PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12606824-0	2002	Betulinic acid-induced Mcl-1 expression in human melanoma--mode of action and functional significance.	betulinic acid	0-14	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	23-28	
32277808-11	2020	Western blotting of HKULC2 cells showed that betulinic acid nanoparticles promoted the expression of p21 and p53 and downregulated CD133, ALDH, BCL2, MCL1, and c-Myc expression.	betulinic acid	45-59	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	150-154	
12606824-7	2002	RESULTS: Upregulation of Mcl-1 in human melanoma cells by betulinic acid is mediated via a signal-transduction pathway that is inhibited by LY294002 and wortmannin.	betulinic acid	58-72	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	25-30	
12606824-9	2002	The inhibitor PD98059 reduced expression levels of Mcl-1 in melanoma cells and this effect was counteracted by betulinic acid.	betulinic acid	111-125	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	51-56	
12606824-11	2002	CONCLUSIONS: These results suggest that in human melanoma cells Mcl-1 is (i) of functional relevance for survival and (ii) subject to dual regulation by the MAP- kinase pathway and a pathway involving protein kinase B/Akt, the latter of which is modulated in response to betulinic acid.	betulinic acid	271-285	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	64-69	
26425662-5	2015	Knockdown of Mcl-1 in CRPC cells leads to elevated gammaH2AX, DNA strand breaks, and cell death after treatment with 1198 + BA- or doxorubicin.	betulinic acid	124-126	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	13-18	
12606824-2	2002	This study investigates the regulation and expression of Mcl-1 in human melanoma cells, which was recently found to be induced by betulinic acid, a compound with anti-melanoma and apoptosis-inducing potential.	betulinic acid	130-144	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	57-62	
10771474-7	2000	Notably, despite the induction of apoptosis, analysis of the expression of Bcl-2 family members in betulinic-acid-treated cells revealed that expression of the anti-apoptotic protein Mcl-1 was induced.	betulinic acid	99-113	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	183-188