PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33443645-11 2021 Thirdly, febuxostat alleviated MPP+-induced inflammatory responses in astrocytes by reducing the expressions of IL-8, IL-1beta, TNF-alpha, GFAP, MMP-2, and MMP-9. Febuxostat 9-19 interleukin 1 alpha Rattus norvegicus 118-126 33010420-10 2021 Mechanistically, FEB dose-dependently improved oxidative damage, decreased levels of IL-1beta and Runx2, lessened expression of TNF-alpha, iNOS and MMP-9 and enhanced expression of OPN and alpha-SMA in VDN aortas relative to controls. Febuxostat 17-20 interleukin 1 alpha Rattus norvegicus 85-93