PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9843839-2	1998	Human SP-A was nitrated by incubation with tetranitromethane at pH 8.0 or synthetic peroxynitrite (ONOO-) at pH 7.4, which resulted in significant nitration of tyrosines in its carbohydrate recognition domain [0.63 +/- 0.001 (SE) and 1.25 +/- 0.02 mol nitrotyrosine/mol monomeric SP-A, respectively; n = 3 samples].	Peroxynitrous Acid	84-97	surfactant protein A1	Homo sapiens	6-10	
10781434-6	2000	CO(2) (0-1.2 mM) also augmented peroxynitrite (0.5 mM)-induced SP-A nitration in a dose-dependent fashion.	Peroxynitrous Acid	32-45	surfactant protein A1	Homo sapiens	63-67	
10781434-7	2000	Peroxynitrite decreased the ability of SP-A to aggregate lipids, and this inhibition was augmented by 1.2 mM CO(2).	Peroxynitrous Acid	0-13	surfactant protein A1	Homo sapiens	39-43	
10781434-8	2000	Mass spectrometry analysis of chymotryptic fragments of peroxynitrite-exposed SP-A showed nitration of two tyrosines (Tyr(164) and Tyr(166)) in the absence of CO(2) and three tyrosines (Tyr(164), Tyr(166), and Tyr(161)) in the presence of 1.2 mM CO(2).	Peroxynitrous Acid	56-69	surfactant protein A1	Homo sapiens	78-82	
10781434-9	2000	These findings indicate that physiological levels of peroxynitrite, produced by activated AMs, nitrate SP-A and that CO(2) increased nitration, at least partially, by enhancing enzymatic nitric oxide production.	Peroxynitrous Acid	53-66	surfactant protein A1	Homo sapiens	103-107	
8914938-1	1996	Previous studies have shown that exposure of human surfactant protein A (SP-A) to nitrating agents [peroxynitrite (ONOO-); tetranitromethane (TNM; pH 8)] leads to nitrotyrosine formation.	Peroxynitrous Acid	100-113	surfactant protein A1	Homo sapiens	51-71	
8914938-1	1996	Previous studies have shown that exposure of human surfactant protein A (SP-A) to nitrating agents [peroxynitrite (ONOO-); tetranitromethane (TNM; pH 8)] leads to nitrotyrosine formation.	Peroxynitrous Acid	100-113	surfactant protein A1	Homo sapiens	73-77	
8870120-8	1996	Peroxynitrite added to surfactant in vitro is capable of decreasing the surface activity, inducing lipid peroxidation, decreasing the function of surfactant proteins, SP-A and SP-B, and inducing protein-associated nitro-tyrosine.	Peroxynitrous Acid	0-13	surfactant protein A1	Homo sapiens	167-171	
7943250-3	1994	The simultaneous generation of .NO and superoxide by 3-morpholinosydnonimine (SIN-1, 0.1-2 mM) resulted in oxidation of dihydrorhodamine, a marker of peroxynitrite production, and a dose-dependent decrease in the ability of SP-A to enhance lipid aggregation.	Peroxynitrous Acid	150-163	surfactant protein A1	Homo sapiens	224-228	
7943250-7	1994	We concluded that peroxynitrite, but not .NO or superoxide and hydrogen peroxide, in concentrations likely to be encountered in vivo, caused nitrotyrosine formation and decreased the ability of SP-A to aggregate lipids.	Peroxynitrous Acid	18-31	surfactant protein A1	Homo sapiens	194-198	
8131621-0	1994	Structural and functional alterations of surfactant protein A by peroxynitrite.	Peroxynitrous Acid	65-78	surfactant protein A1	Homo sapiens	41-61