PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25656933-4	2015	Inhibition of Smad1/5/8 with dorsomorphin partially blocked Runx2 activity; however, inhibition of the BMP2 receptor with Noggin nearly fully suppressed Runx2 activity.	dorsomorphin	29-41	SMAD family member 1	Homo sapiens	14-21	
34134766-10	2021	Dorsomorphin (DM), a SMAD1 inhibitor, exerted a dose-dependent cytotoxic effect on drug-resistant MM cells with minimal cytotoxicity to normal hematopoietic cells, and further synergized with the proteasomal-inhibitor bortezomib to effectively kill drug-resistant MM cells in vitro and in a myeloma xenograft model.	dorsomorphin	0-12	SMAD family member 1	Homo sapiens	21-26	
33043005-7	2020	Additionally, BMP2 induced an increase in the levels of phosphorylated SMAD1/5/8, and this effect was completely abolished by the addition of the inhibitors DMH-1 and dorsomorphin, but not by SB431542.	dorsomorphin	167-179	SMAD family member 1	Homo sapiens	71-80	
28578012-5	2017	Using dual inhibition approaches, our results showed that BMP2 activated SMAD1/5/8 phosphorylation and up-regulated BAMBI mRNA levels, which was reversed by the BMP type I receptor inhibitors, DMH-1 and dorsomorphin, but not by SB431542 (activin/TGF-beta type I receptor inhibitor).	dorsomorphin	203-215	SMAD family member 1	Homo sapiens	73-80	
27794120-3	2016	This positive effect was attenuated by inhibitors of BMP-SMAD signaling (Dorsomorphin or LDN1931890) or transducing inhibitory SMADs (SMAD6 or SMAD7).	dorsomorphin	73-85	SMAD family member 1	Homo sapiens	57-61	
26450990-6	2016	Similarly, siRNA-mediated knockdown of Smad8 in Smad1/5-null MABs or inhibition of SMAD1/5/8 phosphorylation with Dorsomorphin (DM) also improved myogenic differentiation, demonstrating a novel role of SMAD8.	dorsomorphin	114-126	SMAD family member 1	Homo sapiens	83-90	
25514099-12	2015	These suppressive effects, along with the induction of Smad1/5/8 phosphorylation, were attenuated by cotreatment with 2 BMP type I receptor inhibitors (dorsomorphin and/or DMH-1).	dorsomorphin	152-164	SMAD family member 1	Homo sapiens	55-62	
24140593-6	2013	These suppressive effects, along with the induction of Sma and Mad-related protein (SMAD)1/5/8 phosphorylation, are attenuated by cotreatment with 2 different BMP type I receptor inhibitors (dorsomorphin and DMH-1).	dorsomorphin	191-203	SMAD family member 1	Homo sapiens	63-92	
24413384-7	2014	These suppressive effects, along with the induction of Smad1/5/8 phosphorylation, were attenuated by co-treatment with a BMP type I receptor inhibitor, dorsomorphin.	dorsomorphin	152-164	SMAD family member 1	Homo sapiens	55-62	
23362023-7	2013	In dissociated Muller glial culture, treatment with EGF induced the upregulation of Bmp7, and this upregulation was blocked significantly by co-treatment with the BMP inhibitor dorsomorphin, suggesting that BMP/Smad1/5/8 activation is mediated at least in part by an autocrine mechanism in Muller glia.	dorsomorphin	177-189	SMAD family member 1	Homo sapiens	211-218	
20689554-6	2011	Similarly, blockade of BMP signalling by siRNA-mediated knockdown of BMPR-1A, disruption of the intracellular pathway by either Smad5 or Smad4 knockdown or inhibition of Smad1/5/8 phosphorylation with Dorsomorphin, also caused premature myogenic differentiation.	dorsomorphin	201-213	SMAD family member 1	Homo sapiens	170-177	
21515935-8	2011	Dorsomorphin, a selective inhibitor of the bone morphogenetic protein (BMP) receptor type 1 (BMPR1), blocked Cmp-induced SMAD 1/5/8 phosphorylation, as well as Osteoprotegrin, Msx2 and Runx2 gene expression.	dorsomorphin	0-12	SMAD family member 1	Homo sapiens	121-129	
19950207-7	2010	The BMP-Smad inhibitor, dorsomorphin, inhibited phosphorylation of Smad1/5/8, and blocked hESC differentiation to CD34+CD31+ progenitor cells, suggesting that BMP Smad-dependent signaling is critical for CD34+CD31+ vascular progenitor development.	dorsomorphin	24-36	SMAD family member 1	Homo sapiens	8-12	
19950207-7	2010	The BMP-Smad inhibitor, dorsomorphin, inhibited phosphorylation of Smad1/5/8, and blocked hESC differentiation to CD34+CD31+ progenitor cells, suggesting that BMP Smad-dependent signaling is critical for CD34+CD31+ vascular progenitor development.	dorsomorphin	24-36	SMAD family member 1	Homo sapiens	67-74	
19950207-7	2010	The BMP-Smad inhibitor, dorsomorphin, inhibited phosphorylation of Smad1/5/8, and blocked hESC differentiation to CD34+CD31+ progenitor cells, suggesting that BMP Smad-dependent signaling is critical for CD34+CD31+ vascular progenitor development.	dorsomorphin	24-36	SMAD family member 1	Homo sapiens	67-71	
22144105-4	2012	Dorsomorphin suppressed phosphorylation of SMAD1/5/8, suggesting that BMP signalling naturally occurs in T cells.	dorsomorphin	0-12	SMAD family member 1	Homo sapiens	43-52	
22144105-7	2012	Dorsomorphin efficiently suppressed IL-2 production even at low doses in mouse CD4(+)  T cells, suggesting that the BMP-Smad signalling physiologically regulates IL-2 transcription in these cells.	dorsomorphin	0-12	SMAD family member 1	Homo sapiens	120-124