PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24086554-0 2013 Febuxostat, an inhibitor of xanthine oxidase, suppresses lipopolysaccharide-induced MCP-1 production via MAPK phosphatase-1-mediated inactivation of JNK. Febuxostat 0-10 mitogen-activated protein kinase 8 Homo sapiens 149-152 24086554-5 2013 Here we show that febuxostat suppresses LPS-induced MCP-1 production and mRNA expression via activating MAPK phosphatase-1 (MKP-1) which, in turn, leads to dephosphorylation and inactivation of JNK in macrophages. Febuxostat 18-28 mitogen-activated protein kinase 8 Homo sapiens 194-197