PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31654211-0	2019	Molecular insights into the inhibitory mechanism of bi-functional bis-tryptoline triazole against beta-secretase (BACE1) enzyme.	Triazoles	81-89	beta-secretase 1	Homo sapiens	114-119	
28043778-4	2017	Herein, multifunctional triazole-based compounds acting on multiple targets, namely beta-secretase (BACE1), beta-amyloid peptides (Abeta) as well as those possessing metal chelation and antioxidant properties, were developed and evaluated for neuritogenic activity in P19-derived neurons.	Triazoles	24-32	beta-secretase 1	Homo sapiens	100-105	
23988410-4	2013	As revealed by the crystal structures of BACE1 in complex with our triazole compound 12, we found that Pro70 and Thr72 located in the flap region were the critical components for binding with these inhibitors.	Triazoles	67-75	beta-secretase 1	Homo sapiens	41-46	
21621412-0	2011	Triazole-linked reduced amide isosteres: an approach for the fragment-based drug discovery of anti-Alzheimer"s BACE1 inhibitors.	Triazoles	0-8	beta-secretase 1	Homo sapiens	111-116	
21621412-1	2011	In the course of a beta-site APP-cleaving enzyme 1 (BACE1) inhibitor discovery project an in situ synthesis/screening protocol was employed to prepare 120 triazole-linked reduced amide isostere inhibitors.	Triazoles	155-163	beta-secretase 1	Homo sapiens	19-50	
21621412-1	2011	In the course of a beta-site APP-cleaving enzyme 1 (BACE1) inhibitor discovery project an in situ synthesis/screening protocol was employed to prepare 120 triazole-linked reduced amide isostere inhibitors.	Triazoles	155-163	beta-secretase 1	Homo sapiens	52-57	
21621412-5	2011	Docking studies of triazole-linked reduced amide isostere A3Z10 and potent oxadiazole-linked tertiary carbinamine 2a with BACE1 suggests that the docking poses of A3Z10 and 2a in the active sites are quite similar, with one exception.	Triazoles	19-27	beta-secretase 1	Homo sapiens	122-127