP) 51 gene in the presence of TNFalpha. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 130-137 mitogen-activated protein kinase 1 Homo sapiens 113-116 16785991-9 2006 PRL-induced PTP101-reactive phosphorylation was prevented by pretreatment with PD98059, an ERK pathway inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 79-86 mitogen-activated protein kinase 1 Homo sapiens 91-94 17052670-9 2006 PD98059 (an inhibitor of ERK) or LY294002 (an inhibitor of Akt), but not an inhibitor of p38 MAPK and JNK, significantly decreased cell viability and increased lactate dehydrogenase (LDH) release. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 25-28 16972261-2 2006 This effect was potentiated by co-treatment with MEK/ERK (PD98059, U0126) and JNK (SP600125, AS601245) inhibitors, but not with p38 (SB203580, SB220025) inhibitors. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 mitogen-activated protein kinase 1 Homo sapiens 53-56 17054996-5 2006 Inhibition of the ERK pathway by PD98059 sensitized cells to 5-fluorouracil (5-FU), whereas cells became more resistant to Adriamycin (ADM; Meiji Seika, Tokyo, Japan) and gemcitabine (GEM). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-40 mitogen-activated protein kinase 1 Homo sapiens 18-21 17189385-10 2006 In addition, MEK/ERK inhibitor (PD98059) reduced the interaction between p65 and ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 17-20 17189385-10 2006 In addition, MEK/ERK inhibitor (PD98059) reduced the interaction between p65 and ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 81-84 16563718-7 2006 Furthermore, inhibition of ERK activity by PD98059 and PI3K/Akt activity by LY294002 or wortmannin significantly reduced the LA-induced activation of nuclear factor kappa B (NF-kappaB). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 43-50 mitogen-activated protein kinase 1 Homo sapiens 27-30 17098545-11 2006 This effect was sustained when cells were treated with L-NAME (32% +/- 1.6% increase, P = .02) but abolished when endothelial cells were treated with calphostin C or PD98059 to block protein kinase C (PKC) or extracellular regulated kinase (ERK). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 166-173 mitogen-activated protein kinase 1 Homo sapiens 209-239 17098545-11 2006 This effect was sustained when cells were treated with L-NAME (32% +/- 1.6% increase, P = .02) but abolished when endothelial cells were treated with calphostin C or PD98059 to block protein kinase C (PKC) or extracellular regulated kinase (ERK). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 166-173 mitogen-activated protein kinase 1 Homo sapiens 241-244 16903868-6 2006 Enhanced neutrophil motility and morphological change were inhibited by MEK [mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase] inhibitors (PD98059 and U0126), and a phosphatidylinositol 3-kinase (PI3K) inhibitor (wortmannin), but not by a p38 MAPK inhibitor (SB203580). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 181-188 mitogen-activated protein kinase 1 Homo sapiens 281-284 17062671-5 2006 We further observed that ligand-induced migration of these cells was blocked by the pure antiestrogen ICI 182780 and the mitogen-activated protein/ERK kinase inhibitor PD98059, indicating that estrogen-induced cell migration is mediated by the activation of ERbeta nongenomic signaling. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 168-175 mitogen-activated protein kinase 1 Homo sapiens 147-150 16840547-11 2006 PD98059 inhibited this delayed activation of ERK and effects of S179D PRL on all measures except p53 levels or activity of the Bax promoter. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 45-48 16982750-8 2006 The G2-M arrest and endoreduplication induced by JAK inhibitors were reduced in cells pretreated with PD98059 to inhibit ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 102-109 mitogen-activated protein kinase 1 Homo sapiens 121-124 16733250-9 2006 Epigallocatechin-3-gallate, a potent Mnb/Dyrk1A inhibitor in vitro, apparently reduced the phosphorylation at Ser-293, whereas PD98059, a potent MAPK/ERK inhibitor, did not. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 127-134 mitogen-activated protein kinase 1 Homo sapiens 145-149 16946501-6 2006 However, inhibition of ERK by PD98059 reversed oridonin-induced cell death as well as the activation of caspase 8, indicating that ERK-mediated control occured upstream of caspase 8. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 mitogen-activated protein kinase 1 Homo sapiens 23-26 16897441-5 2006 The pro-apoptotic action of CAP was antagonized by the antioxidant agent N-acetylcysteine, the protein synthesis inhibitor cycloheximide, and PD98059, a selective inhibitor of extracellular signal-regulated kinase (ERK) activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 142-149 mitogen-activated protein kinase 1 Homo sapiens 176-213 16897441-5 2006 The pro-apoptotic action of CAP was antagonized by the antioxidant agent N-acetylcysteine, the protein synthesis inhibitor cycloheximide, and PD98059, a selective inhibitor of extracellular signal-regulated kinase (ERK) activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 142-149 mitogen-activated protein kinase 1 Homo sapiens 215-218 16697418-5 2006 Of the three MAP kinase blockers used, the selective p38 MAP kinase inhibitor SB203580 and ERK inhibitor PD98059 protected IHOK and HN4 cells against iron chelator-induced cell death, which indicates that the p38 and ERK MAP kinase is a major mediator of apoptosis induced by this iron chelator. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 105-112 mitogen-activated protein kinase 1 Homo sapiens 91-94 16697418-5 2006 Of the three MAP kinase blockers used, the selective p38 MAP kinase inhibitor SB203580 and ERK inhibitor PD98059 protected IHOK and HN4 cells against iron chelator-induced cell death, which indicates that the p38 and ERK MAP kinase is a major mediator of apoptosis induced by this iron chelator. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 105-112 mitogen-activated protein kinase 1 Homo sapiens 217-220 16361081-8 2006 Moreover, TGF-beta stimulates cell proliferation by activating the MEK-ERK pathway, as the MEK inhibitor PD98059 blocks this effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 105-112 mitogen-activated protein kinase 1 Homo sapiens 71-74 16616945-8 2006 Ciglitazone-induced cell death was significantly prevented by PD98059, an inhibitor of ERK upstream kinase MEK1/2, and SB203580, a p38 inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 62-69 mitogen-activated protein kinase 1 Homo sapiens 87-90 16733250-9 2006 Epigallocatechin-3-gallate, a potent Mnb/Dyrk1A inhibitor in vitro, apparently reduced the phosphorylation at Ser-293, whereas PD98059, a potent MAPK/ERK inhibitor, did not. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 127-134 mitogen-activated protein kinase 1 Homo sapiens 150-153 16880823-3 2006 Moreover, both the ERK5 and the ERK1/2 pathways are sensitive to PD98059 and U0126, which are two well-known inhibitors of the ERK pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 65-72 mitogen-activated protein kinase 1 Homo sapiens 19-22 16637058-6 2006 ERK cascade activation was detected with phosphoERK immunoblotting and inhibited with 20 microM PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 96-103 mitogen-activated protein kinase 1 Homo sapiens 0-3 16729971-0 2006 Elevated expression of ERK 2 in human tumor cells chronically treated with PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 75-82 mitogen-activated protein kinase 1 Homo sapiens 23-28 16788844-6 2006 RESULTS: The culture of SiHa cells in the presence of 50 microg/1.5 ml fibronectin led to expression of pro-MMP-9 and activation of MMP-2 within 2 h. When cells were treated with ERK inhibitor (PD98059) and grown in the presence of fibronectin MMP-2 activation was partially inhibited, but when cells were treated with PI-3K inhibitor (LY294002) and grown in the presence of fibronectin MMP-2 activation was appreciably reduced. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 194-201 mitogen-activated protein kinase 1 Homo sapiens 179-182 16773182-7 2006 Inhibitors of mitogen-activated protein/extracellular signal regulated kinase (MEK), such as ERK inhibitor PD98059 and JNK inhibitors dicumarol and SP60015, but not p38 inhibitor SB203580, inhibited PMA-induced MUC5AC reporter activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 107-114 mitogen-activated protein kinase 1 Homo sapiens 93-96 16440334-4 2006 The p38 mitogen activated protein kinase (MAPK) inhibitor, SB203580, inhibited and the extracellular signal regulated kinase (ERK) inhibitor, PD98059, enhanced the expression and promoter activities of alpha-globin and zeta-globin by activin A, indicating that p38 MAPK and ERK are crucial for activin A-induced erythroid genes expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 142-149 mitogen-activated protein kinase 1 Homo sapiens 42-46 16440334-4 2006 The p38 mitogen activated protein kinase (MAPK) inhibitor, SB203580, inhibited and the extracellular signal regulated kinase (ERK) inhibitor, PD98059, enhanced the expression and promoter activities of alpha-globin and zeta-globin by activin A, indicating that p38 MAPK and ERK are crucial for activin A-induced erythroid genes expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 142-149 mitogen-activated protein kinase 1 Homo sapiens 87-124 16440334-4 2006 The p38 mitogen activated protein kinase (MAPK) inhibitor, SB203580, inhibited and the extracellular signal regulated kinase (ERK) inhibitor, PD98059, enhanced the expression and promoter activities of alpha-globin and zeta-globin by activin A, indicating that p38 MAPK and ERK are crucial for activin A-induced erythroid genes expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 142-149 mitogen-activated protein kinase 1 Homo sapiens 126-129 16440334-4 2006 The p38 mitogen activated protein kinase (MAPK) inhibitor, SB203580, inhibited and the extracellular signal regulated kinase (ERK) inhibitor, PD98059, enhanced the expression and promoter activities of alpha-globin and zeta-globin by activin A, indicating that p38 MAPK and ERK are crucial for activin A-induced erythroid genes expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 142-149 mitogen-activated protein kinase 1 Homo sapiens 274-277 16376940-12 2006 Additionally, these effects were also abrogated by the extracellular signal-regulated kinase (ERK) inhibitor, PD98059, but not by the p38 mitogen-activated protein kinase inhibitor, SB203580. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 110-117 mitogen-activated protein kinase 1 Homo sapiens 94-97 16376940-12 2006 Additionally, these effects were also abrogated by the extracellular signal-regulated kinase (ERK) inhibitor, PD98059, but not by the p38 mitogen-activated protein kinase inhibitor, SB203580. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 110-117 mitogen-activated protein kinase 1 Homo sapiens 55-92 16636681-5 2006 Upon treatment with ERK kinase (MEK) inhibitor PD98059, adhered KYN-2 cell scattering was inhibited, tight cell-to-cell contact was recovered, and both E-cadherin and actin filaments accumulated in the area of intercellular contact zone. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-54 mitogen-activated protein kinase 1 Homo sapiens 20-23 16678794-6 2006 Growth factor-induced TTC9 protein expression was inhibited by estrogen and abolished by ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 103-110 mitogen-activated protein kinase 1 Homo sapiens 89-92 16636012-9 2006 Moreover, we demonstrated, using inhibitor selective for ERK cascade (PD98059), that the prolonged ERK activation contributed a positive signal for iNOS expression and a negative signal for IL-12p40 expression in resident pMphi. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 70-77 mitogen-activated protein kinase 1 Homo sapiens 57-60 16636012-9 2006 Moreover, we demonstrated, using inhibitor selective for ERK cascade (PD98059), that the prolonged ERK activation contributed a positive signal for iNOS expression and a negative signal for IL-12p40 expression in resident pMphi. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 70-77 mitogen-activated protein kinase 1 Homo sapiens 99-102 16440309-5 2006 The ERK inhibitor (PD98059) blocked Elk-1 phosphorylation, as well as COL1 and OPN gene expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-26 mitogen-activated protein kinase 1 Homo sapiens 4-7 16453302-8 2006 Here we show that IL-1beta stimulation of chondrocytes induced phosphorylation of C/EBP-beta on threonine 235, and that the ERK pathway inhibitor PD98059 reduced this phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 146-153 mitogen-activated protein kinase 1 Homo sapiens 124-127 16818503-4 2006 The monocytic differentiation induced by CDDO-Im was partially blocked by the mitogen-activated protein kinase/ERK kinase 1 inhibitor PD98059, suggesting that the mitogen-activated protein kinase-ERK1/2 pathway plays a role in the differentiation induced by CDDO-Im. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 134-141 mitogen-activated protein kinase 1 Homo sapiens 111-114 16617094-8 2006 AS-602868, an inhibitor of IKK-2, and PD-98059, an inhibitor of ERK, inhibited GRO-alpha release and mRNA expression, whereas SP-600125, an inhibitor of JNK, reduced GRO-alpha release without effect on mRNA expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 38-46 mitogen-activated protein kinase 1 Homo sapiens 64-67 16819171-8 2006 Pretreatment of THP-1 cells with the MAPK kinase inhibitor, PD98059, inhibited THP-1 cell-mediated rotenone neurotoxicity towards SH-SY5Y, whereas the p38 MEK inhibitor, SB203580, had no effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 60-67 mitogen-activated protein kinase 1 Homo sapiens 37-41 16761312-5 2006 sPLA(2) induced the phosphorylation of the MAPK p38 and ERK1/2, and inhibition of these kinases by SB203580 and PD98059, respectively, reduced TNF-alpha and CXCL8 release. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 112-119 mitogen-activated protein kinase 1 Homo sapiens 48-51 16624284-5 2006 Attenuation of the MEK-ERK MAPK pathway by the inhibitor PD98059 markedly reduced the expression, 1,25D-induced phosphorylation and nuclear localization of C/EBPbeta-2 and C/EBPbeta-3. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 57-64 mitogen-activated protein kinase 1 Homo sapiens 23-26 16624284-5 2006 Attenuation of the MEK-ERK MAPK pathway by the inhibitor PD98059 markedly reduced the expression, 1,25D-induced phosphorylation and nuclear localization of C/EBPbeta-2 and C/EBPbeta-3. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 57-64 mitogen-activated protein kinase 1 Homo sapiens 27-31 16729971-8 2006 Taken together, chronic exposure of tumor cells to PD98059 induced elevated expression of ERK 2, which was associated with decreased sensitivity of cellular proliferation to PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 51-58 mitogen-activated protein kinase 1 Homo sapiens 90-95 16729971-8 2006 Taken together, chronic exposure of tumor cells to PD98059 induced elevated expression of ERK 2, which was associated with decreased sensitivity of cellular proliferation to PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 174-181 mitogen-activated protein kinase 1 Homo sapiens 90-95 16651638-5 2006 Inhibition of ERK activation with MEK inhibitors (PD98059 or U0126) diminished induction of the antioxidant enzyme heme oxygenase-1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 50-57 mitogen-activated protein kinase 1 Homo sapiens 14-17 16800929-3 2006 The effect of NaB in combination with the ERK inhibitor PD98059 on the proliferation/differentiation of SKM-1 cells was studied, and then the expression levels of the P21 and HDAC protein were detected by Western blot. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 56-63 mitogen-activated protein kinase 1 Homo sapiens 42-45 16515784-10 2006 Paclitaxel-resistance of TB4-HeLa cells was overcome by the inhibition of basal ERK activity with PD98059 pre-treatment. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 98-105 mitogen-activated protein kinase 1 Homo sapiens 80-83 16632111-4 2006 Blockade of ERK signaling by the MEK1/2 inhibitor PD098059 abolished DFO-induced class A scavenger receptor (SR-A) expression and phagocytic activity, indicating that ERK cascades mediate the induction of THP-1 differentiation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 50-58 mitogen-activated protein kinase 1 Homo sapiens 12-15 16632111-4 2006 Blockade of ERK signaling by the MEK1/2 inhibitor PD098059 abolished DFO-induced class A scavenger receptor (SR-A) expression and phagocytic activity, indicating that ERK cascades mediate the induction of THP-1 differentiation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 50-58 mitogen-activated protein kinase 1 Homo sapiens 167-170 16331603-6 2006 These anti-VEGF effects were partly reproduced by pharmacological inhibitors such as PD98059 and PTK787, suggesting that PCK3145 inhibits the tyrosine kinase activity associated to VEGFR-2, which in turn prevents intracellular signalling through the MAPK cascade. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 85-92 mitogen-activated protein kinase 1 Homo sapiens 250-254 16550001-12 2006 The mitogen-activated protein kinase/ERK (MEK) inhibitor PD98059 as well as native laminin and SIKVAV laminin-derived peptide prevented that downregulation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 57-64 mitogen-activated protein kinase 1 Homo sapiens 37-40 16524430-7 2006 Moreover, the specific ERK pathway inhibitor, PD98059, blocked the hypopigmentation effect of SPC, and abrogated the SPC-mediated downregulation of MITF. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 46-53 mitogen-activated protein kinase 1 Homo sapiens 23-26 16202406-11 2006 SB202190, PD98059 and doxycycline markedly suppressed the levels of p-JNK-1/p-JNK-2 and/or p-ERK1/p-ERK2, as well as IL-1beta, TNF-alpha and IL-8 mRNAs and proteins stimulated by hyperosmolar media. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 10-17 mitogen-activated protein kinase 1 Homo sapiens 100-104 16458614-3 2006 TNF-alpha significantly increased extracellular signal-related kinases (ERK) and protein kinase B (PKB) activation and, which was blocked by notoginsenoside R1, PD098059, U0126 or wortmannin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 161-169 mitogen-activated protein kinase 1 Homo sapiens 34-70 16458614-3 2006 TNF-alpha significantly increased extracellular signal-related kinases (ERK) and protein kinase B (PKB) activation and, which was blocked by notoginsenoside R1, PD098059, U0126 or wortmannin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 161-169 mitogen-activated protein kinase 1 Homo sapiens 72-75 16458614-4 2006 Our data demonstrates that TNF-alpha-induced up-regulation of PAI-1 mRNA and protein levels and secretion occur via activation of ERK and PKB, which was prevented by treatment of notoginsenoside R1, PD098059, U0126 or wortmannin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 199-207 mitogen-activated protein kinase 1 Homo sapiens 130-133 16480952-5 2006 Inhibitors of JNK (SP600125) and PKC (GF109203X) mainly blocked expression and phosphorylation of c-Jun, while inhibition of MEK-ERK activity with PD98059 (an inhibitor of MEK) had little effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 147-154 mitogen-activated protein kinase 1 Homo sapiens 129-132 16180010-6 2006 In contrast, a specific inhibitor of ERK kinase (U0126 or PD98059) could abolish the accumulation as well as the phosphorylation of p53 at Ser15. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 mitogen-activated protein kinase 1 Homo sapiens 37-40 16573830-7 2006 The effects of heterodimeric S100A8/S100A9 were reduced by inhibition of the MAP-kinase pathways ERK1/2 and p38 by PD 98059 and SB 203580, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 115-123 mitogen-activated protein kinase 1 Homo sapiens 108-111 16251475-3 2006 In cultured MVECs, Hcy induced activation of ERK, which was blocked by PD-98059 and U0126 (MEK inhibitors). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 71-79 mitogen-activated protein kinase 1 Homo sapiens 45-48 16399623-8 2006 Moreover, ERK inhibitor (PD98059) and p38 inhibitor (SB203580) augmented UV-induced apoptosis in silymarin treated A375-S2 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 25-32 mitogen-activated protein kinase 1 Homo sapiens 10-13 16453176-5 2006 The major phosphorylation sites of h-CaD when activated by phorbol ester are the Erk-specific sites, modification of which is attenuated by the MEK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 158-165 mitogen-activated protein kinase 1 Homo sapiens 81-84 16214385-7 2006 ERK (PD98059) or caspase-3-specific (Z-DEVD-FMK) inhibitors were discovered to significantly attenuate echinomycin-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 5-12 mitogen-activated protein kinase 1 Homo sapiens 0-3 16399631-6 2006 Further studies revealed that oridonin induced IkappaBalpha degradation, which was prevented by Ras inhibitor manumycin A, ERK inhibitor PD98059, but not prevented by c-Jun N-terminal kinase (JNK) MAPK inhibitor SP600125, and up-regulated expression of IL-1beta precursor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 137-144 mitogen-activated protein kinase 1 Homo sapiens 123-126 16430772-13 2006 These events were specifically inhibited by the ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 62-69 mitogen-activated protein kinase 1 Homo sapiens 48-51 16085674-6 2006 PD-98059, an inhibitor of MAP kinase/ERK kinase, inhibited CAM-induced IL-8 (P < 0.0001) and GM-CSF (P < 0.01) release. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-8 mitogen-activated protein kinase 1 Homo sapiens 37-40 16385547-11 2006 However, the MEK-1/ERK inhibitor PD98059 did not affect aPL-induced NF-kappaB binding activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-40 mitogen-activated protein kinase 1 Homo sapiens 19-22 16914889-7 2006 Inhibition of the ERK pathway with the MEK antagonist PD98059 (25 muM, for 5 days) virtually suppressed the IK(Ca) current in GL-15 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 54-61 mitogen-activated protein kinase 1 Homo sapiens 18-21 17167226-2 2006 METHODS: Pharmacological inhibition with cariporide (highly specific inhibitor of NHE1) and PD98059 (specific inhibitor of the upstream activator of ERK) was implemented. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 92-99 mitogen-activated protein kinase 1 Homo sapiens 149-152 16491014-8 2006 Ro-31-8220, a PKC inhibitor, and PD98059, a mitogen-activated protein/ERK kinase inhibitor, suppressed the histamine-induced ERK activation and the production of granulocyte macrophage colony-stimulating factor and IL-8. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-40 mitogen-activated protein kinase 1 Homo sapiens 70-73 16491014-8 2006 Ro-31-8220, a PKC inhibitor, and PD98059, a mitogen-activated protein/ERK kinase inhibitor, suppressed the histamine-induced ERK activation and the production of granulocyte macrophage colony-stimulating factor and IL-8. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-40 mitogen-activated protein kinase 1 Homo sapiens 125-128 17024969-10 2006 While JNK inhibitor SP600125 and p38 inhibitor SB203580, abolished the cytotoxic effect of BITC, MEK inhibitor, PD98059 and PI3 kinase inhibitor, LY294002 failed to show such reversal indicating a critical role played by JNK1/2 and p38 signaling in apoptosis induced by BITC. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 112-119 mitogen-activated protein kinase 1 Homo sapiens 33-36 16598650-5 2006 The induction of alpha-SMA by TGF-beta1 was suppressed by p38 kinase inhibitor (SB203580) and Erk inhibitor (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 109-116 mitogen-activated protein kinase 1 Homo sapiens 94-97 16302268-5 2006 Furthermore, PD98059, a mitogen-activated protein (MAP) kinase/ERK kinase (MEK) inhibitor, or SP600125, c-Jun N-terminal kinase (JNK) inhibitor, decreased cell growth, EGF-induced DNA synthesis and transformation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 63-66 16033772-5 2005 SB203580, a specific inhibitor of p38 and PD98059, a specific inhibitor of ERK, abolished sulforaphane-induced MT protein expression, whereas SP600125, a specific inhibitor of JNK, had no significant effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 42-49 mitogen-activated protein kinase 1 Homo sapiens 75-78 16186792-3 2006 While ectopic MEK1Q56P sensitized HU-induced S-phase arrest, inhibition of Erk activation via U0126, PD98059, and MEK1K97M attenuated the arrest, and thereby enhanced cells to HU-induced toxicity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 101-108 mitogen-activated protein kinase 1 Homo sapiens 75-78 16186792-6 2006 Inhibition of Erk activation with U0126/PD98059 and MEK1K97M substantially reduced HU-induced ATR nuclear foci, leading to a dramatic reduction of gammaH2AX and its nuclear foci. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 40-47 mitogen-activated protein kinase 1 Homo sapiens 14-17 16257255-3 2006 This action could be mediated by mitogen-activated protein kinase/extracellular signal regulated kinase 1/2 (MAPK/ERK1/2) and MAPK/p38 because their activation could be distinctly blocked by MAPK inhibitors, PD098059 or SB203580. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 208-216 mitogen-activated protein kinase 1 Homo sapiens 131-134 16391870-6 2006 In semi-confluent cells the induction of mitotic death involves the activity of both the extracellular signal regulated kinases (ERKs) and the M-phase promoting factor: okadaic acid overstimulates ERK activity, and PD98059 (inhibitor of ERK activation) as well as roscovitine (S)-isomer (specific inhibitor of M-phase promoting factor activity) counteract the induction of mitotic death. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 215-222 mitogen-activated protein kinase 1 Homo sapiens 129-133 16391870-6 2006 In semi-confluent cells the induction of mitotic death involves the activity of both the extracellular signal regulated kinases (ERKs) and the M-phase promoting factor: okadaic acid overstimulates ERK activity, and PD98059 (inhibitor of ERK activation) as well as roscovitine (S)-isomer (specific inhibitor of M-phase promoting factor activity) counteract the induction of mitotic death. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 215-222 mitogen-activated protein kinase 1 Homo sapiens 129-132 16433890-11 2006 In contrast, extracellular signal-regulated kinase (ERK) inhibitors U0126 and PD98059 strongly potentiated the apoptotic effect of trimidox. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 78-85 mitogen-activated protein kinase 1 Homo sapiens 13-50 16433890-11 2006 In contrast, extracellular signal-regulated kinase (ERK) inhibitors U0126 and PD98059 strongly potentiated the apoptotic effect of trimidox. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 78-85 mitogen-activated protein kinase 1 Homo sapiens 52-55 16467878-5 2006 Cells were incubated in a hypoxic or normoxic incubator and treated with PD98059 (a MEK 1/2 inhibitor, which abrogates ERK phosphorylation) and aminoguanidine (a selective iNOS inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 73-80 mitogen-activated protein kinase 1 Homo sapiens 119-122 16467878-7 2006 Moreover, when cells were treated with PD98059 under hypoxic conditions, uPAR was downregulated, whereas aminoguanidine markedly increased ERK phosphorylation in a dose dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 39-46 mitogen-activated protein kinase 1 Homo sapiens 139-142 16914897-5 2006 ATP-dependent activation of MAPK/ERK was prevented by pretreatment of HUVEC with pertussis toxin or MEK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 114-121 mitogen-activated protein kinase 1 Homo sapiens 33-36 16697690-6 2006 It was also found that PD98059, a mitogen-activated protein kinase (MAPK) pathway inhibitor and U0126, an inhibitor of extracellular signal-regulated kinase (ERK) blocks thrombin-induced phosphorylation of ERK1/2 and IL-8 secretion, indicating the involvement of MAPK/ERK signaling pathway in thrombin-induced IL-8 secretion. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 23-30 mitogen-activated protein kinase 1 Homo sapiens 206-209 17341207-7 2006 When HT-1080 cells were treated with PI-3K inhibitor (LY294002) and grown in presence of fibronectin, MMP-2 activation was partially inhibited, but when cells were treated with ERK inhibitor (PD98059) and grown in presence of fibronectin, MMP-2 activation was almost completely inhibited. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 192-199 mitogen-activated protein kinase 1 Homo sapiens 177-180 16499027-6 2005 ERK inhibitor PD98059 partially blocked the growth-inhibitory effect as well as DNA fragmentation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 14-21 mitogen-activated protein kinase 1 Homo sapiens 0-3 16272352-6 2005 PGE2 also blocked IL-1beta/TNF-alpha-stimulated ERK activation, and the ERK inhibitor, PD98059, mimicked PGE2 in blocking p65, but enhancing p50 nuclear translocation, suggesting that the effects of PGE2 on p65 and p50 are mediated via effects on ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 87-94 mitogen-activated protein kinase 1 Homo sapiens 72-75 16272352-6 2005 PGE2 also blocked IL-1beta/TNF-alpha-stimulated ERK activation, and the ERK inhibitor, PD98059, mimicked PGE2 in blocking p65, but enhancing p50 nuclear translocation, suggesting that the effects of PGE2 on p65 and p50 are mediated via effects on ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 87-94 mitogen-activated protein kinase 1 Homo sapiens 72-75 16125295-8 2005 Cell death induced by H2O2 was prevented by PD98059, an inhibitor of ERK upstream kinase MEK1/2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 44-51 mitogen-activated protein kinase 1 Homo sapiens 69-72 16211242-6 2005 Both PI3K/Akt and MEK/ERK inhibitors, LY294002 and PD98059, attenuated the extent of BITC-induced cell death. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 51-58 mitogen-activated protein kinase 1 Homo sapiens 22-25 16197467-8 2005 Similarly, ACh significantly increased neutrophil chemotactic activity and LTB4 released from SC of COPD patients only, and these effects were blocked by pretreatment with the inhibitor of ERK pathway PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 201-208 mitogen-activated protein kinase 1 Homo sapiens 189-192 16222076-7 2005 Metastin-induced synaptic potentiation was abolished by 50 microM PD98059 and 20 microM U0126, two inhibitors of the MAP kinases ERK1 and ERK2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 66-73 mitogen-activated protein kinase 1 Homo sapiens 138-142 16052512-8 2005 Inhibition of p38 and ERK1/2 by SB-203589 and PD-098059, respectively, did not abrogate NFkappaB activity, suggesting an independent induction of NFkappaB by PAR1 stimulation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 46-55 mitogen-activated protein kinase 1 Homo sapiens 14-17 16164642-12 2005 VEGF also activated extracellular signal-regulated protein kinase (ERK) in a time-dependent manner; and VEGF-stimulated eNOS phosphorylation on Ser1177 was prevented by PD098059, an upstream inhibitor of ERK, demonstrating that ERK was involved in VEGF regulation of eNOS. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 169-177 mitogen-activated protein kinase 1 Homo sapiens 20-65 16038800-6 2005 Furthermore, whilst pre-treatment of cells with either the JNK inhibitor SP600125, or the MEK-1 inhibitor PD98059, also reverses UV-C and cisplatin-induced apoptosis, the anti-apoptotic effect of MKP-2 overexpression is not additive with SP600125 but is with PD098059, suggesting that MKP-2 is involved in specifically terminating JNK activity and not ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 106-113 mitogen-activated protein kinase 1 Homo sapiens 352-355 16081065-8 2005 Moreover, MKP-1 suppression leads to enhanced HIF-1 activity, which can be counteracted by PD98059, an ERK kinase inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 91-98 mitogen-activated protein kinase 1 Homo sapiens 103-106 16164642-12 2005 VEGF also activated extracellular signal-regulated protein kinase (ERK) in a time-dependent manner; and VEGF-stimulated eNOS phosphorylation on Ser1177 was prevented by PD098059, an upstream inhibitor of ERK, demonstrating that ERK was involved in VEGF regulation of eNOS. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 169-177 mitogen-activated protein kinase 1 Homo sapiens 67-70 16164642-12 2005 VEGF also activated extracellular signal-regulated protein kinase (ERK) in a time-dependent manner; and VEGF-stimulated eNOS phosphorylation on Ser1177 was prevented by PD098059, an upstream inhibitor of ERK, demonstrating that ERK was involved in VEGF regulation of eNOS. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 169-177 mitogen-activated protein kinase 1 Homo sapiens 204-207 16164642-12 2005 VEGF also activated extracellular signal-regulated protein kinase (ERK) in a time-dependent manner; and VEGF-stimulated eNOS phosphorylation on Ser1177 was prevented by PD098059, an upstream inhibitor of ERK, demonstrating that ERK was involved in VEGF regulation of eNOS. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 169-177 mitogen-activated protein kinase 1 Homo sapiens 204-207 16100051-7 2005 In addition, adenosine- and CCPA-induced phosphorylation of ERK, JNK, and AKT is inhibited, respectively, by U0126, PD98059 (mitogen-activated protein kinase kinase inhibitors), SP600125 (JNK kinase inhibitor), and wortmannin (phosphatidylinositol 3-kinase inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 116-123 mitogen-activated protein kinase 1 Homo sapiens 60-63 15976193-3 2005 At concentrations which partially inhibit translation, DON induced phosphorylation of p38 and ERK 1/2 mitogen activated protein kinases within 15 min in RAW 264.7 macrophages and these effects lasted up to 3 h. DON-exposed cells exhibited marked caspase 3-dependent DNA fragmentation after 6 h which was suppressed and attenuated by the p38 inhibitor SB203580 and ERK inhibitor PD98059, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 378-385 mitogen-activated protein kinase 1 Homo sapiens 86-89 16034127-5 2005 Monocytes stimulated with the analog presented an increased ERK-2 phosphorylation, which was reduced by PD98059, a selective inhibitor of the MEK 1/2 pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 104-111 mitogen-activated protein kinase 1 Homo sapiens 60-65 16079470-6 2005 In addition, an extracellular signal-regulated kinase (ERK) MAPK inhibitor, PD98059, suppressed oridonin-augmented phagocytosis, whereas the p38 MAPK inhibitor (SB203580) and c-Jun N-terminal kinase (JNK) MAPK inhibitor (SP98059) had no inhibitory effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 76-83 mitogen-activated protein kinase 1 Homo sapiens 16-53 16079470-6 2005 In addition, an extracellular signal-regulated kinase (ERK) MAPK inhibitor, PD98059, suppressed oridonin-augmented phagocytosis, whereas the p38 MAPK inhibitor (SB203580) and c-Jun N-terminal kinase (JNK) MAPK inhibitor (SP98059) had no inhibitory effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 76-83 mitogen-activated protein kinase 1 Homo sapiens 55-58 16153436-5 2005 The relative contribution of RET in phosphorylation of ERK was tested by treating cells with PD98059, an inhibitor of MEK, and the RET inhibitor PP2, then measuring ERK activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 93-100 mitogen-activated protein kinase 1 Homo sapiens 55-58 15886210-8 2005 PD98059, a specific inhibitor of MEK1, almost completely blocked 2-AG-induced ERK phosphorylation and AP-1 activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 78-81 15851480-8 2005 At higher collagen coverage densities (0.8 microg/cm2) supporting vWF binding, the inhibition of ERK2 activity by PD 98059 decreased adhesion by 47 +/- 6% at 300 s(-1) and 72 +/- 3% at 1500 s(-1), whereas p38 inhibition had only a small effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 114-122 mitogen-activated protein kinase 1 Homo sapiens 97-101 15851480-8 2005 At higher collagen coverage densities (0.8 microg/cm2) supporting vWF binding, the inhibition of ERK2 activity by PD 98059 decreased adhesion by 47 +/- 6% at 300 s(-1) and 72 +/- 3% at 1500 s(-1), whereas p38 inhibition had only a small effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 114-122 mitogen-activated protein kinase 1 Homo sapiens 205-208 15701678-1 2005 Insulin and TNF-alpha exert opposing effects on skeletal muscle protein synthesis that are mediated in part by the rapamycin-sensitive mammalian target of rapamycin (mTOR) pathway and the PD-98059-sensitive, extracellular signal-regulated kinase (ERK)1/2 pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 188-196 mitogen-activated protein kinase 1 Homo sapiens 208-254 15944243-6 2005 Animals were randomized to receive PD98059, which is an inhibitor of MAPK3/MAPK1 (10 mg/kg i.p. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 35-42 mitogen-activated protein kinase 1 Homo sapiens 75-80 15944243-11 2005 Expression of TNF was evident after 1 h of reperfusion and reached its maximum increase after 3 h. PD98059 blunted MAPK3/MAPK1 and MAPK8, reduced TNF expression, and improved the testicular damage caused by ischemia-reperfusion injury in both testes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 99-106 mitogen-activated protein kinase 1 Homo sapiens 121-126 16123451-9 2005 The mitogen-activated protein kinase kinase (MEK) inhibitor PD98059 inhibited VPA-induced Erk 1/2 phosphorylation but did not affect VPA-induced increased HCMV replication. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 60-67 mitogen-activated protein kinase 1 Homo sapiens 90-97 15880691-6 2005 Furthermore, inhibition of ERK through addition of PD98059 stimulated p53 activation in MCF7 cells and also led to upregulation of p53 downstream targets, p21 and Bax, which is a proapototic member of Bcl-2 family triggering mitochondrial pore opening. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 51-58 mitogen-activated protein kinase 1 Homo sapiens 27-30 15801908-6 2005 The MEK (MAPK/ERK kinase) inhibitors PD98059 and U0126 blocked IGF-I-stimulated ERK phosphorylation but did not block the phosphorylation of Akt and did not decrease proteoglycan synthesis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 37-44 mitogen-activated protein kinase 1 Homo sapiens 14-17 15905316-4 2005 Either treating human MSC cultures with the MAPK/ERK kinase inhibitor PD98059 or transferring them to serum-free medium with insulin or IGF-I permits BMP-dependent increases in the expression of the early osteoblast-associated genes, alkaline phosphatase and osteopontin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 70-77 mitogen-activated protein kinase 1 Homo sapiens 44-48 15905316-4 2005 Either treating human MSC cultures with the MAPK/ERK kinase inhibitor PD98059 or transferring them to serum-free medium with insulin or IGF-I permits BMP-dependent increases in the expression of the early osteoblast-associated genes, alkaline phosphatase and osteopontin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 70-77 mitogen-activated protein kinase 1 Homo sapiens 49-52 15993334-9 2005 Whereas inhibiting the ERK pathway with the MEK inhibitor PD98059 significantly decreased HNE-mediated ERK phosphorylation, c-Fos protein induction, AP-1 binding, and HO-1 protein induction, inhibition of the ERK pathway had no effect on HNE-induced HO-1 mRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 mitogen-activated protein kinase 1 Homo sapiens 23-26 15993334-9 2005 Whereas inhibiting the ERK pathway with the MEK inhibitor PD98059 significantly decreased HNE-mediated ERK phosphorylation, c-Fos protein induction, AP-1 binding, and HO-1 protein induction, inhibition of the ERK pathway had no effect on HNE-induced HO-1 mRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 mitogen-activated protein kinase 1 Homo sapiens 103-106 15993334-9 2005 Whereas inhibiting the ERK pathway with the MEK inhibitor PD98059 significantly decreased HNE-mediated ERK phosphorylation, c-Fos protein induction, AP-1 binding, and HO-1 protein induction, inhibition of the ERK pathway had no effect on HNE-induced HO-1 mRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 mitogen-activated protein kinase 1 Homo sapiens 103-106 15843428-7 2005 Finally, PD98059, a specific inhibitor of p44/p42 MAPK pathway, was able to abolish the effects of CNTF on both myoblast fate and MRF expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 9-16 mitogen-activated protein kinase 1 Homo sapiens 50-54 15665049-7 2005 PD-098059 inhibited phosphorylation of ERK(44/42) and the initial peak phosphorylation of MYPT-1/Thr(850) but did not affect CPI-17/Thr(38) phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-9 mitogen-activated protein kinase 1 Homo sapiens 39-42 15689414-9 2005 Isoproterenol induced marked overexpression of the cell growth-related adhesion molecule CD44, and this effect of isoproterenol was abolished by the ERK pathway inhibitor PD-98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 171-179 mitogen-activated protein kinase 1 Homo sapiens 149-152 15671081-10 2005 ET-1-induced lipolysis was blocked by inhibition of extracellular signal-regulated kinase (ERK) activation using PD-98059 (75 microM), whereas a p38 MAPK inhibitor (SB-203580; 20 microM) had no effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 113-121 mitogen-activated protein kinase 1 Homo sapiens 52-89 15671081-10 2005 ET-1-induced lipolysis was blocked by inhibition of extracellular signal-regulated kinase (ERK) activation using PD-98059 (75 microM), whereas a p38 MAPK inhibitor (SB-203580; 20 microM) had no effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 113-121 mitogen-activated protein kinase 1 Homo sapiens 91-94 15760920-6 2005 Reduction of ERK activity, either by an ERK inhibitor PD98059 or by high-density seeding, significantly reduced AGS cell growth judged by CFSE labeling. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 54-61 mitogen-activated protein kinase 1 Homo sapiens 13-16 15995627-7 2005 Meanwhile, incubation of MKN28 with PD098059 reduced PGE2-induced ERK2 activity and VEGF mRNA and protein expression, but had no effect on EGFR activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 36-44 mitogen-activated protein kinase 1 Homo sapiens 66-70 15882255-9 2005 Factor Xa-induced cell proliferation and ERK activation were inhibited by PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 74-81 mitogen-activated protein kinase 1 Homo sapiens 41-44 15930183-16 2005 The MAPK/ERK kinase inhibitor PD 98059 downregulated both c-Jun phosphorylation and VDR expression indicating that upstream and downstream events in the signaling cascade are all related to the control of VDR expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-38 mitogen-activated protein kinase 1 Homo sapiens 9-12 15955090-6 2005 Pre-treatment of cells with PD98059, an inhibitor for extracellular signal-regulated kinase (ERK)1/2-activator mitogen-activated protein kinase (MAPK)/ERK kinase (MEK)1, potently inhibited the TGF-beta-induced expression of CTGF. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 28-35 mitogen-activated protein kinase 1 Homo sapiens 54-100 15899123-9 2005 Phosphorylation of ERK resulted in up-regulation of p53 expression, which was blocked by mitogen-activated protein kinase (MEK), inhibitor PD 98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 139-147 mitogen-activated protein kinase 1 Homo sapiens 19-22 15795063-9 2005 Simultaneous treatment with catalase or PD98059, a potent MEK protein inhibitor, reduced cell recruitment into the S-phase and also abolished the ERK1/2 protein phosphorylation induced by BQ, suggesting that MEK/ERK is an important pathway involved in BQ-induced ROS mediated proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 40-47 mitogen-activated protein kinase 1 Homo sapiens 146-149 15867384-8 2005 Addition of PD98059, a MEK-1 inhibitor, suppressed ERK activation and significantly but incompletely reversed these signaling events and apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 12-19 mitogen-activated protein kinase 1 Homo sapiens 51-54 15843040-3 2005 Cisplatin stimulated ERK1/2 phosphorylation and caused apoptosis in U-937 promonocytic cells, an effect which was attenuated by the MEK/ERK inhibitors PD98059 and U0126. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 151-158 mitogen-activated protein kinase 1 Homo sapiens 21-24 15670752-5 2005 TLR2 expression in response to TPA was attenuated by pretreatments with GF109203X and Go6976 (inhibitors of protein kinase C (PKC)) and PD98059 (an inhibitor of extracellular signal-regulated kinases (ERKs)), but not SB203580 (an inhibitor of p38s) and SP600125 (an inhibitor of c-Jun N-terminal kinases), suggesting involvement of PKC and ERKs in this response. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 136-143 mitogen-activated protein kinase 1 Homo sapiens 201-205 15805288-4 2005 The biological significance of ERK-mediated inhibition of STAT3((Tyr705)) phosphorylation was further assessed by treating the cells with an inhibitor (PD98059) of mitogen-activated protein kinase kinase (MEK) or by transfecting the cells with a vector that expresses constitutively active MEK-1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 152-159 mitogen-activated protein kinase 1 Homo sapiens 31-34 15805288-6 2005 Conversely, inhibition of ERK activity by PD98059 reversed the R115777-induced inhibition of STAT3((Tyr705)) phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 42-49 mitogen-activated protein kinase 1 Homo sapiens 26-29 15642734-6 2005 Overexpression of dominant negative Erk (DN-Erk) or pre-exposure to ERK inhibitor PD98059 inhibited NF-kappaB. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 82-89 mitogen-activated protein kinase 1 Homo sapiens 68-71 15780642-12 2005 Inhibition of Erk (p44/42) by PD98059 canceled the adipogenesis suppression by AG-041R in CL-1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 mitogen-activated protein kinase 1 Homo sapiens 14-17 15626772-3 2005 We found that the MEK inhibitor PD98059 significantly affected agonist-induced DNA synthesis of HASM cells, which suggests that extracellular signal-regulated kinases (ERK) are involved. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 128-166 15626772-3 2005 We found that the MEK inhibitor PD98059 significantly affected agonist-induced DNA synthesis of HASM cells, which suggests that extracellular signal-regulated kinases (ERK) are involved. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 168-171 15810889-8 2005 Conversely, the inhibition of ERK by the specific inhibitor (PD98059), but not the p-38 inhibitor SB203580, restored CD1a expression (P=0.011, n=4) in iC3b-stimulated MDDC. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 61-68 mitogen-activated protein kinase 1 Homo sapiens 30-33 15816868-6 2005 This SDF1alpha-induced ERK activity was dose dependent and could be inhibited by pre-treatment of the cells with either pertussis toxin, an inactivator of G-protein-coupled receptors, or PD98059, a MEK1 inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 187-194 mitogen-activated protein kinase 1 Homo sapiens 23-26 15874933-7 2005 The ERK1/2 and p38 MAPK inhibitors PD98059 (PD) and SB203580 (SB) blocked cell proliferation, but only PD blocked cell migration. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 35-42 mitogen-activated protein kinase 1 Homo sapiens 15-18 16105451-5 2005 (3) The inhibitors SB203580 and PD98059 suppressed TGF-beta1-induced p38 kinase and Erk phosphorylation respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 84-87 15613433-4 2005 Cells were cultured and treated with different combinations of insulin; wortmannin, an inhibitor of the phosphatidylinositide-3-kinase (PI3-kinase) pathway; and PD98059, an inhibitor of the MAPK pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 161-168 mitogen-activated protein kinase 1 Homo sapiens 190-194 15733640-7 2005 Intrathecal injection of the MEK (ERK kinase) inhibitor PD98059 on Day 2, 10 or 21 reduces SNL-induced mechanical allodynia. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 56-63 mitogen-activated protein kinase 1 Homo sapiens 34-37 15750341-7 2005 In addition, pretreatment of the RASMCs with a cell-permeable mitogen-activated protein kinase kinase (MEK) inhibitor (PD98059, 5 microM) markedly decreased ERK phosphorylation in response to native and glycated LDL. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 119-126 mitogen-activated protein kinase 1 Homo sapiens 157-160 15719130-5 2005 It has reported that PD98059, an ERK inhibitor, was able to blunt the hypoxia-induced activation of the expression of VEGF gene. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 21-28 mitogen-activated protein kinase 1 Homo sapiens 33-36 15652235-9 2005 PD98059, a MEK inhibitor, and BAY 11-8702, an I kappa B-alpha inhibitor, reduced ERK and NF-kappa B cascade activation, respectively, with little effect on PKC phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 81-84 15780952-7 2005 IL-1alpha-induced TRAP+ cell formation was completely blocked by either NS398, a selective inhibitor of cyclooxygenase (COX)-2, or PD98059, a specific inhibitor of extracellular signal-regulated kinase (ERK). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 131-138 mitogen-activated protein kinase 1 Homo sapiens 164-201 15840220-4 2005 The translocation process of ERK induced by AngII was blocked distinctly by Valsartan (10(-5) mol/L) and PD98059 (5 x 10(-5) mol/L), but not by CGP42112A (10(-5) mol/L). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 105-112 mitogen-activated protein kinase 1 Homo sapiens 29-32 15949415-4 2005 RESULTS: ERK activity increased and reached the peak at 30 min after treatment with anti-Fas antibody and decreased in PD98059 pretreated group. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 119-126 mitogen-activated protein kinase 1 Homo sapiens 9-12 15629451-10 2005 IL-1beta plus IFN-gamma-induced synergistic production of HGF was potently inhibited by treatment of cells with the extracellular signal-regulated kinase (ERK) kinase inhibitor PD98059 and the p38 inhibitor SB203580 but not by the c-Jun N-terminal kinase (JNK) inhibitor SP600125. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 177-184 mitogen-activated protein kinase 1 Homo sapiens 116-153 15629451-10 2005 IL-1beta plus IFN-gamma-induced synergistic production of HGF was potently inhibited by treatment of cells with the extracellular signal-regulated kinase (ERK) kinase inhibitor PD98059 and the p38 inhibitor SB203580 but not by the c-Jun N-terminal kinase (JNK) inhibitor SP600125. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 177-184 mitogen-activated protein kinase 1 Homo sapiens 155-158 15655524-10 2005 These latter effects were antagonized by L-365,260 or GV150013, and could be blocked also by PD98059 (inhibitor of ERK-1/ERK-2 phosphorylation) or wortmannin (inhibitor of phosphatidylinositol 3-kinase). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 93-100 mitogen-activated protein kinase 1 Homo sapiens 121-126 15572039-9 2005 Finally, the proliferative, antiapoptotic, and cytoskeletal effects of constitutively active Ras in MG63 cells on the hydrophobic surface were blocked by wortmannin and PD98059 that inhibit Akt and ERK activation, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 169-176 mitogen-activated protein kinase 1 Homo sapiens 198-201 15574877-6 2005 Addition of the ERK inhibitor PD98059 mitigates these effects. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 mitogen-activated protein kinase 1 Homo sapiens 16-19 15629076-5 2005 The cytotoxicity and CD69 expression of gammadeltaT cells pre-treated with or without PD98059 (Erk inhibitor) or SB203580 (p38 inhibitor) were detected by MTT colorimetry assay and FCM, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 86-93 mitogen-activated protein kinase 1 Homo sapiens 95-98 15454113-5 2004 However, the up-regulation of CD83 by PA/TNF-alpha on KG1 was significantly abrogated by PD98059, a specific inhibitor of ERK kinase, but was enhanced by SP600125, a JNK inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 89-96 mitogen-activated protein kinase 1 Homo sapiens 122-125 15459189-7 2004 Using the selective mitogen-activated protein kinase kinase inhibitor PD98059, we found that Nef-induced Erk signaling is essential for Bcl-XL up-regulation and cell survival. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 70-77 mitogen-activated protein kinase 1 Homo sapiens 105-108 15670752-5 2005 TLR2 expression in response to TPA was attenuated by pretreatments with GF109203X and Go6976 (inhibitors of protein kinase C (PKC)) and PD98059 (an inhibitor of extracellular signal-regulated kinases (ERKs)), but not SB203580 (an inhibitor of p38s) and SP600125 (an inhibitor of c-Jun N-terminal kinases), suggesting involvement of PKC and ERKs in this response. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 136-143 mitogen-activated protein kinase 1 Homo sapiens 340-344 15469966-8 2004 Inhibition of ERK activation by the MEK1 inhibitor PD98059 was associated with a reduction of CTGF-promoted alpha-SMA protein expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 51-58 mitogen-activated protein kinase 1 Homo sapiens 14-17 15635266-3 2004 This attenuation of X-ray-induced apoptosis by SCF was abolished by PD98059 (an ERK inhibitor), but not by wortmannin (a PI3-K inhibitor) or GF109203X (a PKC inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 68-75 mitogen-activated protein kinase 1 Homo sapiens 80-83 15474610-5 2004 Western blot analysis demonstrated that cisplatin treatment induced time-dependent activation of ERK, which was inhibited by chemical inhibitors of the MEK signaling pathway (PD98059 and U0126) and N-acetylcysteine. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 175-182 mitogen-activated protein kinase 1 Homo sapiens 97-100 15381709-1 2004 The role of the extracellular signal-regulated kinase (ERK) 1 and ERK2 in the neutrophil chemotactic response remains to be identified since a previously used specific inhibitor of MEK1 and MEK2, PD98059, that was used to provide evidence for a role of ERK1 and ERK2 in regulating chemotaxis, has recently been reported to also inhibit MEK5. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 196-203 mitogen-activated protein kinase 1 Homo sapiens 16-61 15381709-1 2004 The role of the extracellular signal-regulated kinase (ERK) 1 and ERK2 in the neutrophil chemotactic response remains to be identified since a previously used specific inhibitor of MEK1 and MEK2, PD98059, that was used to provide evidence for a role of ERK1 and ERK2 in regulating chemotaxis, has recently been reported to also inhibit MEK5. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 196-203 mitogen-activated protein kinase 1 Homo sapiens 66-70 15381709-1 2004 The role of the extracellular signal-regulated kinase (ERK) 1 and ERK2 in the neutrophil chemotactic response remains to be identified since a previously used specific inhibitor of MEK1 and MEK2, PD98059, that was used to provide evidence for a role of ERK1 and ERK2 in regulating chemotaxis, has recently been reported to also inhibit MEK5. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 196-203 mitogen-activated protein kinase 1 Homo sapiens 262-266 15389877-5 2004 Moreover, inhibition of Akt or ERK activity with respectively a PI-3K inhibitor (LY294002) or MEK inhibitors (PD98059, UO126), partially or totally suppressed the anti-apoptotic capacity of 1,25(OH)2D3. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 110-117 mitogen-activated protein kinase 1 Homo sapiens 31-34 15310753-6 2004 Prolonged activation of p38(MAPK) is accompanied by a rapid and sustained phosphorylation of Ras and ERK; inhibition of ERK phosphorylation using the MEK-1 inhibitor PD98059 rescued approximately 30% of cells from bFGF-induced death suggesting ERK plays a secondary role in the induction of death. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 166-173 mitogen-activated protein kinase 1 Homo sapiens 101-104 15310753-6 2004 Prolonged activation of p38(MAPK) is accompanied by a rapid and sustained phosphorylation of Ras and ERK; inhibition of ERK phosphorylation using the MEK-1 inhibitor PD98059 rescued approximately 30% of cells from bFGF-induced death suggesting ERK plays a secondary role in the induction of death. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 166-173 mitogen-activated protein kinase 1 Homo sapiens 120-123 15310753-6 2004 Prolonged activation of p38(MAPK) is accompanied by a rapid and sustained phosphorylation of Ras and ERK; inhibition of ERK phosphorylation using the MEK-1 inhibitor PD98059 rescued approximately 30% of cells from bFGF-induced death suggesting ERK plays a secondary role in the induction of death. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 166-173 mitogen-activated protein kinase 1 Homo sapiens 120-123 15537881-5 2004 Post-training intra-EC infusion of ERK cascade inhibitors (PD098059, UO126) at 40 min, but not at 10 min, resulted in increased freezing to the context, but not to the tone, during a 48 hr retention test. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 59-67 mitogen-activated protein kinase 1 Homo sapiens 35-38 15339908-8 2004 Inhibition of ERK activation by PD98059 in endothelial cells was shown to potentiate thrombin-induced expression of PDGF-B (approximately 3-fold) while inhibiting thrombin-induced VCAM-1 and E-selectin gene expression by 60 and 70%, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 14-17 15525474-12 2004 Although p38 MAPK inhibitor (SB203580) failed to block cell death, ERK MAPK inhibitor (PD98059) and JNK MAPK inhibitor (SP600125) had marked inhibitory effects on norcantharidin-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 87-94 mitogen-activated protein kinase 1 Homo sapiens 67-70 15536411-12 2004 Treatment with PD98059 and UO126 (specific mitogen-activated protein kinase kinase [MEK]/ERK inhibitors), but not a p38 inhibitor or a c-Jun N-terminal kinase inhibitor, restored the response to steroids, as indicated by proliferation assays. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 15-22 mitogen-activated protein kinase 1 Homo sapiens 89-92 15448709-7 2004 In addition, we treated cells exposed to high glucose levels with specific MAPK/ERK inhibitor PD098059 (50 microM), dual ET-receptor antagonist, bosentan (10 microM), and PKC blocker, chelerythrine (1 microM). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 94-102 mitogen-activated protein kinase 1 Homo sapiens 75-79 15448709-11 2004 Our data demonstrates that high glucose-induced upregulation of FN messenger RNA and protein levels occur via activation of MAPK/ERK pathway, which was prevented by treatment of cells with bosentan, PD098059 and PKC blocker chelerythrine. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 199-207 mitogen-activated protein kinase 1 Homo sapiens 124-128 15448709-11 2004 Our data demonstrates that high glucose-induced upregulation of FN messenger RNA and protein levels occur via activation of MAPK/ERK pathway, which was prevented by treatment of cells with bosentan, PD098059 and PKC blocker chelerythrine. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 199-207 mitogen-activated protein kinase 1 Homo sapiens 129-132 15345332-6 2004 Furthermore, both SB203580 (an inhibitor of p38 mitogen-activated protein kinase [MAPK]) and PD98059 (an inhibitor of MEK, upstream of ERK) attenuated the BK-induced IL-6 and PGE(2) synthesis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 93-100 mitogen-activated protein kinase 1 Homo sapiens 135-138 15319373-7 2004 Further, the PI-3 kinase inhibitor LY294002 and MAPK inhibitor PD98059 were found to significantly reduce leptin-induced HSC proliferation, thereby indicating that leptin induced HSC proliferation is Akt- and Erk-dependent. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 63-70 mitogen-activated protein kinase 1 Homo sapiens 209-212 15205451-9 2004 IL-1beta significantly increased the phosphorylation of extracellular signal-regulated kinase 1 (ERK1)/ERK2 MAPKs and cPLA(2) and IL-1beta-induced cPLA(2) phosphorylation was blocked by PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 186-193 mitogen-activated protein kinase 1 Homo sapiens 56-95 15205451-9 2004 IL-1beta significantly increased the phosphorylation of extracellular signal-regulated kinase 1 (ERK1)/ERK2 MAPKs and cPLA(2) and IL-1beta-induced cPLA(2) phosphorylation was blocked by PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 186-193 mitogen-activated protein kinase 1 Homo sapiens 103-107 15492467-3 2004 Twelve hours after treatment with oridonin, the ratio of Bax/Bcl-xL protein expression was increased and release of cytochrome c was decreased by an extracellular signal-regulated kinase (ERK) MAPK inhibitor (PD98059) and a phosphoinositide 3-kinases (PI3-K) inhibitor (wortmannin). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 209-216 mitogen-activated protein kinase 1 Homo sapiens 188-191 15533756-5 2004 Furthermore, using the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059, we show that the extracellular signal-regulated kinase (ERK) pathway is a negative regulator of the TGF-beta-induced stabilization of type I collagen mRNA, and that the activation of the ERK pathway by LPA mediates their inhibitory effects on collagen production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 79-86 mitogen-activated protein kinase 1 Homo sapiens 105-142 15356166-8 2004 Using specific pharmalogical inhibitors of ERK (PD098059) and p38 MAPK (SB203580), we found that PACAP-mediated calcium increase was ERK and PLC dependent and p38 independent. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 48-56 mitogen-activated protein kinase 1 Homo sapiens 43-46 15356166-8 2004 Using specific pharmalogical inhibitors of ERK (PD098059) and p38 MAPK (SB203580), we found that PACAP-mediated calcium increase was ERK and PLC dependent and p38 independent. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 48-56 mitogen-activated protein kinase 1 Homo sapiens 133-136 15374955-11 2004 Indeed, down-regulation of the Raf/MEK/ERK pathway potentiates statin-induced apoptosis because exposure to the MEK1 inhibitor PD98059 sensitizes AML cells to low, physiologically achievable concentrations of lovastatin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 127-134 mitogen-activated protein kinase 1 Homo sapiens 39-42 16194881-2 2004 We found that addition of beta1 and alpha(v)beta3 integrin blocking antibodies inhibited ECM-induced ERK activation, while addition of the MEK inhibitor PD98059 blocked ERK activation, serine phosphorylation of the osteogenic transcription factor runx2/cbfa-1, osteogenic gene expression, and calcium deposition. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 153-160 mitogen-activated protein kinase 1 Homo sapiens 169-172 15533756-5 2004 Furthermore, using the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059, we show that the extracellular signal-regulated kinase (ERK) pathway is a negative regulator of the TGF-beta-induced stabilization of type I collagen mRNA, and that the activation of the ERK pathway by LPA mediates their inhibitory effects on collagen production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 79-86 mitogen-activated protein kinase 1 Homo sapiens 144-147 15533756-5 2004 Furthermore, using the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059, we show that the extracellular signal-regulated kinase (ERK) pathway is a negative regulator of the TGF-beta-induced stabilization of type I collagen mRNA, and that the activation of the ERK pathway by LPA mediates their inhibitory effects on collagen production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 79-86 mitogen-activated protein kinase 1 Homo sapiens 275-278 15254971-5 2004 The P2Y6 induced cell proliferation was blocked by the mitogen-activated protein kinase kinase (MAPKK) inhibitor PD098059, thereby indicating that the ERK pathway mediates the mitogenic signalling of P2Y6. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 113-121 mitogen-activated protein kinase 1 Homo sapiens 151-154 15515342-6 2004 All experiments were performed in the presence of the ERK signaling inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 78-85 mitogen-activated protein kinase 1 Homo sapiens 54-57 15197768-9 2004 Selective inhibition of ERK/MAPK (by PD98059 or U0126) and PI3K (by LY294002 or wortmannin) led to marked reduction of both basal and BTC-induced MMP-9 activity and invasive ability of HNSCC cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 37-44 mitogen-activated protein kinase 1 Homo sapiens 24-27 15328055-4 2004 Exposure of cells to PD98059, an inhibitor of the MAP kinase kinase MEK, at a concentration that fully cancelled ERK activation, did not inhibit RVD. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 21-28 mitogen-activated protein kinase 1 Homo sapiens 113-116 15284289-6 2004 In contrast, a mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK inhibitor, PD98059, completely abrogated the effect of high glucose. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 126-133 mitogen-activated protein kinase 1 Homo sapiens 93-96 15265705-6 2004 Either Ly294002 or PD98059, specific inhibitor of the PI3K and ERK/MAPK pathways, respectively, blocked the HGF-induced activation of SPK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-26 mitogen-activated protein kinase 1 Homo sapiens 63-66 15284289-6 2004 In contrast, a mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK inhibitor, PD98059, completely abrogated the effect of high glucose. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 126-133 mitogen-activated protein kinase 1 Homo sapiens 111-114 15255937-6 2004 PD98059 and U0126, two distinct inhibitors of MEK, block the activation of ERK by GW5074 but have no effect on its ability to prevent cell death. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 75-78 15245433-11 2004 E2 stimulated the phosphorylation of extracellular signal-regulated kinase (ERK), which was suppressed by PD98059, Go6976, and U73122. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 106-113 mitogen-activated protein kinase 1 Homo sapiens 37-74 15212949-3 2004 Decreasing phospho-ERK with the pharmacological inhibitors, PD98059 and U0126, markedly suppresses hyperoxia-stimulated phospho-p53(Ser15), p53, and p21(CIP1), and also restores the hyperoxia-reduced kinase activities of cyclin D1/E1-Cdks. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 60-67 mitogen-activated protein kinase 1 Homo sapiens 19-22 15245433-11 2004 E2 stimulated the phosphorylation of extracellular signal-regulated kinase (ERK), which was suppressed by PD98059, Go6976, and U73122. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 106-113 mitogen-activated protein kinase 1 Homo sapiens 76-79 15194007-2 2004 ERKs are activated by the dual phosphorylation kinase MEK1 and MEK1 inhibitors PD98059, U0126 and CI-1040 are now widely used to inhibit ERKs in cell and animal studies. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 79-86 mitogen-activated protein kinase 1 Homo sapiens 0-4 15194007-2 2004 ERKs are activated by the dual phosphorylation kinase MEK1 and MEK1 inhibitors PD98059, U0126 and CI-1040 are now widely used to inhibit ERKs in cell and animal studies. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 79-86 mitogen-activated protein kinase 1 Homo sapiens 137-141 15207247-3 2004 In this report, we demonstrate, using two potent and selective inhibitors of MEK activation by Raf-1 (PD-098059) and p38 (SB-203580), that both ERK1/2 and p38 pathways play a key role in the production of IL-8 by porins and LPS. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 102-111 mitogen-activated protein kinase 1 Homo sapiens 155-158 15194479-3 2004 Hsp60 from different species increased cell migration by two- to fivefold and this effect was inhibited by ERK inhibitor PD 98059, p38 inhibitor SB 203580, and a function-blocking epidermal growth factor receptor (EGFR) antibody. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 121-129 mitogen-activated protein kinase 1 Homo sapiens 107-110 14963018-4 2004 Our experimental results show that UVA-induced Ser727 phosphorylation of STAT1 was, to different degrees, diminished by PD98059 and U0126, two specific inhibitors of MEKs, and SB202190 and PD169316, inhibitors of p38 kinase and c-Jun N-terminal kinases (JNKs), respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 120-127 mitogen-activated protein kinase 1 Homo sapiens 213-216 14761895-10 2004 PD-98059 (50 microM), an ERK activation inhibitor, increased basal phagocytosis (26.9 +/- 1.8 vs. 31.7 +/- 1.1%, n = 15, P < 0.05), but pressure did not further increase phagocytosis in PD-98059-treated cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-8 mitogen-activated protein kinase 1 Homo sapiens 25-28 15115659-5 2004 These actions of PAF were markedly attenuated by the MAPKK/ERK inhibitor PD98059, but not by the phosphatidylinositol 3-kinase inhibitor wortmannin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 73-80 mitogen-activated protein kinase 1 Homo sapiens 59-62 15220194-8 2004 Similarly, 1 micromol/l of the mitogen-activated protein kinase/ERK kinase 1/2 inhibitor PD098059 or 1 micromol/l of the l-type Ca(2+) channel blocker nimodipine prevented glucose- and IL-1beta-induced ERK activation, beta-cell apoptosis, and impaired function. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 89-97 mitogen-activated protein kinase 1 Homo sapiens 64-67 15220194-8 2004 Similarly, 1 micromol/l of the mitogen-activated protein kinase/ERK kinase 1/2 inhibitor PD098059 or 1 micromol/l of the l-type Ca(2+) channel blocker nimodipine prevented glucose- and IL-1beta-induced ERK activation, beta-cell apoptosis, and impaired function. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 89-97 mitogen-activated protein kinase 1 Homo sapiens 202-205 15211572-9 2004 Important differences in the ability of PD98059 to inhibit phosphorylation of ERK in both types of cells were also observed, as well as the effect that this inhibition produced on calcium deposition. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 40-47 mitogen-activated protein kinase 1 Homo sapiens 78-81 15122344-5 2004 Moreover, p21 induction was dramatically attenuated by ERK inhibitors PD98059 and U0126. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 70-77 mitogen-activated protein kinase 1 Homo sapiens 55-58 15241888-7 2004 Pre-treatment with the MEK inhibitor PD98059, which suppresses ERK activation, paradoxically promoted PC-induced mitochondrial cytochrome c release, procaspase-3 and -8 cleavage, and enhanced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 37-44 mitogen-activated protein kinase 1 Homo sapiens 63-66 15250250-4 2004 The effect of PD98059 on ERK activity induced by cisplatin was detected by MTT assay. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 14-21 mitogen-activated protein kinase 1 Homo sapiens 25-28 15250250-9 2004 The effect of PD 98059 on ERK activity induced by cisplatin at the concentration of 100 micromol/L PD 98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 14-22 mitogen-activated protein kinase 1 Homo sapiens 26-29 15250250-9 2004 The effect of PD 98059 on ERK activity induced by cisplatin at the concentration of 100 micromol/L PD 98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 99-107 mitogen-activated protein kinase 1 Homo sapiens 26-29 15218990-3 2004 IL-8 production was dependent on phosphorylation of ERK-1 and -2 and p38 MAPK, as examined by PD 098059 (10 microM), an inhibitor of the upstream activator of MAPK kinase (MKK)-1, and SB 203580 (10 microM), an inhibitor of p38 MAPK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 94-103 mitogen-activated protein kinase 1 Homo sapiens 69-72 15218990-3 2004 IL-8 production was dependent on phosphorylation of ERK-1 and -2 and p38 MAPK, as examined by PD 098059 (10 microM), an inhibitor of the upstream activator of MAPK kinase (MKK)-1, and SB 203580 (10 microM), an inhibitor of p38 MAPK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 94-103 mitogen-activated protein kinase 1 Homo sapiens 223-226 14742313-6 2004 Additionally, the treatment of inhibitors of MEK (PD98059) and p38 (SB203580) to DU145 cells resulted in the reduction of FCM-induced phosphorylation of ERK1/2 and p38 concomitantly marked reduction in MMP-2 and -9 expressions. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 50-57 mitogen-activated protein kinase 1 Homo sapiens 164-167 15081869-8 2004 The inhibition of MEK/ERK with a pharmacologic inhibitor, 2"-amino-3"-methoxyflavone (PD 98059), resulted in a synergistic enhancement of PBR-ligand-induced growth inhibition, apoptosis and cell cycle arrest. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-84 mitogen-activated protein kinase 1 Homo sapiens 22-25 15147892-5 2004 Pretreatment with ERK inhibitor PD98059, and p38 MAPK inhibitor SB203580, attenuated the induction of p65 translocation, IkappaB phosphorylation, and NF-kappaB luciferase activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 18-21 15274354-13 2004 Pre-incubating cells with ERK inhibitors (U0126 and PD98059) attenuated the HMJ-38-induced ERK activation and apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 52-59 mitogen-activated protein kinase 1 Homo sapiens 26-29 15274354-13 2004 Pre-incubating cells with ERK inhibitors (U0126 and PD98059) attenuated the HMJ-38-induced ERK activation and apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 52-59 mitogen-activated protein kinase 1 Homo sapiens 91-94 15081869-8 2004 The inhibition of MEK/ERK with a pharmacologic inhibitor, 2"-amino-3"-methoxyflavone (PD 98059), resulted in a synergistic enhancement of PBR-ligand-induced growth inhibition, apoptosis and cell cycle arrest. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 86-94 mitogen-activated protein kinase 1 Homo sapiens 22-25 14985174-4 2004 The mitogenic response was also decreased when extracellular signal-regulated protein kinase (ERK) signalling was inhibited by PD98059; however, PD98059 did not reverse the effects of platelet-released supernatants on migration and osteogenic differentiation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 127-134 mitogen-activated protein kinase 1 Homo sapiens 47-92 15144225-6 2004 This benzo[a]pyrene-induced osteoblast proliferation could be inhibited by the estrogen receptor antagonist ICI182780 and tamoxifen, PD98059 [extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) inhibitor], and LY294002 [phosphatidylinositol 3-kinase (PI3K) inhibitor] but not alpha-naphthoflavone (aryl hydrocarbon receptor antagonist) and SB203580 (p38 MAPK inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 133-140 mitogen-activated protein kinase 1 Homo sapiens 142-179 15144225-6 2004 This benzo[a]pyrene-induced osteoblast proliferation could be inhibited by the estrogen receptor antagonist ICI182780 and tamoxifen, PD98059 [extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) inhibitor], and LY294002 [phosphatidylinositol 3-kinase (PI3K) inhibitor] but not alpha-naphthoflavone (aryl hydrocarbon receptor antagonist) and SB203580 (p38 MAPK inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 133-140 mitogen-activated protein kinase 1 Homo sapiens 181-184 14687609-8 2004 PD98059, an extracellular signal-regulated kinase 1/2 (ERK1/2) inhibitor, also significantly inhibited ERK1/2 phosphorylation and reduced the numbers of SMC migration. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 12-53 15116093-4 2004 Pretreatment of MCF7 cells with an ERK2 chemical inhibitor, PD98059 or U0126, blocked doxorubicin-induced p53 activation and suppressed phosphorylation of p53Thr55. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 60-67 mitogen-activated protein kinase 1 Homo sapiens 35-39 14604860-9 2004 PP2 inhibited Caco-2 migration on collagen IV much more strongly than the mitogen-activated protein kinase kinase inhibitor PD-98059, which completely inhibited collagen IV ERK activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 124-132 mitogen-activated protein kinase 1 Homo sapiens 173-176 15001425-5 2004 ATP (10 microM) increased ERK2 phosphorylation from basal 17 +/- 3 to 53 +/- 4%, an effect suppressed in the presence of the MEK inhibitors PD-98059 (20 microM) or U0126 (10 microM). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 140-148 mitogen-activated protein kinase 1 Homo sapiens 26-30 15194225-7 2004 The HCH induced Cx43 hyperphosphorylation was abolished by the ERK inhibitor PD98059 suggesting that this effect could be mediated through activation of the ERK pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 77-84 mitogen-activated protein kinase 1 Homo sapiens 63-66 15194225-7 2004 The HCH induced Cx43 hyperphosphorylation was abolished by the ERK inhibitor PD98059 suggesting that this effect could be mediated through activation of the ERK pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 77-84 mitogen-activated protein kinase 1 Homo sapiens 157-160 14998726-6 2004 Furthermore, we found that PD98059, an ERK pathway inhibitor, and SB203580, a p38 MAPK inhibitor, diminished AAPH-induced COX-2 expression and PGE(2) production, whereas JNK inhibitor did not suppress COX-2 expression or PGE(2) production by AAPH. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 27-34 mitogen-activated protein kinase 1 Homo sapiens 39-42 15130437-5 2004 Although the inhibitor of ERK (PD98059) could partly weaken the inhibited effects of BaP on HSP70 expression, HSP70 expression levels of endothelial cells pre-treated with PD98059 were still significantly lower than that of control cells (P < 0.05). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 31-38 mitogen-activated protein kinase 1 Homo sapiens 26-29 15130437-5 2004 Although the inhibitor of ERK (PD98059) could partly weaken the inhibited effects of BaP on HSP70 expression, HSP70 expression levels of endothelial cells pre-treated with PD98059 were still significantly lower than that of control cells (P < 0.05). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 172-179 mitogen-activated protein kinase 1 Homo sapiens 26-29 14981539-6 2004 In addition, the MEK/ERK inhibitors, PD98059 and UO126, suppressed PMA-stimulated TRAF1 promoter activity indicating a role for ERK in TRAF1 induction. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 37-44 mitogen-activated protein kinase 1 Homo sapiens 21-24 14981539-6 2004 In addition, the MEK/ERK inhibitors, PD98059 and UO126, suppressed PMA-stimulated TRAF1 promoter activity indicating a role for ERK in TRAF1 induction. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 37-44 mitogen-activated protein kinase 1 Homo sapiens 128-131 15291360-7 2004 Interestingly, the ERK inhibitor, PD98059 inhibited Mcl-1 expression but had little effect on Bryostatin-induced survival suggesting that the ERK pathway predominantly affects differentiation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 34-41 mitogen-activated protein kinase 1 Homo sapiens 19-22 14761947-10 2004 Further, ERK activation also was found to be important for cell survival in hyperoxia, as treatment with PD98059 enhanced hyperoxia-mediated cell death. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 105-112 mitogen-activated protein kinase 1 Homo sapiens 9-12 14656708-14 2004 This effect was also blocked by PD-98059, an ERK inhibitor, but not by LY-294002. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-40 mitogen-activated protein kinase 1 Homo sapiens 45-48 16997735-7 2004 PD98059, a specific inhibitor of ERK-MAPK, significantly blocked the CSE effect on ERK1/2 phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 33-36 15034936-6 2004 In support of the involvement ERK, we demonstrated that magnolol-induced lipolysis was inhibited by PD98059, an inhibitor of mitogen-activated protein kinase kinase (MEK), and PD98059 reversed magnolol-induced ERK phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 100-107 mitogen-activated protein kinase 1 Homo sapiens 30-33 15034936-6 2004 In support of the involvement ERK, we demonstrated that magnolol-induced lipolysis was inhibited by PD98059, an inhibitor of mitogen-activated protein kinase kinase (MEK), and PD98059 reversed magnolol-induced ERK phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 100-107 mitogen-activated protein kinase 1 Homo sapiens 210-213 15034936-6 2004 In support of the involvement ERK, we demonstrated that magnolol-induced lipolysis was inhibited by PD98059, an inhibitor of mitogen-activated protein kinase kinase (MEK), and PD98059 reversed magnolol-induced ERK phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 176-183 mitogen-activated protein kinase 1 Homo sapiens 30-33 15034936-6 2004 In support of the involvement ERK, we demonstrated that magnolol-induced lipolysis was inhibited by PD98059, an inhibitor of mitogen-activated protein kinase kinase (MEK), and PD98059 reversed magnolol-induced ERK phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 176-183 mitogen-activated protein kinase 1 Homo sapiens 210-213 14704150-10 2004 OPN-induced ERK phosphorylation, AP-1 activation, uPA secretion, and cell motility were suppressed when cells were transfected with dn c-Src or pretreated with alpha(v)beta(3) integrin antibody, c-Src kinase inhibitor (pp2), EGFR tyrosine kinase inhibitor (PD153035), and MEK-1 inhibitor (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 289-296 mitogen-activated protein kinase 1 Homo sapiens 12-15 14688282-10 2004 However, PD98059, a specific inhibitor of mitogen-activated protein kinase kinase (MEK1), inhibited ERK activation by TGF-beta(1), and consequently attenuated TGF-beta(1) enhancement of its own mRNA expression in PSCs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 9-16 mitogen-activated protein kinase 1 Homo sapiens 100-103 15041541-5 2004 Both SB203580 (specific inhibitor of the p38 MAPK) and PD98059 (specific inhibitor of the ERK), when preincubated for 30 min with the cytotrophoblastic cells, substantially reduced MMP-9 mRNA accumulation in PMA-primed cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 55-62 mitogen-activated protein kinase 1 Homo sapiens 90-93 15054132-6 2004 The MEK (ERK kinase) inhibitors PD98059 and U0126 completely prevented the increase in spine density induced by BDNF, without having an effect on spine density by themselves. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 9-12 15030175-9 2004 Similarly, inhibition of the MEK/ERK pathway with either PD98059 or U0126 decreased beta-AR mRNA stability substantially. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 57-64 mitogen-activated protein kinase 1 Homo sapiens 33-36 15031777-5 2004 PD98059 decreased the basal PGF and PGE output, as well as reduced both ERK-1 and ERK-2 accumulation in cell lysates. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 82-87 15031777-8 2004 However, PD98059 reduced either basal or OT-induced p-ERK level. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 9-16 mitogen-activated protein kinase 1 Homo sapiens 54-57 14871182-8 2004 The thrombin-induced mitogenic activity was decreased by the extracellular signal-regulated protein kinase (ERK) signalling inhibitor PD98059 (P < 0.05), and by SB203580 (P < 0.05), a p38 MAPK inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 134-141 mitogen-activated protein kinase 1 Homo sapiens 61-106 14871182-8 2004 The thrombin-induced mitogenic activity was decreased by the extracellular signal-regulated protein kinase (ERK) signalling inhibitor PD98059 (P < 0.05), and by SB203580 (P < 0.05), a p38 MAPK inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 134-141 mitogen-activated protein kinase 1 Homo sapiens 108-111 15106733-3 2004 The inhibition of the ERK pathway with selective inhibitor, PD098059, blocked cytokine-induced COX-2 expression and PGE2 release. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 60-68 mitogen-activated protein kinase 1 Homo sapiens 22-25 14720214-5 2004 Inhibition of ERK activation using PD98059 considerably increased cell death. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 35-42 mitogen-activated protein kinase 1 Homo sapiens 14-17 14985174-4 2004 The mitogenic response was also decreased when extracellular signal-regulated protein kinase (ERK) signalling was inhibited by PD98059; however, PD98059 did not reverse the effects of platelet-released supernatants on migration and osteogenic differentiation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 127-134 mitogen-activated protein kinase 1 Homo sapiens 94-97 14610070-5 2004 The addition of N-acetyl-L-cysteine, the PKC inhibitor GF109203X, and the MEK/ERK inhibitors PD98059 and U0126 attenuated both apoptosis induction and GSH decrease, whereas the p38 inhibitor SB203580 and the JNK inhibitor SP600125 were ineffective. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 93-100 mitogen-activated protein kinase 1 Homo sapiens 78-81 12969966-6 2004 Consistently with a key role of ERK1/2 in mediating the negative effects of TRAIL on erythroid maturation, PD98059, a pharmacologic inhibitor of the ERK pathway, but not z-VAD-fmk or SB203580, a pharmacologic inhibitor of p38/MAPK, reverted the antidifferentiative effect of TRAIL on CB-derived erythroblasts. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 107-114 mitogen-activated protein kinase 1 Homo sapiens 32-35 14647439-8 2004 The levels of HO-1 and p21 induced were significantly inhibited by p38 mitogen-activated protein kinase (p38 MAPK) inhibitor (SB203580) and extracellular-regulated kinase (ERK) inhibitor (PD098059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 188-196 mitogen-activated protein kinase 1 Homo sapiens 140-170 14647439-8 2004 The levels of HO-1 and p21 induced were significantly inhibited by p38 mitogen-activated protein kinase (p38 MAPK) inhibitor (SB203580) and extracellular-regulated kinase (ERK) inhibitor (PD098059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 188-196 mitogen-activated protein kinase 1 Homo sapiens 172-175 15516330-6 2004 In the presence of acLDL, the ERK inhibitor PD98059 decreased cholesterol esterification in HMDM by about 35%. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 44-51 mitogen-activated protein kinase 1 Homo sapiens 30-33 12954601-6 2004 TNF- and GM-CSF-induced actin depolymerization and morphological changes, but not FMLP-induced responses, were partially inhibited by either PD-98059, an inhibitor of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase, or SB-203580, an inhibitor of p38 MAPK, and were almost completely abolished by these inhibitors in combination. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 141-149 mitogen-activated protein kinase 1 Homo sapiens 201-205 12954601-6 2004 TNF- and GM-CSF-induced actin depolymerization and morphological changes, but not FMLP-induced responses, were partially inhibited by either PD-98059, an inhibitor of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase, or SB-203580, an inhibitor of p38 MAPK, and were almost completely abolished by these inhibitors in combination. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 141-149 mitogen-activated protein kinase 1 Homo sapiens 246-249 14514659-5 2004 A low level (2 micro M) of arsenite stimulated extracellular signal-regulated kinase (ERK) signaling pathway and enhanced cell proliferation, and this arsenite-induced ERK activity was blocked by MEK inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 211-218 mitogen-activated protein kinase 1 Homo sapiens 47-84 14514659-5 2004 A low level (2 micro M) of arsenite stimulated extracellular signal-regulated kinase (ERK) signaling pathway and enhanced cell proliferation, and this arsenite-induced ERK activity was blocked by MEK inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 211-218 mitogen-activated protein kinase 1 Homo sapiens 86-89 14514659-5 2004 A low level (2 micro M) of arsenite stimulated extracellular signal-regulated kinase (ERK) signaling pathway and enhanced cell proliferation, and this arsenite-induced ERK activity was blocked by MEK inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 211-218 mitogen-activated protein kinase 1 Homo sapiens 168-171 14761784-9 2004 The cerivastatin cooperated with a MEK1/MEK2 inhibitor PD98059 to induce apoptosis, which appeared to correlate with down-regulation of ERK activation (phospho-ERKs expression) induced by the combination. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 55-62 mitogen-activated protein kinase 1 Homo sapiens 136-139 14761784-9 2004 The cerivastatin cooperated with a MEK1/MEK2 inhibitor PD98059 to induce apoptosis, which appeared to correlate with down-regulation of ERK activation (phospho-ERKs expression) induced by the combination. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 55-62 mitogen-activated protein kinase 1 Homo sapiens 160-164 14723340-6 2003 However, the specific inhibition of the ERK or JNK pathways by PD98059 or D-JNKI1, respectively, did not restore the antiproliferative effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 63-70 mitogen-activated protein kinase 1 Homo sapiens 40-43 15672871-9 2004 PD98059 completely blocked the stimulatory effect of DFMO on TSP-1 production, which supports a mediatory role for activation of the MAPK pathway in the upregulation of this anti-metastatic peptide by DFMO. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 133-137 14694442-6 2004 Moreover, we found that inhibition of 2-ME-induced extracellular signal-regulated kinase (ERK) activation by the upstream kinase inhibitor PD98059 significantly enhanced 2-ME-mediated suppression of Akt activation, resulting in much greater sensitization to apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 139-146 mitogen-activated protein kinase 1 Homo sapiens 51-88 14694442-6 2004 Moreover, we found that inhibition of 2-ME-induced extracellular signal-regulated kinase (ERK) activation by the upstream kinase inhibitor PD98059 significantly enhanced 2-ME-mediated suppression of Akt activation, resulting in much greater sensitization to apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 139-146 mitogen-activated protein kinase 1 Homo sapiens 90-93 17028806-5 2004 PD98059 that inhibits the ERK pathway blocked HBFN-f-stimulated production of MMP-1 and MMP-13 in explant culture. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 26-29 14971655-15 2004 However, inhibition of ERK activation with PD98059 had no effect on the Cr-induced alterations in gene expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 43-50 mitogen-activated protein kinase 1 Homo sapiens 23-26 14592419-4 2003 This PACAP38-mediated effect was also abolished by the ERK kinase inhibitor PD98059, suggesting the involvement of ERK in PACAP-induced proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 76-83 mitogen-activated protein kinase 1 Homo sapiens 55-58 14534369-8 2003 Together, PD98059 and emodin completely inhibited TNF-alpha-induced PAI-1 secretion, suggesting that both NF-kappaB-dependent and NF-kappaB-independent pathways are involved in TNF-alpha-induced signal pathway to PAI-1 production and that the latter pathway is mediated by activation of ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 10-17 mitogen-activated protein kinase 1 Homo sapiens 287-290 14649717-4 2003 The effect of ACM on A beta-induced injury was blocked by the ERK kinase inhibitor 2"-amino-3"-methoxyflavone. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 83-109 mitogen-activated protein kinase 1 Homo sapiens 62-65 14659794-9 2003 Inhibition of the mitogen-activated protein kinase/extracellular-signal-regulated kinase (ERK) kinase 1/2 (MEK/ERK) pathway by PD98059 prevented the LSS-induced up-regulation of IKCa1 expression levels and IK(Ca) whole-cell currents indicating that augmentation of IKCa1 expression levels is mediated by the LSS-induced activation of the MEK/ERK pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 127-134 mitogen-activated protein kinase 1 Homo sapiens 90-93 14659794-9 2003 Inhibition of the mitogen-activated protein kinase/extracellular-signal-regulated kinase (ERK) kinase 1/2 (MEK/ERK) pathway by PD98059 prevented the LSS-induced up-regulation of IKCa1 expression levels and IK(Ca) whole-cell currents indicating that augmentation of IKCa1 expression levels is mediated by the LSS-induced activation of the MEK/ERK pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 127-134 mitogen-activated protein kinase 1 Homo sapiens 111-114 14659794-9 2003 Inhibition of the mitogen-activated protein kinase/extracellular-signal-regulated kinase (ERK) kinase 1/2 (MEK/ERK) pathway by PD98059 prevented the LSS-induced up-regulation of IKCa1 expression levels and IK(Ca) whole-cell currents indicating that augmentation of IKCa1 expression levels is mediated by the LSS-induced activation of the MEK/ERK pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 127-134 mitogen-activated protein kinase 1 Homo sapiens 111-114 14713309-6 2003 Furthermore, we show that ethanol-induced ERK activation triggers the stimulation of cyclo-oxygenase-2 (COX-2) and the release of prostaglandin E2, and that blockade of the mitogen-activated protein kinase kinase (MEK)/ERK pathway by PD98059 abolishes the up-regulation of COX-2 induced by ethanol plus ceramide, and decreases the ethanol-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 234-241 mitogen-activated protein kinase 1 Homo sapiens 42-45 14713309-6 2003 Furthermore, we show that ethanol-induced ERK activation triggers the stimulation of cyclo-oxygenase-2 (COX-2) and the release of prostaglandin E2, and that blockade of the mitogen-activated protein kinase kinase (MEK)/ERK pathway by PD98059 abolishes the up-regulation of COX-2 induced by ethanol plus ceramide, and decreases the ethanol-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 234-241 mitogen-activated protein kinase 1 Homo sapiens 219-222 14706142-5 2003 The results showed that the specific inhibitor PD98059 of ERK kinase 1 (MEK(1)) enhanced the sensitivity of HL-60/E6 leukemia cell lines to harringtonine (HRT) or COC1/DDP ovarian carcinoma cell lines to cis-dichlorodiamine platinum (DDP). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-54 mitogen-activated protein kinase 1 Homo sapiens 58-61 14706142-6 2003 Both PD98059 and chemotherapy drugs HRT and DDP reduced the phosphorylated ERK(1) and ERK(2) protein expression level, and down-regulated the telomerase activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 5-12 mitogen-activated protein kinase 1 Homo sapiens 75-78 14706142-6 2003 Both PD98059 and chemotherapy drugs HRT and DDP reduced the phosphorylated ERK(1) and ERK(2) protein expression level, and down-regulated the telomerase activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 5-12 mitogen-activated protein kinase 1 Homo sapiens 86-89 14592419-4 2003 This PACAP38-mediated effect was also abolished by the ERK kinase inhibitor PD98059, suggesting the involvement of ERK in PACAP-induced proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 76-83 mitogen-activated protein kinase 1 Homo sapiens 115-118 14506750-0 2003 ERK inhibitor PD98059 enhances docetaxel-induced apoptosis of androgen-independent human prostate cancer cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 14-21 mitogen-activated protein kinase 1 Homo sapiens 0-3 14506750-6 2003 In androgen-independent C-81 LNCaP cells, inhibition of ERK by PD98059, but not U0126, plus docetaxel resulted in enhanced growth suppression by an additional 20% compared to the sum of each agent alone (p < 0.02). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 63-70 mitogen-activated protein kinase 1 Homo sapiens 56-59 14600398-5 2003 After 24 h incubation with evodiamine, no caspase inhibitor had any influence on cell death, but p38 mitogen-activated protein kinase (MAPK) inhibitor (SB203580) attenuated cell death; in contrast, extracellular signal-regulated protein kinase (ERK) MAPK inhibitor (PD98059) augmented cell death, as was further confirmed by cotreatment with SB203580 or PD98059 and pan-caspase inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 266-273 mitogen-activated protein kinase 1 Homo sapiens 198-243 14600398-5 2003 After 24 h incubation with evodiamine, no caspase inhibitor had any influence on cell death, but p38 mitogen-activated protein kinase (MAPK) inhibitor (SB203580) attenuated cell death; in contrast, extracellular signal-regulated protein kinase (ERK) MAPK inhibitor (PD98059) augmented cell death, as was further confirmed by cotreatment with SB203580 or PD98059 and pan-caspase inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 354-361 mitogen-activated protein kinase 1 Homo sapiens 198-243 14499342-7 2003 Inhibition of extracellular signal-regulated kinase (ERK) activity by PD98059 attenuated superoxide release and chemotaxis, and simultaneous treatment with SB203580 and PD98059 demonstrated additive inhibition. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 70-77 mitogen-activated protein kinase 1 Homo sapiens 14-51 14499342-7 2003 Inhibition of extracellular signal-regulated kinase (ERK) activity by PD98059 attenuated superoxide release and chemotaxis, and simultaneous treatment with SB203580 and PD98059 demonstrated additive inhibition. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 70-77 mitogen-activated protein kinase 1 Homo sapiens 53-56 14563359-6 2003 Experiments based on inhibitors of specific signaling pathways, such as manumycin A, toxin A, U0126, PD98059 and wortmannin revealed that Ras, MEK and PI-3K are involved in the activation of ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 101-108 mitogen-activated protein kinase 1 Homo sapiens 191-194 14708598-4 2003 Induction of MMP-19 expression by TNF-alpha was prevented partially by blocking the activation of extracellular signal-regulated kinase (ERK)-1/2 by PD98059 and p38 activity by SB203580. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 149-156 mitogen-activated protein kinase 1 Homo sapiens 98-145 14516785-5 2003 Pretreatment with PD98059, a specific inhibitor of the extracellular signal-regulated kinases (ERK)-mitogen-activated protein kinase (MAPK), competely inhibited the mitogen-induced MCM6 and MCM7 mRNA and protein expression, demonstrating a critical role for this pathway in transmitting transmembrane signals required for the initiation of DNA replication. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-25 mitogen-activated protein kinase 1 Homo sapiens 55-93 14516785-5 2003 Pretreatment with PD98059, a specific inhibitor of the extracellular signal-regulated kinases (ERK)-mitogen-activated protein kinase (MAPK), competely inhibited the mitogen-induced MCM6 and MCM7 mRNA and protein expression, demonstrating a critical role for this pathway in transmitting transmembrane signals required for the initiation of DNA replication. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-25 mitogen-activated protein kinase 1 Homo sapiens 95-98 14516785-5 2003 Pretreatment with PD98059, a specific inhibitor of the extracellular signal-regulated kinases (ERK)-mitogen-activated protein kinase (MAPK), competely inhibited the mitogen-induced MCM6 and MCM7 mRNA and protein expression, demonstrating a critical role for this pathway in transmitting transmembrane signals required for the initiation of DNA replication. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-25 mitogen-activated protein kinase 1 Homo sapiens 134-138 14516785-8 2003 In addition, blockade of ERK/MAPK signaling with PD98059 strongly inhibited phosphorylation of the retinoblastoma protein (Rb) and activity of a luciferase reporter plasmid driven by multiple E2F elements. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 49-56 mitogen-activated protein kinase 1 Homo sapiens 25-28 14516785-8 2003 In addition, blockade of ERK/MAPK signaling with PD98059 strongly inhibited phosphorylation of the retinoblastoma protein (Rb) and activity of a luciferase reporter plasmid driven by multiple E2F elements. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 49-56 mitogen-activated protein kinase 1 Homo sapiens 29-33 14516785-9 2003 Inhibition of mitogen-induced MCM6 and MCM7 expression by PD98059 was reversed by ectopic overexpression of E2F, indicating that ERK/MAPK signaling is required for events that occur upstream of E2F release from phosphorylated Rb. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 mitogen-activated protein kinase 1 Homo sapiens 129-132 12942541-7 2003 The previously reported proliferation of MCF-7 cells induced by Ang II was blocked by PD098059 and by wortmannin in a dose-dependent manner, thereby indicating that in MCF-7 cells the PI3K and ERK pathways mediate the mitogenic signalling of AT1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 86-94 mitogen-activated protein kinase 1 Homo sapiens 193-196 14515181-7 2003 Moreover, the MEK (ERK kinase) inhibitors, PD98059 and UO126, completely prevented PAI-1 induction by Wy-14,643 without inhibiting the activation of a reporter gene carrying the PPRE element. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 43-50 mitogen-activated protein kinase 1 Homo sapiens 19-22 14560924-10 2003 In contrast, S1P clearly stimulated the phosphorylation of ERK, and the specific inhibition of the ERK pathway using PD98059 abolished the cytoprotective effect of S1P. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 117-124 mitogen-activated protein kinase 1 Homo sapiens 99-102 12910476-10 2003 Intriguingly, the use of a selective inhibitor (PD98059) of ERK activation by its classical activating kinase, Mek, to restrict such strain-induced increases, produced an enhanced strain-related increase in UDPGD mRNA expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 48-55 mitogen-activated protein kinase 1 Homo sapiens 60-63 14596931-9 2003 Moreover, inhibition of ERK activity by PD98059 suppressed US augmentation of Cbfa1/Runx2 and osteocalcin mRNA expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 40-47 mitogen-activated protein kinase 1 Homo sapiens 24-27 14556080-5 2003 Proliferation and ERK1/2 activation could be inhibited by the specific ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 85-92 mitogen-activated protein kinase 1 Homo sapiens 18-21 14692651-6 2003 This study demonstrates that when these cells are treated with PD098059, an ERK-specific inhibitor, MMP-1 mRNA levels are significantly decreased, suggesting that high constitutive expression of MMP-1 in these cells results from continuous ERK 1/2 activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 63-71 mitogen-activated protein kinase 1 Homo sapiens 76-79 14631113-5 2003 We found that the MEK inhibitors, PD98059 and U0126, inhibited the induction of PAI-1 gene and protein expression during cell adhesion, PD98059 also inhibited the adhesion of cells to the culture plate, and cell adhesion elicited the kinase activities of MEK and ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 34-41 mitogen-activated protein kinase 1 Homo sapiens 263-266 14631113-5 2003 We found that the MEK inhibitors, PD98059 and U0126, inhibited the induction of PAI-1 gene and protein expression during cell adhesion, PD98059 also inhibited the adhesion of cells to the culture plate, and cell adhesion elicited the kinase activities of MEK and ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 136-143 mitogen-activated protein kinase 1 Homo sapiens 263-266 12966153-9 2003 In addition, mitogen-activated protein kinase kinase (MEK) 1/2 inhibitor PD98059 (2"-amino-3"-methoxyflavone) decreased 15-deoxy-PGJ2-induced ERK2 activation, and expression of PPAR-gamma, capase-3, and cyclin B1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 73-80 mitogen-activated protein kinase 1 Homo sapiens 142-146 12966153-9 2003 In addition, mitogen-activated protein kinase kinase (MEK) 1/2 inhibitor PD98059 (2"-amino-3"-methoxyflavone) decreased 15-deoxy-PGJ2-induced ERK2 activation, and expression of PPAR-gamma, capase-3, and cyclin B1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 82-108 mitogen-activated protein kinase 1 Homo sapiens 142-146 14586407-6 2003 Inhibition of the ERK activation by PD98059 and transfection of a dominant-negative ERK2 completely blocked the protection of IL-6 against apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 36-43 mitogen-activated protein kinase 1 Homo sapiens 18-21 12834585-9 2003 Suppression of ERK pathway by PD98059 resulted in dose-dependent and time-dependent decreases. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 mitogen-activated protein kinase 1 Homo sapiens 15-18 12970086-9 2003 The inhibitor of ERK pathway (U0126 or PD98059) or JNK pathway (SP600125) markedly prevented kinase activation, and also greatly reduced NCTD-induced apoptotic cell death. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 39-46 mitogen-activated protein kinase 1 Homo sapiens 17-20 14506750-5 2003 We analyzed the effect of ERK inhibitors PD98059 and U0126 on vinorelbine- and docetaxel-induced cell growth suppression of androgen-independent prostate cancer cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 41-48 mitogen-activated protein kinase 1 Homo sapiens 26-29 12970778-4 2003 After 24 h incubation of the AML blasts with high ERK activity using PD98059 (New England BioLabs, Beverly, MA, USA), a selective inhibitor of MEK1 phosphorylation, at concentrations of 20 and 40 microM, we observed a strong decrease in the levels of ERK1/2 activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 69-76 mitogen-activated protein kinase 1 Homo sapiens 50-53 12796504-9 2003 S1P-induced COX-2 expression was blocked completely by PD-98059 but not by SB-203580, suggesting that ERK has a critical role in the process. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 55-63 mitogen-activated protein kinase 1 Homo sapiens 102-105 12917326-4 2003 Binding of HSF1 to 14-3-3 epsilon occurs in cells in which extracellular signal regulated kinase (ERK) is activated and blockade of the ERK pathway by treatment with the specific ERK pathway inhibitor PD98059 in vivo strongly suppresses the binding. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 201-208 mitogen-activated protein kinase 1 Homo sapiens 59-96 12917326-4 2003 Binding of HSF1 to 14-3-3 epsilon occurs in cells in which extracellular signal regulated kinase (ERK) is activated and blockade of the ERK pathway by treatment with the specific ERK pathway inhibitor PD98059 in vivo strongly suppresses the binding. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 201-208 mitogen-activated protein kinase 1 Homo sapiens 136-139 12917326-4 2003 Binding of HSF1 to 14-3-3 epsilon occurs in cells in which extracellular signal regulated kinase (ERK) is activated and blockade of the ERK pathway by treatment with the specific ERK pathway inhibitor PD98059 in vivo strongly suppresses the binding. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 201-208 mitogen-activated protein kinase 1 Homo sapiens 136-139 12898507-4 2003 We demonstrated that U0126 or PD98059 blocked TNF-alpha-induced ERK activity and decreased TNF-alpha-induced lipolysis by 65 or 76% respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 mitogen-activated protein kinase 1 Homo sapiens 64-67 12898511-7 2003 The ERK/MAPK inhibitor PD-98059 decreased EPR induced wound closure by 88%. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 23-31 mitogen-activated protein kinase 1 Homo sapiens 4-7 12828555-8 2003 In addition, inhibition of ERK by PD98059 significantly suppressed IL-10 and increased the IL-12 production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 34-41 mitogen-activated protein kinase 1 Homo sapiens 27-30 12913253-8 2003 Tyr phosphorylation of Erk and Ser phosphorylation of STAT-3 were inhibited by PD98059, while Tyr phosphorylation of STAT-3 was not inhibited by PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 79-86 mitogen-activated protein kinase 1 Homo sapiens 23-26 12847121-3 2003 p43-ERK activation by H(2)O(2) was inhibited by PD98059 but not by SB203580. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 48-55 mitogen-activated protein kinase 1 Homo sapiens 4-7 15012721-5 2003 Inhibition of ERK by PD98059 supported its role in a fibroblast death pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 21-28 mitogen-activated protein kinase 1 Homo sapiens 14-17 12821943-4 2003 Treatment with either PD98059 (PD) or LY294002 (LY), the pharmacological inhibitors of MEK-ERK and PI3K, respectively, markedly increased GAS-Luc activity in LU1205, but not in FEMX cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 22-29 mitogen-activated protein kinase 1 Homo sapiens 91-94 12770614-5 2003 In addition, phosphorylations of MAPKs (ERK 1/2, p38, JNK 1/2) were increased by LT. LT-induced iNOS mRNA level was inhibited by PD98059 (MEK 1/2 inhibitor), SB203580 (p38 inhibitor), and cycloheximide (a protein synthesis blocker), indicating that the phosphorylation of ERK 1/2 and p38, and on-going protein synthesis are necessary for LT-induced iNOS expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 129-136 mitogen-activated protein kinase 1 Homo sapiens 168-171 12770614-5 2003 In addition, phosphorylations of MAPKs (ERK 1/2, p38, JNK 1/2) were increased by LT. LT-induced iNOS mRNA level was inhibited by PD98059 (MEK 1/2 inhibitor), SB203580 (p38 inhibitor), and cycloheximide (a protein synthesis blocker), indicating that the phosphorylation of ERK 1/2 and p38, and on-going protein synthesis are necessary for LT-induced iNOS expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 129-136 mitogen-activated protein kinase 1 Homo sapiens 168-171 12663671-3 2003 Interruption of p38 and ERK1/2 signaling pathways by pretreatment with inhibitors SB203580 and PD98059 and subsequent stimulation with HGF or KGF abolished the activation and nuclear localization. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 95-102 mitogen-activated protein kinase 1 Homo sapiens 16-19 12663671-7 2003 In contrast, PD98059 seemed to slightly increase the migration, through concomitant activation of p38. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 98-101 12665505-8 2003 Leptin activated ERK, but not p38 and JNK, and up-regulated cPLA2 activity; the latter was abolished by pre-treatment of cells with the MEK inhibitor (PD98059 or U0126) or cPLA2 inhibitor (AACOCF3). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 151-158 mitogen-activated protein kinase 1 Homo sapiens 17-20 12869532-6 2003 The latter effect was again antagonized by the addition of EGF to IFNalpha-pretreated cells, probably through the activation of the EGF-->ERK-dependent pathway, since the addition of the specific MEK-1 inhibitor PD098059 abrogated the recovery of intracellular hypusine content induced by EGF in IFNalpha-pretreated cancer cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 215-223 mitogen-activated protein kinase 1 Homo sapiens 141-144 12868492-5 2003 Inhibition of ERK phosphorylation by pre-treatment with PD98059 resulted in enhanced apoptosis after H2O2-exposure. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 56-63 mitogen-activated protein kinase 1 Homo sapiens 14-17 12963547-5 2003 In addition, DHT significantly up-regulated c-jun expression through extracellular stress-regulated kinase (ERK) activation, and transfection of an antisense oligonucleotide for c-jun or ERK inhibition by PD98059 cancelled DHT-mediated suppression of radiation-induced transactivation of Fas gene and sensitization to Fas-mediated apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 205-212 mitogen-activated protein kinase 1 Homo sapiens 187-190 12798950-9 2003 Both these actions were blocked by CGRP-(8-37) and mimicked by a specific inhibitor of ERK (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 92-99 mitogen-activated protein kinase 1 Homo sapiens 87-90 12791183-12 2003 ERK phosphorylated level of ET-1 group was evidently increased compared with PD98059 group (P<0.05), Cyclin D1 protein expression also was increased compared with PD98059 group (P<0.05). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 77-84 mitogen-activated protein kinase 1 Homo sapiens 0-3 12711332-10 2003 PD098059 and U0126 completely abrogated ERK2 phosphorylation; whereas, LY294002 completely blocked PKB/Akt and p70(S6k) phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-8 mitogen-activated protein kinase 1 Homo sapiens 40-44 12753285-7 2003 Inhibition of PKA by H89 strikingly decreased cAMP-stimulated phosphorylation of ERK and B-Raf, and MAPK inhibition by PD98059 blocked the effect of the nucleotide to activate ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 119-126 mitogen-activated protein kinase 1 Homo sapiens 176-179 12657625-5 2003 Treatment of cells with selective mitogen-activated protein kinase kinase (MEK) inhibitors PD098059 and U0126 showed that integrin alpha2 expression, cell adhesion, and activation of ERK are inhibited in a parallel concentration-dependent fashion. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 91-99 mitogen-activated protein kinase 1 Homo sapiens 183-186 12609984-6 2003 Preventing ERK activation with PD98059 blocked CNTF suppression of DBH protein in sympathetic neurons but did not prevent the loss of DBH mRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 31-38 mitogen-activated protein kinase 1 Homo sapiens 11-14 12753285-10 2003 8-Br-cAMP and EGF conjointly increased ERK activation above that of either agonist alone in ADPKD cells, and this combined effect was abolished by PD98059, indicating that ERK was activated by EGF- and cAMP-responsive cascades that converge at MAPK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 147-154 mitogen-activated protein kinase 1 Homo sapiens 172-175 12732214-9 2003 Elevated ERK activity that contributed to apoptosis by EGCG plus vanadate was supported by PD98059 and U0126, chemical inhibitor of MEK/ERK signaling pathway, prevented apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 91-98 mitogen-activated protein kinase 1 Homo sapiens 9-12 12748850-7 2003 This effect was inhibited by PD98059, an inhibitor of extracellular signal-regulated protein kinase kinase, which also blocked carbachol activation of cell proliferation, indicating that the p21Ras-ERK pathway is an important signaling cascade in the mitogenic effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 29-36 mitogen-activated protein kinase 1 Homo sapiens 54-99 12540365-4 2003 The PKC-mediated decreases in beta- and gamma-ENaC were significantly reversed by simultaneous addition of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase-1/2 inhibitors U-0126 and PD-98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 215-223 mitogen-activated protein kinase 1 Homo sapiens 151-190 12704121-8 2003 Moreover, using selective inhibitors for MAP kinase kinase (PD98059) and p38 (SB203580), we show that ERK1/2 exhibited differential effects on production of TNF-alpha and IL-12 p40 by human monocytes, whereas MPL-induced activation of p38 appeared to be predominantly involved in production of IL-10 and IL-12 p40 by MPL-stimulated monocytes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 60-67 mitogen-activated protein kinase 1 Homo sapiens 177-180 12652650-9 2003 P2Y2 stimulation increased cell proliferation and this effect was attenuated by PD098059 in a dose-dependent manner, thereby indicating that the ERK pathway mediates mitogenic signaling by P2Y2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 80-88 mitogen-activated protein kinase 1 Homo sapiens 145-148 12797541-3 2003 Using highly specific inhibitors of p38 (SB203580) and of MAPK kinase-1 (U0126 and PD98059), we found that both p38 and ERK were essential for M. tuberculosis H37Rv-induced TNF-alpha production, whereas activation of the p38 pathway, but not that of ERK, was essential for M. tuberculosis H37Rv-induced IL-10 production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 83-90 mitogen-activated protein kinase 1 Homo sapiens 112-115 12797541-3 2003 Using highly specific inhibitors of p38 (SB203580) and of MAPK kinase-1 (U0126 and PD98059), we found that both p38 and ERK were essential for M. tuberculosis H37Rv-induced TNF-alpha production, whereas activation of the p38 pathway, but not that of ERK, was essential for M. tuberculosis H37Rv-induced IL-10 production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 83-90 mitogen-activated protein kinase 1 Homo sapiens 120-123 12797541-3 2003 Using highly specific inhibitors of p38 (SB203580) and of MAPK kinase-1 (U0126 and PD98059), we found that both p38 and ERK were essential for M. tuberculosis H37Rv-induced TNF-alpha production, whereas activation of the p38 pathway, but not that of ERK, was essential for M. tuberculosis H37Rv-induced IL-10 production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 83-90 mitogen-activated protein kinase 1 Homo sapiens 112-115 12748850-7 2003 This effect was inhibited by PD98059, an inhibitor of extracellular signal-regulated protein kinase kinase, which also blocked carbachol activation of cell proliferation, indicating that the p21Ras-ERK pathway is an important signaling cascade in the mitogenic effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 29-36 mitogen-activated protein kinase 1 Homo sapiens 198-201 12647305-5 2003 The synergistic effect of MG with IGF-I in activation of ERK was completely abolished by PD98059 but not by a specific PI3K inhibitor, LY294002, or a specific PKC inhibitor, bisindolylmaleimide. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 89-96 mitogen-activated protein kinase 1 Homo sapiens 57-60 12691824-6 2003 However, it appeared that PD 98059, which turns off ERK through mitogen-activated protein kinase kinase (MEK) inhibition, enhanced basal Raf-1 kinase activity in MCF-7/Adr cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 26-34 mitogen-activated protein kinase 1 Homo sapiens 52-55 12677169-4 2003 RAW cells were cultured in medium containing 5.5 mmol/L glucose and glycated or nonglycated albumin, with and without the addition of PD98059, a specific inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK), followed by analysis of phosphorylated ERK and the nuclear translocation of nuclear factor (NF)-kappa B and measurement of cellular content of thiobarbituric acid-reactive substances and the concentration of transforming growth factor (TGF)-beta(1) in the spent medium. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 134-141 mitogen-activated protein kinase 1 Homo sapiens 239-242 12605455-5 2003 In addition, they showed that PD98059 and SB202190, synthetic inhibitors of ERK1/ERK2 and p38 respectively, prevented the changes in the rate of neurite elongation induced by agrin in cultured hippocampal neurons. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 mitogen-activated protein kinase 1 Homo sapiens 81-85 12605455-5 2003 In addition, they showed that PD98059 and SB202190, synthetic inhibitors of ERK1/ERK2 and p38 respectively, prevented the changes in the rate of neurite elongation induced by agrin in cultured hippocampal neurons. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 mitogen-activated protein kinase 1 Homo sapiens 90-93 12457461-6 2003 Inhibition of MEK1/ERK by PD98059 not only abrogated the induction of Egr-1 but also abolished the rapid and transient induction of PPAR gamma by TGF beta. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 26-33 mitogen-activated protein kinase 1 Homo sapiens 19-22 12637634-11 2003 The addition of PD98059 and SB203580, which blocked the activation of ERK1/2 and p38(HOG), respectively, suppressed the TGF-beta-induced collagen alpha1(I) mRNA expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 16-23 mitogen-activated protein kinase 1 Homo sapiens 81-84 12551910-3 2003 First, we showed that two specific mitogen-activated protein kinase/ERK kinase-inhibitors, PD98059 and U0126, both counteracted TPA-mediated suppression of Fas-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 91-98 mitogen-activated protein kinase 1 Homo sapiens 68-71 12514175-6 2003 In contrast, mitogen-activated protein kinase (MEK)/extracellular-signal-regulated kinase (ERK) pathway inhibitors U0126 and PD98059 potentiated GDF-15 mediated survival and prevented cell death in low K(+) even without factor treatment. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 125-132 mitogen-activated protein kinase 1 Homo sapiens 91-94 12644304-5 2003 PD98059, a specific inhibitor of the upstream kinase that activates extracellular signal-regulated kinase (ERK), significantly suppressed the induction by both PDGF-BB and bFGF. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 68-105 12643264-10 2003 The specific MEK-1 kinase inhibitor, PD98059, inhibited all the effects of increasing [Ca2+]i, indicating that the MAPK/ERK pathway activation is essential for TF-1 cell survival and proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 37-44 mitogen-activated protein kinase 1 Homo sapiens 120-123 12667551-4 2003 PD98059, U0126, and N(omega)-nitro-L-arginine methyl ester completely blocked the shear stress-induced increases in ERK phosphorylation, [(3)H]thymidine incorporation, and alkaline phosphatase, but without an effect on integrin beta1 expression, indicating that the ERK and nitric oxide synthase pathways are essential for the shear stress-induced proliferation and differentiation of normal human osteoblasts and that each involves ERK activation but not integrin beta1 upregulation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 116-119 12667551-4 2003 PD98059, U0126, and N(omega)-nitro-L-arginine methyl ester completely blocked the shear stress-induced increases in ERK phosphorylation, [(3)H]thymidine incorporation, and alkaline phosphatase, but without an effect on integrin beta1 expression, indicating that the ERK and nitric oxide synthase pathways are essential for the shear stress-induced proliferation and differentiation of normal human osteoblasts and that each involves ERK activation but not integrin beta1 upregulation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 266-269 12667551-4 2003 PD98059, U0126, and N(omega)-nitro-L-arginine methyl ester completely blocked the shear stress-induced increases in ERK phosphorylation, [(3)H]thymidine incorporation, and alkaline phosphatase, but without an effect on integrin beta1 expression, indicating that the ERK and nitric oxide synthase pathways are essential for the shear stress-induced proliferation and differentiation of normal human osteoblasts and that each involves ERK activation but not integrin beta1 upregulation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 266-269 12667793-10 2003 ICAM-1 mRNA upregulation was inhibited upon incubation with several chemicals, namely, the ERK1/2 inhibitors PD98059 and AG1288 (by 98 and 67%, respectively), of the p38/MAPK pathway SB203580 (by 50%), of the JNK pathway dimethylaminopurine (by 83%), and of the NF-kappaB parthenolide (by 96%). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 109-116 mitogen-activated protein kinase 1 Homo sapiens 166-169 12644304-5 2003 PD98059, a specific inhibitor of the upstream kinase that activates extracellular signal-regulated kinase (ERK), significantly suppressed the induction by both PDGF-BB and bFGF. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 107-110 14501030-7 2003 Inhibiting ERKs with PD98059 attenuated H2O2-induced AP-1 activation but did not affect H2O2-induced p70S6K1 activation or cardiomyocyte enlargement as measured by increases in cell volume and protein content. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 21-28 mitogen-activated protein kinase 1 Homo sapiens 11-15 12388102-8 2003 When cells were pretreated with SB-203580 and PD-98059 to simultaneously inhibit p38 and ERK MAPKs, respectively, I(sc) responses to TG and CCh were significantly greater than those observed with either inhibitor alone. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 46-54 mitogen-activated protein kinase 1 Homo sapiens 89-92 12588763-7 2003 MEK inhibitors U0126 and PD98059 blocked both ERK activation and the increase in TF mRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 25-32 mitogen-activated protein kinase 1 Homo sapiens 46-49 12495783-8 2003 Furthermore, UII-induced proliferation of VSMCs was inhibited by ERK kinase inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 86-93 mitogen-activated protein kinase 1 Homo sapiens 65-68 12592382-5 2003 Pretreatment of 20 microg/ml PD98059, an inhibitor of MEK which is the upstream kinase of ERK, prevents the TPA- and Saikosaponin a-triggered HepG2 growth inhibition by 50 and 30%, respectively, accompanied by a 50 - 85% decrease of the p15(INK4b)/p16(INK4a) RNAs and proteins induced by both drugs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 29-36 mitogen-activated protein kinase 1 Homo sapiens 90-93 12494267-4 2003 PD98059 was found to inhibit angiotensin II-induced Erk activation and STAT3 Ser727 phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 52-55 12655182-5 2003 Cell survival induced by serum or by follicle-stimulating hormone (FSH) was inhibited when ERK activity was attenuated with PD98059, which led to the induction of apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 124-131 mitogen-activated protein kinase 1 Homo sapiens 91-94 12403788-4 2003 SB203580, a p38 MAPK inhibitor, and PD98059, an ERK inhibitor, but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor, prevented AA toxicity in pyrazole hepatocytes and E47 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 36-43 mitogen-activated protein kinase 1 Homo sapiens 48-51 14598883-3 2003 Pretreatment of PD98059 decreased HGF-mediated phosphorylation of extracellular receptor kinase (ERK), uPA secretion and expression of matrix metalloproteinases (MMP-2 and MMP-9) in a dose-dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 16-23 mitogen-activated protein kinase 1 Homo sapiens 66-95 14598883-3 2003 Pretreatment of PD98059 decreased HGF-mediated phosphorylation of extracellular receptor kinase (ERK), uPA secretion and expression of matrix metalloproteinases (MMP-2 and MMP-9) in a dose-dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 16-23 mitogen-activated protein kinase 1 Homo sapiens 97-100 14598883-5 2003 SB203580 also reversed the inhibition of HGF-mediated ERK activation and uPA secretion in the PD98059-pretreated cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 94-101 mitogen-activated protein kinase 1 Homo sapiens 54-57 12447987-8 2003 PD98059, an inhibitor of the ERK pathway as well as a ERK1 dominant negative mutant also blocked HIF-1 activation by hypoxia and by ionomycin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 29-32 12506144-9 2003 Through the use of selective inhibitors of p38 MAP kinase (SB203580) or MEKK (PD98059), p38 but not ERK activation was shown to be essential for the induction of ICAM-1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 78-85 mitogen-activated protein kinase 1 Homo sapiens 88-91 12472895-10 2002 More importantly, both neurite outgrowth and phosphorylation of ERK by TPA were blocked by PD 098059, a specific inhibitor of MEK (MAP kinase/ERK kinase-1), but not by SB203580, a specific inhibitor of p38 MAP kinase. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 91-100 mitogen-activated protein kinase 1 Homo sapiens 64-67 14526152-10 2003 The effects of IL-1beta and TNF-alpha were significantly inhibited by PD98059 MEK/ERK inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 70-77 mitogen-activated protein kinase 1 Homo sapiens 82-85 12467066-13 2002 ERK was constitutively activated in SCC68 cells and treatment of cells with an inhibitor of ERK activation (PD98059) reduced uPA expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 108-115 mitogen-activated protein kinase 1 Homo sapiens 0-3 12467066-13 2002 ERK was constitutively activated in SCC68 cells and treatment of cells with an inhibitor of ERK activation (PD98059) reduced uPA expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 108-115 mitogen-activated protein kinase 1 Homo sapiens 92-95 12483323-4 2002 Involvement of p44/p42 MAPK pathway in this signaling was assessed using PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 73-80 mitogen-activated protein kinase 1 Homo sapiens 23-27 12444151-4 2002 Investigating the biochemical pathways regulated by PI 3-kinase to activate Erk, we found that, in response to M-CSF, normal human monocytes induced reactive oxygen species (ROS), which were suppressed by the PI 3-kinase inhibitor wortmannin but not by the solvent control DMSO or the MAP/Erk kinase inhibitor PD098059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 310-318 mitogen-activated protein kinase 1 Homo sapiens 76-79 12482999-5 2002 PD98059 (MEK/ERK inhibitor) suppressed IL-1beta-mediated MUC2 gene expression and mucin secretion, while SB203580 (p38 inhibitor) did not. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 13-16 12472895-10 2002 More importantly, both neurite outgrowth and phosphorylation of ERK by TPA were blocked by PD 098059, a specific inhibitor of MEK (MAP kinase/ERK kinase-1), but not by SB203580, a specific inhibitor of p38 MAP kinase. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 91-100 mitogen-activated protein kinase 1 Homo sapiens 202-205 12169099-5 2002 Up-regulation of c- jun mRNA by endothelin-1 was attenuated by inhibitors of protein kinase C (GF109203X) and the extracellular signal-regulated kinase (ERK) cascade (PD98059 or U0126), but not by inhibitors of the JNK (SP600125) or p38-MAPK (SB203580) cascades. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 167-174 mitogen-activated protein kinase 1 Homo sapiens 114-151 12169099-5 2002 Up-regulation of c- jun mRNA by endothelin-1 was attenuated by inhibitors of protein kinase C (GF109203X) and the extracellular signal-regulated kinase (ERK) cascade (PD98059 or U0126), but not by inhibitors of the JNK (SP600125) or p38-MAPK (SB203580) cascades. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 167-174 mitogen-activated protein kinase 1 Homo sapiens 153-156 12485909-8 2002 PD98059, an inhibitor of the ERK pathway, but not KN-93, an inhibitor of calmodulin kinases II and IV, also blocked HIF-1 activation by hypoxia and by ionomycin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 29-32 12439598-6 2002 Incubation of cell lines with the MEK1 inhibitors PD98059 or UO126 after, but not during, cisplatin treatment completely inhibited cisplatin-induced activation of ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 50-57 mitogen-activated protein kinase 1 Homo sapiens 163-166 12393099-6 2002 MCP-1 also induced secretion of matrix metalloproteinase (MMP)-2 which along with ERK activation was inhibited by PD098059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 114-122 mitogen-activated protein kinase 1 Homo sapiens 82-85 12439598-8 2002 Treatment of cells with PD98059 or UO126 after cisplatin incubation or inhibition of signaling through ERK by tetracycline-regulated expression of dominant-inhibitory ERK enhanced resistance to cisplatin in p53-negative osteosarcoma cells and reduced cisplatin-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 24-31 mitogen-activated protein kinase 1 Homo sapiens 103-106 12439598-8 2002 Treatment of cells with PD98059 or UO126 after cisplatin incubation or inhibition of signaling through ERK by tetracycline-regulated expression of dominant-inhibitory ERK enhanced resistance to cisplatin in p53-negative osteosarcoma cells and reduced cisplatin-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 24-31 mitogen-activated protein kinase 1 Homo sapiens 167-170 12587977-4 2002 Inhibition of ERK with PD98059 accelerated (up to 23.8%) the NO-induced decrease in mucin synthesis, and cause further enhancement in caspase-3 activity and apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 23-30 mitogen-activated protein kinase 1 Homo sapiens 14-17 12423667-5 2002 PD98059, an upstream inhibitor of extracellular signal-regulated kinases 1 and 2 (ERK1/2), reversed all these events. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 34-80 12391274-7 2002 Cells activated by IL-1beta showed increased extracellular signal-regulated kinase (ERK)1/2 and p38 phosphorylation, and IL-1beta-induced MUC2 and MUC5AC production was blocked by the ERK pathway inhibitor PD98059 or the p38 inhibitor SB203580. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 206-213 mitogen-activated protein kinase 1 Homo sapiens 45-91 12391274-7 2002 Cells activated by IL-1beta showed increased extracellular signal-regulated kinase (ERK)1/2 and p38 phosphorylation, and IL-1beta-induced MUC2 and MUC5AC production was blocked by the ERK pathway inhibitor PD98059 or the p38 inhibitor SB203580. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 206-213 mitogen-activated protein kinase 1 Homo sapiens 221-224 12509924-16 2002 Blocking of ERK with PD98059 could inhibit the effect of aIgA(1) from patients with IgAN on the proliferation of HMC but could not inhibit the effects of aIgA(1) from healthy controls. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 21-28 mitogen-activated protein kinase 1 Homo sapiens 12-15 12181747-5 2002 The inhibitory effect of TPA was mostly abrogated by pretreatment of a specific MEK inhibitor PD98059, indicating that the effect depends upon MEK/ERK-mediated signals. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 94-101 mitogen-activated protein kinase 1 Homo sapiens 147-150 12412617-4 2002 Tyrosine kinases were inhibited by herbimycin (1 microM), the mitogen-activated protein (MAP) kinase ERK was inhibited with PD98059 (50 microM), and p38 MAP kinase was inhibited with SB203580 (5 microM). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 124-131 mitogen-activated protein kinase 1 Homo sapiens 101-104 12351429-4 2002 TNF-alpha activated ERK and increased lipolysis; these effects were inhibited by two specific MEK inhibitors, PD98059 and U0126. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 110-117 mitogen-activated protein kinase 1 Homo sapiens 20-23 12082101-9 2002 In contrast, the suppression of Erk activation with PD98059, a specific inhibitor of MEK1, inhibited UV- and TPA-induced junD mRNA expression, UV-induced increases in caspase-3 activities, and cell death. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 52-59 mitogen-activated protein kinase 1 Homo sapiens 32-35 12087097-4 2002 Interference with the ERK cascade by treatment with an MEK inhibitor, PD98059, in SW626 cells also caused decreased cell viability following treatment with paclitaxel. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 70-77 mitogen-activated protein kinase 1 Homo sapiens 22-25 12393171-3 2002 Inhibition of extracellular signal-regulated (ERK) or p38 mitogen-activated protein kinase by PD98059 and SB203580 respectively, significantly affected chemokine production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 94-101 mitogen-activated protein kinase 1 Homo sapiens 46-49 12034359-13 2002 In addition, the specific inhibition of the ERK and the Akt signalling pathways by PD98059 and LY294002, respectively, increased melanin synthesis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 83-90 mitogen-activated protein kinase 1 Homo sapiens 44-47 12369731-4 2002 Inhibition of ERK with PD98059 accelerated (up to 35.4%) the NO-induced decrease in the glycoprotein synthesis, and cause further enhancement in caspase-3 (up to 27.2%) activity and apoptosis (64.9%). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 23-30 mitogen-activated protein kinase 1 Homo sapiens 14-17 12193740-4 2002 TAT-dnRas or PD98059, a pharmacological mitogen-activated protein/ERK kinase inhibitor, blocked both focal surface clustering of Mac-1 and the change to active conformational structure of this integrin assessed by the mAb CBRM1/5, which binds the activation epitope. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 66-69 12060661-3 2002 Inhibition of p38 activity by SB203580 markedly (by 80-90%) inhibited induction of MMP-1 and MMP-3 expression by tumor necrosis factor-alpha, whereas blocking the activation of ERK1/2 by PD98059 had no effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 187-194 mitogen-activated protein kinase 1 Homo sapiens 14-17 12186939-5 2002 The phosphorylation could be inhibited by the ERK pathway inhibitor PD98059, indicating that ERK may contribute to the phosphorylation of c-Jun in LMP2A-expressing cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 68-75 mitogen-activated protein kinase 1 Homo sapiens 46-49 12186939-5 2002 The phosphorylation could be inhibited by the ERK pathway inhibitor PD98059, indicating that ERK may contribute to the phosphorylation of c-Jun in LMP2A-expressing cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 68-75 mitogen-activated protein kinase 1 Homo sapiens 93-96 12164862-5 2002 ERK inactivation by PD98059, and p38MAPK inhibitor SB203580 also showed significant inhibitory effects. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 20-27 mitogen-activated protein kinase 1 Homo sapiens 0-3 12127156-3 2002 The activation of ERK1 and ERK2 had a maximum at 15 min, returned to baseline by 60 min, and was partially depleted after incubation of cells with a MAPKK inhibitor (PD 098059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 166-175 mitogen-activated protein kinase 1 Homo sapiens 27-31 12145097-6 2002 3: Both PD98059 (MAPK/ERK kinase inhibitor) and SB203580 (p38 MAPK inhibitor) attenuated FCS-induced LIF protein production and gene expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 8-15 mitogen-activated protein kinase 1 Homo sapiens 17-21 12145097-6 2002 3: Both PD98059 (MAPK/ERK kinase inhibitor) and SB203580 (p38 MAPK inhibitor) attenuated FCS-induced LIF protein production and gene expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 8-15 mitogen-activated protein kinase 1 Homo sapiens 22-25 12016209-2 2002 The MEK inhibitor PD98059 produced near-complete (97-98%) inhibition of ERK phosphorylation, whereas inhibition of c-Fos, c-Jun, HB-EGF, AR, and VEGF mRNA by this compound was incomplete (41-65%). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-25 mitogen-activated protein kinase 1 Homo sapiens 72-75 12234375-7 2002 In addition, both IFNalpha-induced growth-stimulation effect and the up-regulated activation of ERK in U266 cells were efficiently inhibited by PD98059, the specific inhibitor of MAPK/ERK kinase (MEK). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 144-151 mitogen-activated protein kinase 1 Homo sapiens 96-99 12016209-3 2002 PD98059 was significantly more effective than either PD158780 or BB2516 as an inhibitor of ERK phosphorylation and of the rapid rise in c-Fos and c-Jun mRNA expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 91-94 12083801-6 2002 On the contrary, the ERK phosphorylation by PPARgamma agonists is inhibited by the MEK inhibitor PD98059, GSH, and permeable SOD mimetic MnTBAP. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 97-104 mitogen-activated protein kinase 1 Homo sapiens 21-24 12234375-7 2002 In addition, both IFNalpha-induced growth-stimulation effect and the up-regulated activation of ERK in U266 cells were efficiently inhibited by PD98059, the specific inhibitor of MAPK/ERK kinase (MEK). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 144-151 mitogen-activated protein kinase 1 Homo sapiens 179-183 12234375-7 2002 In addition, both IFNalpha-induced growth-stimulation effect and the up-regulated activation of ERK in U266 cells were efficiently inhibited by PD98059, the specific inhibitor of MAPK/ERK kinase (MEK). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 144-151 mitogen-activated protein kinase 1 Homo sapiens 184-187 12055096-8 2002 The MEK inhibitors PD-98059 and U-0126 blocked ERK activation mediated by diazoxide. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-27 mitogen-activated protein kinase 1 Homo sapiens 47-50 12063024-3 2002 Inhibition of the ERK pathway was performed using PD98059, a specific inhibitor of this pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 50-57 mitogen-activated protein kinase 1 Homo sapiens 18-21 12095134-9 2002 Tyrosine kinase inhibition with genistein (10 microg/mL) blocked transmigration, whereas selective ERK inhibition with PD98059 (50 microM) or p38 inhibition with SB203580 (20 microM) did not. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 119-126 mitogen-activated protein kinase 1 Homo sapiens 99-102 12095140-6 2002 Mitogen-activated protein kinase (MAPK) activity was determined using functional kinase assays and was inhibited with the compounds SB202190 and PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 145-152 mitogen-activated protein kinase 1 Homo sapiens 34-38 11956184-7 2002 The mitogenic action of cAMP was blocked by the ERK pathway inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 70-77 mitogen-activated protein kinase 1 Homo sapiens 48-51 12063024-6 2002 In addition, PD98059, a specific inhibitor of ERK pathway, almost completely abolished this prolonged phosphorylation of ERK and completely blocked differentiation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 46-49 12063024-6 2002 In addition, PD98059, a specific inhibitor of ERK pathway, almost completely abolished this prolonged phosphorylation of ERK and completely blocked differentiation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 121-124 11888673-4 2002 The induction and nuclear localization of p21Cip/WAF1 by TRO were blocked by PD98059 pre-treatment, which suggested a role for the ERK pathway in p21Cip/WAF1 activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 77-84 mitogen-activated protein kinase 1 Homo sapiens 131-134 12065679-7 2002 In these studies using mitogen-activated protein kinase inhibitors, infection-induced increases in the p53 level were partially blocked by PD98059, a synthetic inhibitor of MEK1 that is the immediate upstream kinase of extracellular signal-regulated kinases 1/2 (ERK1/2), but not by SB202190, a potent p38 kinase inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 139-146 mitogen-activated protein kinase 1 Homo sapiens 219-261 11912188-5 2002 Phosphorylation of mitogen-activated protein kinases (MAPKs) such as p38 MAPK and ERK was markedly increased by the heat shock, and SB203580 (a p38 MAPK kinase inhibitor) and/or PD098059 (a MEK inhibitor) inhibited the phosphorylation of HSP25, indicating that p38 MAPK and ERK are upstream regulators of HSP25 phosphorylation in the heat shock condition. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 178-186 mitogen-activated protein kinase 1 Homo sapiens 82-85 11912188-5 2002 Phosphorylation of mitogen-activated protein kinases (MAPKs) such as p38 MAPK and ERK was markedly increased by the heat shock, and SB203580 (a p38 MAPK kinase inhibitor) and/or PD098059 (a MEK inhibitor) inhibited the phosphorylation of HSP25, indicating that p38 MAPK and ERK are upstream regulators of HSP25 phosphorylation in the heat shock condition. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 178-186 mitogen-activated protein kinase 1 Homo sapiens 54-58 11912188-5 2002 Phosphorylation of mitogen-activated protein kinases (MAPKs) such as p38 MAPK and ERK was markedly increased by the heat shock, and SB203580 (a p38 MAPK kinase inhibitor) and/or PD098059 (a MEK inhibitor) inhibited the phosphorylation of HSP25, indicating that p38 MAPK and ERK are upstream regulators of HSP25 phosphorylation in the heat shock condition. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 178-186 mitogen-activated protein kinase 1 Homo sapiens 274-277 11889128-4 2002 The stimulatory effect of NE on ERK is abrogated in the presence of anti-EGF-neutralizing antibodies, EGFR tyrosine kinase inhibitor (AG1478), and ERK kinase inhibitor (PD98059), as well as abolished in both EGFR-desensitized and endocytosis-arrested fibroblasts. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 169-176 mitogen-activated protein kinase 1 Homo sapiens 32-35 11889128-4 2002 The stimulatory effect of NE on ERK is abrogated in the presence of anti-EGF-neutralizing antibodies, EGFR tyrosine kinase inhibitor (AG1478), and ERK kinase inhibitor (PD98059), as well as abolished in both EGFR-desensitized and endocytosis-arrested fibroblasts. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 169-176 mitogen-activated protein kinase 1 Homo sapiens 147-150 11986211-10 2002 PD98059 and GF109203X, inhibitors of ERK1/ERK2 pathway and PKC, respectively, blocked PPF, while adhesion, spreading, and polyploidy were normal. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 42-46 11842088-3 2002 Blockade of extracellular signal-regulated kinase (ERK) signaling by the MEK-1/2 inhibitor PD 98059 reversed the inhibitory effects of TGF-beta, suggesting that cross-talk between MAPKs is essential for this response. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 91-99 mitogen-activated protein kinase 1 Homo sapiens 12-49 11997045-5 2002 Activating ERK by overexpressing constitutive active MEK-1 or Ras elevated GRK2 protein levels while blocking ERK using PD98059 or dominant negative Ras abolished this effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 120-127 mitogen-activated protein kinase 1 Homo sapiens 110-113 11872747-5 2002 Activation was inhibited by wortmannin, rapamycin, and the ERK inhibitors PD98059 and UO126, as well as by a dominant negative mutant of AKT. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 74-81 mitogen-activated protein kinase 1 Homo sapiens 59-62 11969294-4 2002 Use of PD98059 to inhibit MAPK/Erk and cytochalasin D (Cyto D) to disrupt the actin CSK at progressive time points in G(1) revealed that the requirement for MAPK/Erk activation lasts only to mid-G(1), while the actin CSK must remain intact up to late G(1) restriction point, R, in order for capillary endothelial cells to enter S phase. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 7-14 mitogen-activated protein kinase 1 Homo sapiens 31-34 11981761-4 2002 Addition of aspirin or NS-398, similar to PD98059, which acts as a specific inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK), an upstream kinase regulating extracellular signal-regulated kinase (ERK)1/2, abrogated such actions of HGF without affecting cell viability. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 42-49 mitogen-activated protein kinase 1 Homo sapiens 197-243 11842088-3 2002 Blockade of extracellular signal-regulated kinase (ERK) signaling by the MEK-1/2 inhibitor PD 98059 reversed the inhibitory effects of TGF-beta, suggesting that cross-talk between MAPKs is essential for this response. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 91-99 mitogen-activated protein kinase 1 Homo sapiens 51-54 12039071-6 2002 Exposure of cells to the mitogen-activated protein kinase kinase (MAPK kinase; MEK) inhibitor (PD98059; PD 10, 25 and 50 microM) completely blocked GnRH-induced increase in ERKs activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 95-102 mitogen-activated protein kinase 1 Homo sapiens 173-177 11996883-1 2002 In this study, we showed that suppression of the MEK-ERK transduction pathway by a selective inhibitor, 2"-amino-3"-methoxyflavone (PD98059), increased drug resistance of SiHa cells to cisplatin, but not to another common anticancer drug, doxorubicin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 104-130 mitogen-activated protein kinase 1 Homo sapiens 53-56 11821415-4 2002 The MEK1 inhibitor PD98059 prevented ERK activation but not p53 stabilization. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-26 mitogen-activated protein kinase 1 Homo sapiens 37-40 11821415-7 2002 Inhibition of ERK activation by PD98059 or U0126 attenuated p21(CIP1) induction, resulting in partial release of the G(2)/M cell cycle arrest induced by ETOP. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 14-17 12197778-6 2002 We assessed ERK1, ERK2, and p38 activation by Western blotting with antibodies specific for their active forms and proliferation by Coulter counting at 24 h. Specific MAP kinase kinase (MEK) and p38 inhibitors PD98059 (20 microM) and SB202190 and SB203580 (10 and 20 microM) were used to probe the role of ERK and p38 in S-1-P-mediated proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 210-217 mitogen-activated protein kinase 1 Homo sapiens 195-198 12197778-6 2002 We assessed ERK1, ERK2, and p38 activation by Western blotting with antibodies specific for their active forms and proliferation by Coulter counting at 24 h. Specific MAP kinase kinase (MEK) and p38 inhibitors PD98059 (20 microM) and SB202190 and SB203580 (10 and 20 microM) were used to probe the role of ERK and p38 in S-1-P-mediated proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 210-217 mitogen-activated protein kinase 1 Homo sapiens 195-198 12009331-4 2002 The ERK-MAPK pathway inhibitor, PD98059, attained 46-53% (MMP-3) and 59-66% (MMP-13) inhibition of RNA induction in human OA and 47-52% (MMP-3) and 69-73% (MMP-13) inhibition in bovine chondrocytes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 4-7 12009331-4 2002 The ERK-MAPK pathway inhibitor, PD98059, attained 46-53% (MMP-3) and 59-66% (MMP-13) inhibition of RNA induction in human OA and 47-52% (MMP-3) and 69-73% (MMP-13) inhibition in bovine chondrocytes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 8-12 12083372-5 2002 PD98059, which inhibits Erk2 by directly inhibiting the MAPK-kinase (MEK), and SB202192, a selective antagonist of p38MAPK, blocked the Erk2 and p38MAPK activities, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 24-28 11866440-5 2002 In HeLa cells, within 6 h of PMA treatment, HABP1 was completely translocated to the nucleus, which was prevented by PD98059, a selective inhibitor of ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 117-124 mitogen-activated protein kinase 1 Homo sapiens 151-154 11773061-9 2002 Transient overexpression of wild type NIK results in increased phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2), which is inhibited in a concentration-dependent manner by PD98059, an inhibitor of p42/44 MAPK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 197-204 mitogen-activated protein kinase 1 Homo sapiens 82-128 12489846-11 2002 PD98059, in anchored cells, was more selective for the ERK pathway and did not significantly block the p70(S6K) pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 55-58 11877323-13 2002 Neutrophil responses to ET-1 were markedly attenuated by the MAPK/ERK kinase inhibitor PD98059, whereas inhibitors of p38 MAPK, tyrosine kinases and phosphatidylinositol 3-kinase had no detectable effects. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 87-94 mitogen-activated protein kinase 1 Homo sapiens 66-69 11880483-5 2002 Local infusion of MEK (MAP kinase kinase) inhibitors (PD98059 and U0126) during BDNF delivery abolished BDNF-LTP and the associated ERK activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 54-61 mitogen-activated protein kinase 1 Homo sapiens 132-135 11911463-6 2002 VES-induced ERK phosphorylation was abolished by the ERK inhibitor, PD98059, which resulted in a remarkable prevention of VES-induced monocytic differentiation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 68-75 mitogen-activated protein kinase 1 Homo sapiens 12-15 11911463-6 2002 VES-induced ERK phosphorylation was abolished by the ERK inhibitor, PD98059, which resulted in a remarkable prevention of VES-induced monocytic differentiation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 68-75 mitogen-activated protein kinase 1 Homo sapiens 53-56 11911463-7 2002 Inhibition of the ERK activity by PD98059 also diminished the VES-induced p21WAF1 protein expression, but did not change the phosphorylation state of the retinoblastoma protein. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 34-41 mitogen-activated protein kinase 1 Homo sapiens 18-21 11909643-9 2002 PD-98059, an inhibitor of the ERK cascade, reduced ERK activity and bumetanide-sensitive 36Cl uptake. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-8 mitogen-activated protein kinase 1 Homo sapiens 30-33 11909643-9 2002 PD-98059, an inhibitor of the ERK cascade, reduced ERK activity and bumetanide-sensitive 36Cl uptake. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-8 mitogen-activated protein kinase 1 Homo sapiens 51-54 11804875-6 2002 Further, we investigated the molecular mechanisms underlying the effects of HGF and IFN-gamma in BEAS-2B cells and found that the MEK1 inhibitor PD98059, but not the p38 M-associated protein kinase inhibitor SB203580, abrogates HGF-induced ERK activation and proliferation in response to HGF and serum. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 145-152 mitogen-activated protein kinase 1 Homo sapiens 240-243 11996182-1 2002 In a previous study involving the inhibition the mitogen-activated protein kinase (MAPK), extracellular signal regulated kinase (ERK), we found that the very specific MAPK kinase (MEK) inhibitor, PD098059, inhibited the zona pellucida (ZP) induced acrosome reaction. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 196-204 mitogen-activated protein kinase 1 Homo sapiens 83-87 11996182-1 2002 In a previous study involving the inhibition the mitogen-activated protein kinase (MAPK), extracellular signal regulated kinase (ERK), we found that the very specific MAPK kinase (MEK) inhibitor, PD098059, inhibited the zona pellucida (ZP) induced acrosome reaction. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 196-204 mitogen-activated protein kinase 1 Homo sapiens 90-127 11996182-1 2002 In a previous study involving the inhibition the mitogen-activated protein kinase (MAPK), extracellular signal regulated kinase (ERK), we found that the very specific MAPK kinase (MEK) inhibitor, PD098059, inhibited the zona pellucida (ZP) induced acrosome reaction. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 196-204 mitogen-activated protein kinase 1 Homo sapiens 129-132 12022443-3 2002 The treatment of PD098059, an ERK MAP Kinase inhibitor, had a reducing effect on ALP activity, a differentiation marker in 1,25(OH)2D3-treated primary human osteoblasts. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 17-25 mitogen-activated protein kinase 1 Homo sapiens 30-33 11996883-1 2002 In this study, we showed that suppression of the MEK-ERK transduction pathway by a selective inhibitor, 2"-amino-3"-methoxyflavone (PD98059), increased drug resistance of SiHa cells to cisplatin, but not to another common anticancer drug, doxorubicin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 132-139 mitogen-activated protein kinase 1 Homo sapiens 53-56 11996883-4 2002 However, suppression of the MEK-ERK2 pathway by PD98059 resulted in a further enhancement of cisplatin-induced NF kappa B activation, while no further regulation of NF kappa B was noted in doxorubicin-treated cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 48-55 mitogen-activated protein kinase 1 Homo sapiens 32-36 11781135-3 2002 Either of these treatments increased the cellular levels of p21 by an Erk1/Erk2 MAP kinase cascade-dependent way, since this increase was prevented by the MEK-inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 169-176 mitogen-activated protein kinase 1 Homo sapiens 75-79 11834245-5 2002 Furthermore, mitogen-activated protein kinase kinase (MEK)-1-specific inhibitor, 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one (PD 98059), blocked the lipopolysaccharide-induced p44/42 ERK activation and PDGF production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 81-130 mitogen-activated protein kinase 1 Homo sapiens 189-192 11834245-5 2002 Furthermore, mitogen-activated protein kinase kinase (MEK)-1-specific inhibitor, 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one (PD 98059), blocked the lipopolysaccharide-induced p44/42 ERK activation and PDGF production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 132-140 mitogen-activated protein kinase 1 Homo sapiens 189-192 11677248-12 2002 High concentrations of SB203580, which inhibit both JNK and p38 MAPK, and PD98059 a selective inhibitor of MEK1/2 that blocks ERK activation, inhibited FN-f induced NO production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 74-81 mitogen-activated protein kinase 1 Homo sapiens 126-129 11752171-4 2002 Treatment of infected cells with PD98059, a specific inhibitor of the ERK/MAPK pathway, abolishes visna virus replication, as evidenced by extremely low levels of Gag protein expression and reverse transcriptase activity in culture supernatants. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-40 mitogen-activated protein kinase 1 Homo sapiens 70-73 11916243-7 2002 This activation directly correlates with cytotoxicity, because inhibition of the MAP kinase extracellular regulated kinase (Erk) by PD98059, reversed GCV-mediated cytotoxicity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 132-139 mitogen-activated protein kinase 1 Homo sapiens 92-122 11916243-7 2002 This activation directly correlates with cytotoxicity, because inhibition of the MAP kinase extracellular regulated kinase (Erk) by PD98059, reversed GCV-mediated cytotoxicity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 132-139 mitogen-activated protein kinase 1 Homo sapiens 124-127 11948693-5 2002 Proliferation, activation of ERK, and biosynthesis of Egr-1 was completely inhibited in EGF or thrombin-treated HaCaT cells by the MAP kinase kinase inhibitor PD98059 and by AG1487, an EGF receptor-specific tyrosine kinase inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 159-166 mitogen-activated protein kinase 1 Homo sapiens 29-32 11754748-7 2002 PD98059, a specific inhibitor of the ERK-activating kinase MEK1, also abolished the effects of IL-1alpha on ERK activation and osteoclast survival. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 37-40 11754748-7 2002 PD98059, a specific inhibitor of the ERK-activating kinase MEK1, also abolished the effects of IL-1alpha on ERK activation and osteoclast survival. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 108-111 11752171-6 2002 Interestingly, further examination demonstrated that treatment with PD98059 results in decreased cytoplasmic expression of gag and env, but not rev, mRNA, highly suggestive of an ERK/MAPK-dependent defect in Rev function. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 68-75 mitogen-activated protein kinase 1 Homo sapiens 179-182 11922392-6 2002 Treating the cells with MEK1/2 inhibitor (PD98059) eliminated ERK activation completely and blocked FGF-1-mediated induction of promatrilysin expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 42-49 mitogen-activated protein kinase 1 Homo sapiens 62-65 11687581-6 2001 15-d-PGJ2-induced expression of c-fos mRNA was blocked by PD98059 or U0126, two ERK kinase inhibitors, suggesting that the MEK/ERK pathway mediates 15-d-PGJ2-induced c-fos gene expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 mitogen-activated protein kinase 1 Homo sapiens 80-83 11675379-10 2001 PD98059, a specific inhibitor of the ERK-activating kinase MEK-1, abolished the TNF-alpha-induced ERK phosphorylation and osteoclast survival, and in these responses the involvement of Grb2 and ceramide was observed. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 37-40 11675379-10 2001 PD98059, a specific inhibitor of the ERK-activating kinase MEK-1, abolished the TNF-alpha-induced ERK phosphorylation and osteoclast survival, and in these responses the involvement of Grb2 and ceramide was observed. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 98-101 11745456-9 2001 The specific MEK inhibitors PD098059 and U0126, which in turn suppress ERK, abolished 12(S)-HETE-stimulated proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 28-36 mitogen-activated protein kinase 1 Homo sapiens 71-74 11551901-3 2001 This conclusion is based on observations indicating that cyclin D1 induction by transforming Ha-Ras was depressed in a dose-dependent manner by PD98059, a selective inhibitor of the mitogen-activated kinase kinase MEK-1, demonstrating that Ha-Ras employs extracellular signal-regulated kinases (ERKs) for signal transmission to the cyclin D1 promoter. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 144-151 mitogen-activated protein kinase 1 Homo sapiens 295-299 11688977-6 2001 However, inhibition of ERK activity by PD98059 showed no significant effect on VES-induced PKC activity and apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 39-46 mitogen-activated protein kinase 1 Homo sapiens 23-26 11761456-6 2001 Inhibition of cisplatin-induced ERK activity by PD98059 resulted in decreased levels of p21WAF1, Gadd45 and Mdm2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 48-55 mitogen-activated protein kinase 1 Homo sapiens 32-35 11641266-7 2001 Inhibition of ERK by the mitogen-activated protein kinase kinase (MEK1) inhibitor PD98059 (10 microM) abolished AP-1 activation and apoptosis induction with SNAP. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 82-89 mitogen-activated protein kinase 1 Homo sapiens 14-17 11641267-6 2001 Exogenous ATP activated the extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) pathway, which was blunted by the MAPK/ERK kinase 1/2 (MEK1/2) antagonist PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 193-200 mitogen-activated protein kinase 1 Homo sapiens 28-69 11684091-9 2001 This increase was also prevented by the MEK inhibitor PD98059, thus demonstrating the role of the MEK/ERK pathway in this system. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 54-61 mitogen-activated protein kinase 1 Homo sapiens 102-105 11483613-9 2001 PD98059 and the PKC inhibitor H7 also blocked the phosphorylation of ERK1 and ERK2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 78-82 11483613-10 2001 PD98059 but not LY294002 inhibited Epo induction of ERK1 and ERK2 phosphorylation in normal erythroid cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 61-65 11641781-6 2001 Overexpression of dominant negative MEK1 or treatment with PD98059 abolishes MST4-induced ERK activity, whereas dominant-negative Ras or c-Raf-1 mutants failed to do so, indicating MST4 activates MEK1/ERK via a Ras/Raf-1 independent pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 59-66 mitogen-activated protein kinase 1 Homo sapiens 90-93 11568005-4 2001 This study found that in the presence of the mitogen-activated protein kinase kinase 1-extracellular signal-regulated kinase (ERK) inhibitors PD98059 or U0126, TNF-alpha- and LPS-induced phenotypic and functional maturation is enhanced. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 142-149 mitogen-activated protein kinase 1 Homo sapiens 126-129 11590203-5 2001 In addition, the ERK inhibitor PD98059 did not block phagocytosis of IgG-coated erythrocytes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 31-38 mitogen-activated protein kinase 1 Homo sapiens 17-20 11595755-6 2001 Blockade of the p38 or the ERK MAP kinase pathways (by SB202190 and PD98059, respectively) prevented the H2O2-induced increase in pENK and pOFQ mRNA levels indicating a central role for these cascades in the regulation of pOFQ and pENK genes in response to oxidative stress. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 68-75 mitogen-activated protein kinase 1 Homo sapiens 16-19 11595755-6 2001 Blockade of the p38 or the ERK MAP kinase pathways (by SB202190 and PD98059, respectively) prevented the H2O2-induced increase in pENK and pOFQ mRNA levels indicating a central role for these cascades in the regulation of pOFQ and pENK genes in response to oxidative stress. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 68-75 mitogen-activated protein kinase 1 Homo sapiens 27-30 11590318-9 2001 Inhibition of MAPK kinases by PD98059 led to a reduction of proliferation but did not interfere with cellular differentiation of PaTu-II cells on matrigel. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 mitogen-activated protein kinase 1 Homo sapiens 14-18 11577023-11 2001 On the other hand, inhibition of ERK1 and ERK2 activation by PD98059 (50 micromol/L) prevented the upregulation of ECE-1 expression by thrombin as well as the increase in ECE activity and ET-1 accumulation in the medium. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 61-68 mitogen-activated protein kinase 1 Homo sapiens 42-46 11549724-8 2001 Blocking either the ERK1/ERK2 or the p38 pathway (with PD98059 or SB203580, respectively) significantly inhibited Bz-ATP-induced MCP-1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 55-62 mitogen-activated protein kinase 1 Homo sapiens 37-40 11549292-6 2001 PD98059--a specific inhibitor of MAP or Erk kinase 1 (MEK 1), the upstream kinase that phosphorylates Erk1/2--abolishes angiogenin-induced Erk phosphorylation and cell proliferation without affecting nuclear translocation of angiogenin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 40-43 11549292-6 2001 PD98059--a specific inhibitor of MAP or Erk kinase 1 (MEK 1), the upstream kinase that phosphorylates Erk1/2--abolishes angiogenin-induced Erk phosphorylation and cell proliferation without affecting nuclear translocation of angiogenin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 102-105 11525640-5 2001 Inhibition of JNK1 and ERK kinase activities either by expression of the dominant negative mutant JNK1 or by treatment with a selective chemical inhibitor of ERK (PD098059) substantially abrogates the UV induction of the GADD45 promoter. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 163-171 mitogen-activated protein kinase 1 Homo sapiens 23-26 11525640-5 2001 Inhibition of JNK1 and ERK kinase activities either by expression of the dominant negative mutant JNK1 or by treatment with a selective chemical inhibitor of ERK (PD098059) substantially abrogates the UV induction of the GADD45 promoter. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 163-171 mitogen-activated protein kinase 1 Homo sapiens 158-161 11709424-4 2001 Addition of PD-98059 up to 4 h after IL-1 beta stimulation significantly inhibited MMP-9 induction, suggesting a role for sustained ERK activation in MMP-9 induction. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 12-20 mitogen-activated protein kinase 1 Homo sapiens 132-135 11751459-9 2001 Treatment of Reh cells with 20 microM PD98059, a specific inhibitor of MEK, inhibited bryo 1-induced ERK activity and DNA binding. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 38-45 mitogen-activated protein kinase 1 Homo sapiens 101-104 11719466-5 2001 Induction of GRP78 by chronic hypoxia was completely abolished by pretreatment with PD98059 [a specific inhibitor of mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK1)] or by overexpression of a dominant-negative MEK1 mutant, demonstrating a direct involvement of ERK in the induction of transcription at the GRP78 promoter under these conditions. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 84-91 mitogen-activated protein kinase 1 Homo sapiens 182-185 11719466-5 2001 Induction of GRP78 by chronic hypoxia was completely abolished by pretreatment with PD98059 [a specific inhibitor of mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK1)] or by overexpression of a dominant-negative MEK1 mutant, demonstrating a direct involvement of ERK in the induction of transcription at the GRP78 promoter under these conditions. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 84-91 mitogen-activated protein kinase 1 Homo sapiens 297-300 11533045-5 2001 Although the serum-dependent proliferation of HepG2 cells was inhibited by the MEK inhibitor PD98059 in a dose-dependent manner, 10 microM PD98059 reduced the HGF-induced strong activation of ERK to a weak activation; and as a result, the proliferation inhibited by HGF was completely restored. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 93-100 mitogen-activated protein kinase 1 Homo sapiens 192-195 11533045-5 2001 Although the serum-dependent proliferation of HepG2 cells was inhibited by the MEK inhibitor PD98059 in a dose-dependent manner, 10 microM PD98059 reduced the HGF-induced strong activation of ERK to a weak activation; and as a result, the proliferation inhibited by HGF was completely restored. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 139-146 mitogen-activated protein kinase 1 Homo sapiens 192-195 11581403-5 2001 Inhibition of HBx-induced ERK activation following intravenous administration of PD98059, a mitogen-activated protein kinase kinase kinase (MEK) inhibitor, confirmed the requirement for MEK in the activation of ERKs by HBx. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 81-88 mitogen-activated protein kinase 1 Homo sapiens 26-29 11581403-5 2001 Inhibition of HBx-induced ERK activation following intravenous administration of PD98059, a mitogen-activated protein kinase kinase kinase (MEK) inhibitor, confirmed the requirement for MEK in the activation of ERKs by HBx. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 81-88 mitogen-activated protein kinase 1 Homo sapiens 211-215 11641439-5 2001 PMA promoted the generation of PGE(2) in the medium of HASMC and caused activation of both extracellular signal-regulated kinase (ERK) and PKA through a process ablated by indomethacin, NS-398, quinacrine, and PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 210-217 mitogen-activated protein kinase 1 Homo sapiens 91-128 11641439-5 2001 PMA promoted the generation of PGE(2) in the medium of HASMC and caused activation of both extracellular signal-regulated kinase (ERK) and PKA through a process ablated by indomethacin, NS-398, quinacrine, and PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 210-217 mitogen-activated protein kinase 1 Homo sapiens 130-133 11594774-4 2001 ERK activation by insulin, IGF-I, or PDGF was unaffected by the phosphatidylinositol 3-kinase inhibitor wortmannin but was abolished by the MEK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 154-161 mitogen-activated protein kinase 1 Homo sapiens 0-3 11517214-6 2001 Cell adhesion was partially restored when the activation of the extracellular signal-regulated kinase (ERK) was inhibited with PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 127-134 mitogen-activated protein kinase 1 Homo sapiens 64-101 11517214-6 2001 Cell adhesion was partially restored when the activation of the extracellular signal-regulated kinase (ERK) was inhibited with PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 127-134 mitogen-activated protein kinase 1 Homo sapiens 103-106 11567778-8 2001 Inhibition of the MAP kinase p38 by SB202190 partially reduced the IL-8 response to NaF, whereas a reduction in ERK activity by PD98059 led to an increased response. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 128-135 mitogen-activated protein kinase 1 Homo sapiens 112-115 11546664-4 2001 The mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitors, PD-98059 and U-0126, blocked IL-1 alpha-induced ERK activation and partially attenuated cPLA(2)alpha phosphorylation and PGI(2) release, suggesting that ERK-dependent and -independent pathways regulate cPLA(2)alpha phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 69-77 mitogen-activated protein kinase 1 Homo sapiens 222-225 11687581-6 2001 15-d-PGJ2-induced expression of c-fos mRNA was blocked by PD98059 or U0126, two ERK kinase inhibitors, suggesting that the MEK/ERK pathway mediates 15-d-PGJ2-induced c-fos gene expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 mitogen-activated protein kinase 1 Homo sapiens 127-130 11559033-8 2001 Conversely, PD98059, an inhibitor of the ERK upstream activators MKK1/2, enhanced micronucleus and apoptosis in Cd-treated early-G(2) cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 12-19 mitogen-activated protein kinase 1 Homo sapiens 41-44 11571231-5 2001 Moreover, inhibition of ERK activity by PD98059 induced erythroid differentiation, and it acted synergistically with hydroxyurea on hemoglobin synthesis, whereas inhibition of p38 activity by SB203580 inhibited induction of hemoglobin production by hydroxyurea. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 40-47 mitogen-activated protein kinase 1 Homo sapiens 24-27 11536169-6 2001 PD98059, a selective MEK inhibitor, inhibited sPLA(2)-induced nitrite production and iNOS expression as well as ERK phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 112-115 11562079-8 2001 PD98059 and SB203580, known as a specific inhibitor of MEKI and p38 kinase, respectively, inhibited IL-8 gene expression showing that both of the kinase pathways are involved in IL-8 regulation in human monocytes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 64-67 11509539-7 2001 In addition, pretreatment of VSM cells with a specific ERK pathway inhibitor, PD-98059, or DETA NONOate inhibited IL-1 beta-stimulated ERK activation and MMP-9 induction. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 78-86 mitogen-activated protein kinase 1 Homo sapiens 135-138 11509539-8 2001 Direct exposure of VSM cells to increased superoxide levels by treatment with xanthine/xanthine oxidase increased ERK activation and MMP-9 induction, whereas pretreatment of cells with PD-98059 significantly (P < 0.05) inhibited xanthine/xanthine oxidase-stimulated ERK activation and MMP-9 induction. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 185-193 mitogen-activated protein kinase 1 Homo sapiens 269-272 11553671-4 2001 Similarly, FGF-2-induced glial proliferation was attenuated in the presence of the MEK inhibitor, PD98059, thus, confirming a direct correlation between FGF-2-induced ERK activation and glial cell proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 98-105 mitogen-activated protein kinase 1 Homo sapiens 167-170 11553671-6 2001 Moreover, the effects of cAMP on the time-course of FGF-2-dependent CREB phosphorylation were mimicked by PD98059, suggesting that the cAMP-induced redirection of FGF-2-signalling is linked to the RAF-MEK-ERK signalling pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 106-113 mitogen-activated protein kinase 1 Homo sapiens 205-208 11418608-3 2001 VPA-induced activation of ERK was blocked by the mitogen-activated protein kinase/ERK kinase inhibitor PD098059 and dominant-negative Ras and Raf mutants but not by dominant-negative stress-activated protein kinase/ERK kinase and mitogen-activated protein kinase kinase 6 mutants. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 103-111 mitogen-activated protein kinase 1 Homo sapiens 26-29 11418608-3 2001 VPA-induced activation of ERK was blocked by the mitogen-activated protein kinase/ERK kinase inhibitor PD098059 and dominant-negative Ras and Raf mutants but not by dominant-negative stress-activated protein kinase/ERK kinase and mitogen-activated protein kinase kinase 6 mutants. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 103-111 mitogen-activated protein kinase 1 Homo sapiens 82-85 11418608-3 2001 VPA-induced activation of ERK was blocked by the mitogen-activated protein kinase/ERK kinase inhibitor PD098059 and dominant-negative Ras and Raf mutants but not by dominant-negative stress-activated protein kinase/ERK kinase and mitogen-activated protein kinase kinase 6 mutants. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 103-111 mitogen-activated protein kinase 1 Homo sapiens 82-85 11427538-10 2001 The cytoprotective actions of HDL and S1P were associated with extracellular signal-regulated kinase (ERK) activation and were almost completely inhibited by pertussis toxin and PD98059, an ERK kinase inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 178-185 mitogen-activated protein kinase 1 Homo sapiens 63-100 11427538-10 2001 The cytoprotective actions of HDL and S1P were associated with extracellular signal-regulated kinase (ERK) activation and were almost completely inhibited by pertussis toxin and PD98059, an ERK kinase inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 178-185 mitogen-activated protein kinase 1 Homo sapiens 102-105 11427538-10 2001 The cytoprotective actions of HDL and S1P were associated with extracellular signal-regulated kinase (ERK) activation and were almost completely inhibited by pertussis toxin and PD98059, an ERK kinase inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 178-185 mitogen-activated protein kinase 1 Homo sapiens 190-193 11371552-8 2001 Further, PD98059, a specific inhibitor of the MEK/ERK/mitogen-activated protein kinase pathway prevented the Ras-induced decrease in Smad4 expression and complex formation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 9-16 mitogen-activated protein kinase 1 Homo sapiens 50-53 11683493-9 2001 Inhibition of MEK with a PD98059 dose which inhibits ERK2 phosphorylation and subsequent cell differentiation also inhibits RAF phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 25-32 mitogen-activated protein kinase 1 Homo sapiens 53-57 11447172-7 2001 The stimulatory effect of the fimbriae on the expression of the p21 protein was inhibited by treatment with PD98059, a specific inhibitor of ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 108-115 mitogen-activated protein kinase 1 Homo sapiens 141-144 11481274-13 2001 ERK activation was also blocked by the ERK-mitogen-activated protein kinase (MAPK) inhibitor PD98059, but not by the protein kinase A (PKA) inhibitor H-89. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 93-100 mitogen-activated protein kinase 1 Homo sapiens 0-3 11481274-13 2001 ERK activation was also blocked by the ERK-mitogen-activated protein kinase (MAPK) inhibitor PD98059, but not by the protein kinase A (PKA) inhibitor H-89. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 93-100 mitogen-activated protein kinase 1 Homo sapiens 39-42 11481274-13 2001 ERK activation was also blocked by the ERK-mitogen-activated protein kinase (MAPK) inhibitor PD98059, but not by the protein kinase A (PKA) inhibitor H-89. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 93-100 mitogen-activated protein kinase 1 Homo sapiens 77-81 11489936-7 2001 PD98059 suppression of early Erk1/2 activation correlated with reduction of SDF-1 alpha-induced TNF-alpha expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 29-35 11466342-8 2001 Although both CD72 and BCR induced Btk-dependent ERK activation, CD72-mediated proliferation is more resistant to blocking of ERK activity than that of BCR, as shown by the proliferation response of B cells treated with PD98059 and dibutyryl cAMP, agents that inhibit ERK activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 220-227 mitogen-activated protein kinase 1 Homo sapiens 126-129 11585751-11 2001 An inhibitor of MAPK/ERK kinase 1, PD98059, also inhibited ECGS-stimulated DNA synthesis (IC(50), approximately 55 microM), but combining PD98059 with MSeA had an effect similar to that when PD98059 was used alone. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 35-42 mitogen-activated protein kinase 1 Homo sapiens 21-24 11466342-8 2001 Although both CD72 and BCR induced Btk-dependent ERK activation, CD72-mediated proliferation is more resistant to blocking of ERK activity than that of BCR, as shown by the proliferation response of B cells treated with PD98059 and dibutyryl cAMP, agents that inhibit ERK activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 220-227 mitogen-activated protein kinase 1 Homo sapiens 126-129 11454948-3 2001 In the present study, we examined the effects of PD098059 and U0126, two structurally dissimilar inhibitors of MAP kinase kinase (MEK1/2), on the activation of ERK and Akt stimulated by human 5-hydroxytryptamine(1B) (serotonin) (5-HT1B) receptors. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 49-57 mitogen-activated protein kinase 1 Homo sapiens 160-163 11454948-9 2001 Nevertheless, our findings that PD098059 and U0126 inhibit activation of Akt at commonly used concentrations demonstrate that in at least some systems, these compounds inhibit activation of both ERK and Akt, and cannot be used to discern the relative roles of each pathway in mediating cellular responses. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-40 mitogen-activated protein kinase 1 Homo sapiens 195-198 11454659-5 2001 Immunoblots also demonstrated an increase in the phosphorylated (activated) form of Erk in palmar lateral vein segments after contraction with UK14304, which was inhibited by PD98059 and U0126. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 175-182 mitogen-activated protein kinase 1 Homo sapiens 84-87 11359772-8 2001 Serum-stimulated c-Fos expression is dependent on MAPK/Erk activity because the MEK inhibitor PD98059 suppresses Erk activity and c-Fos expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 94-101 mitogen-activated protein kinase 1 Homo sapiens 55-58 11359772-8 2001 Serum-stimulated c-Fos expression is dependent on MAPK/Erk activity because the MEK inhibitor PD98059 suppresses Erk activity and c-Fos expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 94-101 mitogen-activated protein kinase 1 Homo sapiens 113-116 11404249-4 2001 Analysis of total RNA and protein showed a 1.5-fold increase in the Na-K-ATPase beta1-subunit mRNA levels and up to a fivefold increase in beta1-subunit protein abundance after DA stimulation, which was blocked by the MAPK kinase (MEK) inhibitors PD-98059 and U-0126. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 247-255 mitogen-activated protein kinase 1 Homo sapiens 218-222 11461971-6 2001 TPA-dependent ERK phosphorylation was also blocked by the MEK1 inhibitors PD098059 or U0126. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 74-82 mitogen-activated protein kinase 1 Homo sapiens 14-17 11306564-6 2001 Furthermore, PD98059 and SB202190, specific inhibitors of ERK or p38 MAPK respectively, efficiently suppressed CT(105)-induced effects whereas only PD98059 was effective at reducing Abeta-induced effects. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 58-61 11439356-4 2001 In addition, treating the cells with p38 inhibitor SB202190 or MEK inhibitor PD98059 specifically inhibited UVB induced p38 or ERK activation, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 77-84 mitogen-activated protein kinase 1 Homo sapiens 127-130 11292824-5 2001 Treatment of human osteoblasts with a MAP kinase kinase inhibitor, PD98059, impaired both basal and [Ca(2+)](o)-stimulated phosphorylation of ERKs and also reduced both basal and [Ca(2+)](o)-stimulated proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 67-74 mitogen-activated protein kinase 1 Homo sapiens 142-146 11443739-6 2001 Inhibition of ERK activation using the drug PD98059 effectively prevented cells from beginning to migrate. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 44-51 mitogen-activated protein kinase 1 Homo sapiens 14-17 11573595-10 2001 PD98059 (50 microM) also inhibited chemotaxis stimulated by FMLP, suggesting the involvement of p42 MAPK in the response. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 96-104 11678615-12 2001 PD98059, an inhibitor of the ERK upstream activators MKK1/2, greatly enhanced the cytotoxicity and apoptosis of cells treated with low Cd doses. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 29-32 11360301-7 2001 By 30 min, the entire monolayer showed activation, which persisted for 4 to 8 h. ERK/MAPK activation was specifically blocked by application of the MEK inhibitors, PD98059 and U0126. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 164-171 mitogen-activated protein kinase 1 Homo sapiens 81-84 11355882-5 2001 In addition, PTX induced phosphorylation of Akt and of ERK2, which could be completely blocked by LY294002 and PD098059, respectively, and by genistein or tyrphostin 47 as well. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 111-119 mitogen-activated protein kinase 1 Homo sapiens 55-59 11348889-7 2001 Furthermore, PD98059, an inhibitor of extracellular signal-regulated kinase (ERK) kinase (MEK), almost completely suppressed Ang II-induced PAI-1 upregulation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 77-80 11278279-5 2001 Both PD98059 and a dominant negative mutant of ERK2 blocked ERKs and p90(RSK) Ser(381) phosphorylation, as well as p90(RSK) activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 5-12 mitogen-activated protein kinase 1 Homo sapiens 60-64 11369515-3 2001 Inhibition of extracellular signal-regulated kinase (ERK) with PD098059 significantly inhibited the anti-apoptotic effect of both LPS and LTB(4), while inhibition of p38 kinase with SB203580 had no effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 63-71 mitogen-activated protein kinase 1 Homo sapiens 14-51 11369515-3 2001 Inhibition of extracellular signal-regulated kinase (ERK) with PD098059 significantly inhibited the anti-apoptotic effect of both LPS and LTB(4), while inhibition of p38 kinase with SB203580 had no effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 63-71 mitogen-activated protein kinase 1 Homo sapiens 53-56 11294978-6 2001 Inhibition of ERK with the MEK1,2 inhibitor PD98059 increased apoptosis 2-fold, whereas the inhibitor of p38, SB202190, decreased the level of apoptotic cells by approximately 40%. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 44-51 mitogen-activated protein kinase 1 Homo sapiens 14-17 11359871-5 2001 6-OHDA-elicited ERK phosphorylation was blocked by PD98059, an inhibitor of the upstream mitogen activated protein kinase kinase (MEK) that phosphorylates and activates ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 51-58 mitogen-activated protein kinase 1 Homo sapiens 16-19 11359871-5 2001 6-OHDA-elicited ERK phosphorylation was blocked by PD98059, an inhibitor of the upstream mitogen activated protein kinase kinase (MEK) that phosphorylates and activates ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 51-58 mitogen-activated protein kinase 1 Homo sapiens 169-172 11294978-7 2001 SB202190 also inhibited apoptosis by almost 40% when ERK activity was reduced in the presence of PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 97-104 mitogen-activated protein kinase 1 Homo sapiens 53-56 11290612-4 2001 PD98059 inhibited the activation of p42(ERK2) by GM-CSF, TNF-alpha, and FMLP, but it did not inhibit FMLP-stimulated superoxide production in either unprimed or primed neutrophils. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 40-44 11278385-6 2001 PMA-stimulated activation of ERK/MAPK, RSK1, and NF-kappaB and the PMA-induced megakaryocytic differentiation were prevented by pretreatment with PD98059, a specific inhibitor of the mitogen-activated ERK kinase (MEK). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 146-153 mitogen-activated protein kinase 1 Homo sapiens 29-32 11278385-6 2001 PMA-stimulated activation of ERK/MAPK, RSK1, and NF-kappaB and the PMA-induced megakaryocytic differentiation were prevented by pretreatment with PD98059, a specific inhibitor of the mitogen-activated ERK kinase (MEK). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 146-153 mitogen-activated protein kinase 1 Homo sapiens 33-37 11278974-4 2001 Furthermore, when normally induced 3T3-L1 preadipocytes were treated with PD98059 (an inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1) to block the activation of extracellular signal-regulated kinase (Erk) 1 and Erk2, the mitotic clonal expansion was blocked, but adipocyte differentiation was not affected. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 74-81 mitogen-activated protein kinase 1 Homo sapiens 207-252 11352660-7 2001 The effects of VEGF on NO production and the expression of endothelial NOS (eNOS) were attenuated by treating BeWo cells with the selective inhibitor of MAPK kinase, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 166-173 mitogen-activated protein kinase 1 Homo sapiens 153-157 11278974-4 2001 Furthermore, when normally induced 3T3-L1 preadipocytes were treated with PD98059 (an inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1) to block the activation of extracellular signal-regulated kinase (Erk) 1 and Erk2, the mitotic clonal expansion was blocked, but adipocyte differentiation was not affected. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 74-81 mitogen-activated protein kinase 1 Homo sapiens 257-261 11401480-9 2001 Furthermore, inhibition of the MEK/ERK cascade using the MEK inhibitor, PD098059 abolished SB203580-induced PANC-1 cell proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 72-80 mitogen-activated protein kinase 1 Homo sapiens 35-38 11264178-7 2001 Furthermore, ERK phosphorylation was substantially prolonged in LC/BRY-treated cells compared to those exposed to BRY alone, and pretreatment with the highly specific MEK inhibitors, PD98059, U0126, and SL327, opposed ERK activation while protecting cells from LC/BRY-induced lethality. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 183-190 mitogen-activated protein kinase 1 Homo sapiens 13-16 11264178-7 2001 Furthermore, ERK phosphorylation was substantially prolonged in LC/BRY-treated cells compared to those exposed to BRY alone, and pretreatment with the highly specific MEK inhibitors, PD98059, U0126, and SL327, opposed ERK activation while protecting cells from LC/BRY-induced lethality. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 183-190 mitogen-activated protein kinase 1 Homo sapiens 218-221 11279606-6 2001 However, we found that the MEK1 inhibitor PD98059, but not the p38 kinase inhibitor SB203580, potently induced apoptosis of the liver cancer cells in the presence of serum, indicating that the MEK-ERK signaling pathway is required for serum-dependent survival of HepG2 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 42-49 mitogen-activated protein kinase 1 Homo sapiens 197-200 11241670-5 2001 Activation of ERK1 and ERK2 by PDGF-BB and FGF-2 was inhibited by PD 098059 (100 microM), a specific inhibitor of MEK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 66-75 mitogen-activated protein kinase 1 Homo sapiens 23-27 11573595-4 2001 MAPKs have been shown to be involved in neutrophil chemotaxis by the use of PD98059, the specific inhibitor of MAPK/ERK kinase (MEK). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 76-83 mitogen-activated protein kinase 1 Homo sapiens 0-4 11237743-3 2001 The MAPK kinase (MEK) inhibitor, PD98059, blocked GSA-stimulated MAPK activation and resulted in an inhibition of GSA-stimulated VSMC proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-40 mitogen-activated protein kinase 1 Homo sapiens 4-8 11237744-5 2001 RSK activity was reduced by PI3 kinase inhibitor LY294002 or MEK1 inhibitor PD98059, suggesting that the ERK as well as the PI3 kinase pathways are involved in regulation of RSK activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 76-83 mitogen-activated protein kinase 1 Homo sapiens 105-108 11298121-7 2001 Complement-induced ERK activation was blocked in cells treated with GF109203X or Go6976, two selective PKC inhibitors, as well as by treatment with PD098059, an inhibitor of MEK1, the ERK kinase. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 148-156 mitogen-activated protein kinase 1 Homo sapiens 19-22 11298121-7 2001 Complement-induced ERK activation was blocked in cells treated with GF109203X or Go6976, two selective PKC inhibitors, as well as by treatment with PD098059, an inhibitor of MEK1, the ERK kinase. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 148-156 mitogen-activated protein kinase 1 Homo sapiens 184-187 11179516-10 2001 We found that IL-1 beta-induced ERK phosphorylation, PD153035 and MEK inhibitor PD98059 blocked IL-1 beta-induced ERK activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 80-87 mitogen-activated protein kinase 1 Homo sapiens 114-117 11231341-8 2001 Insulin-stimulated phosphorylation of 4E-BP1 was also inhibited by PD098059, implying involvement of Erk-1/-2 mitogen-activated protein (MAP) kinase. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 67-75 mitogen-activated protein kinase 1 Homo sapiens 101-109 11178960-6 2001 15d-PGJ2-mediated ERK activation is however blocked by the MEK inhibitor PD 098059, appears to require phosphatidylinositol-3 kinase, but is independent of protein kinase C activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 73-82 mitogen-activated protein kinase 1 Homo sapiens 18-21 11245462-5 2001 Strikingly, the abrogation of extracellular signal-regulated kinase (ERK)-signaling by the MAPK/ERK kinase (MEK)1/2 inhibitor PD098059 in combination with vinblastine robustly induced apoptosis in ML-1 cells at a rate much faster than treatment with vinblastine alone and occurred at all phases of the cell cycle. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 126-134 mitogen-activated protein kinase 1 Homo sapiens 30-67 11245462-5 2001 Strikingly, the abrogation of extracellular signal-regulated kinase (ERK)-signaling by the MAPK/ERK kinase (MEK)1/2 inhibitor PD098059 in combination with vinblastine robustly induced apoptosis in ML-1 cells at a rate much faster than treatment with vinblastine alone and occurred at all phases of the cell cycle. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 126-134 mitogen-activated protein kinase 1 Homo sapiens 69-72 11245462-5 2001 Strikingly, the abrogation of extracellular signal-regulated kinase (ERK)-signaling by the MAPK/ERK kinase (MEK)1/2 inhibitor PD098059 in combination with vinblastine robustly induced apoptosis in ML-1 cells at a rate much faster than treatment with vinblastine alone and occurred at all phases of the cell cycle. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 126-134 mitogen-activated protein kinase 1 Homo sapiens 91-95 11245472-5 2001 Stable expression of a dominant negative mutant of ERK2 or p38 kinase or their respective inhibitor, PD98059 or SB202190, repressed the phosphorylation of p53 at serine 15. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 101-108 mitogen-activated protein kinase 1 Homo sapiens 51-55 11164710-10 2001 PD98059, a specific MAP kinase kinase (MAPKK) 1 (also referred to as MEK1) inhibitor, inhibited EGF-dependent cell proliferation, that was associated with the inhibition of ERK and JNK phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 173-176 11170175-6 2001 The inhibition of ERK activation by using the pharmacological MEK1/2 inhibitor, PD98059 (50 microM), or an antisense strategy, reduced tau phosphorylation and neuronal apoptosis (P < 0.001), indicating a link between ERK activation, tau phosphorylation and apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 80-87 mitogen-activated protein kinase 1 Homo sapiens 18-21 11031257-2 2001 Blockade of the ERK pathway by treatment with PD98059, a specific inhibitor of mitogen-activated protein (MAP) kinase/ERK kinase (MEK), completely suppressed the growth of tumor cells in which the pathway is constitutively activated (RPMI-SE and HT1080 cells). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 46-53 mitogen-activated protein kinase 1 Homo sapiens 16-19 11031257-2 2001 Blockade of the ERK pathway by treatment with PD98059, a specific inhibitor of mitogen-activated protein (MAP) kinase/ERK kinase (MEK), completely suppressed the growth of tumor cells in which the pathway is constitutively activated (RPMI-SE and HT1080 cells). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 46-53 mitogen-activated protein kinase 1 Homo sapiens 118-121 11145700-7 2001 In addition, GM-CSF- and TNF-induced superoxide release and adherence were inhibited by PD98059 MAPK/ERK kinase inhibitor) as well as SB203580 (p38 MAPK inhibitor), suggesting possible involvement of ERK and p38 MAPK in superoxide release and adherence induced by these cytokines. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 88-95 mitogen-activated protein kinase 1 Homo sapiens 101-104 11145700-7 2001 In addition, GM-CSF- and TNF-induced superoxide release and adherence were inhibited by PD98059 MAPK/ERK kinase inhibitor) as well as SB203580 (p38 MAPK inhibitor), suggesting possible involvement of ERK and p38 MAPK in superoxide release and adherence induced by these cytokines. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 88-95 mitogen-activated protein kinase 1 Homo sapiens 200-203 11313944-5 2001 PD98059 or SB203580, specific inhibitors of ERK and p38 kinase activities, significantly decreased apoptosis, leaving the surviving cells arrested in G2/M. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 44-47 11123200-5 2001 MAPK-extracellular signal-regulated kinase (ERK) kinase inhibition (20 microM PD-98059) blocked strain mitogenicity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 78-86 mitogen-activated protein kinase 1 Homo sapiens 0-42 11123200-5 2001 MAPK-extracellular signal-regulated kinase (ERK) kinase inhibition (20 microM PD-98059) blocked strain mitogenicity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 78-86 mitogen-activated protein kinase 1 Homo sapiens 44-47 11089552-4 2000 In DCT cells, PTH stimulates phosphorylation of ERK2 and activation of ERK2 kinase and is blocked by the MEK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 119-126 mitogen-activated protein kinase 1 Homo sapiens 48-52 11211936-7 2001 PD98059 inhibited induced blr1 mRNA expression, due to RA or activated RARalpha plus RXR ligands, indicating that ERK2 activation is necessary for blr1 mRNA expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 114-118 11099490-4 2001 ONOO- stimulation of Erk activity was accompanied by activation of Ras, Raf-1 and MEK (mitogen-activated protein kinase kinase), and was sensitive to the MEK inhibitor PD 98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 168-176 mitogen-activated protein kinase 1 Homo sapiens 21-24 11134248-10 2001 The p38-MAPK inhibitor (SB202190) and the ERK inhibitor (PD98059) diminished PR3-ANCA-mediated superoxide production dose dependently (11.6 +/- 1.7 nmol O(2)(-) to 1.9 +/- 0.6 with 50 microM SB202190 and 4.0 +/- 0.6 with 50 microM PD098059, respectively). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 57-64 mitogen-activated protein kinase 1 Homo sapiens 42-45 11134248-10 2001 The p38-MAPK inhibitor (SB202190) and the ERK inhibitor (PD98059) diminished PR3-ANCA-mediated superoxide production dose dependently (11.6 +/- 1.7 nmol O(2)(-) to 1.9 +/- 0.6 with 50 microM SB202190 and 4.0 +/- 0.6 with 50 microM PD098059, respectively). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 231-239 mitogen-activated protein kinase 1 Homo sapiens 42-45 11147816-7 2001 Finally, mechanistic studies to examine the mechanism by which alpha1-antitrypsin acts, showed that alpha1-antitrypsin induced the rapid activation of p42MAPK and p44MAPK (also known as ERK1/2) and that the specific MEK1 inhibitor PD98059 totally blocked alpha1-antitrypsin"s mitogenic effects. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 231-238 mitogen-activated protein kinase 1 Homo sapiens 151-158 11005808-5 2000 A MEK-specific inhibitor, PD98059, inhibited heat shock ERK MAPK activation by >75%. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 26-33 mitogen-activated protein kinase 1 Homo sapiens 56-59 11005808-5 2000 A MEK-specific inhibitor, PD98059, inhibited heat shock ERK MAPK activation by >75%. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 26-33 mitogen-activated protein kinase 1 Homo sapiens 60-64 11005808-10 2000 Inhibiting ERK MAPK activation during heat shock with PD98059 enhanced losses in cell viability. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 54-61 mitogen-activated protein kinase 1 Homo sapiens 11-14 11005808-10 2000 Inhibiting ERK MAPK activation during heat shock with PD98059 enhanced losses in cell viability. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 54-61 mitogen-activated protein kinase 1 Homo sapiens 15-19 11120854-7 2000 The fMLP-induced chemokine production was blocked by pertussis toxin, PD98059, and cyclosporin A, which respectively inhibit G(i)alpha activation, mitgen-activated protein kinase kinase-mediated ERK phosphorylation, and calcineurin-mediated activation of NFAT. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 70-77 mitogen-activated protein kinase 1 Homo sapiens 195-198 11228049-8 2000 PD98059 inhibited activation of Erk and LY294002 repressed activation of Akt in response to IGF-I, but did not affect tyrosine phosphorylation of the IGF-IR, IRS-1, IRS-2, or Shc. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 32-35 11170260-5 2000 In addition, inhibition of cisplatin-induced ERK activation, using the MAP/ERK kinase 1 synthetic inhibitor PD98059, resulted in enhanced sensitivity to cisplatin in all three cell lines. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 108-115 mitogen-activated protein kinase 1 Homo sapiens 45-48 11170260-5 2000 In addition, inhibition of cisplatin-induced ERK activation, using the MAP/ERK kinase 1 synthetic inhibitor PD98059, resulted in enhanced sensitivity to cisplatin in all three cell lines. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 108-115 mitogen-activated protein kinase 1 Homo sapiens 75-78 11053056-5 2000 Suppression of ERK by PD098059 abrogated induction of c-fos and c-jun, and the p38 MAP kinase inhibitor SB203580 attenuated c-fos expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 22-30 mitogen-activated protein kinase 1 Homo sapiens 15-18 11085518-4 2000 Whereas the phosphorylation of BAD at Ser-136 was blocked by treatment with wortmannin, its phosphorylation at Ser-112 was blocked by a MAP/ERK kinase inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 162-169 mitogen-activated protein kinase 1 Homo sapiens 140-143 11089552-4 2000 In DCT cells, PTH stimulates phosphorylation of ERK2 and activation of ERK2 kinase and is blocked by the MEK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 119-126 mitogen-activated protein kinase 1 Homo sapiens 71-75 11089552-7 2000 PD98059 abolished the increase of intracellular calcium induced by PTH demonstrating that ERK2 activation is directly involved in the increase of intracellular calcium activated by PTH in the DCT. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 90-94 11089552-10 2000 However, this effect is not involved in the transient rise of intracellular calcium because PD98059 did not inhibit the PTH-stimulated rise of intracellular calcium but abolished ERK2 activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 92-99 mitogen-activated protein kinase 1 Homo sapiens 179-183 11053253-5 2000 Palmitate-induced apoptosis of astrocytes was prevented by L-cycloserine and fumonisin B1, two inhibitors of ceramide synthesis de novo, and by PD098059, an inhibitor of the extracellular signal-regulated kinase (ERK) cascade. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 144-152 mitogen-activated protein kinase 1 Homo sapiens 174-211 11053253-5 2000 Palmitate-induced apoptosis of astrocytes was prevented by L-cycloserine and fumonisin B1, two inhibitors of ceramide synthesis de novo, and by PD098059, an inhibitor of the extracellular signal-regulated kinase (ERK) cascade. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 144-152 mitogen-activated protein kinase 1 Homo sapiens 213-216 11000134-10 2000 The mitogen-activated protein kinase-1 inhibitor PD-98059 enhanced DNA fragmentation, suggesting that increased ERK1 activity is a result but not a cause of apoptosis in adenosine-treated ECs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 49-57 mitogen-activated protein kinase 1 Homo sapiens 4-38 11050045-7 2000 Moreover, the MAPK/ERK activation by HCV core protein was blocked in the presence of the specific MEK1 inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 114-121 mitogen-activated protein kinase 1 Homo sapiens 14-18 11050045-7 2000 Moreover, the MAPK/ERK activation by HCV core protein was blocked in the presence of the specific MEK1 inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 114-121 mitogen-activated protein kinase 1 Homo sapiens 19-22 11057428-8 2000 The contribution of ERK to cell growth was supported by the observation that addition of PD98059, a specific inhibitor of MAPK kinase, significantly attenuated the increase in endothelial cell numbers induced by HGF, in a dose-dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 89-96 mitogen-activated protein kinase 1 Homo sapiens 20-23 11057428-8 2000 The contribution of ERK to cell growth was supported by the observation that addition of PD98059, a specific inhibitor of MAPK kinase, significantly attenuated the increase in endothelial cell numbers induced by HGF, in a dose-dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 89-96 mitogen-activated protein kinase 1 Homo sapiens 122-126 10862759-5 2000 AP-1 binding was dependent on ERK activation, since the MEK-1 (mitogen-activated protein kinase kinase) inhibitor PD98059 inhibited TGF-beta1-induced binding. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 114-121 mitogen-activated protein kinase 1 Homo sapiens 30-33 11279537-3 2000 Cytosolic PLA2 activation was controlled by the MAPK pathway as indicated by the ability of the specific MEK inhibitor, PD098059, to abolish cPLA2 activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 120-128 mitogen-activated protein kinase 1 Homo sapiens 48-52 10993784-6 2000 However, 50 microM PD-98059, a MAPK/ERK kinase-MAPK kinase blocker, reduced MAPK phosphorylation below resting levels, even though the magnitude of the isometric tension development was unaltered. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-27 mitogen-activated protein kinase 1 Homo sapiens 36-39 10981855-5 2000 PD98059, which inhibited ERK activity, attenuated cardiac-specific gene expression in a dose-dependent manner, but had no influence on protein synthesis or cell size. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 25-28 11164895-11 2000 Treatment of Jurkat cells with the MEK inhibitor PD98059 blocked ionomycin-induced ERK activation, but not the shift in the mobility of p56(Lck). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 49-56 mitogen-activated protein kinase 1 Homo sapiens 83-86 10955916-6 2000 PD098059 (25 microM), an inhibitor of MAPK kinase (MEK 1/2), blocked the bFGF mitogenic effects, but did not affect the 8-bromo-cAMP-induced mitogenic effects in MDCKEI1 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-8 mitogen-activated protein kinase 1 Homo sapiens 38-42 10891386-5 2000 We have found that pretreatment with PD98059, which selectively blocks the activity of ERK pathway at the level of MAPK kinase, decreased Ang II-induced AP-1 activation and that TRO is capable of inhibiting Ang II-induced AP-1 activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 37-44 mitogen-activated protein kinase 1 Homo sapiens 87-90 10898713-7 2000 H(2)O(2) mediates changes in ERK1/ERK2 phosphorylation, increases endothelial solute permeability, and alters occludin localization and phosphorylation were all blocked by PD-98059, a specific mitogen-activated protein (MAP) or ERK kinase 1 inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 172-180 mitogen-activated protein kinase 1 Homo sapiens 34-38 10930980-7 2000 In contrast, treatment of ECFCs with PD98059, a specific inhibitor of MAP kinase/ERK kinase (MEK), inhibited cell growth but had no effect on the antiapoptotic activity of either SCF or EPO, suggesting that SCF and EPO prevent apoptosis of human ECFCs independent of the extracellular signal-regulated kinase (ERK) pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 37-44 mitogen-activated protein kinase 1 Homo sapiens 271-308 10930980-7 2000 In contrast, treatment of ECFCs with PD98059, a specific inhibitor of MAP kinase/ERK kinase (MEK), inhibited cell growth but had no effect on the antiapoptotic activity of either SCF or EPO, suggesting that SCF and EPO prevent apoptosis of human ECFCs independent of the extracellular signal-regulated kinase (ERK) pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 37-44 mitogen-activated protein kinase 1 Homo sapiens 81-84 10874022-8 2000 PD98059, an inhibitor of ERK upstream activators MAPK kinase (MKK) 1 and MKK2, greatly enhanced cytotoxicity and apoptosis in cells treated with low Cd doses. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 25-28 10949153-2 2000 Using PD98059, an inhibitor of the ERK-kinase MEK1, we have here assessed the effects of ERK inhibition on the pattern of protein expression in the metastatic human breast cancer cell line MDA-MB-231. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 6-13 mitogen-activated protein kinase 1 Homo sapiens 35-38 10918570-6 2000 HT1080 cells have one activated allele of N-ras and PD98059 inhibition of signaling from Ras through ERK increased fibronectin matrix accumulation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 52-59 mitogen-activated protein kinase 1 Homo sapiens 101-104 10871844-5 2000 Preincubation of serum-starved cells with MEK-1 inhibitor PD98059 abolished EGF- and FCS-induced MAPK activation, identifying MEK as the upstream activator of MAPK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 mitogen-activated protein kinase 1 Homo sapiens 97-101 10843677-6 2000 Treatment of NK cells with a specific inhibitor of MKK1/2, PD98059, during the IL-2 stimulation blocked in a dose-dependent manner each of four sequelae, with inhibition of lymphokine-activated killing induction being least sensitive to MKK/ERK pathway blockade. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 59-66 mitogen-activated protein kinase 1 Homo sapiens 241-244 10871844-5 2000 Preincubation of serum-starved cells with MEK-1 inhibitor PD98059 abolished EGF- and FCS-induced MAPK activation, identifying MEK as the upstream activator of MAPK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 mitogen-activated protein kinase 1 Homo sapiens 159-163 10929041-9 2000 To ensure that ERK activation was unnecessary for pVWF-dependent platelet activation, we functionally inhibited ERK-dependent signalling with PD98059, a potent and selective inhibitor of the MAP kinase kinase (MEK-1), which is the upstream kinase of ERK1 and ERK2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 142-149 mitogen-activated protein kinase 1 Homo sapiens 112-115 10828072-7 2000 PD098059, a specific inhibitor of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase inhibited ERK activities but had no significant effect on eIF4E phosphorylation induced by H(2)O(2). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-8 mitogen-activated protein kinase 1 Homo sapiens 68-72 10828072-7 2000 PD098059, a specific inhibitor of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase inhibited ERK activities but had no significant effect on eIF4E phosphorylation induced by H(2)O(2). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-8 mitogen-activated protein kinase 1 Homo sapiens 113-116 10828072-7 2000 PD098059, a specific inhibitor of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase inhibited ERK activities but had no significant effect on eIF4E phosphorylation induced by H(2)O(2). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-8 mitogen-activated protein kinase 1 Homo sapiens 135-138 10929041-9 2000 To ensure that ERK activation was unnecessary for pVWF-dependent platelet activation, we functionally inhibited ERK-dependent signalling with PD98059, a potent and selective inhibitor of the MAP kinase kinase (MEK-1), which is the upstream kinase of ERK1 and ERK2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 142-149 mitogen-activated protein kinase 1 Homo sapiens 259-263 10833473-6 2000 Inhibition of ERK activation with the MEK inhibitor PD98059 blocked IL-17 as well as basal development of tight junctions in T84 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 52-59 mitogen-activated protein kinase 1 Homo sapiens 14-17 10781688-6 2000 K562 cells had a much higher basal activity of ERK/MAPK than other apoptosis-sensitive cell lines, which were very susceptible to apoptosis induced by low dose of PD98059 compared with K562 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 163-170 mitogen-activated protein kinase 1 Homo sapiens 47-50 10781688-6 2000 K562 cells had a much higher basal activity of ERK/MAPK than other apoptosis-sensitive cell lines, which were very susceptible to apoptosis induced by low dose of PD98059 compared with K562 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 163-170 mitogen-activated protein kinase 1 Homo sapiens 51-55 10781688-7 2000 In HL-60 cells, sorbitol-induced apoptosis was prevented by the treatment of phorbol myristate 13-acetate (PMA), which activates the ERK/MAPK pathway, and this was blocked by PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 175-182 mitogen-activated protein kinase 1 Homo sapiens 133-136 10781688-7 2000 In HL-60 cells, sorbitol-induced apoptosis was prevented by the treatment of phorbol myristate 13-acetate (PMA), which activates the ERK/MAPK pathway, and this was blocked by PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 175-182 mitogen-activated protein kinase 1 Homo sapiens 137-141 10872747-5 2000 Pre-treatment of the cells with PD98059, a selective ERK pathway inhibitor, and SB203580, a p38 MAPK inhibitor, blocked the induction of HO-1 by the NO donor in a dose-dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 53-56 10781373-11 2000 PD98059 inhibited the ERK pathway specifically. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 22-25 10753954-4 2000 Addition of a selective inhibitor of ERK phosphorylation (PD98059) prevented the subsequent phosphorylation of p70(S6k) and the increase in p21 protein. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 mitogen-activated protein kinase 1 Homo sapiens 37-40 10733912-3 2000 The PD98059 MEK inhibitor was used to block the ERK pathway and SB203580 inhibitor to block the p38 pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 4-11 mitogen-activated protein kinase 1 Homo sapiens 48-51 10751321-5 2000 Inhibiting ERK MAP kinase activation with 50 microM PD-98059 blocked agonist-induced caldesmon phosphorylation completely. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 52-60 mitogen-activated protein kinase 1 Homo sapiens 11-14 10760794-5 2000 To further examine the role of ERK in negative selection we used the MEK-1 inhitibor, PD98059, a specific pharmacological inhibitor of the ERK pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 86-93 mitogen-activated protein kinase 1 Homo sapiens 139-142 10760794-6 2000 Biochemical data demonstrated a reduction of ERK activity by PD98059 in the presence of the negatively selecting ligand. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 61-68 mitogen-activated protein kinase 1 Homo sapiens 45-48 10852350-5 2000 PD98059 was used to inhibit MEK and consequently ERK2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 49-53 10852350-11 2000 But PD98059 eliminated detectable ERK2 activation, as well as inhibited RAF phosphorylation, in untreated and retinoic acid-treated wild-type HL-60 and cFMS transfectants, consistent with MEK or ERK feedback-regulation of RAF, in all four cases. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 4-11 mitogen-activated protein kinase 1 Homo sapiens 34-38 10852350-11 2000 But PD98059 eliminated detectable ERK2 activation, as well as inhibited RAF phosphorylation, in untreated and retinoic acid-treated wild-type HL-60 and cFMS transfectants, consistent with MEK or ERK feedback-regulation of RAF, in all four cases. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 4-11 mitogen-activated protein kinase 1 Homo sapiens 34-37 10747006-6 2000 Myocytes treated with PD98059, a MAPK/ERK kinase (MEK1/MEK2) inhibitor, displayed a suppression of I/R-induced ERK activation, whereas p38 and JNK activities were increased by 70.3% and 55.0%, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 22-29 mitogen-activated protein kinase 1 Homo sapiens 33-37 10722727-6 2000 The protective effects of Ras(Val-12)T35S against cytosine arabinoside were completely abolished by the ERK pathway inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 126-133 mitogen-activated protein kinase 1 Homo sapiens 104-107 10781688-4 2000 However, apoptosis was induced by the treatment of PD98059, a specific inhibitor of MEK (MAPK or ERK kinase), not by the treatment of sorbitol, a strong activator of SAPK and p38 kinase. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 51-58 mitogen-activated protein kinase 1 Homo sapiens 89-93 10781688-4 2000 However, apoptosis was induced by the treatment of PD98059, a specific inhibitor of MEK (MAPK or ERK kinase), not by the treatment of sorbitol, a strong activator of SAPK and p38 kinase. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 51-58 mitogen-activated protein kinase 1 Homo sapiens 97-100 10748108-7 2000 Inhibition of ERK by the mitogen-activated protein kinase/ERK kinase inhibitor PD 98059 or by expression of a dominant negative mutant ERK suppressed AP-1 activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 79-87 mitogen-activated protein kinase 1 Homo sapiens 14-17 10794715-6 2000 S1P-induced DNA synthesis and ERK activation were inhibited by PD98059, an ERK kinase inhibitor, but not by SB203580, a p38 MAP kinase inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 63-70 mitogen-activated protein kinase 1 Homo sapiens 30-33 10794715-6 2000 S1P-induced DNA synthesis and ERK activation were inhibited by PD98059, an ERK kinase inhibitor, but not by SB203580, a p38 MAP kinase inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 63-70 mitogen-activated protein kinase 1 Homo sapiens 75-78 10754327-10 2000 GM-CSF-dependent inhibition of apoptosis was significantly attenuated by PD98059, an ERK pathway inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 73-80 mitogen-activated protein kinase 1 Homo sapiens 85-88 10753897-7 2000 The biological relevance of ERK activation to IL-5 priming is supported by the observation that inhibition of ERK activity by treatment with the MEK inhibitors PD98059 or U0126 inhibited the release of leukotriene C(4) stimulated by fMet-Leu-Phe in IL-5-primed eosinophils. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 160-167 mitogen-activated protein kinase 1 Homo sapiens 28-31 10753897-7 2000 The biological relevance of ERK activation to IL-5 priming is supported by the observation that inhibition of ERK activity by treatment with the MEK inhibitors PD98059 or U0126 inhibited the release of leukotriene C(4) stimulated by fMet-Leu-Phe in IL-5-primed eosinophils. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 160-167 mitogen-activated protein kinase 1 Homo sapiens 110-113 10764628-10 2000 Apoptosis induction by satratoxin G and vomitoxin was markedly enhanced when ERK activation was selectively inhibited by ERK-specific inhibitor PD98059, thus indicating a negative role for ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 144-151 mitogen-activated protein kinase 1 Homo sapiens 77-80 10764628-10 2000 Apoptosis induction by satratoxin G and vomitoxin was markedly enhanced when ERK activation was selectively inhibited by ERK-specific inhibitor PD98059, thus indicating a negative role for ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 144-151 mitogen-activated protein kinase 1 Homo sapiens 121-124 10764628-10 2000 Apoptosis induction by satratoxin G and vomitoxin was markedly enhanced when ERK activation was selectively inhibited by ERK-specific inhibitor PD98059, thus indicating a negative role for ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 144-151 mitogen-activated protein kinase 1 Homo sapiens 121-124 10733514-6 2000 The MAPK kinase (MEK) inhibitor PD098059 inhibited phagocytosis, MLCK activity, and ERK2 activity by 80% to 90%. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-40 mitogen-activated protein kinase 1 Homo sapiens 84-88 10746662-9 2000 Conversely, blockade of the MEK-ERK pathway with PD98059 completely blocked PDGF-stimulated cell growth, indicating that activation of the MEK-ERK pathway is required for PDGF-stimulated thecal cell growth. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 49-56 mitogen-activated protein kinase 1 Homo sapiens 32-35 10746662-10 2000 Additionally, the MEK inhibitor PD98059 restored LH-stimulated steroid secretion, demonstrating that activation of the MEK-ERK pathway can lead to inhibition of LH-stimulated steroid secretion. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 123-126 10776691-9 2000 PD98059, an inhibitor of MAPKinase kinase (MEK) which activates MAPKinase, inhibited this transient ERK phosphorylation but was unable to block maturation as measured by acquisition of CD15 in samples from 12 patients with low starting numbers of CD15-positive cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 100-103 10734116-6 2000 Inhibition of ERK activation by PD98059, a specific inhibitor of the ERK signaling pathway, blocked the osteogenic differentiation in a dose-dependent manner, as did transfection with a dominant negative form of MAP kinase kinase (MEK-1). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 14-17 10734116-6 2000 Inhibition of ERK activation by PD98059, a specific inhibitor of the ERK signaling pathway, blocked the osteogenic differentiation in a dose-dependent manner, as did transfection with a dominant negative form of MAP kinase kinase (MEK-1). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 69-72 10702288-5 2000 Moreover, abolition of ERK function by the inhibitor PD98059 or by a dominant inhibitory mutant ERK2 had no significant effects on proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 53-60 mitogen-activated protein kinase 1 Homo sapiens 23-26 10712238-4 2000 Pretreatment of THP-1 cells with PD-98059, an inhibitor of the ERK-kinase cascade, abolished bufalin-induced c-fos and IL-1 beta gene expressions, indicating that the ERK-kinase cascade mediates the induction of inflammatory cytokines by bufalin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-41 mitogen-activated protein kinase 1 Homo sapiens 63-66 10712238-4 2000 Pretreatment of THP-1 cells with PD-98059, an inhibitor of the ERK-kinase cascade, abolished bufalin-induced c-fos and IL-1 beta gene expressions, indicating that the ERK-kinase cascade mediates the induction of inflammatory cytokines by bufalin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-41 mitogen-activated protein kinase 1 Homo sapiens 167-170 10745275-2 2000 Here we demonstrate for the first time that inhibition of the ECM-induced Erk 1/Erk 2 (p42/44 MAPK) pathway, by PD 98059, leads to apoptosis in these cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 112-120 mitogen-activated protein kinase 1 Homo sapiens 80-85 10677388-9 2000 These effects on cell proliferation and ERK activity were inhibited by PD98059, and were not reproduced by ovalbumin or mannitol. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 71-78 mitogen-activated protein kinase 1 Homo sapiens 40-43 10929041-10 2000 Although PD98059 inhibited ERK2 activation in platelets, it had no effect on pVWF- or thrombin-induced platelet alpha or lysozomal granule release, modulation of membrane glycoprotein CD41, microparticle formation, platelet shape change or platelet agglutination. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 9-16 mitogen-activated protein kinase 1 Homo sapiens 27-31 10644690-5 2000 NR6 fibroblasts expressing full-length wild type epidermal growth factor receptor required both calpain and ERK activation, as demonstrated by pharmacological inhibitors (calpeptin and calpain inhibitor I and PD98059, respectively) for EGF-induced deadhesion and motility. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 209-216 mitogen-activated protein kinase 1 Homo sapiens 108-111 10688043-8 2000 Inhibition of EGF- and LPA- induced ERK activation with the EGF receptor inhibitor, AG1478, or the MEK inhibitor, PD98059, attenuated their proliferative effects. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 114-121 mitogen-activated protein kinase 1 Homo sapiens 36-39 10674496-3 2000 We also demonstrate that TNF-alpha-induced over-expression of GFAP was significantly attenuated by the MAPK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 118-125 mitogen-activated protein kinase 1 Homo sapiens 103-107 10625698-6 2000 Contraction-stimulated phosphorylation of ERK1/2 and p38(MAPK) was completely inhibited by pretreatment with PD98059 (MAPK kinase inhibitor) and SB203580 (p38(MAPK) inhibitor), respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 109-116 mitogen-activated protein kinase 1 Homo sapiens 53-56 10625622-8 2000 PD98059, an inhibitor of extracellular signal-regulated kinase (ERK) kinase, suppressed NF-kappaB transcriptional activity and SMC proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 25-62 10625622-8 2000 PD98059, an inhibitor of extracellular signal-regulated kinase (ERK) kinase, suppressed NF-kappaB transcriptional activity and SMC proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 64-67 10625698-8 2000 Use of PD98059 or SB203580 revealed that stimulation of p90(Rsk) and MAPKAP-K2 most closely reflects ERK and p38(MAPK) stimulation, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 7-14 mitogen-activated protein kinase 1 Homo sapiens 109-112 10637132-7 2000 Inhibition of Erk activation with PD98059 only partially inhibited c-fos induction, indicating that additional pathways are involved. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 34-41 mitogen-activated protein kinase 1 Homo sapiens 14-17 10667594-10 2000 In contrast, inhibition of ERK activation via a pharmacological approach using a mitogen-activated protein kinase/ERK kinase-specific inhibitor 2-(2"-amino-3"-methoxyphenyl)-oxanaphthalen-4-one is unable to reverse the Ras-induced transformed morphology and c-Jun/AP-1 induction. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 144-193 mitogen-activated protein kinase 1 Homo sapiens 27-30 10645003-6 2000 IFN-gamma also rapidly and transiently activates extracellular signal-regulated kinase 1,2 (ERK1,2) and blocking ERK1,2 pathway (Raf/MEK1,2/ERK1,2) by specific MEK1,2 inhibitor PD98059 partially (by 50%) prevents Ser-727 phosphorylation of STAT1 and suppression of MMP-13 expression by IFN-gamma. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 177-184 mitogen-activated protein kinase 1 Homo sapiens 49-90 10642296-5 2000 Activation of the promoter was inhibited approximately 45% by SB-203580, a p38 MAPK inhibitor, and approximately 70% by PD98059, an inhibitor of the ERK-activating kinase MAPK kinase. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 120-127 mitogen-activated protein kinase 1 Homo sapiens 149-152 10591631-6 2000 Inhibitors of ERK activation, including PD098059 and dominant-negative MEK1, also decreased the migration of LRP-deficient but not control cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 40-48 mitogen-activated protein kinase 1 Homo sapiens 14-17 10617147-3 2000 Exposure of these cells to the MAPK kinase 1 inhibitor PD98059 not only prevented MAPK activation but also inhibited homologous desensitization of the mu-opioid receptor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 55-62 mitogen-activated protein kinase 1 Homo sapiens 31-35 10617147-3 2000 Exposure of these cells to the MAPK kinase 1 inhibitor PD98059 not only prevented MAPK activation but also inhibited homologous desensitization of the mu-opioid receptor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 55-62 mitogen-activated protein kinase 1 Homo sapiens 82-86 10617147-9 2000 U0126, another chemically unrelated inhibitor of the MAPK cascade, mimicked the effect of PD98059 on mu-receptor phosphorylation and desensitization. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 90-97 mitogen-activated protein kinase 1 Homo sapiens 53-57 10702314-6 2000 The use of PD98059, which specifically blocks ERK 1 and 2 activation, demonstrated that ERK activity was necessary for macrophage proliferation in response to these factors. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 11-18 mitogen-activated protein kinase 1 Homo sapiens 46-49 10702314-8 2000 Moreover, PD98059 inhibited the expression of cytokines induced by LPS or PC-PLC, thus suggesting that ERK activity is also required for macrophage activation by these two agents. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 10-17 mitogen-activated protein kinase 1 Homo sapiens 103-106 10601276-4 1999 Inhibition of the MAPK activation by PD98059, however, did not affect IGF-I-stimulated IGFBP-5 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 37-44 mitogen-activated protein kinase 1 Homo sapiens 18-22 10602506-4 1999 Treating the cells with p38 inhibitor SB202190 inhibited p38 activation, but not ERK; treating the cells with MEK-1 inhibitor PD98059 inhibited ERK activation without suppressing p38 activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 126-133 mitogen-activated protein kinase 1 Homo sapiens 144-147 10586030-6 1999 However, studies using inhibitors selective for ERK (PD98059) and p38 (SB203580) show that while p38 plays an essential role in the induction of inducible NO synthase, ERK MAP kinases play only a minor role in promoting NO generation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 53-60 mitogen-activated protein kinase 1 Homo sapiens 48-51 10586114-2 1999 The IL-3- and IL-1-mediated proliferation were both inhibited by the specific p38 and MEK1 inhibitors SB203580 and PD98059, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 115-122 mitogen-activated protein kinase 1 Homo sapiens 78-81 10543994-6 1999 Inhibition of the transient ERK activation by MEK inhibitor PD098059 attenuated the H(2)O(2)-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 60-68 mitogen-activated protein kinase 1 Homo sapiens 28-31 10565839-4 1999 ERK activation by 100 nM NPY was abolished by the Y(1) NPY receptor antagonist BIBP 3226 (1 microM), pertussis toxin treatment (100 ng ml(-1) overnight), the mitogen-activated protein kinase (MAPK) kinase inhibitor PD 98059 (100 microM), and the phosphatidylinositol-3-kinase inhibitor wortmannin (100 nM). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 215-223 mitogen-activated protein kinase 1 Homo sapiens 0-3 10597313-4 1999 Restoration of Par-4 levels by abrogation of the Raf-MEK-ERK pathway with the MEK-inhibitor PD98059 or by ectopic Par-4, that acted to inhibit ERK expression and activation, was sufficient to suppress oncogenic Ras-induced transformation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 92-99 mitogen-activated protein kinase 1 Homo sapiens 57-60 10543994-7 1999 In contrast, inactivation of the constitutive ERK by PD098059 induced morphologic and biochemical features of apoptosis under the unstimulated, basal culture condition. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 53-61 mitogen-activated protein kinase 1 Homo sapiens 46-49 10531416-5 1999 The ERK kinase inhibitor PD98059 (3-30 microM) attenuated thrombin-stimulated ERK phosphorylation and activity and the increase in cyclin D1 protein levels, as did albuterol (1-100 nM) or 8-bromo-cAMP (300 microM). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 25-32 mitogen-activated protein kinase 1 Homo sapiens 4-7 10531416-5 1999 The ERK kinase inhibitor PD98059 (3-30 microM) attenuated thrombin-stimulated ERK phosphorylation and activity and the increase in cyclin D1 protein levels, as did albuterol (1-100 nM) or 8-bromo-cAMP (300 microM). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 25-32 mitogen-activated protein kinase 1 Homo sapiens 78-81 10525543-14 1999 Inhibition of ERK activity by (a) the MAP kinase kinase (MEK) inhibitor, PD98059, (b) antisense oligonucleotide depletion of ERK, and (c) expression of mitogen-activated protein (MAP) kinase phosphatase-1 in SMC all led to increased migration to collagen, 4N1K, or 4N1K plus collagen. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 73-80 mitogen-activated protein kinase 1 Homo sapiens 14-17 10547071-9 1999 The effect of OM on p53 expression seems to be mediated through the extracellular signal-regulated kinase (ERK) pathway, inasmuch as the inhibition of ERK activation with a specific inhibitor (PD98059) to the ERK upstream kinase mitogen/extracellular-regulated protein kinase kinase abrogated the OM inhibitory activity on p53 expression in a dose-dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 193-200 mitogen-activated protein kinase 1 Homo sapiens 68-105 10547071-9 1999 The effect of OM on p53 expression seems to be mediated through the extracellular signal-regulated kinase (ERK) pathway, inasmuch as the inhibition of ERK activation with a specific inhibitor (PD98059) to the ERK upstream kinase mitogen/extracellular-regulated protein kinase kinase abrogated the OM inhibitory activity on p53 expression in a dose-dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 193-200 mitogen-activated protein kinase 1 Homo sapiens 107-110 10547071-9 1999 The effect of OM on p53 expression seems to be mediated through the extracellular signal-regulated kinase (ERK) pathway, inasmuch as the inhibition of ERK activation with a specific inhibitor (PD98059) to the ERK upstream kinase mitogen/extracellular-regulated protein kinase kinase abrogated the OM inhibitory activity on p53 expression in a dose-dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 193-200 mitogen-activated protein kinase 1 Homo sapiens 151-154 10547071-9 1999 The effect of OM on p53 expression seems to be mediated through the extracellular signal-regulated kinase (ERK) pathway, inasmuch as the inhibition of ERK activation with a specific inhibitor (PD98059) to the ERK upstream kinase mitogen/extracellular-regulated protein kinase kinase abrogated the OM inhibitory activity on p53 expression in a dose-dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 193-200 mitogen-activated protein kinase 1 Homo sapiens 151-154 10490955-9 1999 This TSP1 peptide-dependent activation of AP-1 was inhibited by both heparin and the MAP/ERK kinase inhibitor PD98059, providing a functional link between adhesion molecule interaction and nuclear transactivation events via the MAP kinase pathways. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 110-117 mitogen-activated protein kinase 1 Homo sapiens 89-92 10484389-8 1999 Addition of PD-98059 during differentiation interfered with sustained activation of p42 MAPK and sucrase-isomaltase expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 12-20 mitogen-activated protein kinase 1 Homo sapiens 84-92 10628325-2 1999 Activation of JNK by anisomycin, the inhibition of ERK activation by PD098059 or a blockage of the PI3-K/Akt pathway by wortmannin or LY294002 alone, was not sufficient for the induction of apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 69-77 mitogen-activated protein kinase 1 Homo sapiens 51-54 10446204-4 1999 A marked increase was observed in the phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1 and ERK2) 10 min after sst(4) receptor activation, which was blocked by pertussis toxin, decreased by PP1 and the betagamma-sequestrant, but unaffected by PD 98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 264-272 mitogen-activated protein kinase 1 Homo sapiens 57-102 10446204-4 1999 A marked increase was observed in the phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1 and ERK2) 10 min after sst(4) receptor activation, which was blocked by pertussis toxin, decreased by PP1 and the betagamma-sequestrant, but unaffected by PD 98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 264-272 mitogen-activated protein kinase 1 Homo sapiens 113-117 10446204-5 1999 In contrast, the somatostatin-induced phosphorylation of ERK obtained at 4 h, although sensitive to both pertussis toxin and transducin, was unaffected by PP1 but ablated by PD 98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 174-182 mitogen-activated protein kinase 1 Homo sapiens 57-60 10601295-8 1999 Treatment of gingival fibroblasts with TGF-beta1 activated two distinct mitogen-activated protein kinases (MAPKs): extracellular signal-regulated kinase 1/2 (ERK1/2) in 15 min and p38 MAPK in 1 and 2 h. Induction of MMP-13 expression by TGF-beta1 was blocked by SB203580, a specific inhibitor of p38 MAPK, but not by PD98059, a selective inhibitor of ERK1/2 activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 317-324 mitogen-activated protein kinase 1 Homo sapiens 180-183 10564179-4 1999 Pretreating cells with the mitogen-activated protein kinase kinase inhibitor PD-98059 or U-126 (2 h before IL-1beta treatment) decreased ERK phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 77-85 mitogen-activated protein kinase 1 Homo sapiens 137-140 10537288-11 1999 To examine the role of ERK cascade in the antiproliferative effect of GnRHa, PD98059, an inhibitor of mitogen-activated protein/ERK kinase, was used. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 77-84 mitogen-activated protein kinase 1 Homo sapiens 128-131 10523856-10 1999 The MEK inhibitor PD 098059, as well as the PKC inhibitors, completely blocked TPA-mediated ERK activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-27 mitogen-activated protein kinase 1 Homo sapiens 92-95 10492251-6 1999 Experiments conducted on a prostate cancer cell line demonstrated that EGF induced activation of ERK and cellular proliferation was partially inhibited by PD98059, a chemical inhibitor of the immediate upstream signaling component responsible of activation of ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 155-162 mitogen-activated protein kinase 1 Homo sapiens 97-100 10492251-6 1999 Experiments conducted on a prostate cancer cell line demonstrated that EGF induced activation of ERK and cellular proliferation was partially inhibited by PD98059, a chemical inhibitor of the immediate upstream signaling component responsible of activation of ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 155-162 mitogen-activated protein kinase 1 Homo sapiens 260-263 10488090-5 1999 Inhibition of MAPK kinase with its inhibitor, PD98059, abolished ERK2 activation and impaired the induction of quinone reductase, a phase II detoxifying enzyme, and antioxidant response element (ARE)-linked reporter gene by tBHQ and SUL. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 46-53 mitogen-activated protein kinase 1 Homo sapiens 14-18 10488090-5 1999 Inhibition of MAPK kinase with its inhibitor, PD98059, abolished ERK2 activation and impaired the induction of quinone reductase, a phase II detoxifying enzyme, and antioxidant response element (ARE)-linked reporter gene by tBHQ and SUL. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 46-53 mitogen-activated protein kinase 1 Homo sapiens 65-69 10508274-5 1999 PD98059, a specific inhibitor of mitogen-activated extracellular response kinase kinase (MEK), significantly inhibited ERK2 activation and partially inhibited p38 activation triggered by anti-IgM antibody treatment, but did not affect CD40-dependent signaling events. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 119-123 10508274-5 1999 PD98059, a specific inhibitor of mitogen-activated extracellular response kinase kinase (MEK), significantly inhibited ERK2 activation and partially inhibited p38 activation triggered by anti-IgM antibody treatment, but did not affect CD40-dependent signaling events. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 159-162 10417333-4 1999 (2-Amino-3"-methoxyphenyl)oxanaphthalen-4-one (PD 98059), an inhibitor of extracellular signal-regulated protein kinase (ERK) activation, blocked the serine phosphorylation of STAT3 induced by chemotactic factors or PMA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-55 mitogen-activated protein kinase 1 Homo sapiens 74-119 10417333-4 1999 (2-Amino-3"-methoxyphenyl)oxanaphthalen-4-one (PD 98059), an inhibitor of extracellular signal-regulated protein kinase (ERK) activation, blocked the serine phosphorylation of STAT3 induced by chemotactic factors or PMA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-55 mitogen-activated protein kinase 1 Homo sapiens 121-124 10417144-3 1999 In this study, the relevance of ERK1 and ERK2 activation for LPS-induced TNF-alpha production by primary human monocytes has been addressed with PD-098059, which specifically blocks activation of MAPK kinase (MEK) by Raf-1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 145-154 mitogen-activated protein kinase 1 Homo sapiens 41-45 10417144-9 1999 To show the efficacy of PD-098059 and Ro 09-2210, ERK1 and -2 activation was monitored by Western blotting with an antiserum that recognizes the phosphorylated (i.e., activated) forms of ERK1 and ERK2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 24-33 mitogen-activated protein kinase 1 Homo sapiens 196-200 10417144-11 1999 Activation of ERK2 was blocked by PD-098059 (50 microM), whereas ERK1 seemed to be less affected. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 34-43 mitogen-activated protein kinase 1 Homo sapiens 14-18 10455916-6 1999 This antibody or an inhibitor of ERK activation, PD98059, also blocked endothelial cell migration after the wounding. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 49-56 mitogen-activated protein kinase 1 Homo sapiens 33-36 10385595-5 1999 PD98059 (10 microM), an inhibitor of MEK1 activation, markedly attenuated thrombin stimulation of ERK activity and phosphorylation, DNA synthesis, and cyclin D1 levels. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 98-101 10397677-4 1999 The MAPK kinase (MEK) inhibitor PD98059 blocked bFGF-stimulated MAPK phosphorylation and resulted in both a decrease of c-myc expression and inhibition of bFGF-stimulated DNA synthesis in cSMCs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 4-8 10397677-4 1999 The MAPK kinase (MEK) inhibitor PD98059 blocked bFGF-stimulated MAPK phosphorylation and resulted in both a decrease of c-myc expression and inhibition of bFGF-stimulated DNA synthesis in cSMCs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 64-68 10419063-8 1999 ERK activation was determined by Western blot in the absence and presence of PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 77-84 mitogen-activated protein kinase 1 Homo sapiens 0-3 10419063-13 1999 PD98059 inhibited Ang II-stimulated ERK activity and abrogated agonist-induced DNA and protein synthesis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 36-39 10400419-8 1999 In contrast, PD98059, a specific inhibitor of the ERK pathway, counteracted the suppressive effects of SB203580 and IL-1 on the apoptotic process indicating that the protective effect of SB203580 and IL-1 might be the result of a shift in the balance between the ERK1/2 and p38/JNK route. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 274-277 10410306-3 1999 When the K562 cells were treated with herbimycin A (an inhibitor of protein tyrosine kinase), ras antisense oligonucleotide, and PD98059 (a specific inhibitor of MEK), inhibition of ERK/MAPK activity and cell growth, and induction of erythroid differentiation were observed. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 129-136 mitogen-activated protein kinase 1 Homo sapiens 182-185 10410306-7 1999 At low concentration of PD98059, which inhibited the elevated activity of ERK/MAPK to the level of parental cells, the growth rate increased and the erythroid differentiation decreased slightly, and at high concentration of PD98059, which inhibited the elevated activity of ERK/MAPK below that of the parental cells, the growth rate turned down and the erythroid differentiation was restored to the untreated control level. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 24-31 mitogen-activated protein kinase 1 Homo sapiens 74-77 10410306-7 1999 At low concentration of PD98059, which inhibited the elevated activity of ERK/MAPK to the level of parental cells, the growth rate increased and the erythroid differentiation decreased slightly, and at high concentration of PD98059, which inhibited the elevated activity of ERK/MAPK below that of the parental cells, the growth rate turned down and the erythroid differentiation was restored to the untreated control level. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 24-31 mitogen-activated protein kinase 1 Homo sapiens 274-277 10410306-7 1999 At low concentration of PD98059, which inhibited the elevated activity of ERK/MAPK to the level of parental cells, the growth rate increased and the erythroid differentiation decreased slightly, and at high concentration of PD98059, which inhibited the elevated activity of ERK/MAPK below that of the parental cells, the growth rate turned down and the erythroid differentiation was restored to the untreated control level. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 224-231 mitogen-activated protein kinase 1 Homo sapiens 74-77 10383151-4 1999 In contrast, apoptosis was not induced when the cells were treated with: (a) rapamycin, an inhibitor of the ribosomal S6 kinase pp70S6K, which acts downstream of PI3K; (b) PD98059, a specific inhibitor of the extracellular signal-regulated kinase/mitogen-activated protein kinase (Erk/MAPK) kinase (MEK); or (c) the antiandrogen, Casodex; or when the cells were cultured under androgen-depleted conditions. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 172-179 mitogen-activated protein kinase 1 Homo sapiens 281-284 10383151-4 1999 In contrast, apoptosis was not induced when the cells were treated with: (a) rapamycin, an inhibitor of the ribosomal S6 kinase pp70S6K, which acts downstream of PI3K; (b) PD98059, a specific inhibitor of the extracellular signal-regulated kinase/mitogen-activated protein kinase (Erk/MAPK) kinase (MEK); or (c) the antiandrogen, Casodex; or when the cells were cultured under androgen-depleted conditions. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 172-179 mitogen-activated protein kinase 1 Homo sapiens 285-289 10378896-7 1999 Superoxide release stimulated by FMLP was inhibited partially by PD98059 or SB203580, a specific inhibitor of ERK or p38 pathway, and was almost completely inhibited by the combination of both inhibitors, whereas PMA-induced superoxide release was resistant to these two inhibitors in monocytes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 65-72 mitogen-activated protein kinase 1 Homo sapiens 110-113 10378896-7 1999 Superoxide release stimulated by FMLP was inhibited partially by PD98059 or SB203580, a specific inhibitor of ERK or p38 pathway, and was almost completely inhibited by the combination of both inhibitors, whereas PMA-induced superoxide release was resistant to these two inhibitors in monocytes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 65-72 mitogen-activated protein kinase 1 Homo sapiens 117-120 10349837-9 1999 Ethanol also produced prolonged activation of ERK, an effect that was partially eliminated by treatment with PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 109-116 mitogen-activated protein kinase 1 Homo sapiens 46-49 10329719-3 1999 ERK activity was approximately 2-fold higher in cycling BMM compared with growth-arrested BMM; in addition, CSF-1-stimulated BMM DNA synthesis was partially inhibited by PD98059, a specific inhibitor of MEK activation, suggesting a role for a mitogen-activated protein-ERK kinase (MEK)/ERK pathway in the control of DNA synthesis but surprisingly not in the control of cyclin D1 mRNA or c-myc mRNA expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 170-177 mitogen-activated protein kinase 1 Homo sapiens 0-3 10329719-3 1999 ERK activity was approximately 2-fold higher in cycling BMM compared with growth-arrested BMM; in addition, CSF-1-stimulated BMM DNA synthesis was partially inhibited by PD98059, a specific inhibitor of MEK activation, suggesting a role for a mitogen-activated protein-ERK kinase (MEK)/ERK pathway in the control of DNA synthesis but surprisingly not in the control of cyclin D1 mRNA or c-myc mRNA expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 170-177 mitogen-activated protein kinase 1 Homo sapiens 269-272 10362253-5 1999 PD098059 inhibited UVB- or UVC-induced AP-1 activity and phosphorylation of MEK1 and Erks, but not JNKs, in JB6 Cl 41 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-8 mitogen-activated protein kinase 1 Homo sapiens 85-89 10359012-4 1999 Treatment of cells with PD98059, a specific inhibitor of mitogen-activated protein kinase kinase (MEK), inhibited TPA-induced ERK2 activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 24-31 mitogen-activated protein kinase 1 Homo sapiens 126-130 9923649-6 1998 OA-elicited enhancement of MMP-1 mRNA abundance was also strongly prevented by two chemical MAPK inhibitors: PD 98059, a specific inhibitor of the activation of ERK1,2 kinases MEK1,2; and SB 203580, a selective inhibitor of p38 activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 109-117 mitogen-activated protein kinase 1 Homo sapiens 224-227 10217263-10 1999 Moreover, inhibition of ERK kinase activity by PD98059 dramatically reduced PMA-stimulated phosphorylation of ERKs and induction of LIF mRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-54 mitogen-activated protein kinase 1 Homo sapiens 24-27 10217263-10 1999 Moreover, inhibition of ERK kinase activity by PD98059 dramatically reduced PMA-stimulated phosphorylation of ERKs and induction of LIF mRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-54 mitogen-activated protein kinase 1 Homo sapiens 110-114 10356359-7 1999 MAPK2 turns out to be a crucial mediator of the OSM effect in glioma cells since inhibition of MAPK activity by the Mek1 inhibitor PD98059 blocks the OSM-induced inhibition of DNA synthesis by about 70%. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 131-138 mitogen-activated protein kinase 1 Homo sapiens 0-5 10356359-7 1999 MAPK2 turns out to be a crucial mediator of the OSM effect in glioma cells since inhibition of MAPK activity by the Mek1 inhibitor PD98059 blocks the OSM-induced inhibition of DNA synthesis by about 70%. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 131-138 mitogen-activated protein kinase 1 Homo sapiens 0-4 10202034-3 1999 The ERK pathway-specific inhibitor PD98059 inhibited IL-6 secretion from monocytes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 35-42 mitogen-activated protein kinase 1 Homo sapiens 4-7 10319997-3 1999 A direct relationship between sustained p42MAPK activation and differentiation is provided by the demonstration that blockade of MEK activation by PD098059 prevents TPA-induced morphological differentiation of wild type U937 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 147-155 mitogen-activated protein kinase 1 Homo sapiens 40-47 10066377-7 1999 Both the VEGF-induced activation and its anti-apoptotic effect were prevented by the specific MAPK/ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 113-120 mitogen-activated protein kinase 1 Homo sapiens 99-102 10026206-6 1999 PD98059, an inhibitor of the upstream activator of ERK1/2, the MAP/ERK kinase MEK1/2, suppressed IL-1beta and tumor necrosis factor-alpha production in a dose-dependent fashion. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 51-54 9858556-3 1999 Treatment of Ras-transformed cells with the MEK inhibitor PD098059 blocks expression of Fra-1 and Fra-2, showing that in Ras transformation ERK signalling is responsible for Fra-1 and Fra-2 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-66 mitogen-activated protein kinase 1 Homo sapiens 140-143 10410306-7 1999 At low concentration of PD98059, which inhibited the elevated activity of ERK/MAPK to the level of parental cells, the growth rate increased and the erythroid differentiation decreased slightly, and at high concentration of PD98059, which inhibited the elevated activity of ERK/MAPK below that of the parental cells, the growth rate turned down and the erythroid differentiation was restored to the untreated control level. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 224-231 mitogen-activated protein kinase 1 Homo sapiens 274-277 10212283-6 1999 In contrast, inhibition of ERK2 activity by PD 098059 led to a significant loss of PGF2alpha-induced eIF4E and 4E-BP1 phosphorylation, global protein synthesis, and bFGF-2 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 44-53 mitogen-activated protein kinase 1 Homo sapiens 27-31 10101008-5 1999 Inhibition of either the Erk (with PD98059) or p38 (with SB203580) kinase pathway resulted in only a partial reduction in cytokine (interleukin-6 and tumor necrosis factor) messenger RNA accumulation and cytokine release, whereas inhibition of both pathways simultaneously resulted in a decrease in cytokine gene expression to near-control levels. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 35-42 mitogen-activated protein kinase 1 Homo sapiens 25-28 10197638-8 1999 By using the mitogen-activated protein kinase/ERK 1 (MEK1) inhibitor PD98059 and PI3K inhibitors wortmannin and LY294002, we found that blocking the MEK1-ERK pathway had no effect on HRG-pbeta1-enhanced cell aggregation; however, blocking the PI3K pathway greatly inhibited HRG-beta1-mediated cell aggregation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 69-76 mitogen-activated protein kinase 1 Homo sapiens 46-49 10094943-11 1999 PD098059 inhibited activation of p44/p42 MAPK in cholangiocytes and completely blocked DNA synthesis in response to IL-6 or LPS. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-8 mitogen-activated protein kinase 1 Homo sapiens 37-45 10078562-5 1999 Stretch-induced activation of ERK was inhibited by herbimycin A, a tyrosine kinase inhibitor, but not by GF109203X or calphostin C, the inhibitors of protein kinase C. Mechanical stretch also enhanced DNA-binding activity of AP-1, and this enhancement was inhibited by PD98059, an inhibitor of MAPK or ERK kinase (MEK). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 269-276 mitogen-activated protein kinase 1 Homo sapiens 30-33 10024574-3 1999 We have therefore examined the effect of blocking one such pathway, the extracellular signal-regulated protein kinase (ERK) cascade, using the specific inhibitor of the mitogen-activated protein kinase/ERK kinase, PD98059, on the ability of human neutrophils to kill S. aureus and C. albicans. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 214-221 mitogen-activated protein kinase 1 Homo sapiens 119-122 10024574-3 1999 We have therefore examined the effect of blocking one such pathway, the extracellular signal-regulated protein kinase (ERK) cascade, using the specific inhibitor of the mitogen-activated protein kinase/ERK kinase, PD98059, on the ability of human neutrophils to kill S. aureus and C. albicans. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 214-221 mitogen-activated protein kinase 1 Homo sapiens 202-205 10072550-8 1999 Addition of the MEK (MAP/Erk kinase) inhibitor PD98059 reduced expression of VCAM-1 after ICAM-1 cross-linking, suggesting that the Erk pathway is involved in ICAM-1-mediated VCAM-1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-54 mitogen-activated protein kinase 1 Homo sapiens 25-28 10072550-8 1999 Addition of the MEK (MAP/Erk kinase) inhibitor PD98059 reduced expression of VCAM-1 after ICAM-1 cross-linking, suggesting that the Erk pathway is involved in ICAM-1-mediated VCAM-1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-54 mitogen-activated protein kinase 1 Homo sapiens 132-135 10026223-7 1999 ERK activation by NECA or UTP is unaffected by a tyrosine kinase inhibitor (genistein), attenuated by a phospholipase C inhibitor (U73122), and is abolished by a MEK inhibitor (PD098059) or dominant negative Ras. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 177-185 mitogen-activated protein kinase 1 Homo sapiens 0-3 9952396-5 1999 This extracellular signal-regulated protein kinase (ERK) activation was inhibited successfully by the MEK1 inhibitor PD98059, but not by the estrogen receptor (ER) antagonist ICI 182,780, and did not appear to result from estradiol-induced activation of trk. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 117-124 mitogen-activated protein kinase 1 Homo sapiens 5-50 9952396-5 1999 This extracellular signal-regulated protein kinase (ERK) activation was inhibited successfully by the MEK1 inhibitor PD98059, but not by the estrogen receptor (ER) antagonist ICI 182,780, and did not appear to result from estradiol-induced activation of trk. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 117-124 mitogen-activated protein kinase 1 Homo sapiens 52-55 9950805-6 1999 ERK activation and the induction of Egr-1 mRNA were inhibited in a dose-dependent fashion with PD-98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 95-103 mitogen-activated protein kinase 1 Homo sapiens 0-3 9950805-11 1999 Inhibition of injury-induced ERK activation by PD-98059 or direct interference with Egr by expression of a dominant negative mutant led to significantly reduced in vitro monolayer restitution. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-55 mitogen-activated protein kinase 1 Homo sapiens 29-32 9916078-5 1999 By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 9-17 mitogen-activated protein kinase 1 Homo sapiens 110-113 9916078-5 1999 By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 9-17 mitogen-activated protein kinase 1 Homo sapiens 171-174 10048588-5 1999 Selective inhibition of ERK, PI 3-kinase, and p70 S6 kinase with the inhibitors PD098059, LY294002, and rapamycin, respectively, inhibited VEGF-stimulated HUVEC proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 80-88 mitogen-activated protein kinase 1 Homo sapiens 24-27 9927616-8 1999 Furthermore, the activation of ERK by the beta-3 AR is sensitive to PD98059, wortmannin, and LY294002, indicating a crucial role for mitogen-activated protein kinase kinase and phosphatidylinositol-3 kinase (PI3K), respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 68-75 mitogen-activated protein kinase 1 Homo sapiens 31-34 9864179-8 1999 MEK inhibitor (PD98059) reduced tyrosine phosphorylation of ERK, but not p38 MAPK, induced by G-CSF, GM-CSF, or TNF. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 15-22 mitogen-activated protein kinase 1 Homo sapiens 60-63 9889068-11 1999 Inhibition of ERK with PD098059 abrogated the protective effect of LPS and GM-CSF and blocked rescue of PMN from apoptosis by GM-CSF. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 23-31 mitogen-activated protein kinase 1 Homo sapiens 14-17 9880324-7 1999 These data, together with the capacity of the ERK kinase inhibitor PD 098059 to prevent ERK2 activation and uPA upregulation in wt-FGFR1 cells, suggest that signaling through the Ras/Raf-1/ERK kinase/ERK/JunD pathway is necessary but not sufficient for uPA induction in L6 transfectants. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 67-76 mitogen-activated protein kinase 1 Homo sapiens 46-49 9880324-7 1999 These data, together with the capacity of the ERK kinase inhibitor PD 098059 to prevent ERK2 activation and uPA upregulation in wt-FGFR1 cells, suggest that signaling through the Ras/Raf-1/ERK kinase/ERK/JunD pathway is necessary but not sufficient for uPA induction in L6 transfectants. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 67-76 mitogen-activated protein kinase 1 Homo sapiens 88-92 9880324-7 1999 These data, together with the capacity of the ERK kinase inhibitor PD 098059 to prevent ERK2 activation and uPA upregulation in wt-FGFR1 cells, suggest that signaling through the Ras/Raf-1/ERK kinase/ERK/JunD pathway is necessary but not sufficient for uPA induction in L6 transfectants. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 67-76 mitogen-activated protein kinase 1 Homo sapiens 88-91 9880324-7 1999 These data, together with the capacity of the ERK kinase inhibitor PD 098059 to prevent ERK2 activation and uPA upregulation in wt-FGFR1 cells, suggest that signaling through the Ras/Raf-1/ERK kinase/ERK/JunD pathway is necessary but not sufficient for uPA induction in L6 transfectants. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 67-76 mitogen-activated protein kinase 1 Homo sapiens 88-91 10334038-3 1999 The phosphorylation was inhibited by MAPK/ERK kinase specific inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 73-80 mitogen-activated protein kinase 1 Homo sapiens 42-45 9878324-8 1998 Inhibition of tyrosine phosphorylation by genistein (10 microg/ml), or selective ERK inhibition with PD98059 (10 microM), was able to block the integrin-dependent induction of PCA in both THP-1 cells and human monocytes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 101-108 mitogen-activated protein kinase 1 Homo sapiens 81-84 9843579-15 1998 Treatment of cells with the ERK kinase inhibitor PD98059 completely inhibited the attachment-dependent ERK2 phosphorylation but did not inhibit cell spreading, cPLA2 phosphorylation, translocation, or AA release. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 49-56 mitogen-activated protein kinase 1 Homo sapiens 28-31 9843579-15 1998 Treatment of cells with the ERK kinase inhibitor PD98059 completely inhibited the attachment-dependent ERK2 phosphorylation but did not inhibit cell spreading, cPLA2 phosphorylation, translocation, or AA release. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 49-56 mitogen-activated protein kinase 1 Homo sapiens 103-107 9849961-5 1998 Blocking the Raf/MEK/ERK cascade with PD98059 does not block myogenic differentiation; however, myotubes do not survive. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 38-45 mitogen-activated protein kinase 1 Homo sapiens 21-24 9832563-4 1998 When the activation of ERK was blocked with PD098059, the focal adhesion complexes formed under the plasma membrane, and the actin polymerization activity led to a rapid and intense membrane blebbing. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 44-52 mitogen-activated protein kinase 1 Homo sapiens 23-26 9845123-5 1998 Activation of MEK and Erk was blocked with the pharmacological inhibitor of MEK activation, PD098059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 92-100 mitogen-activated protein kinase 1 Homo sapiens 22-25 9845123-8 1998 Pretreatment of the cells with the pharmacological inhibitor of MEK activation, PD098059, effectively blocked IR-induced activation of MEK and Erk. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 80-88 mitogen-activated protein kinase 1 Homo sapiens 143-146 9755064-2 1998 Hypotonicity also activated the transcription factor and ERK substrate Elk-1 in a partially PD-98059-sensitive fashion, as assessed by chimeric reporter gene assay. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 92-100 mitogen-activated protein kinase 1 Homo sapiens 57-60 9560315-3 1998 The hypotonicity-provoked Erk-1/Erk-2 activation was greatly reduced in cells pretreated with the specific mitogen-activated/Erk-activating kinase inhibitor PD098059 and was preceded by a transient stimulation of Raf-1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 157-165 mitogen-activated protein kinase 1 Homo sapiens 32-37 9660836-9 1998 92, 7686-7689) demonstrates that U0126 and PD098059 are noncompetitive inhibitors with respect to both MEK substrates, ATP and ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 43-51 mitogen-activated protein kinase 1 Homo sapiens 127-130 9679985-2 1998 ERK2 activation by mitogen-activated protein/ERK kinase (MEK) was necessary for RA-induced differentiation in studies using PD98059 to block MEK phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 124-131 mitogen-activated protein kinase 1 Homo sapiens 0-4 9679985-2 1998 ERK2 activation by mitogen-activated protein/ERK kinase (MEK) was necessary for RA-induced differentiation in studies using PD98059 to block MEK phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 124-131 mitogen-activated protein kinase 1 Homo sapiens 0-3 9679985-5 1998 ERK2 activation was probably needed early, because delaying the addition of PD98059 relative to that of RA restored most of the RA-induced cellular response. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 76-83 mitogen-activated protein kinase 1 Homo sapiens 0-4 9712155-4 1998 A MEK specific inhibitor, PD98059, which inhibited activation of ERK in response to HRG, completely blocked HRG-induced differentiation and reversed cell growth arrest. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 26-33 mitogen-activated protein kinase 1 Homo sapiens 65-68 9771965-5 1998 ERK activation was necessary for the increase in MCL1, as inhibition of the increase in ERK phosphorylation (with the inhibitor PD 98059) prevented the increase in MCL1 expression and caused rapid cell death by apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 128-136 mitogen-activated protein kinase 1 Homo sapiens 0-3 9771965-5 1998 ERK activation was necessary for the increase in MCL1, as inhibition of the increase in ERK phosphorylation (with the inhibitor PD 98059) prevented the increase in MCL1 expression and caused rapid cell death by apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 128-136 mitogen-activated protein kinase 1 Homo sapiens 88-91 9712920-6 1998 The mitogen-activated protein kinase/extracellular signal-regulated kinase-kinase (MEK) inhibitor PD98059 abolished this phosphorylation, demonstrating that stathmin is targeted by BXB-ER via the MEK/ERK pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 98-105 mitogen-activated protein kinase 1 Homo sapiens 200-203 9687510-4 1998 The activation of MSK1 by growth factors/phorbol esters is prevented by PD 98059, which suppresses activation of the MAPK cascade, while the activation of MSK1 by stress stimuli is prevented by SB 203580, a specific inhibitor of SAPK2/p38. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 72-80 mitogen-activated protein kinase 1 Homo sapiens 235-238 9687510-5 1998 In HeLa, PC12 and SK-N-MC cells, PD 98059 and SB 203580 are both required to suppress the activation of MSK1 by TNF, NGF and FGF, respectively, because these agonists activate both the MAPK/ERK and SAPK2/p38 cascades. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-41 mitogen-activated protein kinase 1 Homo sapiens 190-193 9687510-5 1998 In HeLa, PC12 and SK-N-MC cells, PD 98059 and SB 203580 are both required to suppress the activation of MSK1 by TNF, NGF and FGF, respectively, because these agonists activate both the MAPK/ERK and SAPK2/p38 cascades. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-41 mitogen-activated protein kinase 1 Homo sapiens 204-207 9657968-4 1998 This H2O2-induced apoptosis was markedly enhanced when ERK2 activation was selectively inhibited by PD098059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 100-108 mitogen-activated protein kinase 1 Homo sapiens 55-59 9547255-5 1998 Phosphorylation of the 44 and 42 kDa proteins by one-trial conditioning was inhibited by pretreatment with PD098059, A MEK1 (ERK-Activating kinase) inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 107-115 mitogen-activated protein kinase 1 Homo sapiens 125-128 9547255-8 1998 The increased phosphorylation of ERK after one-trial conditioning was blocked by pretreatment with PD098059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 99-107 mitogen-activated protein kinase 1 Homo sapiens 33-36 9593267-5 1998 Although the Erk activation in KG1 cells is short-lived, using the MEK inhibitor PD98059, we demonstrated that Erk phosphorylation is essential for proliferation of these cell lines. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 81-88 mitogen-activated protein kinase 1 Homo sapiens 13-16 9593267-5 1998 Although the Erk activation in KG1 cells is short-lived, using the MEK inhibitor PD98059, we demonstrated that Erk phosphorylation is essential for proliferation of these cell lines. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 81-88 mitogen-activated protein kinase 1 Homo sapiens 111-114 9518544-7 1998 PD098059, a selective inhibitor of the Erk-activating kinase MEK, blocked the stimulation of PGHS expression by EGF, but did not decrease stimulation in response to OA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-8 mitogen-activated protein kinase 1 Homo sapiens 39-42 9531502-7 1998 In contrast, altering the p21(ras)-dependent pathway with either manumycin, an inhibitor of Ras farnesylation, or PD98059, an inhibitor of the mitogen-activated protein kinase/extracellular signal-regulated protein kinase (ERK) kinase, suppressed the induction of ERCC-1 mRNA by insulin (P<0.001). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 114-121 mitogen-activated protein kinase 1 Homo sapiens 223-226 9535820-8 1998 Lastly, we observed that the use of the MEK1 inhibitor PD98059 inhibited TPA-mediated ERK activity and abrogated the anti-apoptotic effects of TPA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 55-62 mitogen-activated protein kinase 1 Homo sapiens 86-89 9517568-12 1998 Similarly, ATP or TPA promoted AA release was inhibited by the mitogen-activated protein kinase (MAPK) cascade inhibitor PD 98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 121-129 mitogen-activated protein kinase 1 Homo sapiens 97-101 9464988-5 1998 ERK activation was sensitive to PD98059, the kinase inhibitor that is specific for ERK kinase. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 0-3 9464988-5 1998 ERK activation was sensitive to PD98059, the kinase inhibitor that is specific for ERK kinase. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 83-86 9570271-5 1998 To investigate the role of ERKs on the biological effects of progesterone, we used the MAPK cascade inhibitor PD098059, which strongly inhibited progesterone-induced activation of ERK-2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 110-118 mitogen-activated protein kinase 1 Homo sapiens 27-31 9570271-5 1998 To investigate the role of ERKs on the biological effects of progesterone, we used the MAPK cascade inhibitor PD098059, which strongly inhibited progesterone-induced activation of ERK-2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 110-118 mitogen-activated protein kinase 1 Homo sapiens 87-91 9570271-5 1998 To investigate the role of ERKs on the biological effects of progesterone, we used the MAPK cascade inhibitor PD098059, which strongly inhibited progesterone-induced activation of ERK-2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 110-118 mitogen-activated protein kinase 1 Homo sapiens 180-185 9393975-6 1997 Inhibiting the VEGF-induced activation of ERK with PD098059 did not influence actin organization or cell migration but totally inhibited the VEGF-induced incorporation of thymidine into DNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 51-59 mitogen-activated protein kinase 1 Homo sapiens 42-45 9552001-6 1998 This dose of PD098059 virtually abrogated chemoattractant-induced tyrosine phosphorylation and activation of ERK-1 and ERK-2, implying that MEKs are the predominant upstream activators of these mitogen-activated protein kinases. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-21 mitogen-activated protein kinase 1 Homo sapiens 119-124 9360968-8 1997 ERK2 activation by both compounds required the involvement of an upstream signaling kinase MAPK/ERK kinase (MEK), as evidenced by the inhibitory effect of a MEK inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 172-179 mitogen-activated protein kinase 1 Homo sapiens 0-4 9360968-8 1997 ERK2 activation by both compounds required the involvement of an upstream signaling kinase MAPK/ERK kinase (MEK), as evidenced by the inhibitory effect of a MEK inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 172-179 mitogen-activated protein kinase 1 Homo sapiens 91-95 9392422-8 1997 The specific MAPK pathway inhibitor PD98059 blocked TPA-induced ERK activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 36-43 mitogen-activated protein kinase 1 Homo sapiens 13-17 9392422-8 1997 The specific MAPK pathway inhibitor PD98059 blocked TPA-induced ERK activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 36-43 mitogen-activated protein kinase 1 Homo sapiens 64-67 9467952-5 1998 Inhibition of the Erk2 pathway by PD98059, specific for the upstream MAP kinase kinase (MEK1), abolishes TPA-stimulated junB but not insulin-induced c-jun. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 34-41 mitogen-activated protein kinase 1 Homo sapiens 18-22 9467952-8 1998 On the other hand, PD98059 reverts the inhibitory effect of TPA on cell cycle entry as well as on pRB hyperphosphorylation, indicating that Erk effectors function as inhibitors of proliferation in MCF7 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-26 mitogen-activated protein kinase 1 Homo sapiens 140-143 9407138-10 1997 In contrast, specific inhibition of the RAF/ERK pathway by PD98059 (MEK1 inhibitor) completely blocked ERK activation by EGF and basal cell growth but not EGF-stimulated growth, thereby dissociating the growth-promoting roles of each pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 59-66 mitogen-activated protein kinase 1 Homo sapiens 44-47 9407138-10 1997 In contrast, specific inhibition of the RAF/ERK pathway by PD98059 (MEK1 inhibitor) completely blocked ERK activation by EGF and basal cell growth but not EGF-stimulated growth, thereby dissociating the growth-promoting roles of each pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 59-66 mitogen-activated protein kinase 1 Homo sapiens 103-106 9366435-4 1997 The mitogen-activated protein kinase/ERK kinase inhibitor PD098059 reduced ERK activation by 90%, while an inhibitor of p38 MAPK, SB203580, inhibited p38 MAPK activation by 80%. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-66 mitogen-activated protein kinase 1 Homo sapiens 37-40 9366435-4 1997 The mitogen-activated protein kinase/ERK kinase inhibitor PD098059 reduced ERK activation by 90%, while an inhibitor of p38 MAPK, SB203580, inhibited p38 MAPK activation by 80%. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-66 mitogen-activated protein kinase 1 Homo sapiens 75-78 9291137-3 1997 PD98059, an inhibitor of the ERK pathway, inhibited the expression of Cox-2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 29-32 9261137-8 1997 Whereas PD98059 had no effect on IGF-IR phosphorylation, PD98059 reduced IGF-I-mediated ERK tyrosine phosphorylation and ERK phosphorylation of the substrate Elk-1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 57-64 mitogen-activated protein kinase 1 Homo sapiens 88-91 9261137-8 1997 Whereas PD98059 had no effect on IGF-IR phosphorylation, PD98059 reduced IGF-I-mediated ERK tyrosine phosphorylation and ERK phosphorylation of the substrate Elk-1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 57-64 mitogen-activated protein kinase 1 Homo sapiens 121-124 9202001-9 1997 This negative feedback regulatory mechanism is likely due to MKP-1-mediated inhibition of ERK2, as studies utilizing the MEK1/2 inhibitor PD98059 suggest that ERK2 activation is required for PMA-induced MKP-1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 138-145 mitogen-activated protein kinase 1 Homo sapiens 90-94 9202001-9 1997 This negative feedback regulatory mechanism is likely due to MKP-1-mediated inhibition of ERK2, as studies utilizing the MEK1/2 inhibitor PD98059 suggest that ERK2 activation is required for PMA-induced MKP-1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 138-145 mitogen-activated protein kinase 1 Homo sapiens 159-163 9202301-5 1997 Pretreatment with the specific MAP kinase kinase inhibitor PD98059 prevented the GM1-stimulated Erk2 activation and GM1-stimulated DNA synthesis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 59-66 mitogen-activated protein kinase 1 Homo sapiens 96-100 9212060-11 1997 FGF2 activates ERK1/ERK2 signaling in osteoblasts; however, 25 microM MAPK-ERK kinase (MEK) inhibitor PD98059 (inhibits by > 85% the phosphorylation of ERK1/ERK2) has no effect on MMP1 promoter activation by FGF2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 102-109 mitogen-activated protein kinase 1 Homo sapiens 20-24 9212060-11 1997 FGF2 activates ERK1/ERK2 signaling in osteoblasts; however, 25 microM MAPK-ERK kinase (MEK) inhibitor PD98059 (inhibits by > 85% the phosphorylation of ERK1/ERK2) has no effect on MMP1 promoter activation by FGF2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 102-109 mitogen-activated protein kinase 1 Homo sapiens 15-18 9212060-11 1997 FGF2 activates ERK1/ERK2 signaling in osteoblasts; however, 25 microM MAPK-ERK kinase (MEK) inhibitor PD98059 (inhibits by > 85% the phosphorylation of ERK1/ERK2) has no effect on MMP1 promoter activation by FGF2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 102-109 mitogen-activated protein kinase 1 Homo sapiens 160-164 8971188-2 1996 PD 098059 [2-(2"-amino-3"-methoxyphenyl)-oxanaphthalen-4-one], a selective inhibitor of mitogen activated protein kinase (MAPK) kinase 1, prevented activation of p42mapk by PDB in SCLC cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 11-60 mitogen-activated protein kinase 1 Homo sapiens 122-126 9144515-9 1997 In the presence of the MAP kinase kinase (MEK) inhibitor, PD 098059, phagocytosis was reduced by approximately 50%, while ERK1 and ERK2 activity was reduced by 85 to 90%. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-67 mitogen-activated protein kinase 1 Homo sapiens 131-135 9121442-5 1997 The MKK inhibitor PD98059 blocked MKK/ERK activation and cellular responses to phorbol ester, demonstrating that activation of MKK is necessary and sufficient to induce a differentiation program along the megakaryocyte lineage. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-25 mitogen-activated protein kinase 1 Homo sapiens 38-41 9013447-6 1997 The MEK antagonist PD 098059 and selective extracellular agonists of ERK were used to demonstrate the induction of CL100, PAC1, and B23 in response to activation of the ERK cascade. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-28 mitogen-activated protein kinase 1 Homo sapiens 169-172 34716498-7 2021 Moverover, CD95 stimulation induced the phosphorylation of p38 and Erk1/2 and Th17 cell differentiation, and p38 specific inhibitor SB203580 or Erk1/2 specific inhibitor PD98059 could induce opposite changes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 170-177 mitogen-activated protein kinase 1 Homo sapiens 59-62 8626428-7 1996 Both the insulin and osmotic shock-induced activation of ERK was prevented by treatment of cells with the specific MEK inhibitor (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 130-137 mitogen-activated protein kinase 1 Homo sapiens 57-60 34913072-9 2022 Furthermore, the ERK inhibitor, PD98059, reduced CCL28-induced cell proliferation and invasion, as well as the expression levels of MMP2, MMP9, ITGB1 and p-ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 17-20 34913072-9 2022 Furthermore, the ERK inhibitor, PD98059, reduced CCL28-induced cell proliferation and invasion, as well as the expression levels of MMP2, MMP9, ITGB1 and p-ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 156-159 34864005-5 2022 Inhibition of ERK/MAPK pathway with the inhibitor PD98059 in gastric cancer cell lines by in vitro signaling pathway and genome-wide expression profiling revealed the associated signaling pathways. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 50-57 mitogen-activated protein kinase 1 Homo sapiens 14-17 34971708-10 2022 These effects were diminished following the application of NF-kappaB and ERK inhibitors BAY11-7082 and PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 103-110 mitogen-activated protein kinase 1 Homo sapiens 73-76 34160728-7 2021 The ERK signaling inhibitor PD98059 partly reversed the elevation of IL-33 levels mediated by miR-483-3p overexpression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 28-35 mitogen-activated protein kinase 1 Homo sapiens 4-7 30106144-10 2018 Growth inhibition and the apoptotic effects of CRT1 could be reversed by PD98059, an ERK inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 73-80 mitogen-activated protein kinase 1 Homo sapiens 85-88 34748972-6 2022 ET-1 significantly increased HSL phosphorylation and lipolysis, which were completely inhibited by ERK inhibitor (PD98059) and guanylyl cyclase (GC) inhibitor (LY83583). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 114-121 mitogen-activated protein kinase 1 Homo sapiens 99-102 34730869-7 2022 Of note, the AP-1 activation induced by TiO2 NPs could be blocked by specific inhibitors (SB203580, PD98059, and SP 600125, respectively) that inhibit ERKs and p38 kinase but not JNKs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 100-107 mitogen-activated protein kinase 1 Homo sapiens 151-155 34670665-10 2021 Also compared with that in the control group, the expression of p-ERK and PD-L1 in the DDP treatment group increased, and the expression of p-ERK in the group with PD98059 decreased. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 164-171 mitogen-activated protein kinase 1 Homo sapiens 142-145 34670665-11 2021 The expressions of p-ERK and PD-L1 in the group with DDP combined with PD98059 were lower than those in the group with DDP, but higher than those in the group with PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 71-78 mitogen-activated protein kinase 1 Homo sapiens 21-24 34576317-8 2021 However, these increases, induced by gintonin, were markedly blocked by treatment with Ki16425, an LPA inhibitor, PD98059, an ERK inhibitor, 1,2-Bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid tetrakis (acetoxymethyl ester), a calcium chelator, and U73122, a PLC inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 114-121 mitogen-activated protein kinase 1 Homo sapiens 126-129 34638875-3 2021 Here, we attempted to differentiate human UDSCs (hUDSCs) into smooth muscle cells (SMCs) using transforming growth factor-beta 1 (TGF-beta1) and/or PD98059, an extracellular signal-regulated kinase (ERK) inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 148-155 mitogen-activated protein kinase 1 Homo sapiens 160-197 34638875-3 2021 Here, we attempted to differentiate human UDSCs (hUDSCs) into smooth muscle cells (SMCs) using transforming growth factor-beta 1 (TGF-beta1) and/or PD98059, an extracellular signal-regulated kinase (ERK) inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 148-155 mitogen-activated protein kinase 1 Homo sapiens 199-202 34362478-2 2021 METHODS: K562 cells were processed by SLG and PD98059 which was the ERK signaling pathway blocker. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 46-53 mitogen-activated protein kinase 1 Homo sapiens 68-71 34184076-13 2021 In addition, overexpression of TMEM229A reduced the expression levels of phosphorylated (p)-ERK and p-AKT, and this effect was partially suppressed by the incorporation of specific ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 195-202 mitogen-activated protein kinase 1 Homo sapiens 92-95 34184076-13 2021 In addition, overexpression of TMEM229A reduced the expression levels of phosphorylated (p)-ERK and p-AKT, and this effect was partially suppressed by the incorporation of specific ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 195-202 mitogen-activated protein kinase 1 Homo sapiens 181-184 33290316-8 2021 The inhibition of MEK and ERK was confirmed by using MEK stimulators, GM-CSF and phorbol 12-myristate 13-acetate, and MEK-specific inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 142-149 mitogen-activated protein kinase 1 Homo sapiens 26-29 34514104-6 2021 Further analysis revealed that the ERK inhibitor PD98059 and MMP9 antibody (Ab) attenuated H. pylori-induced gastric cancer cell invasion and metastasis in vitro through a semaphorin 5A-dependent mechanism. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 49-56 mitogen-activated protein kinase 1 Homo sapiens 35-38 34066541-7 2021 Thus, we used an MEK/ERK inhibitor, PD98059, to block the MEK/ERK pathway and to identify the role of MAPK1 in the radio-resistance of RT-R-MDA-MB-231 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 36-43 mitogen-activated protein kinase 1 Homo sapiens 21-24 34066541-7 2021 Thus, we used an MEK/ERK inhibitor, PD98059, to block the MEK/ERK pathway and to identify the role of MAPK1 in the radio-resistance of RT-R-MDA-MB-231 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 36-43 mitogen-activated protein kinase 1 Homo sapiens 62-65 34066541-7 2021 Thus, we used an MEK/ERK inhibitor, PD98059, to block the MEK/ERK pathway and to identify the role of MAPK1 in the radio-resistance of RT-R-MDA-MB-231 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 36-43 mitogen-activated protein kinase 1 Homo sapiens 102-107 35142421-7 2022 Moreover, the results demonstrated that the ERK inhibitor (PD98059) and TGF-beta1 inhibitor (LY364947) could inhibit the activation of the ERK signaling pathway, thereby reducing the mitochondrial membrane potential, the total apoptosis rate, and the expression of pro-apoptosis-related genes in the cells, while the expression of the antiapoptosis gene Bcl-2 was significantly increased (P < .05). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 59-66 mitogen-activated protein kinase 1 Homo sapiens 44-47 35142421-7 2022 Moreover, the results demonstrated that the ERK inhibitor (PD98059) and TGF-beta1 inhibitor (LY364947) could inhibit the activation of the ERK signaling pathway, thereby reducing the mitochondrial membrane potential, the total apoptosis rate, and the expression of pro-apoptosis-related genes in the cells, while the expression of the antiapoptosis gene Bcl-2 was significantly increased (P < .05). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 59-66 mitogen-activated protein kinase 1 Homo sapiens 139-142 35294968-9 2022 Pre-treatment with selective inhibitors of p38 and Erk1/2 pathways (SB202190 and PD98059) reversed OGD effects on the expression of Ambra1 and Beclin1, suggesting that these pathways induced oxidative stress-mediated autophagy. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 81-88 mitogen-activated protein kinase 1 Homo sapiens 43-46 35523108-9 2022 PD98059, an ERK specific inhibitor, reversed miR-152-3p knockdown mediated inflammation in HBE cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 12-15 35111045-6 2021 The results show that L-4F significantly upregulates protein levels of HIF-1alpha, Akt, and ERK, which can be inhibited by the PI3K inhibitor, LY294002, or ERK inhibitor, PD98059, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 171-178 mitogen-activated protein kinase 1 Homo sapiens 92-95 35301650-6 2022 MEK/ERK signal transduction was inhibited by pretreatment with the MEK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 81-88 mitogen-activated protein kinase 1 Homo sapiens 4-7 35563057-11 2022 Pretreatment of cells with both PD98059 (an ERK1/2 inhibitor) and BAPTA/AM (a cell-permeable Ca2+ chelator), but not SP600125 (a JNK inhibitor) and SB203580 (a p38 inhibitor), effectively suppressed NK-induced mitochondrial dysfunction, ER stress-related signals, and apoptotic events. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 160-163 35237605-16 2022 Furthermore, doxycycline-induced gene expressions are disturbed by a specific integrin alphavbeta3 inhibitor (HSDVHK-NH2) or a mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinases (ERK) kinase (MAPK/ERK, MEK) inhibitor (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 246-253 mitogen-activated protein kinase 1 Homo sapiens 207-210 35237605-16 2022 Furthermore, doxycycline-induced gene expressions are disturbed by a specific integrin alphavbeta3 inhibitor (HSDVHK-NH2) or a mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinases (ERK) kinase (MAPK/ERK, MEK) inhibitor (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 246-253 mitogen-activated protein kinase 1 Homo sapiens 225-228 35111045-6 2021 The results show that L-4F significantly upregulates protein levels of HIF-1alpha, Akt, and ERK, which can be inhibited by the PI3K inhibitor, LY294002, or ERK inhibitor, PD98059, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 171-178 mitogen-activated protein kinase 1 Homo sapiens 156-159 35078573-3 2022 In the group with A375 cells treated with the MEK/ERK signaling pathway inhibitor PD98059 combined with VPA, the protein expressions of MICA and MICB were detected by Western blotting, the expressions of MICA and MICB were detected by flow cytometry, and the killing effect of NK92 cells on A375 cells was detected by LDH release assay. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 82-89 mitogen-activated protein kinase 1 Homo sapiens 50-53 35069890-8 2022 The promoting effects of salbutamol on EMT, migration and invasion were inhibited by phosphorylation inhibitor of ERK PD98059 in vitro. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 118-125 mitogen-activated protein kinase 1 Homo sapiens 114-117 33784561-7 2021 Furthermore, depletion of BARX1 decreased the phosphorylation (p) levels of ERK and MEK, also reinforced the suppressive effects of ERK/MEK pathway blocker PD98059 on the p-ERK and p-MEK levels. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 156-163 mitogen-activated protein kinase 1 Homo sapiens 132-135 34051057-5 2021 In addition, the reduction in both ChREBPalpha and beta mRNA levels was reversed by PD98059, a selective and cell permeable inhibitor of the MEK/ERK pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 84-91 mitogen-activated protein kinase 1 Homo sapiens 145-148 33999413-11 2022 Moreover, the inhibitors for MAP kinase, including PD98059 (ERK) and SP600125 (JNK), suppressed the CyPA-enhanced MMP-9 in U937. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 51-58 mitogen-activated protein kinase 1 Homo sapiens 60-63 33784561-7 2021 Furthermore, depletion of BARX1 decreased the phosphorylation (p) levels of ERK and MEK, also reinforced the suppressive effects of ERK/MEK pathway blocker PD98059 on the p-ERK and p-MEK levels. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 156-163 mitogen-activated protein kinase 1 Homo sapiens 132-135 33747807-8 2021 The effects of zymosan on Cx43 expression and GJIC activity were attenuated by the administration of PD98059 [an extracellular signal-regulated kinase (ERK) signaling inhibitor] (P<0.05), c-Jun NH2-terminal kinase (JNK) inhibitor II (P<0.05), and IKK2 inhibitor IV (P<0.05). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 101-108 mitogen-activated protein kinase 1 Homo sapiens 113-150 33747807-8 2021 The effects of zymosan on Cx43 expression and GJIC activity were attenuated by the administration of PD98059 [an extracellular signal-regulated kinase (ERK) signaling inhibitor] (P<0.05), c-Jun NH2-terminal kinase (JNK) inhibitor II (P<0.05), and IKK2 inhibitor IV (P<0.05). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 101-108 mitogen-activated protein kinase 1 Homo sapiens 152-155 33731247-10 2021 Furthermore, the ERK inhibitor (PD098059), p38MAPK inhibitor (SB203580), and FAK inhibitor (Y15) reversed these results. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-40 mitogen-activated protein kinase 1 Homo sapiens 17-20 33526070-9 2021 Moreover, we found that treatment with specific ERK1/2 and P38 signaling inhibitors PD98059 and SB239063 impaired EV-mediated cell migration, which suggests that ERK1/2 and P38 signaling is essential for EV-induced wound healing. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 84-91 mitogen-activated protein kinase 1 Homo sapiens 59-62 33169892-11 2021 PD98059, an ERK inhibitor, blocked the odontogenic differentiation of DPSCs induced by TNF-alpha. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 12-15 33526070-9 2021 Moreover, we found that treatment with specific ERK1/2 and P38 signaling inhibitors PD98059 and SB239063 impaired EV-mediated cell migration, which suggests that ERK1/2 and P38 signaling is essential for EV-induced wound healing. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 84-91 mitogen-activated protein kinase 1 Homo sapiens 173-176 33552829-9 2021 The MEK inhibitor, PD98059, reversed these miR-192-5p-induced effects on MEK/ERK signaling-associated protein expression, proliferation promotion, and apoptosis inhibition in TFK-1 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-26 mitogen-activated protein kinase 1 Homo sapiens 77-80 33003239-6 2021 PD98059 was used to elucidate whether extracellular signal regulated kinase (ERK) signaling is involved in the curcumin-regulated gene expression in hGFs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 38-75 33003239-6 2021 PD98059 was used to elucidate whether extracellular signal regulated kinase (ERK) signaling is involved in the curcumin-regulated gene expression in hGFs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 77-80 33328759-8 2020 Subsequently, the rescue experiment was further performed using an ERK/MAPK pathway inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 94-101 mitogen-activated protein kinase 1 Homo sapiens 67-70 33000206-9 2020 Notably, the ERK inhibitor, PD98059, abolished ERK1/2 phosphorylation, whereas it did not exert any marked effects on cell proliferation and EMT-related markers mediated by SRA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 28-35 mitogen-activated protein kinase 1 Homo sapiens 13-16 33157237-5 2020 Furthermore, inhibition of c-Jun N-terminal kinase (JNK) and extracellular regulated protein kinases (ERK) by their inhibitor SP600125 and PD98059 dramatically blocked MMP-1-enhanced ALP activity and mineralization in BMSCs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 139-146 mitogen-activated protein kinase 1 Homo sapiens 102-105 33242203-10 2021 Meanwhile, endothelial dysfunction caused by IH REVs was reversed by Akt activator SC79 as well as Erk kinase inhibitor PD98059, suggesting that PI3K/Akt/eNOS and Erk1/2/ET-1 pathways were implicated in IH REV-induced impaired EDRs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 120-127 mitogen-activated protein kinase 1 Homo sapiens 99-102 32623775-14 2020 While, inhibition of Erk pathway by PD98059, only p-Erk expression was decreased. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 36-43 mitogen-activated protein kinase 1 Homo sapiens 21-24 31951023-6 2020 Notably, treatment with an ERK inhibitor (PD98059) completely abolished the oncogenic effects of TRIM59 overexpression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 42-49 mitogen-activated protein kinase 1 Homo sapiens 27-30 32749897-11 2020 This effect was abolished by the ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-54 mitogen-activated protein kinase 1 Homo sapiens 33-36 32277496-7 2020 RNAi and PD98059 were used to inhibit the expression of CLU and p-ERK, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 9-16 mitogen-activated protein kinase 1 Homo sapiens 66-69 32468028-11 2020 Interestingly, in the presence of inhibitors of these two pathways aforementioned, upregulation of PD-L1 expression was only inhibited by the MEK inhibitor PD98059, which can inhibit ERK activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 156-163 mitogen-activated protein kinase 1 Homo sapiens 183-186 32751124-8 2020 3D differentiated constructs and 2D monolayer cultures treated with PD98059 or U0126 showed decreased mineralization, ALP activity, and the expression of the aforementioned genes BGLAP, SPP1, COL1A1, MAPK1, AKT1, RUNX2, and GLI1 relative to untreated. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 68-75 mitogen-activated protein kinase 1 Homo sapiens 200-205 32471717-6 2020 Similarly, inhibition for ERK (PD98059), NF-kappaB (BAY11-7082) and c-Jun (c-Jun peptide), respectively, also suppressed the HMGB1 cytoplasm translocation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 31-38 mitogen-activated protein kinase 1 Homo sapiens 26-29 32774743-8 2020 However, these beneficial effects can be inhibited by PI3K/AKT inhibitor LY294002 and MEK/ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 104-111 mitogen-activated protein kinase 1 Homo sapiens 90-93 32166572-7 2020 We also determined that the inhibitory effects of NDRG4 on cell apoptosis and Reactive oxygen species release were partially reversed by BDNF silencing, and by application of the PI3K specific inhibitor (LY294002) or ERK inhibitor (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 232-239 mitogen-activated protein kinase 1 Homo sapiens 217-220 32319644-8 2020 Notably, extracellular-regulated kinase (ERK) signaling inhibition by PD98059 induced similar effects on EMT in CRC cells, indicating that Ad.Spred2 regulated EMT in CRC cells in an ERK-dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 70-77 mitogen-activated protein kinase 1 Homo sapiens 9-39 32319644-8 2020 Notably, extracellular-regulated kinase (ERK) signaling inhibition by PD98059 induced similar effects on EMT in CRC cells, indicating that Ad.Spred2 regulated EMT in CRC cells in an ERK-dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 70-77 mitogen-activated protein kinase 1 Homo sapiens 41-44 33911740-10 2020 UVB induced downregulation of AQP1 was significantly attenuated by pretreatment with the MEK/ERK inhibitor (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 108-115 mitogen-activated protein kinase 1 Homo sapiens 93-96 32134157-10 2020 PD98059, the ERK blocker, inhibited upregulations of CSN6 and PD-L1 in EGF-treated cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 13-16 31643092-8 2020 Moreover, ERK/MAPK inhibitor PD98059 reverse the enhancement of cell proliferation, invasion, and migration in BZW2 overexpressing HCT116 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 29-36 mitogen-activated protein kinase 1 Homo sapiens 10-13 31643092-8 2020 Moreover, ERK/MAPK inhibitor PD98059 reverse the enhancement of cell proliferation, invasion, and migration in BZW2 overexpressing HCT116 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 29-36 mitogen-activated protein kinase 1 Homo sapiens 14-18 32031702-6 2020 MUC15 activated Raf/MEK/ERK signaling pathway and the ERK inhibitor PD98059 partly reversed MUC15-enhanced proliferation, invasion, and migration of glioma cells (p<0.05). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 68-75 mitogen-activated protein kinase 1 Homo sapiens 54-57 31622878-6 2019 ROS was the up-stream regulator of extracellular regulated protein kinases (ERK) signaling, and the application of a specific ERK1/2 inhibitor PD98059 confirmed that activation of ERK1/2 signaling was associated with the abnormal mitochondrial fission/fusion and mitochondrial dysfunction. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 143-150 mitogen-activated protein kinase 1 Homo sapiens 35-74 31667838-7 2020 Subsequent mechanistic studies demonstrated that CXCL3 overexpressing influenced the expression of extracellular signal-regulated kinase (ERK) signaling pathway associated genes, including ERK1/2, Bcl-2, and Bax, whereas the CXCL3-induced proliferation and migration effects were attenuated by exogenous administration of the ERK1/2 blocker PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 341-348 mitogen-activated protein kinase 1 Homo sapiens 138-141 31498440-9 2020 In addition, while activation of extracellular signal-regulated kinase 1/2 (ERK1/2) was inhibited by PD98059, phosphorylation of STAT3 at Ser727 induced by GCDA was suppressed. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 101-108 mitogen-activated protein kinase 1 Homo sapiens 33-74 31809793-8 2020 ERK inhibitor PD98059 significantly alleviated BDMC induced decrease in psim, alteration in BCl-2, caspase-8 activation and PS externalization. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 14-21 mitogen-activated protein kinase 1 Homo sapiens 0-3 31938969-10 2020 In vitro experiments showed that addition of the ERK phosphorylation inhibitor, PD98059, down-regulated the expression of N1 neutrophils, while up-regulating that of N2 neutrophils. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 80-87 mitogen-activated protein kinase 1 Homo sapiens 49-52 32054305-9 2020 In addition, PD98059 (ERK inhibitor) and LY294002 (AKT inhibitor) obviously reduced cell invasion and expression of metastasis-associated proteins. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 22-25 31950060-8 2019 Moreover, the extracellular-signal-regulated kinase 1/2 (ERK1/2) inhibitor PD98059 was used to examine the relationship between TRIM11 and ERK1/2 in OS cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 75-82 mitogen-activated protein kinase 1 Homo sapiens 14-55 31076999-8 2019 NGN activated both ERK and PI3 K/Akt, and treatments with the specific ERK inhibitor PD98059, the PI3 K inhibitor LY294002, and the specific Nrf2 shRNA suppressed the NGN-induced HO-1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 85-92 mitogen-activated protein kinase 1 Homo sapiens 19-22 31934280-6 2019 The differentiation occurred in parallel with activation of Erk signaling pathway, and was abolished by PD98059, a potent Erk inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 104-111 mitogen-activated protein kinase 1 Homo sapiens 60-63 31934280-6 2019 The differentiation occurred in parallel with activation of Erk signaling pathway, and was abolished by PD98059, a potent Erk inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 104-111 mitogen-activated protein kinase 1 Homo sapiens 122-125 31485607-13 2019 The protein levels of MAPK1 and p-ERK1/2, which were higher in the mimic MAPK1 group than those in the control or mimic groups, were ameliorated by PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 148-155 mitogen-activated protein kinase 1 Homo sapiens 22-27 31485607-13 2019 The protein levels of MAPK1 and p-ERK1/2, which were higher in the mimic MAPK1 group than those in the control or mimic groups, were ameliorated by PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 148-155 mitogen-activated protein kinase 1 Homo sapiens 73-78 31799197-7 2019 The MEK inhibitor PD98059 reduced the biological effects of FAM53A knockdown in MCF-7 cells and FAM53A overexpression in MDA-MB-231 cells, suggesting that FAM53A affects breast cancer through the MEK-ERK pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-25 mitogen-activated protein kinase 1 Homo sapiens 200-203 31076999-8 2019 NGN activated both ERK and PI3 K/Akt, and treatments with the specific ERK inhibitor PD98059, the PI3 K inhibitor LY294002, and the specific Nrf2 shRNA suppressed the NGN-induced HO-1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 85-92 mitogen-activated protein kinase 1 Homo sapiens 71-74 30834595-7 2019 The effects of IGFBP7 overexpression on the expression of EMT-related markers were partially reversed by the ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 123-130 mitogen-activated protein kinase 1 Homo sapiens 109-112 31401382-3 2019 We found that fMLP significantly induced dHL-60 cell and neutrophil migration and superoxide production, which was inhibited by ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 142-149 mitogen-activated protein kinase 1 Homo sapiens 128-131 30998268-12 2019 ANXA3 downregulation reduced Ox resistance in CRC, and treatment with the ERK inhibitor PD098059 or JNK inhibitor SP600125 contributed to this process. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 88-96 mitogen-activated protein kinase 1 Homo sapiens 74-77 31438541-8 2019 Pachypodol increased ERK phosphorylation and ERK inhibition by PD98059 totally abrogated the increase in ARE luciferase activity, nuclear Nrf2 accumulation and mRNA levels of antioxidant enzymes by pachypodol. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 63-70 mitogen-activated protein kinase 1 Homo sapiens 45-48 31270642-10 2019 This was accompanied by an increase in the phosphorylation of Akt and ERK in third stage cell clusters, which was prevented by the addition of the inhibitors PD98059 and LY294002, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 158-165 mitogen-activated protein kinase 1 Homo sapiens 70-73 30311108-6 2019 The addition of ERK inhibitor PD98059 counteracted the upregulation of Snail, Cyclin D1 and Cyclin E1, and restored the expression of E-cadherin, which indicated that C6orf106 was an upstream factor of ERK signaling pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 mitogen-activated protein kinase 1 Homo sapiens 16-19 30689107-4 2019 Inhibition of ERK activity with the MEK inhibitor PD98059 resulted in increased expression of cadherins, while constitutive activation of ERK through the use of expression of an ERK construct with a D319N sevenmaker mutation resulted in decreased expression of cadherins and enhanced colony formation of HT-1080 fibrosarcoma cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 50-57 mitogen-activated protein kinase 1 Homo sapiens 14-17 30246289-7 2019 Furthermore, cells treated with the inhibitors of ERK1/2 (PD98059) and p38 (SB203580) mitigated the expression of cytokines induced by LPS, thus suggesting that ERK1/2 and p38 activity are required for the inflammatory response. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 mitogen-activated protein kinase 1 Homo sapiens 172-175 30311108-6 2019 The addition of ERK inhibitor PD98059 counteracted the upregulation of Snail, Cyclin D1 and Cyclin E1, and restored the expression of E-cadherin, which indicated that C6orf106 was an upstream factor of ERK signaling pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 mitogen-activated protein kinase 1 Homo sapiens 202-205 30771312-10 2019 The ERK inhibitor PD98059 decreased NET formation but did not inhibit PMA-induced HOCl generation, and aminopyrine did not reduce ERK phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-25 mitogen-activated protein kinase 1 Homo sapiens 4-7 30461130-7 2019 Furthermore, the inhibitors for NF-kappaB (JSH-23) and mitogen-activated protein kinases (MAPKs) p38 (SB203580) and JNK (SP600125) could also attenuate the effects of SAA1, while the inhibitor for MAPK ERK1/2 (PD 98059) could block the effects of SAA1 only on MMP-1, MMP-8, and LOXL1 but not on MMP-13. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 210-218 mitogen-activated protein kinase 1 Homo sapiens 97-100 30383252-10 2019 These inhibitory effects were blocked by ADM antagonist ADM22-52, cAMP-dependent protein kinase A inhibitor KT5720, and Erk inhibitor PD98059, but not by PI-3K the inhibitor wortmannin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 134-141 mitogen-activated protein kinase 1 Homo sapiens 120-123 30257039-5 2019 Additionally, lupeol compensated MMPs expression when p-ERK phosphorylation was inhibited by p-ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 109-116 mitogen-activated protein kinase 1 Homo sapiens 56-59 30465574-7 2018 Cotreatment with LicA and PD98059 synergistically inhibited the ADAM9 expression, cell migration, and cell invasion, which suggested that the MEK-ERK signaling pathway was involved in the LicA-induced inhibition of the ADAM9 expression and the invasion activity of human glioma cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 26-33 mitogen-activated protein kinase 1 Homo sapiens 146-149 31502430-11 2019 Inhibiting PKC and ERK with respectively calphostin C and PD98059 abolished the effect of FTY720-P on the ATPase and on IkappaB, but not that of exogenous PGE2 indicating that the two kinases are upstream of NF-kappaB and PGE2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 mitogen-activated protein kinase 1 Homo sapiens 19-22 30662622-9 2018 Additionally, rh CXCL16 treatment led to effects like those of H2O2 treatment in HK-2 cells, with symptoms being effectively improved by CXCR6 siRNA and the ERK inhibitor (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 172-179 mitogen-activated protein kinase 1 Homo sapiens 157-160 30622592-8 2018 The effect of GST preventing mitochondrial dysfunction was antagonized by pretreatment of PD98059 and LY294002, selective inhibitors of ERK and Akt, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 90-97 mitogen-activated protein kinase 1 Homo sapiens 136-139 30555255-11 2018 Furthermore, knockdown of GIT1 substantially downregulated the protein levels of p-ERK and HIF-1alpha in OST cells and inhibition of p-ERK by PD98059 could significantly decrease the expression of HIF-1alpha and concentration of VEGF in GIT1-shRNA-treated cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 142-149 mitogen-activated protein kinase 1 Homo sapiens 135-138 30081092-7 2018 While inhibition of p38 activation using SB203580 did not affect TGFbeta-induced Notch3 expression, inhibition of ERK activation with a MEK1 inhibitor PD98059 dramatically reduced the event. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 151-158 mitogen-activated protein kinase 1 Homo sapiens 114-117 30081092-8 2018 Furthermore, enforced ERK activation through overexpression of the constitutively active MEK1 mutant MEK1Q56P upregulated Notch3 expression in HK-2 cells, and PD98059 reduced ERK activation and Notch3 expression in HK-2 cells expressing MEK1Q56P. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 159-166 mitogen-activated protein kinase 1 Homo sapiens 22-25 30081092-8 2018 Furthermore, enforced ERK activation through overexpression of the constitutively active MEK1 mutant MEK1Q56P upregulated Notch3 expression in HK-2 cells, and PD98059 reduced ERK activation and Notch3 expression in HK-2 cells expressing MEK1Q56P. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 159-166 mitogen-activated protein kinase 1 Homo sapiens 175-178 30337961-6 2018 Methods: BCPAP and K1 cells were exposed to increasing concentrations of BRAF V600E inhibitor PLX4032 (0.01 muM, 0.1 muM, 1 muM) or MEK/ERK inhibitor PD98059 (0.01 muM, 0.1 muM, 1 muM) or with their association or/and in the presence of 3 mM perchlorate (ClO- 4) for 0-72 h. Iodide uptake and expression of BRAF, phosphorylated (p) ERK1/2, NIS were detected. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 150-157 mitogen-activated protein kinase 1 Homo sapiens 136-139 30132504-8 2018 Inhibition of the mitogen-activated protein kinase kinase/ERK pathway with PD-98059 resulted in an increased expression of Cav-1 and a reduction in the expression of Cx43. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 75-83 mitogen-activated protein kinase 1 Homo sapiens 58-61 30335889-8 2018 Furthermore, inhibition of extracellular signal-regulated kinase (ERK) activity with PD98059 prevented the upregulation of LDLR and downregulation of PCSK9 induced by A8. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 85-92 mitogen-activated protein kinase 1 Homo sapiens 27-64 30335889-8 2018 Furthermore, inhibition of extracellular signal-regulated kinase (ERK) activity with PD98059 prevented the upregulation of LDLR and downregulation of PCSK9 induced by A8. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 85-92 mitogen-activated protein kinase 1 Homo sapiens 66-69 30337961-0 2018 Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 54-61 mitogen-activated protein kinase 1 Homo sapiens 30-33 30337961-10 2018 However, combined treatment of PLX4032 and PD98059 completely inhibited p-ERK expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 43-50 mitogen-activated protein kinase 1 Homo sapiens 74-77 30007092-10 2018 PD98059, an ERK inhibitor, decreased IL-6 generation under low dose of IL-17 but not with high dose. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 12-15 29964149-3 2018 In this study we demonstrate that a MAPK inhibitor, PD98059, inhibits both AKT and ERK phosphorylation in a human myeloid leukemia cell line (TF-1), but not in PTEN-deficient leukemia cells (TF-1a). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 52-59 mitogen-activated protein kinase 1 Homo sapiens 83-86 29066411-5 2018 Additionally, GA induced phosphorylated activation of extracellular regulated kinase (ERK), and ERK inhibitor PD98059 partially decreased GA-induced hepatoprotection, and downregulated the increased protein expressions of Nrf2, GCLC and HO-1 induced by GA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 110-117 mitogen-activated protein kinase 1 Homo sapiens 96-99 30021868-6 2018 Histamine-induced migration of mast cells was also sensitive to PD98059, an inhibitor of the mitogen-activated protein kinase kinase, indicating that the Rac-ERK pathway was involved in chemotaxis through the H4 receptor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 64-71 mitogen-activated protein kinase 1 Homo sapiens 158-161 29874112-9 2018 Furthermore, treatment of PD98059 (ERK inhibitor) significantly alleviated CSE-induced apoptosis, as well as reduced the methylation of mitochondrial transcription factor A (mtTFA) promoter, which was correlated with CS-induced endothelial apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 26-33 mitogen-activated protein kinase 1 Homo sapiens 35-38 29781537-10 2018 The effects of miR-508 inhibitors on OC cells were lost when the MAPK1/ERK signaling pathway was inhibited by PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 110-117 mitogen-activated protein kinase 1 Homo sapiens 65-70 29781537-10 2018 The effects of miR-508 inhibitors on OC cells were lost when the MAPK1/ERK signaling pathway was inhibited by PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 110-117 mitogen-activated protein kinase 1 Homo sapiens 71-74 29735364-11 2018 Treatment of PD98059 (an ERK phosphorylation inhibitor) abrogated ERK phosphorylation, downregulation of MITF and tyrosinase as well as the decrease of melanin contents by MAHDP. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 25-28 29901173-7 2018 Furthermore, the AKT pathway inhibitor LY294002, the ERK pathway inhibitor PD98059 and the TAK1 pathway inhibitor 5Z-7 inhibited the expression of PD-L1 in A549 and H1650 cells, but not in H1975 cells, during the EMT process. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 75-82 mitogen-activated protein kinase 1 Homo sapiens 53-56 29648633-9 2018 Inhibition of mitogen-activated protein kinase/ERK signaling by the kinase antagonist U0126 and PD98059 completely abolished the UT-R-mediated IA decrease. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 96-103 mitogen-activated protein kinase 1 Homo sapiens 47-50 29497174-12 2018 Specific inhibition of HSS-shRNA-induced ERK phosphorylation by PD98059 attenuated HCC cell migration in a dose-dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 64-71 mitogen-activated protein kinase 1 Homo sapiens 41-44 29770357-2 2018 Methods: The MAPK pathways (p38, ERK1/2, JNK) were inhibited by SB203580, PD98059, and SP600125 in normal human epidermal keratinocytes (NHEKs), respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 74-81 mitogen-activated protein kinase 1 Homo sapiens 28-31 29735364-11 2018 Treatment of PD98059 (an ERK phosphorylation inhibitor) abrogated ERK phosphorylation, downregulation of MITF and tyrosinase as well as the decrease of melanin contents by MAHDP. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 66-69 28833404-7 2018 The ERK inhibitor PD98059 and siRNA-mediated ERK silencing induced G1 arrest and p21WAF1/CIP1 expression by downregulating c-Myc in p53-deficient cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-25 mitogen-activated protein kinase 1 Homo sapiens 4-7 29528486-8 2018 After the cells were induced to differentiate, the effect of LED irradiation on osteogenic differentiation and mineralization was examined, with particular focus on the extracellular signal-regulated kinase (ERK)1/2 signaling pathway using an ERK inhibitor (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 258-265 mitogen-activated protein kinase 1 Homo sapiens 208-211 29524402-5 2018 PI3K inhibitor (LY 294002), ERK inhibitor (PD98059) and mTOR inhibitor (Rapamycin) inhibited ghrelin-induced A549 cell proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 43-50 mitogen-activated protein kinase 1 Homo sapiens 28-31 28492141-10 2018 Furthermore, the ERK inhibitor (PD098059), p38MAPK inhibitor (SB203580), and FAK inhibitor (Y15) reversed these results. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-40 mitogen-activated protein kinase 1 Homo sapiens 17-20 29328374-11 2018 In addition, the ERK inhibitor, PD98059, reduced cell proliferation with estrogen, ATX and LPA treatment. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 17-20 29581781-12 2018 ERK inhibitor PD98059 suppressed Drp1 phosphorylation and abrogated the effects of LASS2 depletion. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 14-21 mitogen-activated protein kinase 1 Homo sapiens 0-3 29466417-10 2018 Treatment with indomethacin, PP2, SB202190, and PD98059, respective inhibitors of COX enzymes, Src, p38MAPK, and ERK completely abrogated the effect of epinephrine. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 48-55 mitogen-activated protein kinase 1 Homo sapiens 113-116 29108991-5 2018 In addition, MEK inhibitor (PD98059) blocked the SETDB1 regulation of the FosB promoter activity via ERK2 activation during doxorubicin treatment. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 28-35 mitogen-activated protein kinase 1 Homo sapiens 101-105 29257270-11 2018 In addition, it was elucidated that inactivation of the Erk signaling pathway by PD98059 reversed the effect of FAF1 on NP cell proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 81-88 mitogen-activated protein kinase 1 Homo sapiens 56-59 29546069-9 2018 PD98059, an inhibitor of the MEK/ERK pathway, blocked the increased proliferation and migration of glioma cells activated by BzATP. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 33-36 28990053-8 2017 Treatment with the mitogen-activated protein kinase (MAPK) inhibitors, SB203580 and PD98059, significantly inhibited the effects of IL-17 on the gene and protein expression levels of FLG and IVL. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 84-91 mitogen-activated protein kinase 1 Homo sapiens 53-57 28851073-8 2018 Consistently, the ERK inhibitor PD98059 also partially prevented 4-PBA-induced cell migration. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 32-39 mitogen-activated protein kinase 1 Homo sapiens 18-21 30458452-8 2018 These SFN-NAC-induced effects were reversed by inhibiting the ERK pathway with its inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 93-100 mitogen-activated protein kinase 1 Homo sapiens 62-65 30562745-10 2018 The stimulatory effect of LRP16 was diminished by suppressing Rac1 expression and treating the cells with the ERK specific inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 134-141 mitogen-activated protein kinase 1 Homo sapiens 110-113 29103028-0 2017 PD98059 impairs the cisplatin-resistance of ovarian cancer cells by suppressing ERK pathway and epithelial mesenchymal transition process. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 80-83 29103028-9 2017 PD98059, a MEK inhibitor, suppresses the ERK pathway and the EMT process of SKOV-3/DDP. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 41-44 29103028-11 2017 CONCLUSION: PD98059 efficiently impairs the DDP-resistance of ovarian cancer cells via downregulating the ERK pathway and the EMT process. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 12-19 mitogen-activated protein kinase 1 Homo sapiens 106-109 28945007-3 2017 This work utilizes a canonical BMPR inhibitor (dorsomorphin homologue 1, DMH1) and an inhibitor of the mitogen activated protein kinase/ERK kinase (MEK)/(ERK) cascade (PD98059) to characterize the necessity of each pathway for osteogenesis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 168-175 mitogen-activated protein kinase 1 Homo sapiens 136-139 28945007-3 2017 This work utilizes a canonical BMPR inhibitor (dorsomorphin homologue 1, DMH1) and an inhibitor of the mitogen activated protein kinase/ERK kinase (MEK)/(ERK) cascade (PD98059) to characterize the necessity of each pathway for osteogenesis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 168-175 mitogen-activated protein kinase 1 Homo sapiens 154-157 28983584-9 2017 The application of PD98059, an ERK inhibitor, and LY-294002, an AKT inhibitor, attenuated the protective effect induced by DRSAb in the U251 cells subjected to H/R. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-26 mitogen-activated protein kinase 1 Homo sapiens 31-34 28977593-9 2017 CB NPs rapidly activated extracellular signal-regulated kinase 1 and 2 in KGN cells and pharmacological inhibition of this signaling pathway using PD 98059 significantly attenuated the inhibitory effects of CB NPs on CYP19A1 gene expression and aromatase activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 147-155 mitogen-activated protein kinase 1 Homo sapiens 25-70 28921713-8 2017 Our data also demonstrate that chebulinic acid-induced apoptosis in HL-60 and NB4 cells involves activation of extracellular signal-regulated kinases, which, when inhibited with ERK inhibitor PD98059, mitigates the chebulinic acid-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 192-199 mitogen-activated protein kinase 1 Homo sapiens 178-181 28849149-11 2017 ERK inhibitor PD98059 partially inhibited the role of Rab5a on MMP-2, cyclin D1, cell proliferation and invasion. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 14-21 mitogen-activated protein kinase 1 Homo sapiens 0-3 28867541-5 2017 Inhibition of ERK phosphorylation by PD098059 markedly attenuated the malignant phenotypes mediated by HMGCS2 siRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 37-45 mitogen-activated protein kinase 1 Homo sapiens 14-17 28791359-8 2017 The protective effect of SDF-1 was partially inhibited by treatment with PD98059, a MAPK/ERK inhibitor, which decreased cell viability. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 73-80 mitogen-activated protein kinase 1 Homo sapiens 84-88 28791359-8 2017 The protective effect of SDF-1 was partially inhibited by treatment with PD98059, a MAPK/ERK inhibitor, which decreased cell viability. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 73-80 mitogen-activated protein kinase 1 Homo sapiens 89-92 29070145-1 2017 OBJECTIVE: To investigate the effect of ERK1 / 2 signaling pathway inhibitor PD98059 on Ras, Raf, MEK, ERK1, ERK2 expression in order to explore a new way for basic research and clinical treatment of the chronic mountain sickness(CMS). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 77-84 mitogen-activated protein kinase 1 Homo sapiens 109-113 31966844-1 2017 OBJECTIVE: This study aimed to observe the inhibitory effects of mitogen activated protein kinase (MAPK/ERK) specific inhibitor PD98059 on Mtb-Ag activated gammadeltaTau cells and to investigate the role of MAPK in MAPK/ERK pathway of gammadeltaTau cells activated by Mtb-Ag. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 128-135 mitogen-activated protein kinase 1 Homo sapiens 104-107 28988530-5 2017 To verify this suggestion, the effect of a specific Erk inhibitor, PD98059, on the resistance to doxorubicin of control and alpha5 cDNA-transduced MCF-7 cells was investigated. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 67-74 mitogen-activated protein kinase 1 Homo sapiens 52-55 31966844-1 2017 OBJECTIVE: This study aimed to observe the inhibitory effects of mitogen activated protein kinase (MAPK/ERK) specific inhibitor PD98059 on Mtb-Ag activated gammadeltaTau cells and to investigate the role of MAPK in MAPK/ERK pathway of gammadeltaTau cells activated by Mtb-Ag. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 128-135 mitogen-activated protein kinase 1 Homo sapiens 220-223 28647515-11 2017 The enhanced expression of LIF, IL-11, integrin alphaV, and HOXA10 induced by AglyMax-Sup was abolished by the ER antagonist fulvestrant and the ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 159-166 mitogen-activated protein kinase 1 Homo sapiens 145-148 29050311-6 2017 The effects were reversed by the incorporation of specific ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 73-80 mitogen-activated protein kinase 1 Homo sapiens 59-62 28842382-9 2017 MLA (100nM), PD98059 (an ERK inhibitor; 20muM), SB203580 (a p38 inhibitor; 20muM) and SP600125 (a JNK inhibitor; 20muM) also blocked cell migration and varenicline-induced downregulation of VE-cadherin expression in HUVECs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 25-28 28629997-6 2017 The IL-1alpha-induced increase of TRPA1 responsiveness was inhibited by an extracellular-regulated kinase (Erk) inhibitor (PD98059) but not by inhibitors of c-Jun kinase, p38 mitogen-activated protein kinase or phosphatidylinositol-3 kinase. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 123-130 mitogen-activated protein kinase 1 Homo sapiens 75-105 28629997-6 2017 The IL-1alpha-induced increase of TRPA1 responsiveness was inhibited by an extracellular-regulated kinase (Erk) inhibitor (PD98059) but not by inhibitors of c-Jun kinase, p38 mitogen-activated protein kinase or phosphatidylinositol-3 kinase. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 123-130 mitogen-activated protein kinase 1 Homo sapiens 107-110 29152067-4 2017 PD98059, a MEK inhibitor, was administered to block the ERK/MAPK pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 56-59 28381458-5 2017 However, sanguinarine and VP significantly increased phosphorylation of ERK, a kinase that can phosphorylate S261; inhibition of ERK by PD98059 partially decreased baseline S261 phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 136-143 mitogen-activated protein kinase 1 Homo sapiens 72-75 28381458-5 2017 However, sanguinarine and VP significantly increased phosphorylation of ERK, a kinase that can phosphorylate S261; inhibition of ERK by PD98059 partially decreased baseline S261 phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 136-143 mitogen-activated protein kinase 1 Homo sapiens 129-132 28543279-6 2017 Inhibition of NMDAR activation with D-AP5 or ERK MAPK phosphorylation with PD98059 attenuates homocysteine-induced decrease in surface expression of GluA2-AMPAR subunit. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 75-82 mitogen-activated protein kinase 1 Homo sapiens 45-48 28543279-6 2017 Inhibition of NMDAR activation with D-AP5 or ERK MAPK phosphorylation with PD98059 attenuates homocysteine-induced decrease in surface expression of GluA2-AMPAR subunit. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 75-82 mitogen-activated protein kinase 1 Homo sapiens 49-53 28726203-1 2017 We analyzed migration of monocytes under the effect of apocinin (NADPH inhibitor) and PD98059 (blocker of extracellular MEK/ERK kinase involved in Nox4 oxidase-mediated migration of monocytes). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 86-93 mitogen-activated protein kinase 1 Homo sapiens 124-127 31966619-9 2017 Furthermore, the inhibitor of the ERK pathway, PD98059, suppressed the effect of HNs on bone marker expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-54 mitogen-activated protein kinase 1 Homo sapiens 34-37 28641719-8 2017 PD98059 (an extracellular signal-regulated kinase [ERK] inhibitor) blunted induction of SIRPalpha expression by GM-CSF. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 12-49 28641719-8 2017 PD98059 (an extracellular signal-regulated kinase [ERK] inhibitor) blunted induction of SIRPalpha expression by GM-CSF. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 51-54 28535663-5 2017 The ability of insulin to regulate RANK expression depends on extracellular signal-regulated kinase 1/2 (ERK1/2) since only PD98059, an ERK1/2 inhibitor, specifically inhibited its expression by insulin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 124-131 mitogen-activated protein kinase 1 Homo sapiens 62-103 28487957-8 2017 In addition, the ERK inhibitor PD98059 may inhibit EMT caused by CCL21, and decreased cell migration and invasion initiated by CCL21. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 31-38 mitogen-activated protein kinase 1 Homo sapiens 17-20 28572744-7 2017 The specific extracellular signal-regulated kinases 1/2 (ERK1/2) inhibitor, PD98059, partially inhibited BBR effects including reduction of cell viability, and up-regulation of KLF6 and ATF3 expressions; although, PD98059 did not alter the down-regulation of E2F1 and PTTG1 expression by BBR. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 76-83 mitogen-activated protein kinase 1 Homo sapiens 13-55 28383556-9 2017 However, TNF-alpha-induced BAFF expression and promoter activity decreased after treatment with the ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 114-121 mitogen-activated protein kinase 1 Homo sapiens 100-103 28524116-10 2017 However, pretreatment with PD98059 and SB203580, an extracellular signal-regulated kinases (ERK), and p38 inhibitors, suppressed the salinomycin-induced autophagy by reversing the upregulation of ERK and p38. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 27-34 mitogen-activated protein kinase 1 Homo sapiens 52-90 28524116-10 2017 However, pretreatment with PD98059 and SB203580, an extracellular signal-regulated kinases (ERK), and p38 inhibitors, suppressed the salinomycin-induced autophagy by reversing the upregulation of ERK and p38. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 27-34 mitogen-activated protein kinase 1 Homo sapiens 92-95 28524116-10 2017 However, pretreatment with PD98059 and SB203580, an extracellular signal-regulated kinases (ERK), and p38 inhibitors, suppressed the salinomycin-induced autophagy by reversing the upregulation of ERK and p38. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 27-34 mitogen-activated protein kinase 1 Homo sapiens 196-199 28524116-10 2017 However, pretreatment with PD98059 and SB203580, an extracellular signal-regulated kinases (ERK), and p38 inhibitors, suppressed the salinomycin-induced autophagy by reversing the upregulation of ERK and p38. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 27-34 mitogen-activated protein kinase 1 Homo sapiens 204-207 28000882-8 2017 LSS-stimulated phosphorylation of eNOS-Ser1177 and -Thr495 were suppressed by the Akt inhibitor, perifosine, and extracellular signal regulated kinases1/2 (ERK1/2) inhibitor, PD98059, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 175-182 mitogen-activated protein kinase 1 Homo sapiens 113-154 28178193-11 2017 Moreover, co-treatment with ERK inhibitor PD98059 partially reversed cearoin-induced cell death, indicating the involvement of ERK in cearoin anticancer effects. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 42-49 mitogen-activated protein kinase 1 Homo sapiens 28-31 28178193-11 2017 Moreover, co-treatment with ERK inhibitor PD98059 partially reversed cearoin-induced cell death, indicating the involvement of ERK in cearoin anticancer effects. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 42-49 mitogen-activated protein kinase 1 Homo sapiens 127-130 28223944-7 2017 ERK1/2 inhibition by the specific MEK1/2 inhibitors PD98059/U0126 significantly attenuated the IL-1beta mediated downregulation of PDZK1, while NF-kappaB, p38 MAPK, and JNK inhibition did not. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 52-59 mitogen-activated protein kinase 1 Homo sapiens 155-158 27864646-7 2017 Furthermore, blockade of ERK using PD98059 inhibitor reduced p-CREB and Bdnf mRNA transcription induced by LLL. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 35-42 mitogen-activated protein kinase 1 Homo sapiens 25-28 29073620-11 2017 Furthermore, we found that ATL-1 stimulated phosphorylation of ERK1/2, inhibited phosphorylation and protein expressions of Stat3 and SP1; the latter were abrogated in the presence of MEK/ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 202-209 mitogen-activated protein kinase 1 Homo sapiens 63-66 27484838-11 2016 Furthermore, inhibition of JNK by its inhibitor, SP600125, or MEK/Erk signalling by its inhibitor, PD98059, dramatically blocked IGFBP5-enhanced ALP activity and in vitro mineralization in both PDLSCs and WJCMSCs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 99-106 mitogen-activated protein kinase 1 Homo sapiens 66-69 27423452-6 2016 Since SCH 79797, a PAR-1 antagonist, and PD98059, an inhibitor of ERK inhibited thrombin- and SFLLR-NH2-induced TNF-alpha release, the action of thrombin is most likely through a PAR-1- and ERK-mediated signaling mechanism. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 41-48 mitogen-activated protein kinase 1 Homo sapiens 66-69 27423452-6 2016 Since SCH 79797, a PAR-1 antagonist, and PD98059, an inhibitor of ERK inhibited thrombin- and SFLLR-NH2-induced TNF-alpha release, the action of thrombin is most likely through a PAR-1- and ERK-mediated signaling mechanism. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 41-48 mitogen-activated protein kinase 1 Homo sapiens 190-193 28167851-6 2017 The ERK inhibitor PD98059 diminished the expression of proinflammatory markers as well as the accumulation of beta-amyloid. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-25 mitogen-activated protein kinase 1 Homo sapiens 4-7 26320741-5 2016 LPS and Pam3csk4 also induced IRAK1/4-, ERK- and ROS-dependent activation of activator protein-1 (AP-1), IL-1beta transcription, and IL-1beta processing because significant inhibition in AP-1 activity, IL-1beta transcription, Pro- and mature IL-beta expression, and caspase-1 activity was observed with PD98059, U0126, DPI, NAC, an IRAK1/4 inhibitor, tanshinone IIa, and IRAK1 siRNA treatment. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 303-310 mitogen-activated protein kinase 1 Homo sapiens 40-43 27612090-9 2016 The enhanced adhesion and vasculogenesis of EOCs can be blocked by short interfering RNA (siRNA) against CXCR7 and ERK inhibitor PD098059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 129-137 mitogen-activated protein kinase 1 Homo sapiens 115-118 26497030-8 2016 Moreover, PD98059 significantly decreased the levels of p-Erk and p-p53; however, p53 siRNA had little effect on the level of p-Erk. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 10-17 mitogen-activated protein kinase 1 Homo sapiens 58-61 27372058-6 2016 Furthermore, Artemisinin failed to suppress H2O2-induced cytotoxicity and the increase of caspase 3/7 activity in the presence of the ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 148-155 mitogen-activated protein kinase 1 Homo sapiens 134-137 27021876-6 2016 Chebulic acid was also found to induce translocation of Nrf2 into the nucleus, which was attenuated by inhibition of ERK phosphorylation through treatment with PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 160-167 mitogen-activated protein kinase 1 Homo sapiens 117-120 27240591-11 2016 Specific inhibitors, LY294002 and PD98059, suppressed activation of AKT and ERK, which attenuated DU-145 cell clone formation and invasion induced by S100A16 overexpression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 34-41 mitogen-activated protein kinase 1 Homo sapiens 76-79 26346882-9 2016 The PI3/Akt inhibitor, LY294002, impeded the changes induced by agmatine, while ERK inhibitor (PD98059) did not disturb the effects of agmatine, and by itself, it preserved the cells against 6-OHDA toxicity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 95-102 mitogen-activated protein kinase 1 Homo sapiens 80-83 27216977-8 2016 An extracellular signal-regulated kinase (ERK) inhibitor, PD98059, significantly suppressed the secretion and the gelatinolytic activity of MMP3, and invasion in MCF10A cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 mitogen-activated protein kinase 1 Homo sapiens 3-40 27216977-8 2016 An extracellular signal-regulated kinase (ERK) inhibitor, PD98059, significantly suppressed the secretion and the gelatinolytic activity of MMP3, and invasion in MCF10A cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 mitogen-activated protein kinase 1 Homo sapiens 42-45 27632912-8 2016 Similarly, apple extract-induced phosphorylation of the mTOR/p70S6K/S6RP/eIF4B/eIF4E pathway was blocked by pretreatment with PD98059, a specific ERK inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 126-133 mitogen-activated protein kinase 1 Homo sapiens 146-149 27216486-6 2016 Protein analyses revealed low phospho-ERK1/2 (p-ERK) content in fibroblasts from BD patients vs. CONTROLS: Pharmacological inhibition of ERK1/2 by PD98059 attenuated the rhythm amplification effect of lithium, while inhibition of two related kinases, c-Jun N-terminal kinase (JNK), and P38 did not. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 147-154 mitogen-activated protein kinase 1 Homo sapiens 38-41 27216486-6 2016 Protein analyses revealed low phospho-ERK1/2 (p-ERK) content in fibroblasts from BD patients vs. CONTROLS: Pharmacological inhibition of ERK1/2 by PD98059 attenuated the rhythm amplification effect of lithium, while inhibition of two related kinases, c-Jun N-terminal kinase (JNK), and P38 did not. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 147-154 mitogen-activated protein kinase 1 Homo sapiens 286-289 27384485-6 2016 Inhibition of ERalpha-ERK-P62 cascades in MCF-7 cells by small interfering RNA or PD98059 impairs the autophagic degradation, and leads to "autophagic switch" - from cytotoxic autophagy to cytoprotection. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 82-89 mitogen-activated protein kinase 1 Homo sapiens 22-25 27531797-1 2016 UNLABELLED: Objective: To study the effect of PD98059, a specific inhibitor of Ras/Raf/MEK/ERK signaling pathway, on the proliferation and apoptisis of bone marrow CD71(+), CD235a(+) nucleated erythrocytes in patients with high altitude polycythemia (HAPC) and the pathogenesis of HAPC. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 46-53 mitogen-activated protein kinase 1 Homo sapiens 91-94 27313717-7 2016 Furthermore, the use of PD98059, a specific mitogen-activated protein kinase kinase inhibitor, potentiated the proapoptotic effects of CC, which indicated that CC may induce apoptosis in renal cancer cells partly via inhibition of ERK activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 24-31 mitogen-activated protein kinase 1 Homo sapiens 231-234 27323826-9 2016 PI3K/Akt inhibitor (LY294002) and ERK inhibitor (PD98059) suppressed simvastatin-induced Nrf2 and HO-1 expression in both HT-29 and HCT 116 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 49-56 mitogen-activated protein kinase 1 Homo sapiens 34-37 27354597-7 2016 In addition, the ERK-specific inhibitor, PD98059, triggered the apoptosis of TLR4-activated drug-exposed colon cancer cells, whereas there was no effect on the expression of epithelial-mesenchymal transition markers or GSK3beta phosphorylation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 41-48 mitogen-activated protein kinase 1 Homo sapiens 17-20 27035160-8 2016 Inhibition of PI3-kinase, ERK-1/2, and p38 kinase with LY294002, PD98059, and SB203580, respectively, in the presence of SAL suppressed the metastatic capacity by reducing MMP-2 expression, as determined by gelatin zymography. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 65-72 mitogen-activated protein kinase 1 Homo sapiens 39-42 27347133-9 2016 Mevalonic acid and PD98059 reversed the ERK activation and apoptosis induced by treatment with simvastatin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-26 mitogen-activated protein kinase 1 Homo sapiens 40-43 26923291-9 2016 Treatment of HUVECs with PD98059, SB203580 and Wortmannin, which are the inhibitors of ERK, P38 MAPK and AKT respectively, resulted in decreased SIRT1 expression and reduced migration of HUVEC cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 25-32 mitogen-activated protein kinase 1 Homo sapiens 87-90 26932601-9 2016 In parallel, the application of inhibitors SP600125 and PD98059, inhibitors of the JNK and ERK signaling pathways, respectively, not only reversed such effects of Ex-4 on JNK and ERK but also resulted in lower percentages of S-phase cells and fewer numbers of Edu(+) cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 56-63 mitogen-activated protein kinase 1 Homo sapiens 91-94 26932601-9 2016 In parallel, the application of inhibitors SP600125 and PD98059, inhibitors of the JNK and ERK signaling pathways, respectively, not only reversed such effects of Ex-4 on JNK and ERK but also resulted in lower percentages of S-phase cells and fewer numbers of Edu(+) cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 56-63 mitogen-activated protein kinase 1 Homo sapiens 179-182 25683703-7 2016 Moreover, both ERK inhibitor PD98059 and p38 inhibitor SB203580 almost abolished the G2/M phase arrest and apoptosis induced by aspafilioside B, and reversed the expression of cell cycle- and apoptosis-related proteins. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 29-36 mitogen-activated protein kinase 1 Homo sapiens 15-18 26851786-8 2016 CONCLUSIONS: PD98059 and resveratrol can effectively inhibit the proliferation of SW620 through inhibiting the MEK/ERK signaling pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 115-118 26673746-9 2016 Inhibition of MAPK/ERK signaling by employing inhibitor PD98059 did not antagonize the effects of TKP. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 56-63 mitogen-activated protein kinase 1 Homo sapiens 14-18 26673746-9 2016 Inhibition of MAPK/ERK signaling by employing inhibitor PD98059 did not antagonize the effects of TKP. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 56-63 mitogen-activated protein kinase 1 Homo sapiens 19-22 26918447-8 2016 Similarly, expression of integrin alphaV restored ERK activation and transformed growth in PKCdelta depleted cells, and this could also be inhibited by pretreatment with PD98059.Our studies demonstrate an essential role for alphaVbeta3 and ERK signalingdownstream of PKCdelta in regulating the survival of K-ras dependent NSCLC cells, and identify PKCdelta as a novel therapeutic target for the subset of NSCLC patients with K-ras dependent tumors. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 170-177 mitogen-activated protein kinase 1 Homo sapiens 240-243 26934554-9 2016 VEGF activated CRMP4 expression in gastric cancer cells, and this effect was significantly inhibited by MAPK and PI3K inhibitors (PD98059 and LY294002). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 130-137 mitogen-activated protein kinase 1 Homo sapiens 104-108 26460784-9 2016 All these effects were reversed after blocking ERK with PD98059 (an ERK inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 56-63 mitogen-activated protein kinase 1 Homo sapiens 47-50 26263195-6 2016 Treatment with PD98059, an ERK pathway-specific inhibitor, restored liposomal TMP-induced reductions in melanin, abrogated reductions in tyrosinase activity, and downregulated MITF and tyrosinase protein. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 15-22 mitogen-activated protein kinase 1 Homo sapiens 27-30 27802437-5 2016 However, the MAPK inhibitor PD98059 and/or PI3K inhibitor LY294002 were able to antagonize the effects of VPA by abolishing ERK/Akt activations and cancelling GSK3beta suppression, thus it impaired VPA apoptosis-inducing effects on glioma cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 28-35 mitogen-activated protein kinase 1 Homo sapiens 13-17 27802437-5 2016 However, the MAPK inhibitor PD98059 and/or PI3K inhibitor LY294002 were able to antagonize the effects of VPA by abolishing ERK/Akt activations and cancelling GSK3beta suppression, thus it impaired VPA apoptosis-inducing effects on glioma cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 28-35 mitogen-activated protein kinase 1 Homo sapiens 124-127 26884713-5 2016 Notably, a specific inhibitor of the ERK/MAPK pathway (PD98059), but not p38/MAPK, JNK/MAPK or PI3-K/AKT inhibitors, markedly decreased the cell invasion numbers in a transwell assay. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 55-62 mitogen-activated protein kinase 1 Homo sapiens 37-40 26884713-6 2016 Further experiments demonstrated that blocking the ERK/MAPK pathway by PD98059 resulted in reduced MMP-2/9 protein levels and MMP-9 activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 71-78 mitogen-activated protein kinase 1 Homo sapiens 51-54 27606810-7 2016 The specific inhibitor of extracellular signal-regulated kinases 1/2 (ERK1/2) PD98059 was used to elucidate the involved signaling pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 78-85 mitogen-activated protein kinase 1 Homo sapiens 26-68 26526982-3 2016 In this study, we investigated the effect of c-fos on the steady-state levels of CYP17 and CYP19 in human ovarian granulosa-like tumor cell line (KGN) by inhibiting MEK/ERK pathway with PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 186-193 mitogen-activated protein kinase 1 Homo sapiens 169-172 26460784-9 2016 All these effects were reversed after blocking ERK with PD98059 (an ERK inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 56-63 mitogen-activated protein kinase 1 Homo sapiens 68-71 26596264-9 2016 Furthermore, use of the CGRP (8-37), ERK inhibitor PD 98059, SQ 22536 or H-89 abolished the CGRP mediated increase in IL-1beta. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 51-59 mitogen-activated protein kinase 1 Homo sapiens 37-40 26519986-9 2016 Inhibitors (PD98059, mevastatin and genistein) of specific sites along the Ras/Raf/MEK/ERK signaling pathway, blocked the phosphorylation and concomitantly inhibited 5alphaP-induced stimulation of cell proliferation and detachment. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 12-19 mitogen-activated protein kinase 1 Homo sapiens 87-90 30090349-10 2016 Moreover, the NF-kappaB inhibitor (PDTC), the ERK inhibitor (PD98059), the JNK inhibitor (SP600125), and the p38 MAPK inhibitor (SB203580) markedly attenuated the growth of these cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 61-68 mitogen-activated protein kinase 1 Homo sapiens 46-49 26657209-8 2016 TGF-beta1 markedly stimulated the URG-4/URGCP mRNA and protein that was blocked by MEK1 [MAPK (Mitogen-Activated Protein Kinase)/ERK (extracellular signal-regulated kinase) kinase 1] inhibitor, PD98059 and PI3K inhibitor, wortmannin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 194-201 mitogen-activated protein kinase 1 Homo sapiens 129-132 26359088-8 2015 Widdrol-induced phosphorylation of PKC, MEK, and ERK, which are related to the PKC-MAPK pathway, and their phosphorylation was inhibited by their inhibitors (H-7, U0126, and PD-98059, respectively). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 174-182 mitogen-activated protein kinase 1 Homo sapiens 49-52 26359088-8 2015 Widdrol-induced phosphorylation of PKC, MEK, and ERK, which are related to the PKC-MAPK pathway, and their phosphorylation was inhibited by their inhibitors (H-7, U0126, and PD-98059, respectively). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 174-182 mitogen-activated protein kinase 1 Homo sapiens 83-87 26059188-11 2015 P-Erk upregulation mediated by bortezomib was effectively suppressed by the addition of the MEK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 106-113 mitogen-activated protein kinase 1 Homo sapiens 2-5 26420479-8 2015 The expression of RANKL induced by IL-29 could be completely blocked by the inhibitors of mitogen-activated protein kinase (MAPK) signal pathway, including PD98059 (ERK inhibitor), SB203580 (p38 inhibitor) and SP600125 (JNK inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 156-163 mitogen-activated protein kinase 1 Homo sapiens 124-128 26420479-8 2015 The expression of RANKL induced by IL-29 could be completely blocked by the inhibitors of mitogen-activated protein kinase (MAPK) signal pathway, including PD98059 (ERK inhibitor), SB203580 (p38 inhibitor) and SP600125 (JNK inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 156-163 mitogen-activated protein kinase 1 Homo sapiens 165-168 26558197-12 2015 Treatment with AG1478 and PD98059 abolished siRNA-PTP1B-induced activation of EGFR and ERK, alpha-SMA expression and cell migration. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 26-33 mitogen-activated protein kinase 1 Homo sapiens 87-90 26439801-4 2015 The invasion of pancreatic cancer cells resulting from the activation of the H2O2/MAPK axis under high glucose conditions is effectively inhibited by PD 98059 (ERK inhibitor), SB 203580 (p38 MAPK inhibitor), polyethylene glycol-conjugated catalase (PEG-CAT), or the siRNA specific to SOD2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 150-158 mitogen-activated protein kinase 1 Homo sapiens 82-86 26439801-4 2015 The invasion of pancreatic cancer cells resulting from the activation of the H2O2/MAPK axis under high glucose conditions is effectively inhibited by PD 98059 (ERK inhibitor), SB 203580 (p38 MAPK inhibitor), polyethylene glycol-conjugated catalase (PEG-CAT), or the siRNA specific to SOD2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 150-158 mitogen-activated protein kinase 1 Homo sapiens 160-163 26526356-11 2015 The treatment with MEK1/2 inhibitors PD98059 or PD184352 effectively restored the let-7f level, suggesting that Her2-overexpression-mediated ERK constitutive activation inhibited let-7f, leading to the upregulation of the beta2-AR expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 37-44 mitogen-activated protein kinase 1 Homo sapiens 141-144 26266487-10 2015 Insulin-inhibited ERK activation (phosphorylation) induced by Abeta and PD98059 (as ERK inhibitor) did not affect the protective effect of insulin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 72-79 mitogen-activated protein kinase 1 Homo sapiens 18-21 26266487-10 2015 Insulin-inhibited ERK activation (phosphorylation) induced by Abeta and PD98059 (as ERK inhibitor) did not affect the protective effect of insulin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 72-79 mitogen-activated protein kinase 1 Homo sapiens 84-87 26086160-7 2015 Moreover, the PFOS-induced iNOS expression and NO production were attenuated after the inhibition of ERK or JNK MAPK by their corresponding inhibitors, PD98059 and SP600125. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 152-159 mitogen-activated protein kinase 1 Homo sapiens 101-104 26086160-7 2015 Moreover, the PFOS-induced iNOS expression and NO production were attenuated after the inhibition of ERK or JNK MAPK by their corresponding inhibitors, PD98059 and SP600125. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 152-159 mitogen-activated protein kinase 1 Homo sapiens 112-116 26304749-6 2015 HCRP-1 depletion increased matrix metalloproteinase (MMP)-2 protein level, with increased extracellular signal-regulatedkinase (ERK) phosphorylation, which could be reversed by ERK siRNA or ERK inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 205-212 mitogen-activated protein kinase 1 Homo sapiens 90-126 26096905-7 2015 PD98059, an inhibitor of the ERK pathway, as well as probenecid, a TAS2R16 antagonist, inhibited receptor phosphorylation as well as neurite outgrowth. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 mitogen-activated protein kinase 1 Homo sapiens 29-32 26696477-10 2015 The specific inhibitors (PD98059) of ERK had no influence on the expression of GR isoforms. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 25-32 mitogen-activated protein kinase 1 Homo sapiens 37-40 26304749-6 2015 HCRP-1 depletion increased matrix metalloproteinase (MMP)-2 protein level, with increased extracellular signal-regulatedkinase (ERK) phosphorylation, which could be reversed by ERK siRNA or ERK inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 205-212 mitogen-activated protein kinase 1 Homo sapiens 128-131 26304749-6 2015 HCRP-1 depletion increased matrix metalloproteinase (MMP)-2 protein level, with increased extracellular signal-regulatedkinase (ERK) phosphorylation, which could be reversed by ERK siRNA or ERK inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 205-212 mitogen-activated protein kinase 1 Homo sapiens 177-180 26304749-6 2015 HCRP-1 depletion increased matrix metalloproteinase (MMP)-2 protein level, with increased extracellular signal-regulatedkinase (ERK) phosphorylation, which could be reversed by ERK siRNA or ERK inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 205-212 mitogen-activated protein kinase 1 Homo sapiens 177-180 24395385-10 2015 Further, inhibition of the ERK/MAPK pathway by PD98059 blocks E2-induced ERK/MAPK activation and cell proliferation in CaOV-3 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-54 mitogen-activated protein kinase 1 Homo sapiens 27-30 26357647-11 2015 This decreased expression of adipocyte specific markers caused by GLP-1 was significantly reversed by the treatment of extracellular signal-regulated kinase (ERK) inhibitor, PD98059 (P < 0.05). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 174-181 mitogen-activated protein kinase 1 Homo sapiens 119-156 26357647-11 2015 This decreased expression of adipocyte specific markers caused by GLP-1 was significantly reversed by the treatment of extracellular signal-regulated kinase (ERK) inhibitor, PD98059 (P < 0.05). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 174-181 mitogen-activated protein kinase 1 Homo sapiens 158-161 24395385-10 2015 Further, inhibition of the ERK/MAPK pathway by PD98059 blocks E2-induced ERK/MAPK activation and cell proliferation in CaOV-3 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-54 mitogen-activated protein kinase 1 Homo sapiens 31-35 24395385-10 2015 Further, inhibition of the ERK/MAPK pathway by PD98059 blocks E2-induced ERK/MAPK activation and cell proliferation in CaOV-3 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-54 mitogen-activated protein kinase 1 Homo sapiens 73-76 24395385-10 2015 Further, inhibition of the ERK/MAPK pathway by PD98059 blocks E2-induced ERK/MAPK activation and cell proliferation in CaOV-3 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-54 mitogen-activated protein kinase 1 Homo sapiens 77-81 25936372-10 2015 The use of SB203580, a p38 inhibitor, and PD98059, an ERK inhibitor, resulted in the restoration of dHL-60 cell migration which was significantly inhibited treatment with rhMFG-E8. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 42-49 mitogen-activated protein kinase 1 Homo sapiens 54-57 26347199-9 2015 The employment of specific chemical inhibitors, SB203580, LY294002, PD98059, and AG490, demonstrated the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in the regulatory effect of UA on NOX4 activity and expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 68-75 mitogen-activated protein kinase 1 Homo sapiens 143-147 26220523-7 2015 On the mechanism, the phosphorylation mediated by LK6 and Mnk2a is controlled through ERK signal pathway by phorbolmyristate acetate (PMA) avtivation and PD98059 inhibition. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 154-161 mitogen-activated protein kinase 1 Homo sapiens 86-89 26026912-8 2015 As the PKC inhibitor bisindolylmaleimide I and the ERK inhibitor PD98059 could revert the induced CRH expression, the pathways dictated by PKC and ERK were likely involved in the transcriptional regulation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 65-72 mitogen-activated protein kinase 1 Homo sapiens 51-54 26026912-8 2015 As the PKC inhibitor bisindolylmaleimide I and the ERK inhibitor PD98059 could revert the induced CRH expression, the pathways dictated by PKC and ERK were likely involved in the transcriptional regulation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 65-72 mitogen-activated protein kinase 1 Homo sapiens 147-150 25981695-9 2015 The ERK inhibitor (PD98059) prevented the DFO-induced Egr1 mRNAs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-26 mitogen-activated protein kinase 1 Homo sapiens 4-7 25982794-9 2015 Interestingly, ERK, JNK and p38MAPK pharmacological inhibitors blocked CBG-induced MAPKs activation and ERK inhibitor (PD98059) also prevented the CBG-induced caspase-3 activation and PARP cleavage in U266 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 119-126 mitogen-activated protein kinase 1 Homo sapiens 104-107 25983101-11 2015 In addition, PD98059, a specific ERK inhibitor, increased the sensitivity of cancer cells to a lower concentration of ATO treatment. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 33-36 25748730-4 2015 Concanavalin A (ConA) at 20 mug/mL produced a 5.2-fold increase in IL-8 mRNA by 8h, and a 14.2-fold rise in IL-8 levels by 16 h. Inhibition of MEK (ERK kinase) and extracellular signal-regulated kinase (ERK) by PD98059 and U0126, or inhibition of phosphatidylinositol 3-kinase (PI3K) by LY294002 blocked both ConA-induced IL-8 mRNA expression and IL-8 secretion. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 211-218 mitogen-activated protein kinase 1 Homo sapiens 148-151 24664993-9 2015 Treatment with ERK inhibitor PD98059 in cells with CRKL transfection inhibited ERK activity, cell invasion, and MMP9 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 29-36 mitogen-activated protein kinase 1 Homo sapiens 15-18 24664993-9 2015 Treatment with ERK inhibitor PD98059 in cells with CRKL transfection inhibited ERK activity, cell invasion, and MMP9 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 29-36 mitogen-activated protein kinase 1 Homo sapiens 79-82 25579056-11 2015 The signaling pathway MAPK/ERK was activated by Huh-7 CM but its inhibition by PD98059 did not impair Huh-7 CM-induced MSC migration. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 79-86 mitogen-activated protein kinase 1 Homo sapiens 22-26 25704082-15 2015 Ezetimibe-increased GLP-1 secretion was abrogated by inhibiting the MEK/ERK pathway with PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 89-96 mitogen-activated protein kinase 1 Homo sapiens 72-75 25778668-9 2015 Electrical cell-substrate impedance sensing real-time analysis demonstrated that ERK signaling inhibitor PD98059 comprises the anti-proliferative effects of DHA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 105-112 mitogen-activated protein kinase 1 Homo sapiens 81-84 25117566-8 2015 Furthermore, PD98059, a specific inhibitor for ERK, as well as SP600125, a specific inhibitor for JNK, inhibited LPS-induced mRNA upregulation of inflammatory mediators. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 mitogen-activated protein kinase 1 Homo sapiens 47-50 25898413-7 2015 Moreover, treatment with PD98059, a highly selective ERK inhibitor, blocked PDGF-induced upregulation of cyclin D1 and cyclin E and downregulation of p27kip1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 25-32 mitogen-activated protein kinase 1 Homo sapiens 53-56 25652453-14 2015 SB203580 (p38 kinase), PD98059 (ERK), or SP600125 (JNK) inhibitors significantly reduced this effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 23-30 mitogen-activated protein kinase 1 Homo sapiens 32-35 25832424-8 2015 Pretreatment of the cells with the ROS scavenger N-acetyl-L-cysteine, ERK inhibitor PD98059 or NF-kappaB inhibitor PDTC blocked CRP-stimulated RAGE expression, but pretreatment with the NADPH oxidase inhibitor DPI, JNK inhibitor SP600125 or p38 MAPK inhibitor SB203580 did not significantly alter CRP-stimulated RAGE expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 84-91 mitogen-activated protein kinase 1 Homo sapiens 70-73 25572615-9 2015 The behavior was significantly inhibited by the ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 62-69 mitogen-activated protein kinase 1 Homo sapiens 48-51 25789063-5 2015 The results demonstrated that the 47 C treatment regimen: i) Triggered upregulation of VEGF expression in the SMMC7721 cells, which was reduced by CaMKII or ERK inhibition; ii) induced ERK activation was prevented by KN93; and iii) promoted SMMC7721 cell proliferation, which was greatly inhibited by axitinib, KN93 and PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 320-327 mitogen-activated protein kinase 1 Homo sapiens 185-188 25573072-10 2015 Finally, pharmacological inhibitors OA, SB203580, SP600125 and PD98059 confirm the role of PP2A and its substrates ERK, p38 MAPK and Akt in mediating TP/HCPT-induced apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 63-70 mitogen-activated protein kinase 1 Homo sapiens 115-118 25638174-14 2015 Blocking Akt and/or ERK with the PI3K inhibitor, LY294002, or the ERK inhibitor, PD98059, induced down-regulation of MMP9 and up-regulation of cleaved caspase-3 and PARP-1, resembling the effects of luteolin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 81-88 mitogen-activated protein kinase 1 Homo sapiens 20-23 25638063-8 2015 Blocking the activation of Akt and Erk with their potent inhibitors LY294002 and PD98059, respectively, markedly attenuated the octacosanol-induced proliferation and migration of HUVEC. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 81-88 mitogen-activated protein kinase 1 Homo sapiens 35-38 25769181-8 2015 EMSA experiments revealed a slower migrating band after c-Myc bound the E-box in response to B[a]P treatment, which was abolished upon the addition of the ERK inhibitor PD98059 in H1355 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 169-176 mitogen-activated protein kinase 1 Homo sapiens 155-158 25399887-13 2015 Furthermore, the ERK inhibitor pd98059 (30 mumol/L) and the JNK inhibitor sp600125 (10 mumol/L) blocked CRP-induced COX-1 and COX-2 expression for 12 h. Together, the findings of the present study suggest that CRP can promote the development of the no-reflow phenomenon by increasing COX-1 and COX-2 expression, which is regulated, in part, via ERK and JNK activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 31-38 mitogen-activated protein kinase 1 Homo sapiens 17-20 25399887-13 2015 Furthermore, the ERK inhibitor pd98059 (30 mumol/L) and the JNK inhibitor sp600125 (10 mumol/L) blocked CRP-induced COX-1 and COX-2 expression for 12 h. Together, the findings of the present study suggest that CRP can promote the development of the no-reflow phenomenon by increasing COX-1 and COX-2 expression, which is regulated, in part, via ERK and JNK activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 31-38 mitogen-activated protein kinase 1 Homo sapiens 345-348 25371074-10 2015 The ERK inhibitor PD98059 dramatically reversed the increased expression of VEGF induced by biglycan. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-25 mitogen-activated protein kinase 1 Homo sapiens 4-7 25638174-14 2015 Blocking Akt and/or ERK with the PI3K inhibitor, LY294002, or the ERK inhibitor, PD98059, induced down-regulation of MMP9 and up-regulation of cleaved caspase-3 and PARP-1, resembling the effects of luteolin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 81-88 mitogen-activated protein kinase 1 Homo sapiens 66-69 25291404-8 2015 Inhibition of the expression of ERK by PD98059 partially reversed ACETO-induced cytotoxicity, apoptosis and the expression of caspase-3, -9 and PARP in A549 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 39-46 mitogen-activated protein kinase 1 Homo sapiens 32-35 25464949-7 2015 Furthermore, the vegetable peptone-induced increase in cell proliferation and type I collagen production decreased upon treatment with the ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 153-160 mitogen-activated protein kinase 1 Homo sapiens 139-142 25572360-10 2015 However, the effect of fucoidan on osteogenic differentiation was inhibited by specific inhibitors of ERK (PD98059) and JNK (SP600125) but not p38 (SB203580). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 107-114 mitogen-activated protein kinase 1 Homo sapiens 102-105 25687043-6 2015 XTT assay was performed to determine the cell viability of the combined use of S1 and MEK/ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 104-111 mitogen-activated protein kinase 1 Homo sapiens 90-93 25869769-5 2015 MEK/Erk inhibitors PD98059 and MEK-162 increased NVP-BEZ235 activity on osteosarcoma cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-26 mitogen-activated protein kinase 1 Homo sapiens 4-7 26316083-8 2015 In addition, the activation of ERK1/2 was drastically decreased by 8-MOP as ERK inhibitor PD98059, indicating a role of ERK1/2 signaling pathway in 8-MOP-induced cell apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 90-97 mitogen-activated protein kinase 1 Homo sapiens 31-34 25398968-11 2015 Specific inhibitors of the ERK or NF-kappaB pathway (PD98059 or Bay11-7082) suppressed TNF-alpha-induced MMP-2 expression in leiomyoma SMCs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 53-60 mitogen-activated protein kinase 1 Homo sapiens 27-30 24596063-9 2014 Decreased Bim levels after loss of HSulf-1 were due to increased p-ERK, because inhibition of ERK activity with PD98059 resulted in increased Bim expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 112-119 mitogen-activated protein kinase 1 Homo sapiens 94-97 25239597-6 2014 On the other hand, we found that a MEK inhibitor (PD98059) further enhanced the insulin-stimulated CFTR mRNA expression and the Cl(-) secretion in forskolin-stimulated A6 cells and that insulin induced slight, transient activation of ERK followed by significant inactivation of ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 50-57 mitogen-activated protein kinase 1 Homo sapiens 234-237 25239597-6 2014 On the other hand, we found that a MEK inhibitor (PD98059) further enhanced the insulin-stimulated CFTR mRNA expression and the Cl(-) secretion in forskolin-stimulated A6 cells and that insulin induced slight, transient activation of ERK followed by significant inactivation of ERK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 50-57 mitogen-activated protein kinase 1 Homo sapiens 278-281 25431425-11 2014 PGE2 also activated the Ras/Raf/Erk pathway, and pretreatment with PD98059 abolished the protective effect of PGE2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 67-74 mitogen-activated protein kinase 1 Homo sapiens 32-35 25403108-5 2014 Extracellular regulated protein kinase (ERK) was activated after treatment with GA in HepG2 cells and pretreatment with U0126 or PD98059, the MEK inhibitors, reversed GA-triggered autophagy as evidenced by decreased expression of LC3-II and formation of autophagosomes, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 129-136 mitogen-activated protein kinase 1 Homo sapiens 0-38 25403108-5 2014 Extracellular regulated protein kinase (ERK) was activated after treatment with GA in HepG2 cells and pretreatment with U0126 or PD98059, the MEK inhibitors, reversed GA-triggered autophagy as evidenced by decreased expression of LC3-II and formation of autophagosomes, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 129-136 mitogen-activated protein kinase 1 Homo sapiens 40-43 24700312-5 2014 Further studies demonstrated that the mRNA and protein expression levels of hBD-2 were attenuated by the p38 mitogen-activated protein kinase (p38 MAPK) inhibitor SB203580, the extracellular signal-regulated kinase (ERK) inhibitor PD98059, and the nuclear factor kappa B (NF-kappaB) inhibitor (pyrrolidine dithiocarbamate (PDTC)). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 231-238 mitogen-activated protein kinase 1 Homo sapiens 216-219 25180251-8 2014 The activation of the CaSR-PLC-ERK pathway was associated with increased expression levels of Stc1 and Cox2 as confirmed by the inhibition of Erk using a chemical inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 174-181 mitogen-activated protein kinase 1 Homo sapiens 31-34 25180251-8 2014 The activation of the CaSR-PLC-ERK pathway was associated with increased expression levels of Stc1 and Cox2 as confirmed by the inhibition of Erk using a chemical inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 174-181 mitogen-activated protein kinase 1 Homo sapiens 142-145