PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11597825-0	2001	Acetylcholinesterase inhibitor SDZ ENA 713 (Rivastigmine) increases brain pyrrolidone carboxyl peptidase activity.	Rivastigmine	31-42	acetylcholinesterase	Mus musculus	0-20	
21820013-2	2011	Rivastigmine is a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE); however, the impact of BuChE inhibition on cognitive dysfunction remains to be determined.	Rivastigmine	0-12	acetylcholinesterase	Mus musculus	58-62	
15852394-2	2005	We report that peripheral administration of the acetylcholinesterase inhibitors tacrine, rivastigmine, neostigmine, or EN101 (an antisense oligonucleotide directed at acetylcholinesterase messenger RNA) to mice significantly attenuated the production of interleukin-1beta in the hippocampus and blood, concomitantly with the reduction in acetylcholinesterase activity.	Rivastigmine	89-101	acetylcholinesterase	Mus musculus	48-68	
19470293-3	2009	Rivastigmine is an inhibitor of both AChE and butyrylcholinesterase (BChE) whereas donepezil is a selective inhibitor of AChE.	Rivastigmine	0-12	acetylcholinesterase	Mus musculus	37-41	
19470293-6	2009	Infusion of rivastigmine (1 and 10 microM) caused a further doubling of ACh levels in AChE-/- mice within 90-120 min.	Rivastigmine	12-24	acetylcholinesterase	Mus musculus	86-90	
17395211-5	2007	It was found that administration of tacrine, rivastigmine and donepezil in mice significantly attenuated the LPS induced increased levels of IL-2 along with the significant reduction of AChE activity predominantly in salt soluble (SS) fraction as compared to the detergent soluble (DS) fraction in a dose dependent manner.	Rivastigmine	45-57	acetylcholinesterase	Mus musculus	186-190	
11597825-0	2001	Acetylcholinesterase inhibitor SDZ ENA 713 (Rivastigmine) increases brain pyrrolidone carboxyl peptidase activity.	Rivastigmine	44-56	acetylcholinesterase	Mus musculus	0-20	
34184291-11	2022	In the in vivo study, test compounds (ACV, Chrysin, and Rivastigmine) improved cognitive impairment, increased the SOD and GSH level, reduced the MDA level and AChE activity, and protected the cortex-hippocampal neurons from degeneration.	Rivastigmine	56-68	acetylcholinesterase	Mus musculus	160-164	
30521930-6	2019	Single doses of D1R agonists, SKF38393 and SKF82958, and the acetylcholinesterase inhibitor, rivastigmine, alone and the combination of subeffective doses of both DETQ and rivastigmine, also restored NOR in both subchronic PCP-treated in hD1 mice.	Rivastigmine	93-105	acetylcholinesterase	Mus musculus	61-81	
23026084-3	2012	The three compounds 6a (IC(50)=2.57muM), 6b (IC(50)=0.70 muM) and 6i (IC(50)=2.56 muM) exhibited potent in vitro AChE inhibitory activities comparable to the drug rivastigmine (IC(50)=1.11 muM).	Rivastigmine	163-175	acetylcholinesterase	Mus musculus	113-117	
23026084-5	2012	In addition, the AChE-carbamate Michaelis complexes of these potent compounds including rivastigmine and ganstigmine have been modeled using covalent docking protocol of GOLD and important direct/indirect interactions contributing to stabilization of the AChE-carbamate Michaelis complexes have been investigated.	Rivastigmine	88-100	acetylcholinesterase	Mus musculus	17-21	
23026084-5	2012	In addition, the AChE-carbamate Michaelis complexes of these potent compounds including rivastigmine and ganstigmine have been modeled using covalent docking protocol of GOLD and important direct/indirect interactions contributing to stabilization of the AChE-carbamate Michaelis complexes have been investigated.	Rivastigmine	88-100	acetylcholinesterase	Mus musculus	255-259	
34855998-7	2022	Rivastigmine was found to inhibit AChE whereas HMT and memantine had no effects on AChE or on choline acetyltransferase (ChAT).	Rivastigmine	0-12	acetylcholinesterase	Mus musculus	34-38	
27150930-5	2016	Furthermore, we clarified the pharmacological profiles of the acetylcholinesterase inhibitors donepezil, galantamine, and rivastigmine, providing novel insights into their mechanisms of action.	Rivastigmine	122-134	acetylcholinesterase	Mus musculus	62-82