PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16373398-6	2006	Under similar conditions, insulin- or DHEA-stimulated phosphorylation of Akt (Ser473) and endothelial nitric oxide synthase (Ser1179) was inhibited by pretreatment of cells with wortmannin (but not MAPK kinase inhibitor PD98059).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	220-227	nitric oxide synthase 3	Bos taurus	90-123	
10899167-7	2000	Evidence for the direct phosphorylation of eNOS by MAP kinase in BAEC came from "back-phosphorylation" experiments using [gamma-(32)P]ATP and ERK in vitro to phosphorylate eNOS isolated from cells previously treated with bradykinin or the MAP kinase inhibitor PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	260-267	nitric oxide synthase 3	Bos taurus	43-47	
15191917-5	2004	PD98059, a MEK-1 inhibitor, prevented the Ang II-dependent phosphorylation of extracellular-regulated protein kinases 1 and 2 and increase in eNOS expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	nitric oxide synthase 3	Bos taurus	142-146	
12715114-8	2003	The effect of E(2) and E(2)BSA on eNOS activation was unaffected by actinomycin D 25 microg/ml but was obviously inhibited by tamoxifen (0.1 micromol/L) and PD98059 (50 micromol/L).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	157-164	nitric oxide synthase 3	Bos taurus	34-38	
10899167-9	2000	Conversely, eNOS isolated from endothelial cells pretreated with the MAP kinase inhibitor PD98059 showed increased ERK-promoted phosphorylation in vitro.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	90-97	nitric oxide synthase 3	Bos taurus	12-16