PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18575774-2	2008	However, the effects of IL-18 on Fas-mediated liver injury have not been well elucidated.	ammonium ferrous sulfate	33-36	interleukin 18	Mus musculus	24-29	
18575774-3	2008	Therefore, we examined the effects of IL-18 on Fas-mediated apoptosis in in vitro and in vivo experiments.	ammonium ferrous sulfate	47-50	interleukin 18	Mus musculus	38-43	
18575774-4	2008	We found that recombinant IL-18 protected mouse hepatocellular carcinoma cell lines, BNL5, from Fas-mediated apoptosis in a dose-dependent manner with up-regulation of both nuclear factor (NF) kappaB and X-linked inhibitors of apoptosis (XIAP).	ammonium ferrous sulfate	96-99	interleukin 18	Mus musculus	26-31	
18575774-5	2008	IL-18 transgenic (Tg) mice were also protected from Fas-mediated liver injury and this was further confirmed by histological study and TUNEL staining.	ammonium ferrous sulfate	52-55	interleukin 18	Mus musculus	0-5	
18575774-7	2008	These results suggest that IL-18 suppresses Fas-mediated apoptosis of hepatocytes by up-regulation of NFkappaB and XIAP, following inhibition of caspase-3 activity.	ammonium ferrous sulfate	44-47	interleukin 18	Mus musculus	27-32	
14960523-5	2004	Furthermore, cross linking of Fas increased significantly the apoptosis rate in hepatocytes isolated from wild- type mice but to a much lesser extent in IL-18 Tg mice, suggesting spontaneous activation of the Fas pathway in the latter mice.	ammonium ferrous sulfate	30-33	interleukin 18	Mus musculus	153-158	
10925263-10	2000	Experiments performed in MRL/lpr mice indicated that IL-12/IL-18-derived NK cells displayed their distinct killer activity through a Fas-independent pathway.	ammonium ferrous sulfate	133-136	interleukin 18	Mus musculus	59-64	
26394985-13	2015	Unlike HMGB1, Fas-induced IL-1 and IL-18 were not essential for tEAU induction.	ammonium ferrous sulfate	14-17	interleukin 18	Mus musculus	35-40	
10807517-4	2000	Propionibacterium acnes-primed lipopolysaccharide (LPS)-challenged liver injury is the prototype of IL-18-induced tissue injury, in which IL-18 acts on natural killer cells to increase Fas ligand (FasL) that causes liver injury by induction of Fas-dependent hepatocyte apoptosis.	ammonium ferrous sulfate	185-188	interleukin 18	Mus musculus	100-105	
10807517-4	2000	Propionibacterium acnes-primed lipopolysaccharide (LPS)-challenged liver injury is the prototype of IL-18-induced tissue injury, in which IL-18 acts on natural killer cells to increase Fas ligand (FasL) that causes liver injury by induction of Fas-dependent hepatocyte apoptosis.	ammonium ferrous sulfate	185-188	interleukin 18	Mus musculus	138-143	
10414464-8	1999	When Fas-expressing cells and their parental cells were used as targets, weak Fas-mediated cytolytic activity was observed after exposure to IL-18, and this was further enhanced by combination with IL-10.	ammonium ferrous sulfate	5-8	interleukin 18	Mus musculus	141-146	
10395644-10	1999	We conclude that the antitumor effect of IL-18 is exerted predominantly through a Fas-dependent pathway.	ammonium ferrous sulfate	82-85	interleukin 18	Mus musculus	41-46