PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22246639-0 2012 Caspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytes. ammonium ferrous sulfate 58-61 caspase 3 Mus musculus 0-9 25015658-10 2014 Overall, the results indicate that Fas-initiated, caspase-3-dependent HPC apoptosis increases TF procoagulant activity through a mechanism involving PS externalization. ammonium ferrous sulfate 35-38 caspase 3 Mus musculus 50-59 24928990-7 2014 The rate of caspase 3/7 biosensor activation was unexpectedly rapid following granzyme B- compared with Fas-mediated signal induction in murine CTLs; the latter appeared gradually after a 90-min delay in perforin- or granzyme B-deficient CTLs. ammonium ferrous sulfate 104-107 caspase 3 Mus musculus 12-21 21470397-9 2011 Smaller increases of several apoptosis markers, such as caspase-3 and -8, were demonstrated in Fas-deficient mice, even though the bacterial burdens in Fas-deficient and wild type mice were similar. ammonium ferrous sulfate 95-98 caspase 3 Mus musculus 56-72 16420519-12 2006 CONCLUSION: Fas may rely on both caspase-8 activation (extrinsic pathway) and mitochondria (intrinsic pathway) to activate caspase-3. ammonium ferrous sulfate 12-15 caspase 3 Mus musculus 123-132 17182568-8 2007 In the absence of PKC-theta, Fas-induced activation of apoptotic molecules such as caspase-8, caspase-3, and Bid was not efficient. ammonium ferrous sulfate 29-32 caspase 3 Mus musculus 94-103 16621521-12 2006 However, estradiol enhanced caspase-3 activity in Fas-induced apoptosis on mature osteoclasts, suggesting that this might interact with the Fas-signaling pathway. ammonium ferrous sulfate 50-53 caspase 3 Mus musculus 28-37 19120440-7 2009 The neutralization of Fas ligand (FasL) protected against traumatically induced or Fas-mediated caspase-3 activation and the loss of mitochondrial membrane potential and tBid expression in wild-type spinal cord cultures. ammonium ferrous sulfate 22-25 caspase 3 Mus musculus 96-105 15300908-8 2004 Fas expression in hepatocytes transfected with anti-Fas ribozyme was decreased remarkably and correlated with the resistance to Fas-mediated apoptosis as determined by flow cytometry and caspase-3 proteolytic activity. ammonium ferrous sulfate 0-3 caspase 3 Mus musculus 187-196 15300908-8 2004 Fas expression in hepatocytes transfected with anti-Fas ribozyme was decreased remarkably and correlated with the resistance to Fas-mediated apoptosis as determined by flow cytometry and caspase-3 proteolytic activity. ammonium ferrous sulfate 52-55 caspase 3 Mus musculus 187-196 15202504-6 2004 Fas expression in Yac-1 cells transfected with anti-Fas ribozyme was decreased remarkably and correlated with resistance to Fas-mediated apoptosis as determined by flow cytometry and caspase-3 proteolytic activity. ammonium ferrous sulfate 0-3 caspase 3 Mus musculus 183-192 12802593-16 2003 Caspase-3 was also observed in numerous Fas-positive cells in heavily infiltrated islets. ammonium ferrous sulfate 40-43 caspase 3 Mus musculus 0-9 11559023-9 2001 We conclude that Fas may rely exclusively on caspase-8 activation and mitochondria to activate caspase-3, which can process more procaspase-8 and thus propagate the amplification of the apoptotic signal. ammonium ferrous sulfate 17-20 caspase 3 Mus musculus 95-104 12657159-0 2003 Prostaglandin F2alpha- and FAS-activating antibody-induced regression of the corpus luteum involves caspase-8 and is defective in caspase-3 deficient mice. ammonium ferrous sulfate 27-30 caspase 3 Mus musculus 130-139 11821950-6 2002 Furthermore, cytochrome c release from mitochondria and caspase 3 activation were restored to normal levels in HBx/Bcl-2 mice during transduction of the Fas signal. ammonium ferrous sulfate 153-156 caspase 3 Mus musculus 56-65 11749068-3 2002 Here we show that LEC treated with Fas agonist (Jo2 mAb at 0.1 microg/ml) and TNF had a greater caspase-3 activity (twofold increase) than cells treated with each factor alone. ammonium ferrous sulfate 35-38 caspase 3 Mus musculus 96-105 11276016-6 2001 In conclusion, the typical apoptotic ultrastructure and DNA fragmentation occur simultaneously in association with caspase-3 activation in Fas-stimulated cultured cardiomyocytes. ammonium ferrous sulfate 139-142 caspase 3 Mus musculus 115-124 10811232-7 2000 Inhibition of de novo Fas expression in betaTC-3 cells expressing the anti-Fas ribozyme correlated with resistance to Fas-mediated apoptosis as determined by the number of cells exhibiting caspase 3 proteolytic activity. ammonium ferrous sulfate 22-25 caspase 3 Mus musculus 189-198 11174076-0 2001 Effects of a novel hepatoprotective drug, ZNC-2381, on fas-induced hepatocellular caspase-3 activity and apoptosis in mice. ammonium ferrous sulfate 55-58 caspase 3 Mus musculus 82-91 9521092-0 1998 The dominant role of CPP32 subfamily in fas-mediated hepatitis. ammonium ferrous sulfate 40-43 caspase 3 Mus musculus 21-26 10078546-5 1999 The cross-linking of Fas by anti-Fas resulted in the elevation of caspase-3-like, but not caspase-1-like, protease activity 2-12 h after the addition of the anti-Fas. ammonium ferrous sulfate 21-24 caspase 3 Mus musculus 66-75 10078546-5 1999 The cross-linking of Fas by anti-Fas resulted in the elevation of caspase-3-like, but not caspase-1-like, protease activity 2-12 h after the addition of the anti-Fas. ammonium ferrous sulfate 33-36 caspase 3 Mus musculus 66-75 10078546-6 1999 A caspase-3 inhibitor, Z-Asp-Glu-Val-Asp-fluoromethyl ketone, attenuated the Fas-mediated beta-cell apoptosis, while a caspase-1 inhibitor, acetyl-Tyr-Val-Ala-Asp-chloromethylketone, failed to suppress the apoptosis. ammonium ferrous sulfate 77-80 caspase 3 Mus musculus 2-11 10078546-9 1999 These observations suggest the essential role of caspase-3 in Fas-mediated apoptosis of the beta-cell line. ammonium ferrous sulfate 62-65 caspase 3 Mus musculus 49-58 10528193-0 1999 In vivo evidence that caspase-3 is required for Fas-mediated apoptosis of hepatocytes. ammonium ferrous sulfate 48-51 caspase 3 Mus musculus 22-31 10528193-1 1999 Caspase-3 is essential for Fas-mediated apoptosis in vitro. ammonium ferrous sulfate 27-30 caspase 3 Mus musculus 0-9 10464143-9 1999 CONCLUSIONS: These results suggest that IL-1beta suppresses Fas-mediated hepatocyte apoptosis by inducing molecule(s) that suppress the apoptosis control machinery upstream of caspase 3. ammonium ferrous sulfate 60-63 caspase 3 Mus musculus 176-185 10551900-7 1999 Both compounds inhibited caspases 1, 2, 3, 6, 8, and 9, and both afforded comparable reduction in Fas- and LPS-induced caspase 3-like activity and apoptosis. ammonium ferrous sulfate 98-101 caspase 3 Mus musculus 119-128 9811849-0 1998 Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo. ammonium ferrous sulfate 71-74 caspase 3 Mus musculus 0-9 9811849-2 1998 However, the role of caspase-1 and caspase-3 in mediating Fas-induced cell death is not clear. ammonium ferrous sulfate 58-61 caspase 3 Mus musculus 35-44 9556551-0 1998 Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver. ammonium ferrous sulfate 72-75 caspase 3 Mus musculus 38-47 9521092-9 1998 We propose here that the CPP32 subfamily plays the dominant role in Fas-mediated hepatitis, and DEVD-CHO would be an effective cure for hepatitis. ammonium ferrous sulfate 68-71 caspase 3 Mus musculus 25-30 9036942-9 1997 These results suggest that granzyme B- and Fas-based cytotoxicity exerted by CTL clones converge at the level of CPP32-like protease activation, while granzyme A acts via a different, still undefined, pathway. ammonium ferrous sulfate 43-46 caspase 3 Mus musculus 113-118 8920897-0 1996 Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death. ammonium ferrous sulfate 137-140 caspase 3 Mus musculus 76-81 31010354-9 2019 Upon Fas-SiRNA injection, almost all measured parameters of NASH such as overexpression of Fas receptor, caspase3, NF-kB genes and marked increase of hepatic TNF-alpha were significantly restored and were remained nearly unchanged following recovery liking as scrambled groups. ammonium ferrous sulfate 5-8 caspase 3 Mus musculus 105-113 8614469-4 1996 We show here that specific inhibitors of ICE- or CPP32-like proteases can inhibit Fas-mediated apoptosis. ammonium ferrous sulfate 82-85 caspase 3 Mus musculus 49-54 8614469-9 1996 These results indicate that Fas sequentially activates ICE- and CPP32-like proteases, and that downstream CPP32, together with a component(s) in the cytoplasm, causes apoptosis of nuclei. ammonium ferrous sulfate 28-31 caspase 3 Mus musculus 64-69