PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15695523-6 2005 IFN-gamma-induced neurite outgrowth was abolished by the treatment of MEK1/2 kinase inhibitors, such as U0126 and PD98059, which inhibit the ERK1/2 activation and subsequently prevent the up-regulation of p35 expression and Cdk5 activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 114-121 cyclin dependent kinase 5 Homo sapiens 224-228 21813649-7 2011 Treatment with the MEK inhibitor, PD98059, blocked the TNF-alpha-induced increase in CDK5 phosphorylation and the depolymerization of cortical F-actin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 34-41 cyclin dependent kinase 5 Homo sapiens 85-89 15485494-5 2004 Furthermore, Cdk5 and p35 expression was decreased by ERK1/2 inhibition with PD98059 and increased by overexpression of a constitutive active mitogen-activated protein kinase kinase 1 (MEK1) mutant, suggesting the critical role of ERK1/2 in the induction of Cdk5 and p35. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 77-84 cyclin dependent kinase 5 Homo sapiens 13-17