PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27748864-2 2016 The antitumor pharmacological effects of BA consist of triggering apoptosis via the mitochondrial pathway, regulating the cell cycle and the angiogenic pathway via factors, including specificity protein transcription factors, cyclin D1 and epidermal growth factor receptor, inhibiting the signal transducer and activator of transcription 3 and nuclear factor-kappaB signaling pathways, preventing the invasion and metastasis of tumor cells, and affecting the expression of topoisomerase I, p53 and lamin B1. betulinic acid 41-43 cyclin D1 Homo sapiens 226-235 33719271-10 2020 Conclusion: The betulinic acid regulates the proliferation of SGC-7901 cells by inhibiting the expressions of cyclin D1 and cyclin B1, which leads to cell cycle arrest and proliferative inhibition. betulinic acid 16-30 cyclin D1 Homo sapiens 110-119 34374237-6 2021 Conclusion: At a final concentration of 10~30 mug/ml, betulinic acid can reduce the proliferation of human gastric cancer MGC-803 cells, inhibit cell growth, and down-regulate the expression of CCNB1 and CCND1 to block human gastric cancer MGC-803 cells in the S phase. betulinic acid 54-68 cyclin D1 Homo sapiens 204-209 19937797-6 2010 Betulinic acid also downregulated the expression of STAT3-regulated gene products such as bcl-xL, bcl-2, cyclin D1 and survivin. betulinic acid 0-14 cyclin D1 Homo sapiens 105-114 26013878-0 2016 PI3K target based novel cyano derivative of betulinic acid induces its signalling inhibition by down-regulation of pGSK3beta and cyclin D1 and potentially checks cancer cell proliferation. betulinic acid 44-58 cyclin D1 Homo sapiens 129-138