PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16123332-0	2005	Loss of pentameric symmetry in C-reactive protein induces interleukin-8 secretion through peroxynitrite signaling in human neutrophils.	Peroxynitrous Acid	90-103	C-reactive protein	Homo sapiens	31-49	
14504187-10	2003	By increasing both superoxide and inducible NO synthase, CRP resulted in increased nitration of PGIS by peroxynitrite.	Peroxynitrous Acid	104-117	C-reactive protein	Homo sapiens	57-60	
14504187-11	2003	The increased nitration and decreased activity of PGIS by CRP was reversed with peroxynitrite scavengers.	Peroxynitrous Acid	80-93	C-reactive protein	Homo sapiens	58-61	
19410579-0	2009	C-reactive protein impairs coronary arteriolar dilation to prostacyclin synthase activation: role of peroxynitrite.	Peroxynitrous Acid	101-114	C-reactive protein	Homo sapiens	0-18	
19410579-11	2009	Collectively, our results suggest that CRP stimulates superoxide production and the subsequent formation of peroxynitrite from basal released NO compromises PGI(2) synthesis, and thus endothelium-dependent PGI(2)-mediated dilation, by inhibiting PGI(2)-S activity through tyrosine nitration.	Peroxynitrous Acid	108-121	C-reactive protein	Homo sapiens	39-42	
16123332-9	2005	These results suggest that loss of the pentameric symmetry in CRP, resulting in formation of mCRP, leads to IL-8 release from human neutrophils via peroxynitrite-mediated activation of nuclear factor-kappaB and activator protein-1.	Peroxynitrous Acid	148-161	C-reactive protein	Homo sapiens	62-65