PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34864311-0 2022 Revealing the suppressive role of protein kinase C delta and p38 mitogen-activated protein kinase (MAPK)/NF-kappaB axis associates with lenvatinib-inhibited progression in hepatocellular carcinoma in vitro and in vivo. lenvatinib 136-146 nuclear factor kappa B subunit 1 Homo sapiens 105-114 34864311-5 2022 Therefore, the primary purpose of the present study was to evaluate the inhibitory effect of lenvatinib and its inhibitory mechanism on the NF-kappaB-mediated progression of HCC in vitro and in vivo. lenvatinib 93-103 nuclear factor kappa B subunit 1 Homo sapiens 140-149 34864311-8 2022 An NF-kappaB translocation assay, NF-kappaB reporter gene assay, a Western blotting assay and immunohistochemistry staining were used to investigate the underlying mechanism by which lenvatinib acts on HCC. lenvatinib 183-193 nuclear factor kappa B subunit 1 Homo sapiens 3-12 34864311-8 2022 An NF-kappaB translocation assay, NF-kappaB reporter gene assay, a Western blotting assay and immunohistochemistry staining were used to investigate the underlying mechanism by which lenvatinib acts on HCC. lenvatinib 183-193 nuclear factor kappa B subunit 1 Homo sapiens 34-43 34864311-10 2022 Lenvatinib may also suppress NF-kappaB translocation and activation. lenvatinib 0-10 nuclear factor kappa B subunit 1 Homo sapiens 29-38 34864311-11 2022 We also found both protein kinase C delta (PKC-delta) and p38 mitogen-activated protein kinase (MAPK) inactivation participated in lenvatinib-reduced NF-kappaB signaling. lenvatinib 131-141 nuclear factor kappa B subunit 1 Homo sapiens 150-159 34864311-12 2022 In conclusion, this study reveals that the suppression of PKC-delta, and the p38 MAPK/NF-kappaB axis is associated with the lenvatinib-inhibited progression of HCC in vitro and in vivo. lenvatinib 124-134 nuclear factor kappa B subunit 1 Homo sapiens 86-95 33419805-0 2021 Lenvatinib Inhibits AKT/NF-kappaB Signaling and Induces Apoptosis Through Extrinsic/Intrinsic Pathways in Non-small Cell Lung Cancer. lenvatinib 0-10 nuclear factor kappa B subunit 1 Homo sapiens 24-33 33419805-6 2021 RESULTS: The cell viability and NF-kappaB activity were suppressed by lenvatinib. lenvatinib 70-80 nuclear factor kappa B subunit 1 Homo sapiens 32-41 33419805-9 2021 CONCLUSION: Altogether, lenvatinib induced extrinsic/intrinsic apoptosis and suppressed migration/invasion ability of NSCLC cells that was associated with AKT/NF-kappaB signaling inactivation. lenvatinib 24-34 nuclear factor kappa B subunit 1 Homo sapiens 159-168