PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19155494-7 2009 These Treg, when activated via TCR plus IL-2, up-regulated CD95 and CD95L expression (p < 0.001) and suppressed CD8(+) RC proliferation (p < 0.001) by inducing Fas-mediated apoptosis. ammonium ferrous sulfate 166-169 interleukin 2 Homo sapiens 40-44 27356894-4 2016 Defective IL-2 signaling in these subjects, which drives reduced protection from Fas-mediated apoptosis, was also associated with memory CD4 T-cell loss. ammonium ferrous sulfate 81-84 interleukin 2 Homo sapiens 10-14 17592174-3 2007 In this study, the effect of these FAs on the interleukin-2 (IL-2) signaling pathway in human lymphocytes was investigated. ammonium ferrous sulfate 35-38 interleukin 2 Homo sapiens 46-59 17993614-5 2008 Exposure to interleukin-2 (IL-2) for only 24 hours sensitized leukemic LGL to Fas-mediated apoptosis with enhanced formation of the DISC, and increased caspase-8 and caspase-3 activities. ammonium ferrous sulfate 78-81 interleukin 2 Homo sapiens 12-25 17993614-5 2008 Exposure to interleukin-2 (IL-2) for only 24 hours sensitized leukemic LGL to Fas-mediated apoptosis with enhanced formation of the DISC, and increased caspase-8 and caspase-3 activities. ammonium ferrous sulfate 78-81 interleukin 2 Homo sapiens 27-31 18666849-10 2008 In patients with ESKD and especially in those that are chronically hemodialyzed, oxidative stress induced by oxidized LDLs may increase CD4+/CD25+ Treg sensitivity to Fas-mediated apoptosis as a consequence of specific dysregulation of IL-2 expression. ammonium ferrous sulfate 167-170 interleukin 2 Homo sapiens 236-240 17592174-3 2007 In this study, the effect of these FAs on the interleukin-2 (IL-2) signaling pathway in human lymphocytes was investigated. ammonium ferrous sulfate 35-38 interleukin 2 Homo sapiens 61-65 15163118-3 2004 In an in vitro model system, PHA-stimulated T-cells, upon prolonged culture in IL-2, acquire a sensitive phenotype to Fas-mediated apoptosis. ammonium ferrous sulfate 118-121 interleukin 2 Homo sapiens 79-83 15884050-2 2005 In the presence of IL-2, human CD8(+) T cell blasts were more sensitive than CD4(+) T cell blasts to regulation by APO2 ligand/TNF-related apoptosis-inducing ligand (APO2L/TRAIL), while both T cell subsets were equally sensitive to Fas/CD95 regulation. ammonium ferrous sulfate 232-235 interleukin 2 Homo sapiens 19-23 12023352-4 2002 Paradoxically, autocrine IL-2 negatively regulated the overall magnitude of the CD8 T cell response in nonlymphoid tissues via a Fas-independent mechanism. ammonium ferrous sulfate 129-132 interleukin 2 Homo sapiens 25-29 10227994-6 1999 Inhibition of IL-2 production by cyclosporin A, or inhibition of IL-2 signaling by rapamycin or anti-IL-2 neutralizing Abs prevents the decrease in FLIP levels and confers resistance to Fas-mediated apoptosis following T cell activation. ammonium ferrous sulfate 186-189 interleukin 2 Homo sapiens 65-69 12687214-10 2001 Activation-induced T cell death in surgical infections appeared to be Fas-dependent, involved reactive oxygen intermediates and was partly prevented by pro-inflammatory cytokines, among which IL-2 exhibited the most pronounced anti-apoptotic activity. ammonium ferrous sulfate 70-73 interleukin 2 Homo sapiens 192-196 10514006-1 1999 IL-2 is an important growth and survival factor for T lymphocytes but also sensitizes these cells to Fas-mediated activation-induced cell death (AICD). ammonium ferrous sulfate 101-104 interleukin 2 Homo sapiens 0-4 12471726-5 2002 Our results suggest that IL-2 treated CTL can lyse target cells predominantly via Fas-mediated mechanism and to a lesser extent via a granule exocytosis-based mechanism. ammonium ferrous sulfate 82-85 interleukin 2 Homo sapiens 25-29 11110703-4 2000 Addition of IFN-alpha or interleukin-2 (IL-2) to culture medium resulted in significant protection against spontaneous but not Fas-induced apoptosis. ammonium ferrous sulfate 127-130 interleukin 2 Homo sapiens 25-38 11110703-4 2000 Addition of IFN-alpha or interleukin-2 (IL-2) to culture medium resulted in significant protection against spontaneous but not Fas-induced apoptosis. ammonium ferrous sulfate 127-130 interleukin 2 Homo sapiens 40-44 10227994-6 1999 Inhibition of IL-2 production by cyclosporin A, or inhibition of IL-2 signaling by rapamycin or anti-IL-2 neutralizing Abs prevents the decrease in FLIP levels and confers resistance to Fas-mediated apoptosis following T cell activation. ammonium ferrous sulfate 186-189 interleukin 2 Homo sapiens 65-69 9665752-2 1998 After prolonged treatment with interleukin-2 (IL-2), these T cells develop a Fas-sensitive phenotype. ammonium ferrous sulfate 77-80 interleukin 2 Homo sapiens 31-44 9665752-2 1998 After prolonged treatment with interleukin-2 (IL-2), these T cells develop a Fas-sensitive phenotype. ammonium ferrous sulfate 77-80 interleukin 2 Homo sapiens 46-50 9130610-7 1997 In addition, Fas-mediated apoptotic cell death of AML cells is also induced by interleukin-2-activated T cells expressing functional FasL on their surfaces. ammonium ferrous sulfate 13-16 interleukin 2 Homo sapiens 79-92 14646508-9 1998 (ii) NK cells exposed to Fas+ TC completely recover the Fas lytic pathway and the ability to fragment DNA via the Fas/Fas ligand when incubated in medium supplemented with IL-2 for 18 h. ammonium ferrous sulfate 25-28 interleukin 2 Homo sapiens 172-176 8906804-0 1996 Human T cells require IL-2 but not G1/S transition to acquire susceptibility to Fas-mediated apoptosis. ammonium ferrous sulfate 80-83 interleukin 2 Homo sapiens 22-26