PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15695523-6	2005	IFN-gamma-induced neurite outgrowth was abolished by the treatment of MEK1/2 kinase inhibitors, such as U0126 and PD98059, which inhibit the ERK1/2 activation and subsequently prevent the up-regulation of p35 expression and Cdk5 activity.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	114-121	cyclin dependent kinase 5	Homo sapiens	224-228	
21813649-7	2011	Treatment with the MEK inhibitor, PD98059, blocked the TNF-alpha-induced increase in CDK5 phosphorylation and the depolymerization of cortical F-actin.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	34-41	cyclin dependent kinase 5	Homo sapiens	85-89	
15485494-5	2004	Furthermore, Cdk5 and p35 expression was decreased by ERK1/2 inhibition with PD98059 and increased by overexpression of a constitutive active mitogen-activated protein kinase kinase 1 (MEK1) mutant, suggesting the critical role of ERK1/2 in the induction of Cdk5 and p35.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	77-84	cyclin dependent kinase 5	Homo sapiens	13-17