PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25529148-0 2015 TNF-alpha confers resistance to Fas-mediated apoptosis in rheumatoid arthritis through the induction of soluble Fas. ammonium ferrous sulfate 32-35 tumor necrosis factor Homo sapiens 0-9 26592517-9 2015 Furthermore, treatment with Fe(2+) significantly increased the gene expression of IL-1beta, IL-6 and TNF-alpha, and induced the nuclear translocation of NF-kappaB. ammonium ferrous sulfate 28-34 tumor necrosis factor Homo sapiens 101-110 25529148-0 2015 TNF-alpha confers resistance to Fas-mediated apoptosis in rheumatoid arthritis through the induction of soluble Fas. ammonium ferrous sulfate 112-115 tumor necrosis factor Homo sapiens 0-9 25529148-8 2015 SIGNIFICANCE: These findings suggest that TNF-alpha confers resistance to Fas-mediated apoptosis through sFas induction, which could explain the apparent resistance of RA synovial cells to apoptosis in vivo. ammonium ferrous sulfate 74-77 tumor necrosis factor Homo sapiens 42-51 25179850-0 2014 Disease activity improvement in rheumatoid arthritis treated with tumor necrosis factor-alpha inhibitors correlates with increased soluble Fas levels. ammonium ferrous sulfate 139-142 tumor necrosis factor Homo sapiens 66-93 25179850-11 2014 CONCLUSION: In RA, an increase in sFas levels closely correlates with improvement in disease activity induced by TNF-alpha inhibitors, suggesting their ability to modulate Fas-mediated synoviocyte apoptosis. ammonium ferrous sulfate 35-38 tumor necrosis factor Homo sapiens 113-122 23604035-4 2013 We first observed that Fas was induced by TNF-alpha in the HL60 cell line. ammonium ferrous sulfate 23-26 tumor necrosis factor Homo sapiens 42-51 23912906-3 2013 We previously reported that TNFalpha-induced DcR3 overexpression in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) protects cells from Fas-induced apoptosis. ammonium ferrous sulfate 147-150 tumor necrosis factor Homo sapiens 28-36 21632719-6 2011 Prevention of the increase in Fas expression using Fas small interfering RNAs blocked the ability of TNF-alpha and IFN-gamma to sensitize fibroblasts to Fas ligation-induced apoptosis, whereas enforced adenovirus-mediated Fas overexpression was sufficient to overcome basal resistance to Fas-induced apoptosis. ammonium ferrous sulfate 30-33 tumor necrosis factor Homo sapiens 101-110 21537832-3 2011 We previously reported that TNFalpha-induced DcR3 overexpression in rheumatoid synovial fibroblasts (RA-FLS) protects the cells from Fas-induced apoptosis and that DcR3 induces VLA-4 expression in THP-1 macrophages to inhibit cycloheximide-induced apoptosis. ammonium ferrous sulfate 133-136 tumor necrosis factor Homo sapiens 28-36 23433788-3 2013 RESULTS: Using MTT and flow cytometry, IL-13, TNF-alpha and IL-1beta pretreatment decreased Fas-induced cell death. ammonium ferrous sulfate 92-95 tumor necrosis factor Homo sapiens 46-55 18003704-8 2007 In summary, we demonstrate that IFN-gamma and TNF-alpha sensitize primarily apoptosis-resistant ESCs to Fas-mediated cell death. ammonium ferrous sulfate 104-107 tumor necrosis factor Homo sapiens 46-55 18972582-6 2008 Moreover, TNFalpha induced downregulation of key enzymes in lipogenesis, including LPL, FAS and GPAT, were also attenuated by AS-IV. ammonium ferrous sulfate 88-91 tumor necrosis factor Homo sapiens 10-18 17878376-10 2007 Interestingly, the constitutively expressed IRF8 was also essential for TNF-alpha sensitization of Fas-mediated apoptosis because disruption of IRF8 function also inhibited TNF-alpha-sensitized and Fas-mediated apoptosis. ammonium ferrous sulfate 99-102 tumor necrosis factor Homo sapiens 72-81 17878376-10 2007 Interestingly, the constitutively expressed IRF8 was also essential for TNF-alpha sensitization of Fas-mediated apoptosis because disruption of IRF8 function also inhibited TNF-alpha-sensitized and Fas-mediated apoptosis. ammonium ferrous sulfate 99-102 tumor necrosis factor Homo sapiens 173-182 17878376-10 2007 Interestingly, the constitutively expressed IRF8 was also essential for TNF-alpha sensitization of Fas-mediated apoptosis because disruption of IRF8 function also inhibited TNF-alpha-sensitized and Fas-mediated apoptosis. ammonium ferrous sulfate 198-201 tumor necrosis factor Homo sapiens 72-81 17393415-11 2007 TNFalpha increased DcR3 expression and inhibited Fas-induced apoptosis in RA FLS, but not in OA FLS. ammonium ferrous sulfate 49-52 tumor necrosis factor Homo sapiens 0-8 15879156-0 2005 Gene transfer of tissue inhibitor of metalloproteinases-3 reverses the inhibitory effects of TNF-alpha on Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts. ammonium ferrous sulfate 106-109 tumor necrosis factor Homo sapiens 93-102 16784892-0 2006 Involvement of the TNF-alpha autocrine-paracrine loop, via NF-kappaB and YY1, in the regulation of tumor cell resistance to Fas-induced apoptosis. ammonium ferrous sulfate 124-127 tumor necrosis factor Homo sapiens 19-28 16272460-0 2006 TNF-alpha sensitizes normal and fibrotic human lung fibroblasts to Fas-induced apoptosis. ammonium ferrous sulfate 67-70 tumor necrosis factor Homo sapiens 0-9 16272460-3 2006 Using normal and fibrotic human lung fibroblasts and the human lung fibroblast cell line, MRC-5, we examined the regulation of Fas-induced apoptosis by the proinflammatory cytokines TNF-alpha and IFN-gamma. ammonium ferrous sulfate 127-130 tumor necrosis factor Homo sapiens 182-191 16272460-4 2006 Herein, we show that the basal resistance of lung fibroblasts and myofibroblasts to Fas-induced apoptosis is overcome by sensitization with TNF-alpha. ammonium ferrous sulfate 84-87 tumor necrosis factor Homo sapiens 140-149 16272460-6 2006 Sensitization by TNF-alpha was observed in MRC-5 cells and in fibroblasts and myofibroblasts from normal and fibrotic human lung, suggesting that this represents a conserved mechanism to engage Fas-induced apoptosis. ammonium ferrous sulfate 194-197 tumor necrosis factor Homo sapiens 17-26 15879156-5 2005 Although TNF-alpha inhibits Fas/CD95-induced apoptosis in untransfected and mock-transfected cells, fibroblasts ectopically expressing TIMP-3 are sensitized most strongly to Fas/CD95-mediated cell death by TNF-alpha. ammonium ferrous sulfate 28-31 tumor necrosis factor Homo sapiens 9-18 10817565-13 2000 Moreover, Fas-mediated apoptosis in TNFalpha-treated RA synoviocytes was partially inhibited by FLIP(L) gene transfection. ammonium ferrous sulfate 10-13 tumor necrosis factor Homo sapiens 36-44 14530313-7 2003 However, TNF pretreatment enhanced Fas-mediated apoptosis by up-regulating surface Fas expression in an NF-kappaB-dependent pathway. ammonium ferrous sulfate 35-38 tumor necrosis factor Homo sapiens 9-12 14530313-7 2003 However, TNF pretreatment enhanced Fas-mediated apoptosis by up-regulating surface Fas expression in an NF-kappaB-dependent pathway. ammonium ferrous sulfate 83-86 tumor necrosis factor Homo sapiens 9-12 14530313-9 2003 However, our in vitro results suggest that FDCs proliferate in response to TNF, and die by Fas-mediated apoptosis whose susceptibility is enhanced by TNF, representing a mode of action for TNF in the maintenance of FDC networks by regulating the survival or death of FDC. ammonium ferrous sulfate 91-94 tumor necrosis factor Homo sapiens 150-153 14530313-9 2003 However, our in vitro results suggest that FDCs proliferate in response to TNF, and die by Fas-mediated apoptosis whose susceptibility is enhanced by TNF, representing a mode of action for TNF in the maintenance of FDC networks by regulating the survival or death of FDC. ammonium ferrous sulfate 91-94 tumor necrosis factor Homo sapiens 150-153 12801526-10 2003 IN CONCLUSION: (i) TNF-receptor activation leads to activation of the p70S6K; (ii) TRAF4 is a mediator in this TNF-induced signaling pathway; and (iii) TRAF4 inhibits Fas-induced apoptosis. ammonium ferrous sulfate 167-170 tumor necrosis factor Homo sapiens 19-22 12801526-10 2003 IN CONCLUSION: (i) TNF-receptor activation leads to activation of the p70S6K; (ii) TRAF4 is a mediator in this TNF-induced signaling pathway; and (iii) TRAF4 inhibits Fas-induced apoptosis. ammonium ferrous sulfate 167-170 tumor necrosis factor Homo sapiens 111-114 12021072-8 2002 IFN-gamma and TNFalpha promote Fas expression and sensitivity, whereas IL-6 and IL-10 increase the resistance of trophoblast cells to Fas-mediated apoptosis. ammonium ferrous sulfate 31-34 tumor necrosis factor Homo sapiens 14-22 12169207-11 2002 Thus, upon TNF-alpha induced maturation, MDDC became resistant to Fas-induced apoptosis. ammonium ferrous sulfate 66-69 tumor necrosis factor Homo sapiens 11-20 11859140-1 2002 Treatment of cultured primary human thyroid cells with IFN-gamma and TNF-alpha uniquely allows the induction of Fas-mediated apoptosis. ammonium ferrous sulfate 112-115 tumor necrosis factor Homo sapiens 69-78 12500396-6 2002 RESULTS: Expression of Fas in bladder carcinoma cell line EJ, TNF alpha treated EJ, and Fas gene transfected EJ was 19.18%, 28.03%, and 68.69%, respectively. ammonium ferrous sulfate 23-26 tumor necrosis factor Homo sapiens 62-71 15279653-0 2004 Mechanism of Fas-mediated cell death and its enhancement by TNF-alpha in human salivary gland adenocarcinoma cell line HSG. ammonium ferrous sulfate 13-16 tumor necrosis factor Homo sapiens 60-69 15279653-1 2004 Fas-mediated cell death in a human salivary gland adenocarcinoma cell line (HSG) was induced by treatment of the cells with agonistic anti-Fas antibody (CH-11), and this cell death was enhanced by pretreatment with tumor necrosis factor alpha (TNF-alpha). ammonium ferrous sulfate 0-3 tumor necrosis factor Homo sapiens 215-242 15279653-1 2004 Fas-mediated cell death in a human salivary gland adenocarcinoma cell line (HSG) was induced by treatment of the cells with agonistic anti-Fas antibody (CH-11), and this cell death was enhanced by pretreatment with tumor necrosis factor alpha (TNF-alpha). ammonium ferrous sulfate 0-3 tumor necrosis factor Homo sapiens 244-253 14729358-13 2004 In the primary-cultured cells, TNFalpha induced an important upregulation of ICAM-1, Fas and CD40 whereas CD44 and CD63 were significantly decreased. ammonium ferrous sulfate 85-88 tumor necrosis factor Homo sapiens 31-39 12239098-12 2002 However, TNF-alpha and dexamethasone were also able to blunt anti-FAS-induced apoptosis in the T cells. ammonium ferrous sulfate 66-69 tumor necrosis factor Homo sapiens 9-18 12086912-5 2002 Our work demonstrates that exposure of human CD4+ T cells to physiologically relevant concentrations of ethanol leads to the (i) enhanced activation of TNFalpha-inducible NFkappaB, the transcriptional regulator of the Fas promoter and ii) increased susceptibility to Fas-and activation-induced apoptotic death via augmentation of caspase 3 activity. ammonium ferrous sulfate 218-221 tumor necrosis factor Homo sapiens 152-160 10817565-14 2000 CONCLUSION: Our results suggest that Fas-mediated apoptosis of RA synoviocytes is differentially regulated by TNFalpha and bFGF. ammonium ferrous sulfate 37-40 tumor necrosis factor Homo sapiens 110-118 10457352-6 1999 In contrast, in the presence of tumor necrosis factor alpha (TNFalpha) and/or interferon gamma (IFNgamma), HIEC became highly susceptible to FAS-induced apoptosis. ammonium ferrous sulfate 141-144 tumor necrosis factor Homo sapiens 32-59 10766192-13 2000 In agreement with this model, we show that it was possible to render HT29-D4 cells resistant to Fas-induced apoptosis provided that IGF-I and TNF receptors were activated simultaneously. ammonium ferrous sulfate 96-99 tumor necrosis factor Homo sapiens 142-145 10710535-7 2000 Surface Fas decreased partially during prolonged serum deprivation of cultured HASM cells and was upregulated by TNF-alpha stimulation. ammonium ferrous sulfate 8-11 tumor necrosis factor Homo sapiens 113-122 10710535-8 2000 Fas cross-linking with CH-11 antibody induced apoptosis in cultured HASM cells, and this effect was reduced by long-term serum deprivation and synergistically potentiated by concomitant TNF-alpha exposure. ammonium ferrous sulfate 0-3 tumor necrosis factor Homo sapiens 186-195 10704256-8 2000 Moreover, removal of TNF-alpha activity by a neutralizing anti-TNF-alpha antibody (cA2) restored Fas-ACD. ammonium ferrous sulfate 97-100 tumor necrosis factor Homo sapiens 21-30 10704256-8 2000 Moreover, removal of TNF-alpha activity by a neutralizing anti-TNF-alpha antibody (cA2) restored Fas-ACD. ammonium ferrous sulfate 97-100 tumor necrosis factor Homo sapiens 63-72 10704256-10 2000 These results suggest the following: (1) Fas-ACD might be diminished in vivo by local excessive TNF-alpha and this might contribute in part to RASH. ammonium ferrous sulfate 41-44 tumor necrosis factor Homo sapiens 96-105 10457352-6 1999 In contrast, in the presence of tumor necrosis factor alpha (TNFalpha) and/or interferon gamma (IFNgamma), HIEC became highly susceptible to FAS-induced apoptosis. ammonium ferrous sulfate 141-144 tumor necrosis factor Homo sapiens 61-69 10457352-7 1999 The sensitizing effect to FAS-induced apoptosis was mediated via TNFalpha- and IFNgamma-induced upregulation of FAS expression (maximally 348%). ammonium ferrous sulfate 26-29 tumor necrosis factor Homo sapiens 65-73 10318823-7 1999 Taken together, our findings suggest that ATF2 contributes to UVC-induced apoptosis through transcriptional silencing of TNFalpha, which balances Fas-mediated cell death in melanoma. ammonium ferrous sulfate 146-149 tumor necrosis factor Homo sapiens 121-129 10440872-3 1999 Since resistance to TNF-alpha-mediated killing has been shown to be due, in part, to the presence of protective factors and that inhibitors of protein synthesis can sensitize cells to TNF-alpha killing, we hypothesized that resistance to Fas-mediated killing may be due to similar mechanisms. ammonium ferrous sulfate 238-241 tumor necrosis factor Homo sapiens 20-29 10482306-17 1999 Our results suggest that IL-1beta and TNF-alpha regulate osteoblast cell number by up-regulating the Fas-mediated apoptosis of osteoblasts, one of the putative mechanisms inducing periarticular osteoporosis in patients with RA. ammonium ferrous sulfate 101-104 tumor necrosis factor Homo sapiens 38-47 9792306-10 1998 In marrow cultures, Fas-Ig, rhuTNFR:Fc or anti-TNF-alpha antibody, by blocking Fas or TNF mediated signals, respectively, significantly increased the numbers of haemopoietic colonies compared to untreated cells (P<0.001, P<0.003, P<0.001, respectively). ammonium ferrous sulfate 20-23 tumor necrosis factor Homo sapiens 47-56 10088775-10 1999 A gradual up-regulation of caspase 8 and caspase 3, which played a role in the caspase cascade for Fas-mediated apoptosis, was observed in TNFalpha-treated cultured OA synoviocytes. ammonium ferrous sulfate 99-102 tumor necrosis factor Homo sapiens 139-147 10088775-12 1999 More importantly, Z-IETD-FMK, a caspase 8 inhibitor, and Ac-DEVD-CHO, a caspase 3 inhibitor, almost completely inhibited Fas-mediated apoptosis of TNFalpha-treated cultured OA synoviocytes, whereas Ac-YVAD-CHO, a caspase 1 inhibitor, did not. ammonium ferrous sulfate 121-124 tumor necrosis factor Homo sapiens 147-155 10088775-13 1999 CONCLUSION: Our results clearly demonstrate that TNFalpha stimulates synovial cells to proliferate as well as sensitizes the cells for Fas-mediated apoptosis, at least in part by up-regulation and activation of caspase 8 and caspase 3. ammonium ferrous sulfate 135-138 tumor necrosis factor Homo sapiens 49-57 10088775-14 1999 These findings suggest that TNFalpha may be one of the factors providing sensitization of synovial cells to Fas-mediated apoptosis in RA. ammonium ferrous sulfate 108-111 tumor necrosis factor Homo sapiens 28-36 9792306-10 1998 In marrow cultures, Fas-Ig, rhuTNFR:Fc or anti-TNF-alpha antibody, by blocking Fas or TNF mediated signals, respectively, significantly increased the numbers of haemopoietic colonies compared to untreated cells (P<0.001, P<0.003, P<0.001, respectively). ammonium ferrous sulfate 20-23 tumor necrosis factor Homo sapiens 31-34 9692873-9 1998 From these data, we conclude that IFN-gamma and TNF-alpha can up-regulate cell surface expression of CD95 on eosinophils, which leads to an increased susceptibility of eosinophils to Fas-mediated apoptosis. ammonium ferrous sulfate 183-186 tumor necrosis factor Homo sapiens 48-57 9609953-4 1998 Analysis of transfectants has shown that expression of Fas above a certain critical level leads to redistribution of Fas in the cells and is accompanied by changes in the cell cycles and cell sensitivity to the cytotoxic effects of anti-Fas and tumor necrosis factor (TNF). ammonium ferrous sulfate 55-58 tumor necrosis factor Homo sapiens 268-271 9565035-4 1998 Here we show that the adenovirus RID (for receptor internalization and degradation) protein complex, which is an inhibitor of TNF-induced apoptosis, mediates internalization of cell-surface Fas and its destruction inside lysosomes within the cell. ammonium ferrous sulfate 190-193 tumor necrosis factor Homo sapiens 126-129 9609953-4 1998 Analysis of transfectants has shown that expression of Fas above a certain critical level leads to redistribution of Fas in the cells and is accompanied by changes in the cell cycles and cell sensitivity to the cytotoxic effects of anti-Fas and tumor necrosis factor (TNF). ammonium ferrous sulfate 55-58 tumor necrosis factor Homo sapiens 245-266 9255761-4 1997 However, the viability of OM-10.1 cells further decreased with increasing concentrations of Fas-mAb when exposed simultaneously to TNF-alpha, suggesting that TNF-alpha sensitizes the cells to Fas-mAb-induced cell death. ammonium ferrous sulfate 192-195 tumor necrosis factor Homo sapiens 158-167 9255761-4 1997 However, the viability of OM-10.1 cells further decreased with increasing concentrations of Fas-mAb when exposed simultaneously to TNF-alpha, suggesting that TNF-alpha sensitizes the cells to Fas-mAb-induced cell death. ammonium ferrous sulfate 92-95 tumor necrosis factor Homo sapiens 131-140 9255761-4 1997 However, the viability of OM-10.1 cells further decreased with increasing concentrations of Fas-mAb when exposed simultaneously to TNF-alpha, suggesting that TNF-alpha sensitizes the cells to Fas-mAb-induced cell death. ammonium ferrous sulfate 92-95 tumor necrosis factor Homo sapiens 158-167 9343182-1 1997 Cytotoxic T cells use Fas (CD95), a member of the tumor necrosis factor (TNF) receptor superfamily, to eliminate virus-infected cells by activation of the apoptotic pathway for cell death. ammonium ferrous sulfate 22-25 tumor necrosis factor Homo sapiens 73-76 8652808-2 1996 We report here that CD4+ and CD8+ T cells from HIV-1-infected persons are sensitive to Fas (CD95/APO-1)-mediated death induced either by an agonistic anti-Fas antibody or by the physiologic soluble Fas ligand, although showing no sensitivity to tumor necrosis factor alpha-induced death. ammonium ferrous sulfate 87-90 tumor necrosis factor Homo sapiens 245-272 9187937-7 1997 However, coincubation with NG-monomethyl-L-arginine, an inhibitor of nitric oxide (NO) synthesis, inhibited the upregulation of Fas induced by IL-1 and TNF-alpha. ammonium ferrous sulfate 128-131 tumor necrosis factor Homo sapiens 152-161 8760796-7 1996 Fas-mediated neutrophil apoptosis was suppressed by incubation with G-CSF, GM-CSF, IFN-gamma, TNF-alpha, or dexamethasone, as well as the selective tyrosine kinase inhibitors, herbimycin A and genistein. ammonium ferrous sulfate 0-3 tumor necrosis factor Homo sapiens 94-103 8869358-10 1996 TNF alpha can down- or up-regulate fas and down-regulates TNF-R. Adenovirus E1B 19 kDa blocks the proapoptotic activity of TNF alpha. ammonium ferrous sulfate 35-38 tumor necrosis factor Homo sapiens 0-9 8869358-10 1996 TNF alpha can down- or up-regulate fas and down-regulates TNF-R. Adenovirus E1B 19 kDa blocks the proapoptotic activity of TNF alpha. ammonium ferrous sulfate 35-38 tumor necrosis factor Homo sapiens 123-132 7522637-8 1994 Both INF-gamma and TNF-alpha were found to contribute to Fas Ag upregulation and both anti-IFN-gamma and anti-TNF-alpha antibodies blocked CD4XL-induced Fas Ag upregulation and lymphocyte apoptosis. ammonium ferrous sulfate 57-60 tumor necrosis factor Homo sapiens 19-28 8551219-7 1996 Despite these structural similarities, differences are seen in the way phorbol myristate acetate, interleukin 1, TNF, and various metabolic inhibitors influence the cellular responsiveness to CD40, p55TNFR, and Fas-mediated killing. ammonium ferrous sulfate 211-214 tumor necrosis factor Homo sapiens 113-116 1371242-3 1992 These findings led to speculation that Fas may be associated with TNF-Rs. ammonium ferrous sulfate 39-42 tumor necrosis factor Homo sapiens 66-69