PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22995295-8 2012 Furthermore, febuxostat reduced the induction of endoplasmic reticulum (ER) stress, assessed by GRP-78, ATF4, and CHOP. Febuxostat 13-23 DNA-damage inducible transcript 3 Rattus norvegicus 114-118 35215344-11 2022 FEB also significantly increased TRPC1 and decreased CHOP in parotid gland tissue. Febuxostat 0-3 DNA-damage inducible transcript 3 Rattus norvegicus 53-57 35215344-12 2022 In conclusion, FEB pre-treatment reduced 5-FU-induced parotid salivary gland damage not only through its powerful anti-inflammatory and antioxidant effects, but also through its effect on the TRPC1/CHOP signalling pathway. Febuxostat 15-18 DNA-damage inducible transcript 3 Rattus norvegicus 198-202