PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25281393-6	2014	BA treatment caused a reduction in TNF-alpha production induced by LPS but did not alter IL-6 production.	betulinic acid	0-2	tumor necrosis factor	Mus musculus	35-44	
34345387-11	2021	The results showed that betulinic acid could increase insulin and C-peptide, and decrease fasting blood sugar, kidney lesions and TNF-alpha, IFN-gamma, IL-1 in the treated groups.	betulinic acid	24-38	tumor necrosis factor	Mus musculus	130-139	
33322178-9	2020	Furthermore, treatment with 1 mg/kg BA downregulated the expression of p-NF-kappaB and p-IkappaB-alpha proteins in the intestine, while all doses of BA suppressed the pro-inflammatory cytokines expression of IL-1beta, IL-6 and TNF-alpha mRNAs and increased the anti-inflammatory cytokine expression of IL-10 mRNA in the intestine of T-2 toxin-exposed mice.	betulinic acid	36-38	tumor necrosis factor	Mus musculus	227-236	
31129421-14	2019	Furthermore, BA inhibited gene expression of pro-inflammatory mediators in skin lesions, including RORgammat, IL-17A, IL-6 and TNFalpha.	betulinic acid	13-15	tumor necrosis factor	Mus musculus	127-135	
25281393-11	2014	BA-treated peritoneal exudate macrophages produced lower concentrations of TNF-alpha and NO and higher concentrations of IL-10 upon LPS stimulation.	betulinic acid	0-2	tumor necrosis factor	Mus musculus	75-84	
25281393-13	2014	In conclusion, we have shown that BA has a potent anti-inflammatory activity in vivo, protecting mice against LPS by modulating TNF-alpha production by macrophages in vivo through a mechanism dependent on IL-10.	betulinic acid	34-36	tumor necrosis factor	Mus musculus	128-137	
14723345-2	2003	We postulated that BA modulates the immunomodulatory properties at least two groups of protein mediators of inflammation, interleukin-1beta (IL-1beta) and the tumor necrosis factor-alpha (TNF-alpha) on the basis of the critical role of the monocytes and tissue macrophages in inflammatory and immune responses.	betulinic acid	19-21	tumor necrosis factor	Mus musculus	159-186	
14723345-2	2003	We postulated that BA modulates the immunomodulatory properties at least two groups of protein mediators of inflammation, interleukin-1beta (IL-1beta) and the tumor necrosis factor-alpha (TNF-alpha) on the basis of the critical role of the monocytes and tissue macrophages in inflammatory and immune responses.	betulinic acid	19-21	tumor necrosis factor	Mus musculus	188-197	
14723345-3	2003	TNF-alpha and IL-1beta were produced by BA in a dose dependent manner at concentration of 0.625 and 10 microg/mL.	betulinic acid	40-42	tumor necrosis factor	Mus musculus	0-9	
34628148-6	2021	Meanwhile, BA pretreatment markedly attenuated T-2 toxin-induced renal inflammatory response by decreasing the mRNA expression of IL-1beta, TNF-alpha and IL-10, and increasing IL-6 mRNA expression.	betulinic acid	11-13	tumor necrosis factor	Mus musculus	140-149