PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33061517-1 2020 Purpose: To assess the safety, efficacy and prognostic impact of clinical factors related to lenvatinib treatment in Child-Pugh class A (CP-A) and class B (CP-B) patients with unresectable hepatocellular carcinoma (u-HCC). lenvatinib 93-103 carboxypeptidase A1 Homo sapiens 117-135 33061517-1 2020 Purpose: To assess the safety, efficacy and prognostic impact of clinical factors related to lenvatinib treatment in Child-Pugh class A (CP-A) and class B (CP-B) patients with unresectable hepatocellular carcinoma (u-HCC). lenvatinib 93-103 carboxypeptidase A1 Homo sapiens 137-141 33061517-5 2020 Frequency of lenvatinib-related adverse events, including decreased appetite (P=0.034), diarrhea (P=0.040), elevated serum bilirubin (P=0.016) and vomiting (P=0.009), were higher in CP-B than in CP-A patients. lenvatinib 13-23 carboxypeptidase A1 Homo sapiens 195-199 26500236-11 2016 CONCLUSIONS: Lenvatinib (12 mg once daily) demonstrated preliminary efficacy with manageable toxicity and is the recommended dose for phase II studies in patients with HCC and CP-A. lenvatinib 13-23 carboxypeptidase A1 Homo sapiens 176-180