PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17652735-13 2007 CONCLUSIONS: IFN-alpha and IFN-gamma enhance the susceptibility of HTFs to MMC-induced cell death through a Fas-mediated and a caspase-3-dependent pathway. ammonium ferrous sulfate 108-111 interferon alpha 1 Homo sapiens 13-22 22838736-2 2012 Interferon (IFN) treatment sensitizes MM cells to Fas-induced apoptosis and is associated with an increased activation of Signal transducer and activator of transcription (Stat)1. ammonium ferrous sulfate 50-53 interferon alpha 1 Homo sapiens 0-10 22838736-2 2012 Interferon (IFN) treatment sensitizes MM cells to Fas-induced apoptosis and is associated with an increased activation of Signal transducer and activator of transcription (Stat)1. ammonium ferrous sulfate 50-53 interferon alpha 1 Homo sapiens 12-15 17593372-6 2007 CONCLUSIONS: Our data demonstrated that the IFN-alpha was able to induce Fas-mediated apoptosis together with a reduction in the tumor size; such an observation may suggest the importance to investigate still unexplored mechanisms to be exploited in craniopharyngioma therapy. ammonium ferrous sulfate 73-76 interferon alpha 1 Homo sapiens 44-53 15860671-0 2005 Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells. ammonium ferrous sulfate 38-41 interferon alpha 1 Homo sapiens 12-15 17045692-5 2007 Growth of Fas-positive hepatoma cell lines was inhibited by an agonistic anti-Fas antibody in a dose-dependent manner, and these effects were enhanced by IFNalpha or 5-FU alone, but even more so by combination therapy using both agents. ammonium ferrous sulfate 10-13 interferon alpha 1 Homo sapiens 154-162 16460686-3 2006 In MM cells undergoing IFN-induced sensitization to Fas-mediated apoptosis, the repression of telomerase was increased as compared to IFN-alpha treatment alone. ammonium ferrous sulfate 52-55 interferon alpha 1 Homo sapiens 23-26 16460686-3 2006 In MM cells undergoing IFN-induced sensitization to Fas-mediated apoptosis, the repression of telomerase was increased as compared to IFN-alpha treatment alone. ammonium ferrous sulfate 52-55 interferon alpha 1 Homo sapiens 134-143 15860671-10 2005 Taken together, our results show that IFN-induced up-regulation of Fas sensitizes MM cells to Fas-mediated apoptosis and suggest that attenuation of Stat3 activation may be a potentially important event in this process. ammonium ferrous sulfate 67-70 interferon alpha 1 Homo sapiens 38-41 15860671-9 2005 In addition, IFN treatment attenuated the interleukin 6 (IL-6)-dependent activation of signal transducer and activator of transcription 3 (Stat3), interfering with a known survival pathway in MM that has previously been linked with resistance to Fas-mediated apoptosis. ammonium ferrous sulfate 246-249 interferon alpha 1 Homo sapiens 13-16 10752980-9 2000 Responsiveness to Fas-induced apoptosis following stimulation with IFN-alpha correlates with the clinical effects of IFN-alpha therapy. ammonium ferrous sulfate 18-21 interferon alpha 1 Homo sapiens 67-76 15356120-5 2004 Later, upon activation, T cells that were exposed to IFN-alpha showed increased levels of surface Fas associated with partially processed caspase-8, a key component of the extrinsic apoptotic pathway. ammonium ferrous sulfate 98-101 interferon alpha 1 Homo sapiens 53-62 11804830-3 2002 beta2 microglobulin (BMG), neopterin and soluble (s) Fas increased with IFN-alpha and increased more with IFN-gamma. ammonium ferrous sulfate 53-56 interferon alpha 1 Homo sapiens 72-81 11391574-15 2001 With IFN-alpha therapy, major cytogenetic responses were noted in 30% of patients with high Fas and 53% with low Fas (P = 0.016) and failure to achieve a complete hematologic response (CHR) in 25% versus 2% (P = 0.0001). ammonium ferrous sulfate 113-116 interferon alpha 1 Homo sapiens 5-14 11305523-8 2001 On the other hand, in 55 patients who were examined the long-term response to IFN, about 60% of Fas-positive patients were HCV-RNA negative, whereas 30% of Fas-negative patients were HCV-RNA negative (P = 0.04). ammonium ferrous sulfate 96-99 interferon alpha 1 Homo sapiens 78-81 11391574-15 2001 With IFN-alpha therapy, major cytogenetic responses were noted in 30% of patients with high Fas and 53% with low Fas (P = 0.016) and failure to achieve a complete hematologic response (CHR) in 25% versus 2% (P = 0.0001). ammonium ferrous sulfate 92-95 interferon alpha 1 Homo sapiens 5-14 11391574-19 2001 In ECP CML, high Fas levels were associated with significantly worse response to IFN-alpha therapy and with significantly worse survival. ammonium ferrous sulfate 17-20 interferon alpha 1 Homo sapiens 81-90 10752980-9 2000 Responsiveness to Fas-induced apoptosis following stimulation with IFN-alpha correlates with the clinical effects of IFN-alpha therapy. ammonium ferrous sulfate 18-21 interferon alpha 1 Homo sapiens 117-126 9680367-5 1998 After priming with IFN-alpha, Fas triggering resulted in in vitro suppression of hematopoietic cell growth in seven of eight patients who had optimal hematologic response to IFN-alpha; in the same conditions, no inhibitory response to Fas-R agonist was observed in cells from three of three patients who proved to be poor responders to IFN-alpha. ammonium ferrous sulfate 30-33 interferon alpha 1 Homo sapiens 174-183 9763578-2 1998 In this study, we have examined the possibility to increase the sensitivity to Fas-induced apoptosis by pretreatment of MM cells with interferon-gamma (IFN-gamma) or interferon-alpha (IFN-alpha). ammonium ferrous sulfate 79-82 interferon alpha 1 Homo sapiens 184-193 9763578-3 1998 Both IFN-gamma and IFN-alpha markedly increased the Fas-induced apoptosis in all cell lines tested (U-266-1970, U-266-1984, and U-1958). ammonium ferrous sulfate 52-55 interferon alpha 1 Homo sapiens 19-28 9680367-5 1998 After priming with IFN-alpha, Fas triggering resulted in in vitro suppression of hematopoietic cell growth in seven of eight patients who had optimal hematologic response to IFN-alpha; in the same conditions, no inhibitory response to Fas-R agonist was observed in cells from three of three patients who proved to be poor responders to IFN-alpha. ammonium ferrous sulfate 30-33 interferon alpha 1 Homo sapiens 174-183 9680367-9 1998 It appears that Fas-mediated downmodulation of p210 bcr/abl restores susceptibility to apoptosis of CML cells; in addition, in vitro studies on CML cells may predict response to IFN-alpha treatment. ammonium ferrous sulfate 16-19 interferon alpha 1 Homo sapiens 178-187