PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29762502-6 2018 Pretreatment with NAC and Z-VAD-FMK (ROS scavenger and caspase inhibitor, respectively) on HepaRG cells increased the percentage of viable cells, which indicated that polyphyllin VI induced cell apoptosis through mitochondrial pathway by the generation of ROS and Fas death-dependent pathway. ammonium ferrous sulfate 264-267 synuclein alpha Homo sapiens 18-21 20005574-0 2010 Binding of alpha-synuclein with Fe(III) and with Fe(II) and biological implications of the resultant complexes. ammonium ferrous sulfate 49-55 synuclein alpha Homo sapiens 11-26 28811225-3 2017 Recently, it has been suggested that alpha-synuclein could cause the enzymatic reduction of iron and a cellular increase in Fe(II) levels. ammonium ferrous sulfate 124-130 synuclein alpha Homo sapiens 37-52 22860160-6 2011 In this paper, we sought to map the interactions between the di- and trivalent cations, Cu(II), Pb(II), Fe(II), and Fe(III), and the C-terminal region of alpha-syn encompassing residues 107-140 and to determine how phosphorylation at S129 or Y125 alters the specificity and binding affinity of metals using electrospray ionization-mass spectrometry (ESI-MS) and fluorescence spectroscopy. ammonium ferrous sulfate 104-110 synuclein alpha Homo sapiens 154-163 21249223-7 2011 Overexpression of alpha-synuclein by cells significantly increases the percentage of iron (II) in cells. ammonium ferrous sulfate 85-94 synuclein alpha Homo sapiens 18-33 20005574-2 2010 Amyloidogenic protein alpha-synuclein (alpha-syn) and iron (including both Fe(III) and Fe(II)) are both found to be present in LBs. ammonium ferrous sulfate 87-93 synuclein alpha Homo sapiens 22-31 20005574-4 2010 Previously, a moderate binding affinity between alpha-syn and Fe(II) (5.8x10(3)M(-1)) has been measured, but studies on the binding between alpha-syn and Fe(III) have not been reported. ammonium ferrous sulfate 62-68 synuclein alpha Homo sapiens 48-57 20005574-5 2010 In this work, electrospray mass spectrometry (ES-MS), cyclic voltammetry (CV), and fluorescence spectroscopy were used to study the binding between alpha-syn and Fe(II) and the redox property of the resultant alpha-syn-Fe(II) complex. ammonium ferrous sulfate 162-168 synuclein alpha Homo sapiens 148-157 20005574-5 2010 In this work, electrospray mass spectrometry (ES-MS), cyclic voltammetry (CV), and fluorescence spectroscopy were used to study the binding between alpha-syn and Fe(II) and the redox property of the resultant alpha-syn-Fe(II) complex. ammonium ferrous sulfate 162-168 synuclein alpha Homo sapiens 209-218 20005574-5 2010 In this work, electrospray mass spectrometry (ES-MS), cyclic voltammetry (CV), and fluorescence spectroscopy were used to study the binding between alpha-syn and Fe(II) and the redox property of the resultant alpha-syn-Fe(II) complex. ammonium ferrous sulfate 219-225 synuclein alpha Homo sapiens 148-157 20005574-10 2010 The roles of alpha-syn and its interaction with Fe(III) and/or Fe(II) are discussed in the context of oxidative stress, metal-catalyzed alpha-syn aggregation, and iron transfer processes. ammonium ferrous sulfate 63-69 synuclein alpha Homo sapiens 13-22 18211125-4 2008 Observed reaction rates are highly dependent on the structure of the Fe(II)-complexing ligand, solution composition, Fe(II) speciation, and NAC structure. ammonium ferrous sulfate 69-75 synuclein alpha Homo sapiens 140-143 18211125-8 2008 Tests also show that organothiol ligands can further promote NAC reduction indirectly by re-reducing the Fe(III) that forms when Fe(II) complexes are oxidized by reactions with the NACs. ammonium ferrous sulfate 129-135 synuclein alpha Homo sapiens 61-64 18592045-6 2007 DNMR experiments show that the free energies of activation for rotation of the amide bond are the same for Fe(2)[(SCH(2))(2)NAc](CO)(6) and Fe(2)[(SCH(2))(2)NAc](CO)(4)(PMe(3))(2), which implies that the ligands on the iron centers do not strongly affect the basicity of the nitrogen. ammonium ferrous sulfate 107-112 synuclein alpha Homo sapiens 124-127 18592045-6 2007 DNMR experiments show that the free energies of activation for rotation of the amide bond are the same for Fe(2)[(SCH(2))(2)NAc](CO)(6) and Fe(2)[(SCH(2))(2)NAc](CO)(4)(PMe(3))(2), which implies that the ligands on the iron centers do not strongly affect the basicity of the nitrogen. ammonium ferrous sulfate 140-145 synuclein alpha Homo sapiens 157-160 16246056-6 2005 A cell-permeable version of one such peptide was able to inhibit the DNA damage induced by Fe(II) in neuronal cells transfected with alpha-synuclein (A53T), a familial PD-associated mutation. ammonium ferrous sulfate 91-97 synuclein alpha Homo sapiens 133-148 16866548-4 2006 In this work we investigated the binding features of the divalent metal ions Fe(II), Mn(II), Co(II), and Ni(II), and their effects on AS aggregation. ammonium ferrous sulfate 77-83 synuclein alpha Homo sapiens 134-136 16984000-3 2006 Hydrogen peroxide is catalytically converted to the aggressive hydroxyl radical in the presence of Fe(II) and Cu(I), which renders amyloidogenic proteins such as beta-amyloid and alpha-synuclein (implicated in Alzheimer"s disease (AD) and Parkinson"s disease (PD), respectively) vulnerable to self-inflicted hydroxyl radical attack. ammonium ferrous sulfate 99-105 synuclein alpha Homo sapiens 179-194 14535945-0 2003 Fe(II)-induced DNA damage in alpha-synuclein-transfected human dopaminergic BE(2)-M17 neuroblastoma cells: detection by the Comet assay. ammonium ferrous sulfate 0-6 synuclein alpha Homo sapiens 29-44 15180968-7 2004 This ASID peptide was able to inhibit the DNA damage induced by Fe(II) in neuronal cells transfected with alpha-syn(A53T), a familial PD-associated mutation. ammonium ferrous sulfate 64-70 synuclein alpha Homo sapiens 106-115 16087241-6 2005 By way of contrast, beta-pleated conformers of NAC which were formed in the presence of Al(III) showed much lower levels of thioflavin T fluorescence and were poorer catalysts of the redox cycling of added Fe(II) and these properties were commensurate with an increased abundance of a novel amyloid morphology which consisted of twisted fibrils with a periodicity of about 100 nm. ammonium ferrous sulfate 206-212 synuclein alpha Homo sapiens 47-50 14535945-5 2003 Fe(II) treatment induced significant increases in CTL in cells transfected with A30P alpha-syn or A53T alpha-syn, even at the lowest concentrations of Fe(II) tested. ammonium ferrous sulfate 0-6 synuclein alpha Homo sapiens 85-94 14535945-5 2003 Fe(II) treatment induced significant increases in CTL in cells transfected with A30P alpha-syn or A53T alpha-syn, even at the lowest concentrations of Fe(II) tested. ammonium ferrous sulfate 0-6 synuclein alpha Homo sapiens 103-112 14535945-6 2003 In comparison, untransfected cells, vector control cells or cells transfected with wild-type alpha-syn exhibited increases in SSBs only when exposed to concentrations of 1.0 microm Fe(II) and above. ammonium ferrous sulfate 181-187 synuclein alpha Homo sapiens 93-102 14535945-7 2003 Even when exposed to higher concentrations (10.0-100.0 microm) of Fe(II), untransfected cells, vector control cells or cells transfected with wild-type alpha-syn were less susceptible to DNA-damage induction than cells transfected with A30P alpha-syn or A53T alpha-syn. ammonium ferrous sulfate 66-72 synuclein alpha Homo sapiens 152-161 14535945-7 2003 Even when exposed to higher concentrations (10.0-100.0 microm) of Fe(II), untransfected cells, vector control cells or cells transfected with wild-type alpha-syn were less susceptible to DNA-damage induction than cells transfected with A30P alpha-syn or A53T alpha-syn. ammonium ferrous sulfate 66-72 synuclein alpha Homo sapiens 241-250 14535945-7 2003 Even when exposed to higher concentrations (10.0-100.0 microm) of Fe(II), untransfected cells, vector control cells or cells transfected with wild-type alpha-syn were less susceptible to DNA-damage induction than cells transfected with A30P alpha-syn or A53T alpha-syn. ammonium ferrous sulfate 66-72 synuclein alpha Homo sapiens 241-250 14535945-9 2003 Susceptibility to Fe(II)-induced DNA damage appeared to be dependent on alpha-syn status because cells transfected with wild-type alpha-syn or A53T alpha-syn were equally susceptible to the damaging effects of the mitochondrial respiratory chain inhibitor rotenone. ammonium ferrous sulfate 18-24 synuclein alpha Homo sapiens 72-81 14535945-9 2003 Susceptibility to Fe(II)-induced DNA damage appeared to be dependent on alpha-syn status because cells transfected with wild-type alpha-syn or A53T alpha-syn were equally susceptible to the damaging effects of the mitochondrial respiratory chain inhibitor rotenone. ammonium ferrous sulfate 18-24 synuclein alpha Homo sapiens 130-139 14535945-9 2003 Susceptibility to Fe(II)-induced DNA damage appeared to be dependent on alpha-syn status because cells transfected with wild-type alpha-syn or A53T alpha-syn were equally susceptible to the damaging effects of the mitochondrial respiratory chain inhibitor rotenone. ammonium ferrous sulfate 18-24 synuclein alpha Homo sapiens 130-139 14535945-10 2003 Overall, our data are suggestive of an enhanced susceptibility to the toxic effects of Fe(II) in neuroblastoma cells transfected with mutant alpha-syn associated with inherited forms of PD. ammonium ferrous sulfate 87-93 synuclein alpha Homo sapiens 141-150 33096655-3 2020 Iron deposits are present in the core of Lewy bodies, and there are reports suggesting that divalent metal ions including Cu2+ and Fe2+ enhance the aggregation of alpha-Syn. ammonium ferrous sulfate 131-135 synuclein alpha Homo sapiens 163-172 12031892-3 2002 We have shown recently that solutions of A(beta) 1-40, A(beta) 1-42, A(beta) 25-35, alpha-synuclein and non-A(beta) component (NAC; residues 61-95 of alpha-synuclein) all liberate hydroxyl radicals upon incubation in vitro followed by the addition of small amounts of Fe(II). ammonium ferrous sulfate 268-274 synuclein alpha Homo sapiens 127-130 10208537-5 1999 Ferrous ion was not effective by itself, but it potentially aggregated NACP/alpha-synuclein in the presence of hydrogen peroxide. ammonium ferrous sulfate 0-11 synuclein alpha Homo sapiens 71-75 10208537-5 1999 Ferrous ion was not effective by itself, but it potentially aggregated NACP/alpha-synuclein in the presence of hydrogen peroxide. ammonium ferrous sulfate 0-11 synuclein alpha Homo sapiens 76-91 33096655-7 2020 Research over the past decade has shown that alpha-Syn has iron import functions with an ability to oxidize the Fe3+ form of iron to Fe2+ to facilitate its entry into cells. ammonium ferrous sulfate 133-137 synuclein alpha Homo sapiens 45-54 32104855-3 2020 In the present work, atomic force microscopy (AFM) is combined with Fourier Transform Infrared Spectroscopy (FTIR) measurements to investigate the interaction of wild-type (WT) and A53T mutated alpha synuclein with artificial lipid bilayers mimicking lipid raft (LR) domains, before and after ferrous cations (Fe2+) treatment. ammonium ferrous sulfate 310-314 synuclein alpha Homo sapiens 194-209