PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29718721-5 2018 EXPERT OPINION: Lenvatinib in combination with everolimus has provided encouraging results in both clinical and laboratory investigations showing that blocking angiogenesis and the mTOR signalling pathway could be a remarkable approach for treating RCC. lenvatinib 16-26 mechanistic target of rapamycin kinase Homo sapiens 181-185 33148422-9 2021 KEY FINDINGS: Here, we revealed that overexpressed FGFR1 and its downstream AKT/mTOR and ERK signaling activation could induce lenvatinib resistance in HCC. lenvatinib 127-137 mechanistic target of rapamycin kinase Homo sapiens 80-84 28952411-3 2017 Multiple agents are now available for treatment in subsequent lines.The mammalian target of rapamycin (mTOR) inhibitors (e.g., everolimus alone or with lenvatinib) are among the most effective options. lenvatinib 152-162 mechanistic target of rapamycin kinase Homo sapiens 72-101 28952411-3 2017 Multiple agents are now available for treatment in subsequent lines.The mammalian target of rapamycin (mTOR) inhibitors (e.g., everolimus alone or with lenvatinib) are among the most effective options. lenvatinib 152-162 mechanistic target of rapamycin kinase Homo sapiens 103-107 28107584-1 2017 The combination of lenvatinib, a multiple receptor tyrosine kinase inhibitor, plus everolimus, a mammalian target of rapamycin (mTOR) inhibitor, significantly improved clinical outcomes versus everolimus monotherapy in a phase II clinical study of metastatic renal cell carcinoma (RCC). lenvatinib 19-29 mechanistic target of rapamycin kinase Homo sapiens 128-132