PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31704822-1	2019	BACKGROUND/AIM: Lenvatinib is a potent inhibitor of receptor tyrosine kinases, targeting vascular endothelial growth factor receptors (VEGFR1-3), fibroblast growth factor receptors (FGFR1-4), KIT, and RET.	lenvatinib	16-26	fibroblast growth factor receptor 1	Mus musculus	182-187	
33148422-9	2021	KEY FINDINGS: Here, we revealed that overexpressed FGFR1 and its downstream AKT/mTOR and ERK signaling activation could induce lenvatinib resistance in HCC.	lenvatinib	127-137	fibroblast growth factor receptor 1	Mus musculus	51-56	
33148422-11	2021	Oxysophocarpine could further sensitize FGFR1-overexpressed HCC cells to lenvatinib treatment.	lenvatinib	73-83	fibroblast growth factor receptor 1	Mus musculus	40-45	
33148422-12	2021	Mechanism studies revealed that Oxysophocarpine downregulated FGFR1 expression along with downstream AKT/mTOR and ERK signaling to sensitize lenvatinib against FGFR1-overexpressed HCC.	lenvatinib	141-151	fibroblast growth factor receptor 1	Mus musculus	62-67	
33148422-12	2021	Mechanism studies revealed that Oxysophocarpine downregulated FGFR1 expression along with downstream AKT/mTOR and ERK signaling to sensitize lenvatinib against FGFR1-overexpressed HCC.	lenvatinib	141-151	fibroblast growth factor receptor 1	Mus musculus	160-165	
33148422-13	2021	SIGNIFICANCES: These data collectively provided evidence that FGFR1 overexpression could be a potential cause of lenvatinib resistance and Oxysophocarpine could be an ideal combined therapy with lenvatinib in HCC treatment.	lenvatinib	113-123	fibroblast growth factor receptor 1	Mus musculus	62-67	
28901423-3	2017	Lenvatinib is a multi-targeted anticancer agent that targets of receptor tyrosine kinases including vascular endothelial growth factor receptor 1 and 2, fibroblast growth factor receptor 1, platelet-derived growth factor receptor beta and v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog.	lenvatinib	0-10	fibroblast growth factor receptor 1	Mus musculus	153-234