PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33242203-10	2021	Meanwhile, endothelial dysfunction caused by IH REVs was reversed by Akt activator SC79 as well as Erk kinase inhibitor PD98059, suggesting that PI3K/Akt/eNOS and Erk1/2/ET-1 pathways were implicated in IH REV-induced impaired EDRs.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	120-127	nitric oxide synthase 3	Homo sapiens	154-158	
25555250-9	2015	In addition, blocking ERK1/2 or p38 MAPK by PD98059 and SB203580, respectively attenuated the OMVs-induced eNOS phosphorylation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	44-51	nitric oxide synthase 3	Homo sapiens	107-111	
28000882-8	2017	LSS-stimulated phosphorylation of eNOS-Ser1177 and -Thr495 were suppressed by the Akt inhibitor, perifosine, and extracellular signal regulated kinases1/2 (ERK1/2) inhibitor, PD98059, respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	175-182	nitric oxide synthase 3	Homo sapiens	34-38	
12569550-7	2003	Upregulation of eNOS after treatment with hydrogen peroxide was apparently transduced through receptor tyrosine kinase signaling pathways since it was abolished by the protein kinase C (PKC) inhibitor bisindolylmaleimide-1 (BIM-1), the p21(ras) inhibitor S-trans-trans-farnesylthiosalicylic acid (FTS), the c-Raf inhibitor ZM 336372 and PD98059, which inhibits ERK1/2 activation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	337-344	nitric oxide synthase 3	Homo sapiens	16-20	
19917268-4	2010	The MEK inhibitor PD98059 and the PI3K inhibitor Wortmannin specifically inhibited sesamin-induced activation of the ERK and Akt/eNOS pathways.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	18-25	nitric oxide synthase 3	Homo sapiens	129-133	
20375905-7	2010	IL-6 treatment was found to stabilize caveolin-1 protein and its half-life was estimated to prolong from 7.5 h to longer than 12 h. Furthermore, treatment with PD98059 and short interference RNA of extracellular signal-regulated kinase gene reversed the effects of IL-6 on eNOS and caveolin-1.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	160-167	nitric oxide synthase 3	Homo sapiens	273-277	
17878755-5	2007	The migration can also be nearly completely blocked by phosphoinositide 3-kinase inhibitors (LY294002 and wortmannin) and eNOS inhibitor (N-nitro-arginine methyl ester), whereas mitogen-activated protein kinase/ERK inhibitor (PD98059) had no significant effect on SDF-1alpha-induced migration.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	226-233	nitric oxide synthase 3	Homo sapiens	122-126	
11961297-10	2002	Moreover, the VEGF-induced eNOS expression was reduced by the PD98059, MAPK pathway inhibitor.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	62-69	nitric oxide synthase 3	Homo sapiens	27-31	
11717166-6	2001	Downstream of Ras, MEK1/2 and ERK1/2 are important in this pathway, as 2 inhibitors of MEK1/2, PD98059 and UO126, completely prevented this early increase in eNOS mRNA.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	95-102	nitric oxide synthase 3	Homo sapiens	158-162	
11352660-7	2001	The effects of VEGF on NO production and the expression of endothelial NOS (eNOS) were attenuated by treating BeWo cells with the selective inhibitor of MAPK kinase, PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	166-173	nitric oxide synthase 3	Homo sapiens	59-74	
11443053-9	2001	Finally, PD-98059, a p42/44 MAPK pathway inhibitor, blocked TNF-alpha upregulation by eNOS (P = 0.02).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	9-17	nitric oxide synthase 3	Homo sapiens	86-90